Lorenz @studerl Twitter profile

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Lorenz

@studerl

9 months

Excited to see our work - showing that an epigenetic barrier sets the pace of human neuronal maturation - published @Nature . This is the “opus magnum” of @gabriele_ciceri in the lab @MSKCancerCenter with huge thanks to all the collaborators involved .

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@studerl

2 years

Why do human neurons mature so slowly? Two studies from the lab tackle this issue. The first study led by @gabriele_ciceri identifies an epigenetic barrier that sets protracted maturation timing of human neurons already at the neural precursor stage

An epigenetic barrier sets the timing of human neuronal maturation

The pace of human brain development is highly protracted compared to most other species. The maturation of cortical neurons is particularly slow, extending over months to years to reach adult-like...

www.biorxiv.org

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@studerl

3 years

It’s official… MSK-DA01 is in the clinic with first PD patient dosed (see info @BlueRockTx ). Thanks to everyone involved, most importantly @TabarViviane @MSKNeurosurgery , Mark Tomishima, @biogosi & the @BlueRockTx @sloan_kettering WCM teams and many more

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@studerl

4 years

We recently got FDA clearance for clinical trial in Parkinson’s disease to replace lost nerve cells, and helped co-found @BlueRockTx bringing biotech jobs to NYC. None of that would have been possible without NYSTEM @TabarViviane @SeawrightForNY #SupportNYSTEM @AMSNewYork

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@studerl

10 months

The GENtoniK paper is finally out in Nat Biotech! A chemical cocktail to drive maturation of neurons and other hPSC-derived cell types. Congrats to Emiliano, Andrew, @OberstPolina , @YZorina , @BaggioliniA , @ChenShuibing @gabriele_ciceri and many others.

Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived...

Nature Biotechnology - Neurons derived from stem cells are rapidly matured with a GENtoniK cocktail.

www.nature.com

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@studerl

4 years

Ten years to develop differentiation protocol, another ten to get green light for clinical testing of our dopamine neurons. Thanks also to Viviane and team @MSKNeurosurgery for being part of the whole journey and key to the clinical journey to come @sloan_kettering @BlueRockTx

Stefan Irion

@bigosi

4 years

I could not be more proud and excited to have worked with the brightest minds in the field to bring our dopamine cell therapy into the clinic and to patients in need @BlueRockTx @sloan_kettering @studerl

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@studerl

6 years

Our paper on generating topographically organized human forebrain organoids is out in NBT. For full text access see . Congrats to Gustav and the whole team. For an excellent News & Views on the paper see from @PascaStanford

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@studerl

4 years

Congrats to Sudha for @NatureNeuro paper on microglia differentiation and tri-culture technology to dissect cell type-specific inflammatory cross talk in hPSC model of AD with @jtchieu , @NatSaurat , @harschnitz , Ryan, Gabriele & Lisa, Dana Pe'er and others

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@studerl

3 years

Grateful to be selected for the 2022 ISSCR Achievement Award Thanks to all the trainees @sloankettering @MSK_CSCB and all the colleagues who made the work possible. Congrats to other 2022 ISSCR awardees @CreminsLab @SJMorrison_ and Joanna.

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@studerl

1 year

Excited to share initial press release @BlueRockTx on promising results of Phase 1 trial in 12 PD patients . A major milestone on a 20+ year journey. Amazing leadership by @TabarViviane , @MSKCancerCenter & @BlueRockTx ( @bigosi , Mark Tomishima & many more).

BlueRock’s neuronal stem cell therapy for Parkinson’s disease is first to show positive results in...

Investigational Bemdaneprocel (BRT-DA01) was well tolerated with no major safety issues in all 12 patients through one year Assessment of secondary endpoints demonstrates feasibility of transplanta...

www.bluerocktx.com

Viviane Tabar

@TabarViviane

1 year

Data from Ph 1 trial of dopamine neuron grafts in patients with #Parkinsons are very promising: a long standing dream & lots of work;Excited for #Parkinson patients & proud of the team my lab led by JinghuaPiao @studerl lab, @MSKCancerCenter @BlueRockTx

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@studerl

4 years

For anyone looking for a faculty position here at the Center for Stem Cell Biology and the DB program @sloan_kettering in NYC. We have an open search with an Oct 15, 2020 deadline. For more information see: or contact me at studerl @mskcc .org.

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@studerl

2 years

Congrats to @BaggioliniA from our lab @MSKCancerCenter @MSK_CSCB as a winner of the 2022 Tri-I Breakout Prize. Pic from yesterday at Rockefeller University. Excited to hear about your future achievements in your own lab in Switzerland

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@studerl

3 years

Open search for new faculty positions at the Center for Stem Cell Biology and the DB program @sloan_kettering . Deadline for applications is October 15, 2021. For more info see or contact me directly at studerl @mskcc .org.

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@studerl

2 years

In vivo gut motility controlled by grafted human PSC-derived ENS in severe mouse model of Hirschsprung’s disease. Study now published @CellStemCell on sacral-derived ENS precursors . Huge effort by Yujie Fan and an amazing team of collaborators @MSK_CSCB

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@studerl

4 years

Our cell line pooling paper is out indicating autism-related mutations modulate PFC neurogenesis and response to WNT signaling. Approach may be broadly useful in hPSC disease modeling. Thanks to Gustav, @jtchieu , Scott, others @whitefishlab , @ChenShuibing , Tomishima, @studerl lab

Cell Stem Cell

@CellStemCell

4 years

A new paper from @studerl Lab reports on "A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes"

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@studerl

2 years

Why and when do grafted neurons die? Preprint by @TaeWanKim0 @_SoyeonKoo from lab & collab. uses in vivo CRISPR screen to identify TNFa-NFkB-p53 loop restricting hPSC-DA neuron survival, and offers clinically relevant solution @MSK_CSCB @MSKCancerCenter

TNF-NFkB-p53 axis restricts in vivo survival of hPSC-derived dopamine neuron

Ongoing, first-in-human clinical trials illustrate the feasibility and translational potential of human pluripotent stem cell (hPSC)-based cell therapies in Parkinson’s disease (PD). However, a major...

www.biorxiv.org

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@studerl

1 year

Tomorrow is the deadline for faculty applications at Sloan Kettering (). For applicants interested in the Center for Stem Cell Biology, we are linked closely with the Developmental Biology Program search

Tenure Track Faculty Positions in Developmental Biology - New York City, New York

Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center invites applications for

careers.cell.com

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@studerl

9 months

hPSC midbrain DA neurons are susceptible to SARS-CoV2 and undergo senescence response. This is modulated by a-syn, and autopsy data suggest PD relevance. Thanks to @ChenShuibing and the many collaborators - in my lab especially @TaeWanKim0 & @harschnitz .

SARS-CoV-2 infection causes dopaminergic neuron senescence

Yang and colleagues demonstrate that SARS-CoV-2 can infect hPSC-derived midbrain dopamine (DA) neurons and induce cellular senescence. Several drug candidates were identified to rescue SARS-CoV-2...

www.cell.com

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@studerl

6 years

Humbling, looking through the list of previous awardees. Huge shout-out to all students and postdocs from the lab - current and past - who made this work possible. Parkinson's disease researcher wins Gabbay Award | BrandeisNOW

Parkinson's disease researcher wins Gabbay Award | BrandeisNOW

Pioneering stem cell biologist Lorenz Studer has been awarded the 2018 Jacob Heskel Gabbay Award in Biotechnology and Medicine.

www.brandeis.edu

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@studerl

3 years

hPSC side-by-side with zebrafish approaches to study mechanisms of oncogenic competence in melanoma. Exciting collaboration with @whitefishlab now in @ScienceMagazine . Particular thanks to @BaggioliniA and Scott Callahan & all the amazing collaborators.

Developmental chromatin programs determine oncogenic competence in melanoma

Chromatin factors serve as oncogenic competence factors for melanoma initiation.

www.science.org

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@studerl

6 years

Human pluripotent-derived forebrain organoids; Dopamine neuron grafts from our GMP batch re-innervating striatum. Lab images are spreading through the floors of RRL @sloan_kettering . Thanks to Ryan and to thanks to NYSTEM team, particularly Jinghua.

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@studerl

2 years

The second study led by @ejhergenreder presents chemical strategy , to drive maturation in human neurons. The new GENtoniK cocktail can drive maturation in multiple hPSC-derived cell types and trigger maturation related behavior even in non-neural lineages.

Combined small molecule treatment accelerates timing of maturation in human pluripotent stem...

The maturation of human pluripotent stem cell (hPSC)-derived neurons mimics the protracted timing of human brain development, extending over months and years to reach adult-like function. Prolonged...

www.biorxiv.org

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@studerl

8 months

Our review is out @NatureAging on models on neuronal senescence in aging and neurodegeneration, focusing particularly on human PSC-based approaches . This was an effort led by @IsabelleLuzy working with several other teams part of @ASAP_Research .

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@studerl

2 years

Exciting opportunity in stem cell biology! The Center for Stem Cell Biology @MSK_CSCB @MSKCancerCenter has an ongoing search for new tenure track faculty. Deadline is October 17, 2022. For more info see or contact me directly at studerl @mskcc .org.

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@studerl

9 months

“Why human brain cells grow so slowly?” This is a video piece on our epigenetic barrier paper at @NatureVideoChannel on @YouTube .

Why human brain cells grow so slowly

Growing human neurons in the lab can be a time-consuming process. Some cortical cells take years to reach maturity - many times slower than the equivalent ce...

www.youtube.com

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@studerl

7 months

Very excited to get the opportunity to help shaping the vision of this amazing organization and to work with all the current and new colleagues, leaders and staff who make #ISSCR so successful. Big congrats to Tenneille, @Thomas_Rando and Jacqueline as the new board members!

ISSCR

@ISSCR

7 months

🎉Congratulations #ISSCR vice president-elect @studerl @MSKCancerCenter & to the 3 newly elected Board members: Jacqueline Barry @CGTCatapult , Tenneille Ludwig @WiCellResearch & @Thomas_Rando @UCLA @UCLAnewsroom @ParmarLab @KyotoU_News @lunduniversity

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@studerl

6 years

Jason’s NFIA story (full text: ). Rapidly generating bona fide astrocytes from hPSCs. Mechanism implicates G1 cell cycle length as contributor to gliogenic switch. Having fun mimicking drawings of Ramón y Cajal... @sloan_kettering

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@studerl

1 year

Preprint led by @chaozhangw @NatSaurat @dbetel on a strategy for measuring/manipulating cellular age . “RNAge” is used to track induced aging strategies in iPSC human neurons & to perform in silico screen for identifying novel aging & rejuvenation compounds

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@studerl

4 years

Yes, two papers in current CSC issue: first major update of our mDA neuron diff protocol (since Kriks et al.); data on GMP manufacturing and IND enabling studies. Thanks to everyone involved, @TabarViviane , @TaeWanKim0 , Jinghua Piao, Mark Tomishima, @9soyeon and many more.

Viviane Tabar

@TabarViviane

4 years

Our paper are out! A long and difficult path with the reward of a clinical trial just opened. And nice cover! Thanks to members of the @TabarViviane lab @MSKNeurosurgery and @studerl labs. Thanks as well to @CellstemCell editors and staff. #Parkinsons

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@studerl

5 years

Exciting next step in the journey to bring hPSC cell therapy approaches to the patient - including our own efforts in Parkinson’s disease and other neurological targets.

BlueRock Therapeutics

@BlueRockTx

5 years

We are pleased to announce that one of our founding investors, @BayerPharma , is building a leading position in #celltherapy by acquiring #BlueRock in its entirety.

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@studerl

10 months

GENtoniK factors were identified in a chemical screen and induce morphological, transcriptional, and functional maturation. Compounds target epigenetic (DOT1L, KDM1A) and activity dependent drivers of maturation. See related Research Briefing

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@studerl

4 years

Do dopamine neuron grafts need an additional boost? Our N&V @nature on use of GDNF by Gantner et al. and possibly other genetic strategies to give cells some “extra help”. @sloan_kettering @MSKNeurosurgery

Parkinson’s disease grafts benefit from well-timed growth factor

Nature - Steps to improve function and survival of dopamine-neuron transplants.

www.nature.com

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@studerl

5 years

Outstanding line-up of speaker for anyone interested in pluripotent stem cells in Neuroscience (see ). A meeting completely virtual, without waste/pollution of travel, very low cost and allowing questions from audience. Should be fun! # #SfNvirtual , #

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@studerl

3 years

A belated congrats to Emiliano in our lab who recently defended – brilliantly - his Neuroscience PhD @WeillCornell & @sloan_kettering tackling the intriguing problem of neuronal maturation timing in human PSCs – more on his work hopefully to follow very soon in print…

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@studerl

7 months

Congrats to @BaggioliniA , Ryan Walsh, @giacomelli_eli , @gabriele_ciceri , @Rittenhouse_CA , @rluongo90 and collaborators. A great team effort that emerged organically from within the lab and got a life on its own. Many more stories to come from the @BaggioliniA lab.

Arianna Baggiolini

@BaggioliniA

7 months

📢📢📢How can we obtain a robust outer radial glia (oRG) population in 🧠organoids from guided differentiation? Exogenous LIF does the trick. Our new paper shows that cortical pericytes are among the cell types secreting LIF. Adding pericytes to cortical organoids recapitulates

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@studerl

5 years

Graduation day at @sloan_kettering ! Very proud of my two most recent graduates Gustav Cederquist @TriIMDPhD & Scott Callahan @GSKGradSchool and to Yujie Fan (in the front), a current @WeillCornellGS student in the lab, and the winner of the Frank Lappin Horsfall, Jr. Fellowship.

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@studerl

7 months

Exciting developments for organoid research at @IHB_Research with Juergen @Knoblich_lab taking on the leadership and Matthias @TheLutolfLab as head of translational bioengineering. Many breakthroughs to come - from basic biology to capturing the full translational potential.

Institute of Human Biology

@IHB_Research

7 months

🎇Big news! Prof Juergen Knoblich @IMBA_Vienna @oeaw @MedUni_Wien joins #TeamIHB as its new Head. Bringing extensive leadership experience, he is also a pioneer in #organoids biology. His lab was 1st to develop an organoid model for a human brain disorder. Welcome @Knoblich_lab !

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@studerl

4 years

Interested in helping to lead a major iPSC effort to understand mechanisms of Parkinson’s disease? We have open position for PhD level program manager working on our collaborative @ASAP_Research grant. Please contact me at studerl @mskcc .org for more information.

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@studerl

3 years

Congrats to @FaranakFattahi for her new faculty position at UCSF. I am sure a lot of exciting new science to come on human PSCs, neural crest, the enteric nervous system and beyond!

Krogan Lab

@KroganLab

3 years

Lunch for newest CMP faculty member @FaranakFattahi alongside @JuraLab_UCSF , @realJimWells , and @AWilliamslab . Welcome to UCSF! @QBI_UCSF

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@studerl

5 years

Congratulations to Alex Joyner for winning the ISTT Prize for her pioneering work on homologous recombination in ES cells. There could be no better person for this prize! @sloan_kettering @MSK_CSCB

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@studerl

5 years

Congrats to Daniela, Chao, @dbetel , and rest of team for exciting collaboration on the impact of lipid deprivation in hPSCs. A journey from clinical grade culture conditions & differentiation propensity to metabolic, signaling & epigenetic mechanisms regulating pluripotent state.

Cell Stem Cell

@CellStemCell

5 years

New paper from @studerl & co: Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs #stemcells @sloan_kettering

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@studerl

6 years

For anyone interested in a faculty position here at the Center for Stem Cell Biology and the DB program @sloan_kettering in NYC. We have a newly opened search with an Oct 15 application deadline. For more information see:

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@studerl

1 year

Really enjoyed the meeting #StemCellNiche2023 . Also – an interesting experience to see your talk (and yourself!) being converted in real-time into an artistic illustration.

Novo Nordisk Foundation Science Cluster

@ScienceCluster

1 year

Closing #StemCellNiche2023 with @studerl from @MSKCancerCenter 🧠 From #CellFate to maturation – directing human #PSC -derived neural lineages 🧫 #biology #stemcells #science @novonordiskfond

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@studerl

4 years

NYSTEM support helped @sloan_kettering Institute postdoctoral training @MSK_CSCB obtain over $2 million in additional funding, eliminating NYSTEM puts future funding at risk, #SupportNYSTEM @SeawrightForNY #WomenInSTEM @AMSNewYork

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@studerl

5 years

The lay version of @cornaccd and Chao's @CellStemCell paper. Stem Cells Stay “Young” on a Fat-Free Diet

Stem Cells Stay “Young” on a Fat-Free Diet

Researchers have discovered a simple way to keep stem cells in a more flexible state for research and potential treatments.

www.mskcc.org

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@studerl

1 year

Excited to see this finally published. Thanks to @homamajd & @FaranakFattahi lab for pushing it over finish line after MANY(!) years. An unexpected role for Schwann cells in diabetic neuropathy and for atypical antidepressant (Bupropion) in potentially preventing/treating it.

Homa Majd

@homamajd

1 year

Our Schwann cell paper is out! Huge thank you to the entire team who made this possible, especially @FaranakFattahi and @studerl . The review and editorial processes at @CellStemCell took our study to a new level 😎 I cannot wait for you to check it out!

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@studerl

3 years

Big thanks to @giacomelli_eli & @BVahsen for spearheading effort – @CellStemCell review on progress in iPSC-models for ALS, a window into broader successes & challenges of modeling neurodegeneration. Here, direct link to full text

Elisa Giacomelli

@giacomelli_eli

3 years

As a result of a beautiful collaboration between the @studerl and the Talbot lab, I am pleased to share our review on ALS and iPSC models of neurodegeneration in @CellStemCell . A very special thank you to @BVahsen for his terrific work as co-author!

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@studerl

2 years

Congrats to @FaranakFattahi and @homamajd as well as @ChenShuibing and other co-authors. Excited to see this work in pre-print on optimized Schwann cell derivation, engraftment, disease modeling, drug screen, and assessment of bupropion as candidate drug for diabetic neuropathy.

Faranak Fattahi

@FaranakFattahi

2 years

In collaboration with the @studerl lab, we derived Schwann cells from hPSCs! They can engraft and make myelin in vivo, model Schwann cell damage in diabetes and help identify a therapeutic candidate. Check out our new preprint by @homamajd et al:

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@studerl

3 years

A belated cheer to @harnschnitz for his faculty position @HumanTechnopole starting in Jan, 2022. He will be an outstanding PI, mentor and scientist, so if you are interested in working on human PSCs for modeling neuro-immunological disease, this will be the place to be!

Human Technopole

@humantechnopole

3 years

Introducing new Group Leaders in Genomics and Neurogenomics: a very warm welcome to Blagoje, Lorenzo, Oliver, Elena and Jose! Learn more about the challenges they address through their research and what brought them to HT:

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@studerl

4 years

Congrats to @BaggioliniA and to Scott and many others who made this work possible. After 20 years at MSK finally our first true cancer story from the lab - making use our PSC approaches, combined with a powerful zebrafish model - in an awesome collaboration with @whitefishlab .

Arianna Baggiolini

@BaggioliniA

4 years

Excited to share our work now as a preprint. Using zebrafish and a novel hPSC-derived cancer model, we investigate the mechanisms underlying melanoma competence. Thanks to everybody involved in this work ⁦ @studerl ⁩ ⁦⁦ @whitefishlab ⁩

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@studerl

6 years

Excellent CSC review from Ryan @GSKGradSchool and Viviane @sloan_kettering on the emerging field of tumor modeling in hPSCs. "Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids": Cell Stem Cell

Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids

Smith and Tabar discuss how models of human pluripotent stem cells (hPSCs) and organoids provide insights into tumor development, progression, and treatment, as well as potential opportunities for...

www.cell.com

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@studerl

4 years

Thanks to @Sofialmdo for putting the spotlight on the very unfortunate decision by NY state to terminate the #NYSTEM program as detailed in her article below @NewsfromScience @ScienceMagazine .

Sofia Moutinho

@sofiamoutinhoBR

4 years

Termination of NY State stem cell program stalls research on various diseases, and will likely cause a brain drain in the field. The fund supported groundbreaking studies like 1st Parkinson's clinical trial with off-the-shelf stem cells #nystem #stemcells

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@studerl

5 years

Cool paper from Tabar lab @MSKNeurosurgery , @sloan_kettering , on human RG-like cells in GBMs . Exciting to see functional features beyond scRNAseq, such as oRG-related mitotic somal translocation in tumors! Where do they come from?

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@studerl

4 years

Thanks so much to all the key collaborators @khurana_lab @CroftGist @peng_illinois @drjosephpowell to make this effort happen. We also excited to be part of the greater @ASAP_Research community to tackle mechanisms and potential treatments of #Parkinsons together

Memorial Sloan Kettering Cancer Center

@MSKCancerCenter

4 years

Congratulations to @studerl , a recipient of a multi-institutional grant from @ASAP_Research in partnership with @MichaelJFoxOrg ! As the leading grant recipient, MSK will continue important research into the causes and progression of Parkinson’s disease. 🔬 🧬

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@studerl

5 years

4 different talks on 4 different topics and at 4 different locations within just 4 days. The PRSS lecture among them @sloan_kettering was the most interesting challenge with many lab members in the audience - probably knowing the work better than I myself…

Ryan Smith

@smithr00

5 years

Really nice talk yesterday from @studerl to the hometown crowd at @sloan_kettering . The breadth and the quality of work in his group continue to impress, from studies of human cell development and disease modeling to translational efforts with @MSKNeurosurgery @BlueRockTx & more.

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@studerl

5 years

Congratulations to @FaranakFattahi Very happy for my amazing former student and now equally amazing PI. One of the most rewarding aspect of Science is seeing former trainees to succeed..

Neurosurgery at Memorial Sloan Kettering

@MSKNeurosurgery

5 years

Congratulations @FaranakFattahi , recipietn of New NIH Innovator Award . A brilliant former @sloankettering @studerl lab postdoc, now Sandler Fellow . @MSKEducation @MSK_CSCB

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@studerl

5 years

Congratulations to Gordon for being selected to receive the #OgawaYamanaka Stem Cell Prize! Outstanding news and extremely well-deserved.

Gladstone Institutes

@GladstoneInst

5 years

Gordon Keller receives the 2019 Ogawa-Yamanaka Stem Cell Prize for his work with pluripotent stem cells, which has led to a platform for disease modeling and regenerative medicine. #OgawaYamanaka @UHN @McEwenInstitute

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@studerl

6 years

Our new PNAS paper is out. Continuing our collaboration with @casanova_lab + Smith and Noterangelo labs on modeling HSV-1 encephalitis in iPSC neurons but focusing on the periphery. Putting our updated TG neuron diff to good use..

Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects...

Herpes simplex virus type 1 (HSV-1) encephalitis (HSE) is the most common sporadic viral encephalitis in Western countries. Some HSE children carry...

www.pnas.org

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@studerl

2 years

Another piece in the puzzle on the genetic causes of HSV-1 encephalitis, involving impaired cell death. Great collaboration with @casanova_lab @ShenYingZhang1 and many others. Special thanks to @harschnitz @NoopurKhobrekar and Param Amin from my lab involved in the RIPK3 project.

Casanova Lab

@casanova_lab

2 years

1/ We are happy to share our report of inherited RIPK3 deficiency in a child with HSV-1 encephalitis (HSE) in @SciImmunology (). HUGE thanks to all collaborators (list below)!

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@studerl

8 months

Congrats to @VittoriaBocchi in the lab and the three other amazing women scientists selected @MSKCancerCenter Meet the 4 Winners of the 2024 Kravis WiSE Fellowships

Meet the 4 Winners of the 2024 Kravis WiSE Fellowships

MSK is proud to announce that four Sloan Kettering Institute (SKI) researchers have been named 2024 Marie-Josée Kravis Women in Science Endeavor (Kravis WiSE) fellowship grant recipients.

www.mskcc.org

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@studerl

6 years

New paper on gene-environment interactions looks at commonly used pesticide (propargite) on hPSC-derived b-cells and DA neurons. Link to #diabetes / #Parkinsonsdisease ? It was fun working again with Shuibing’ s team. Congrats particularly to Ting and Tae.

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@studerl

5 years

This was an exciting collaboration with the late Paul Greengard. Congrats to @markus_rie , Ben and TaeWan and all other members of the labs. Particularly intriguing - the neuron subtype specific response and whether neuronal senescence is going to be a widespread feature?

Markus Riessland

@RiesslandLab

5 years

I am happy to announce that the results of great collaboration between the Greengard lab and the @studerl lab are online! We found that loss of SATB1 induces p21-dependent cellular senescence in post-mitotic dopaminergic neurons #Parkinsons #senescence

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Lorenz

@studerl

6 years

Very proud of Viviane! #NAMmtg inducted today..

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Lorenz

@studerl

3 years

Congrats to @M_Vincendeau and her lab on identifying a surprising role for HERV-K during hPSC-derived cortical neuron and organoid differentiation. It was exciting seeing the story develop - moving forth and back across the Atlantic. @HelmholtzMunich @sloan_kettering

Michelle Vincendeau

@M_Vincendeau

3 years

It’s published! Excited to share our publication in Cell Stem Cell. Vidya did an amazing job. 4 years of hard work... worth every single weekend we spent in lab. Many thanks to our great collaborators. @HelmholtzMunich @sloan_kettering @studerl @HadianKamyar

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Lorenz

@studerl

2 years

Great shout-out especially to @gabriele_ciceri and to @ejhergenreder who led the respective studies in huge efforts over the last few years, and thanks to the many outstanding collaborators who made the work possible.

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Lorenz

@studerl

3 years

Only 2 days to deadline ! Excited to consider your applications for faculty positions at CSCB & DB program @sloan_kettering . Join amazing colleagues working on basic stem cell questions all the way to pioneering clinical application of hPSCs. for details

Tenure-Track Faculty Positions - New York City, New York

Applicants should have a PhD and/or MD degree

careers.cell.com

Lorenz

@studerl

3 years

Open search for new faculty positions at the Center for Stem Cell Biology and the DB program @sloan_kettering . Deadline for applications is October 15, 2021. For more info see or contact me directly at studerl @mskcc .org.

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@studerl

3 years

For those interested in the topic - Below the accompanying perspective in the same @ScienceMagazine issue by Vredevoogd & Pepper. Enabling oncogenes

Enabling oncogenes

Melanoma can arise only from cells with a permissive chromatin landscape

www.science.org

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Lorenz

@studerl

4 years

Looking very much forward to tomorrow’s #VISION2030 discussion organized by @ISSCR . This is a very interesting time for our efforts in Parkinson’s disease with @BlueRockTx and for the field in general.

ISSCR

@ISSCR

4 years

#VISION2030 will feature @BlueRockTx Scientific Founders, @studerl and Viviane Tabar, and President/CEO Emile Nuwaysir. Interviewed by Arnold Kriegstein, these execs will share their predictions for engineered #celltherapies in the decade ahead.

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Lorenz

@studerl

6 years

Congratulations to Scott Callahan @GSKGradSchool for his successful thesis defense. Leading our lab's foray into cancer biology and melanoma modeling. Lot of fun co-mentoring Scott with @whitefishlab using both hPSCs and zebrafish for this project.

richard white

@whitefishlab

6 years

Our 3rd Ph.D. from the lab! @GSKGradSchool student Scott Callahan, co-mentored by @studerl . An impressive body of work, now on to new horizons! #zebrafish

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Lorenz

@studerl

5 years

If you are excited about work aimed at the translation of hPSC-derived oligodendrocytes for repair of radiation-damage and other CNS applications, this is an excellent postdoc opportunity in the Tabar lab here @sloan_kettering . For more info:

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@studerl

9 months

For additional information on the work directed at a broader audience see the “in the news” piece from Ian Demsky @MSKCancerCenter directed to a broader audience on “Hacking Neuron’s Internal Clocks..”–

MSK Researchers Hack Neurons’ Internal Clocks To Accelerate the Study

New research led by MSK has uncovered a way to “hack” neurons' internal clocks to speed up their development. The approach promises to accelerate research into neurological disease.

www.mskcc.org

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Lorenz

@studerl

6 years

Human Schwann cells for modeling Charcot Marie Tooth from either patient specific iPSCs, hESCs or via direct reprogramming. Congratulations to Gabsang for a story which started more than 10 years ago… For full text see:

Nature Biomedical Engineering

@natBME

6 years

Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder

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Lorenz

@studerl

6 years

Big congrats to Marius ! Just noticed that this in now official.. Marius Wernig Awarded the 2018 Ogawa-Yamanaka Stem Cell Prize by the Gladstone Institutes . #stemcells #ogawa -yamanaka #

Marius Wernig Awarded the 2018 Ogawa-Yamanaka Stem Cell Prize by the Gladstone Institutes

Wernig was selected for his groundbreaking research in cellular reprogramming and stem cell-based therapies for genetic disease

www.newswire.com

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Lorenz

@studerl

1 year

Visionary effort from Roche @HansClevers & @TheLutolfLab to push the frontiers in organoid research @IHB_Research . At interface of fundamental discoveries, human translation, drug discovery & precision medicine. This will be a very exciting place to make true progress!

Matthias Lutolf

@TheLutolfLab

1 year

Super excited to share that we will be expanding our ambitions to advance #organoid research with a translational goal at @IHB_Research ! Stay tuned for our latest discoveries in the exciting fields of human model systems and human biology. 👉Learn more:

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@studerl

4 years

Thanks to @harschnitz for putting together this excellent (and timely) review @NatRevImmunol and for leading our work in the lab on the many exciting applications of hPSC-based models on this topic.

Oliver Harschnitz

@harschnitz

4 years

I'm delighted to share this @NatRevImmunol review in which @studerl & I discuss how hPSC-models can help study host-virus interactions in the CNS. We discuss the latest insights into viral CNS disease using hPSC models (incl #SARSCoV2 ), & what challenges lie ahead. #immunology

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Lorenz

@studerl

5 years

Only 6 days before I will ride with Team DB - MSK SKI @Cycle4Survival event to raise money for rare cancers, an amazing cause to bring better treatments to patients everywhere. If you want to support the ride, you can make a tax-deductible donation at

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Lorenz

@studerl

5 years

Yes, another fun collaboration with @casanova_lab & co. with a particular shout out to Fabien, @harschnitz & @ShenYingZhang1 . Quite amazing that a small nucleolar RNA protects CNS neurons from HSV-1 infection, and likely just one of many more surprising pieces to the HSE puzzle.

Bastian Zimmer

@bastian_zimmer

5 years

Congrats to everybody involved ⁦ @harschnitz ⁩ ⁦ @ShenYingZhang1 ⁩ ⁦ @casanova_lab ⁩ ⁦ @studerl ⁩ and many more! Great collaborative effort

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Lorenz

@studerl

2 years

Really enjoying excellent meeting at very special location..

Yaron Fuchs

@LabFuchs

2 years

Kicking off our conference with a great talk by Lorenz Studer! @studerl

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Lorenz

@studerl

2 years

Very interesting story in BioRxiv from @FaranakFattahi lab on Schwann cell vs early NC-derived melanocytes.

Faranak Fattahi

@FaranakFattahi

2 years

In our new preprint by Ryan Samuel et al. we used hPSCs to find developmental sources of heterogeneity in human melanocytes. Signature genes in melanocytes that emerge from the Schwann cell lineage promote metastasis in melanoma.

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Lorenz

@studerl

7 months

Huge Congrats @FaranakFattahi for being selected for the @MindPrize and to all the other amazing scientists selected including @hchung03 , @brainevodevo , and @LiddelowSA among others. Outstanding selections, brilliant science to come..!

Faranak Fattahi

@FaranakFattahi

7 months

Truly grateful to @MindPrize and Pershing Square Foundation and honored to be among this group!!

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Lorenz

@studerl

6 years

For enthusiasts of the enteric nervous system, an updated protocol for deriving human ENS lineages from pluripotent stem cells. Big shout-out to @FaranakFattahi and her new team at UCSF. One step closer towards a cell therapy for Hirschsprung's disease?

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Lorenz

@studerl

2 years

A belated congratulations to @NoopurKhobrekar being selected for the @NYSCF Druckenmiller Postdoctoral Fellowship - very well deserved.. I can’t wait to see the results from this exciting project!

Noopur Khobrekar

@NoopurKhobrekar

2 years

Honored and excited to receive the @NYSCF - Druckenmiller Fellowship. Grateful for the incredible support of @Studerl lab @MSK_CSCB @MSKCancerCenter and looking forward to working with the amazing scientists @NYSCF .

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Lorenz

@studerl

7 years

Thanks to all the amazing postdocs and students in the lab and the many collaborators that made the work possible recognized here. I had a wonderful time in SF.

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Lorenz

@studerl

2 years

Exciting study from @khuranalab in Cell ( @CellCellPress ) describing unexpected role of alpha-synuclein in P-bodies and on RNA stability in experiments from yeast to fly to PD-iPSCs and patient brains. Congrats to Vik, @ehallacli et al. - with partial support from @ASAP_Research

Vik Khurana Lab

@khurana_lab

2 years

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Lorenz

@studerl

4 years

Thanks to Madolyn for the detailed discussion in @alzforum of our recent @NatureNeuro paper for work led by @sudhavallii in the lab, and thanks to the interesting comments by the community in response.

Alzforum

@alzforum

4 years

A triculture system of human neurons, microglia, and astrocytes reveals how glial cells cooperate to boost inflammation in #alzheimersdisease . @sloan_kettering

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Lorenz

@studerl

4 years

For some more info on the new collaborative award, other PD research at MSKCC and related topics, see my recent interview with @mtontonoz

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Lorenz

@studerl

6 years

This should be a powerful combo of technologies! Cells to deliver therapeutic genes and genes to make better therapeutic cells…

BlueRock Therapeutics

@BlueRockTx

6 years

Today, we’re thrilled to announce our new strategic collaboration & cross-licensing agreement w/ @Editasmed . Read more here: #CELLplusGENE

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Lorenz

@studerl

2 years

Less than 2 weeks left to Oct 17 deadline! If you are looking for tenure track positions in stem cell biology don’t miss this opportunity @MSK_CSCB @MSKCancerCenter – outstanding environment for studies ranging from basic stem cell biology to actual human translation.

Lorenz

@studerl

2 years

Exciting opportunity in stem cell biology! The Center for Stem Cell Biology @MSK_CSCB @MSKCancerCenter has an ongoing search for new tenure track faculty. Deadline is October 17, 2022. For more info see or contact me directly at studerl @mskcc .org.

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Lorenz

@studerl

4 years

Congrats to Oliver. Excellent news and very well deserved.

Oliver Harschnitz

@harschnitz

4 years

Extremely grateful to receive a NARSAD Young Investigator Award! Many thanks to @BBRFoundation for providing this opportunity, and to my mentor @studerl for his support. Looking forward to all the exciting science yet to come!

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Lorenz

@studerl

6 years

Looking forward to the May 20 event @CrainsNewYork and to meeting the other finalists across the 5 categories.

Center for Stem Cell Biology at Sloan Kettering

@MSK_CSCB

6 years

Congratulations to @studerl for being a finalist on the 2019 Heritage Healthcare Innovation Awards!

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Lorenz

@studerl

7 years

Congratulations to Shen-Ying #CasanovaLab for her new Cell paper on DBR1 mutations in primary brain stem encephalitis. -- Now, we really have to push forward with the iPSC model on this.

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Lorenz

@studerl

4 years

Congrats to @harschnitz for being selected as a Warren Alpert 2021 Distinguished Scholar. Very well deserved for all his amazing work on modeling encephalitis in human stem cells and with exciting future discoveries to come.

Memorial Sloan Kettering Cancer Center

@MSKCancerCenter

4 years

Please join us in congratulating @harschnitz who was just named a Warren Alpert 2021 Distinguished Scholar, a highly competitive national program to advance #neuroscience training! 👏 @HarvardMed See below for other awards recently given to our MSK employees.

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Lorenz

@studerl

6 years

Impressive team at the bench as well as in Central Park. Congratulations to all the runners and thanks to Angela for getting this organized. Hopefully, I won’t miss the opportunity to participate in the next race as well..

Oliver Harschnitz

@harschnitz

6 years

Great morning in Central Park running with a big group of @studerl lab mates!! No amount of rain slowing us down today... plus the post-run brunch was a strong motivator ;)

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Lorenz

@studerl

6 years

Congrats to Shuibing Chen for winning the Susan Lim award for outstanding junior investigator @isscr here in Melbourne

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Lorenz

@studerl

2 years

Congratulations to @BaggioliniA . What a great start to independence and extremely well deserved!

Arianna Baggiolini

@BaggioliniA

2 years

It’s incredible to receive the Christopher Marshall award 🎉! Thank you to the @SocietyMelanoma , the @whitefishlab , and the @studerl lab for all your support along the way 🌟🌟🌟 So much looking forward to SMR meeting in Edinburgh #SMR2022 !

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Lorenz

@studerl

3 years

Why Are Only Some Cells ‘Competent’ to Form Cancer? MSK Scientists Say Context Is Key

Why Are Only Some Cells ‘Competent’ to Form Cancer? MSK Scientists Say

Experiments with zebrafish and human pluripotent stem cells reveal the necessary ingredients, besides genetic mutations, that fuel the development of melanoma.

www.mskcc.org

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Lorenz

@studerl

7 years

New Cell Stem Cell paper from collaboration with Chen lab on compounds that inhibit Zika Virus

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Lorenz

@studerl

9 months

Interesting and very timely forum piece from @TabarViviane and Roger Barker @CellStemCell on the role of sham surgery in the development of PSC-based CNS cell therapies.

Viviane Tabar

@TabarViviane

9 months

A possibly controversial perspective as we look forward to the next decade of #stemcell therapies. Sham surgery for the trialing of cell-based therapies to the CNS may not be necessary: Cell Stem Cell

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Lorenz

@studerl

7 years

Lorenz Studer awarded the 2017 Ogawa-Yamanaka Stem Cell Prize via @GladstoneInst @EurekAlert #stemcells , #iPSC

Lorenz Studer awarded the 2017 Ogawa-Yamanaka Stem Cell Prize

Lorenz P. Studer, MD, was announced today as the winner of the 2017 Ogawa-Yamanaka Stem Cell Prize by the Gladstone Institutes. Studer is the director of the Center for Stem Cell Biology and a member...

www.eurekalert.org

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Lorenz

@studerl

3 years

@harschnitz @sloan_kettering It was truly awesome to have @harschnitz in the lab and see your growth a scientist / colleague who told me a lot about neurovirology. It will be exciting to hear about all the amazing work that will come from your own lab – and yet another great reason to visit Milan!

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