Stem cell biologist
@MSKCancerCenter
studying human PSCs for modeling development & disease and for cell therapy. Opinions are my own and do not represent MSK.
Excited to see our work - showing that an epigenetic barrier sets the pace of human neuronal maturation - published
@Nature
. This is the “opus magnum” of
@gabriele_ciceri
in the lab
@MSKCancerCenter
with huge thanks to all the collaborators involved .
Why do human neurons mature so slowly? Two studies from the lab tackle this issue. The first study led by
@gabriele_ciceri
identifies an epigenetic barrier that sets protracted maturation timing of human neurons already at the neural precursor stage
Ten years to develop differentiation protocol, another ten to get green light for clinical testing of our dopamine neurons. Thanks also to Viviane and team
@MSKNeurosurgery
for being part of the whole journey and key to the clinical journey to come
@sloan_kettering
@BlueRockTx
I could not be more proud and excited to have worked with the brightest minds in the field to bring our dopamine cell therapy into the clinic and to patients in need
@BlueRockTx
@sloan_kettering
@studerl
Our paper on generating topographically organized human forebrain organoids is out in NBT. For full text access see . Congrats to Gustav and the whole team. For an excellent News & Views on the paper see from
@PascaStanford
Congrats to Sudha for
@NatureNeuro
paper on microglia differentiation and tri-culture technology to dissect cell type-specific inflammatory cross talk in hPSC model of AD with
@jtchieu
,
@NatSaurat
,
@harschnitz
, Ryan, Gabriele & Lisa, Dana Pe'er and others
Grateful to be selected for the 2022 ISSCR Achievement Award Thanks to all the trainees
@sloankettering
@MSK_CSCB
and all the colleagues who made the work possible. Congrats to other 2022 ISSCR awardees
@CreminsLab
@SJMorrison_
and Joanna.
For anyone looking for a faculty position here at the Center for Stem Cell Biology and the DB program
@sloan_kettering
in NYC. We have an open search with an Oct 15, 2020 deadline. For more information see: or contact me at studerl
@mskcc
.org.
Congrats to
@BaggioliniA
from our lab
@MSKCancerCenter
@MSK_CSCB
as a winner of the 2022 Tri-I Breakout Prize. Pic from yesterday at Rockefeller University. Excited to hear about your future achievements in your own lab in Switzerland
Open search for new faculty positions at the Center for Stem Cell Biology and the DB program
@sloan_kettering
. Deadline for applications is October 15, 2021. For more info see or contact me directly at studerl
@mskcc
.org.
In vivo gut motility controlled by grafted human PSC-derived ENS in severe mouse model of Hirschsprung’s disease. Study now published
@CellStemCell
on sacral-derived ENS precursors . Huge effort by Yujie Fan and an amazing team of collaborators
@MSK_CSCB
Our cell line pooling paper is out indicating autism-related mutations modulate PFC neurogenesis and response to WNT signaling. Approach may be broadly useful in hPSC disease modeling. Thanks to Gustav,
@jtchieu
, Scott, others
@whitefishlab
,
@ChenShuibing
, Tomishima,
@studerl
lab
A new paper from
@studerl
Lab reports on
"A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes"
Why and when do grafted neurons die? Preprint by
@TaeWanKim0
@_SoyeonKoo
from lab & collab. uses in vivo CRISPR screen to identify TNFa-NFkB-p53 loop restricting hPSC-DA neuron survival, and offers clinically relevant solution
@MSK_CSCB
@MSKCancerCenter
Tomorrow is the deadline for faculty applications at Sloan Kettering (). For applicants interested in the Center for Stem Cell Biology, we are linked closely with the Developmental Biology Program search
hPSC midbrain DA neurons are susceptible to SARS-CoV2 and undergo senescence response. This is modulated by a-syn, and autopsy data suggest PD relevance. Thanks to
@ChenShuibing
and the many collaborators - in my lab especially
@TaeWanKim0
&
@harschnitz
.
Humbling, looking through the list of previous awardees.
Huge shout-out to all students and postdocs from the lab - current and past - who made this work possible.
Parkinson's disease researcher wins Gabbay Award | BrandeisNOW
hPSC side-by-side with zebrafish approaches to study mechanisms of oncogenic competence in melanoma. Exciting collaboration with
@whitefishlab
now in
@ScienceMagazine
. Particular thanks to
@BaggioliniA
and Scott Callahan & all the amazing collaborators.
Human pluripotent-derived forebrain organoids; Dopamine neuron grafts from our GMP batch re-innervating striatum. Lab images are spreading through the floors of RRL
@sloan_kettering
. Thanks to Ryan and to thanks to NYSTEM team, particularly Jinghua.
The second study led by
@ejhergenreder
presents chemical strategy , to drive maturation in human neurons. The new GENtoniK cocktail can drive maturation in multiple hPSC-derived cell types and trigger maturation related behavior even in non-neural lineages.
Our review is out
@NatureAging
on models on neuronal senescence in aging and neurodegeneration, focusing particularly on human PSC-based approaches . This was an effort led by
@IsabelleLuzy
working with several other teams part of
@ASAP_Research
.
Exciting opportunity in stem cell biology! The Center for Stem Cell Biology
@MSK_CSCB
@MSKCancerCenter
has an ongoing search for new tenure track faculty. Deadline is October 17, 2022. For more info see or contact me directly at studerl
@mskcc
.org.
Very excited to get the opportunity to help shaping the vision of this amazing organization and to work with all the current and new colleagues, leaders and staff who make
#ISSCR
so successful. Big congrats to Tenneille,
@Thomas_Rando
and Jacqueline as the new board members!
Jason’s NFIA story (full text: ). Rapidly generating bona fide astrocytes from hPSCs. Mechanism implicates G1 cell cycle length as contributor to gliogenic switch. Having fun mimicking drawings of Ramón y Cajal...
@sloan_kettering
Preprint led by
@chaozhangw
@NatSaurat
@dbetel
on a strategy for measuring/manipulating cellular age . “RNAge” is used to track induced aging strategies in iPSC human neurons & to perform in silico screen for identifying novel aging & rejuvenation compounds
Yes, two papers in current CSC issue: first major update of our mDA neuron diff protocol (since Kriks et al.); data on GMP manufacturing and IND enabling studies. Thanks to everyone involved,
@TabarViviane
,
@TaeWanKim0
, Jinghua Piao, Mark Tomishima,
@9soyeon
and many more.
Exciting next step in the journey to bring hPSC cell therapy approaches to the patient - including our own efforts in Parkinson’s disease and other neurological targets.
We are pleased to announce that one of our founding investors,
@BayerPharma
, is building a leading position in
#celltherapy
by acquiring
#BlueRock
in its entirety.
GENtoniK factors were identified in a chemical screen and induce morphological, transcriptional, and functional maturation. Compounds target epigenetic (DOT1L, KDM1A) and activity dependent drivers of maturation. See related Research Briefing
Do dopamine neuron grafts need an additional boost? Our N&V
@nature
on use of GDNF by Gantner et al. and possibly other genetic strategies to give cells some “extra help”.
@sloan_kettering
@MSKNeurosurgery
Outstanding line-up of speaker for anyone interested in pluripotent stem cells in Neuroscience (see ). A meeting completely virtual, without waste/pollution of travel, very low cost and allowing questions from audience. Should be fun! #
#SfNvirtual
, #
A belated congrats to Emiliano in our lab who recently defended – brilliantly - his Neuroscience PhD
@WeillCornell
&
@sloan_kettering
tackling the intriguing problem of neuronal maturation timing in human PSCs – more on his work hopefully to follow very soon in print…
📢📢📢How can we obtain a robust outer radial glia (oRG) population in 🧠organoids from guided differentiation? Exogenous LIF does the trick.
Our new paper shows that cortical pericytes are among the cell types secreting LIF. Adding pericytes to cortical organoids recapitulates
Graduation day at
@sloan_kettering
! Very proud of my two most recent graduates Gustav Cederquist
@TriIMDPhD
& Scott Callahan
@GSKGradSchool
and to Yujie Fan (in the front), a current
@WeillCornellGS
student in the lab, and the winner of the Frank Lappin Horsfall, Jr. Fellowship.
Exciting developments for organoid research at
@IHB_Research
with Juergen
@Knoblich_lab
taking on the leadership and Matthias
@TheLutolfLab
as head of translational bioengineering. Many breakthroughs to come - from basic biology to capturing the full translational potential.
Interested in helping to lead a major iPSC effort to understand mechanisms of Parkinson’s disease? We have open position for PhD level program manager working on our collaborative
@ASAP_Research
grant. Please contact me at studerl
@mskcc
.org for more information.
Congrats to
@FaranakFattahi
for her new faculty position at UCSF. I am sure a lot of exciting new science to come on human PSCs, neural crest, the enteric nervous system and beyond!
Congratulations to Alex Joyner for winning the ISTT Prize for her pioneering work on homologous recombination in ES cells. There could be no better person for this prize!
@sloan_kettering
@MSK_CSCB
Congrats to Daniela, Chao,
@dbetel
, and rest of team for exciting collaboration on the impact of lipid deprivation in hPSCs. A journey from clinical grade culture conditions & differentiation propensity to metabolic, signaling & epigenetic mechanisms regulating pluripotent state.
For anyone interested in a faculty position here at the Center for Stem Cell Biology and the DB program
@sloan_kettering
in NYC. We have a newly opened search with an Oct 15 application deadline. For more information see:
Really enjoyed the meeting
#StemCellNiche2023
. Also – an interesting experience to see your talk (and yourself!) being converted in real-time into an artistic illustration.
Excited to see this finally published. Thanks to
@homamajd
&
@FaranakFattahi
lab for pushing it over finish line after MANY(!) years. An unexpected role for Schwann cells in diabetic neuropathy and for atypical antidepressant (Bupropion) in potentially preventing/treating it.
Our Schwann cell paper is out! Huge thank you to the entire team who made this possible, especially
@FaranakFattahi
and
@studerl
.
The review and editorial processes at
@CellStemCell
took our study to a new level 😎
I cannot wait for you to check it out!
Big thanks to
@giacomelli_eli
&
@BVahsen
for spearheading effort –
@CellStemCell
review on progress in iPSC-models for ALS, a window into broader successes & challenges of modeling neurodegeneration. Here, direct link to full text
As a result of a beautiful collaboration between the
@studerl
and the Talbot lab, I am pleased to share our review on ALS and iPSC models of neurodegeneration in
@CellStemCell
. A very special thank you to
@BVahsen
for his terrific work as co-author!
Congrats to
@FaranakFattahi
and
@homamajd
as well as
@ChenShuibing
and other co-authors. Excited to see this work in pre-print on optimized Schwann cell derivation, engraftment, disease modeling, drug screen, and assessment of bupropion as candidate drug for diabetic neuropathy.
In collaboration with the
@studerl
lab, we derived Schwann cells from hPSCs! They can engraft and make myelin in vivo, model Schwann cell damage in diabetes and help identify a therapeutic candidate. Check out our new preprint by
@homamajd
et al:
A belated cheer to
@harnschnitz
for his faculty position
@HumanTechnopole
starting in Jan, 2022. He will be an outstanding PI, mentor and scientist, so if you are interested in working on human PSCs for modeling neuro-immunological disease, this will be the place to be!
Introducing new Group Leaders in Genomics and Neurogenomics: a very warm welcome to Blagoje, Lorenzo, Oliver, Elena and Jose! Learn more about the challenges they address through their research and what brought them to HT:
Congrats to
@BaggioliniA
and to Scott and many others who made this work possible. After 20 years at MSK finally our first true cancer story from the lab - making use our PSC approaches, combined with a powerful zebrafish model - in an awesome collaboration with
@whitefishlab
.
Excited to share our work now as a preprint. Using zebrafish and a novel hPSC-derived cancer model, we investigate the mechanisms underlying melanoma competence. Thanks to everybody involved in this work
@studerl
@whitefishlab
Excellent CSC review from Ryan
@GSKGradSchool
and Viviane
@sloan_kettering
on the emerging field of tumor modeling in hPSCs. "Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids": Cell Stem Cell
Termination of NY State stem cell program stalls research on various diseases, and will likely cause a brain drain in the field. The fund supported groundbreaking studies like 1st Parkinson's clinical trial with off-the-shelf stem cells
#nystem
#stemcells
Cool paper from Tabar lab
@MSKNeurosurgery
,
@sloan_kettering
, on human RG-like cells in GBMs . Exciting to see functional features beyond scRNAseq, such as oRG-related mitotic somal translocation in tumors! Where do they come from?
Congratulations to
@studerl
, a recipient of a multi-institutional grant from
@ASAP_Research
in partnership with
@MichaelJFoxOrg
! As the leading grant recipient, MSK will continue important research into the causes and progression of Parkinson’s disease. 🔬 🧬
4 different talks on 4 different topics and at 4 different locations within just 4 days. The PRSS lecture among them
@sloan_kettering
was the most interesting challenge with many lab members in the audience - probably knowing the work better than I myself…
Really nice talk yesterday from
@studerl
to the hometown crowd at
@sloan_kettering
. The breadth and the quality of work in his group continue to impress, from studies of human cell development and disease modeling to translational efforts with
@MSKNeurosurgery
@BlueRockTx
& more.
Congratulations to
@FaranakFattahi
Very happy for my amazing former student and now equally amazing PI. One of the most rewarding aspect of Science is seeing former trainees to succeed..
Gordon Keller receives the 2019 Ogawa-Yamanaka Stem Cell Prize for his work with pluripotent stem cells, which has led to a platform for disease modeling and regenerative medicine.
#OgawaYamanaka
@UHN
@McEwenInstitute
Our new PNAS paper is out. Continuing our collaboration with
@casanova_lab
+ Smith and Noterangelo labs on modeling HSV-1 encephalitis in iPSC neurons but focusing on the periphery. Putting our updated TG neuron diff to good use..
Another piece in the puzzle on the genetic causes of HSV-1 encephalitis, involving impaired cell death. Great collaboration with
@casanova_lab
@ShenYingZhang1
and many others. Special thanks to
@harschnitz
@NoopurKhobrekar
and Param Amin from my lab involved in the RIPK3 project.
1/ We are happy to share our report of inherited RIPK3 deficiency in a child with HSV-1 encephalitis (HSE) in
@SciImmunology
(). HUGE thanks to all collaborators (list below)!
Congrats to
@VittoriaBocchi
in the lab and the three other amazing women scientists selected
@MSKCancerCenter
Meet the 4 Winners of the 2024 Kravis WiSE Fellowships
New paper on gene-environment interactions looks at commonly used pesticide (propargite) on hPSC-derived b-cells and DA neurons. Link to
#diabetes
/
#Parkinsonsdisease
? It was fun working again with Shuibing’ s team. Congrats particularly to Ting and Tae.
This was an exciting collaboration with the late Paul Greengard. Congrats to
@markus_rie
, Ben and TaeWan and all other members of the labs. Particularly intriguing - the neuron subtype specific response and whether neuronal senescence is going to be a widespread feature?
I am happy to announce that the results of great collaboration between the Greengard lab and the
@studerl
lab are online! We found that loss of SATB1 induces p21-dependent cellular senescence in post-mitotic dopaminergic neurons
#Parkinsons
#senescence
Congrats to
@M_Vincendeau
and her lab on identifying a surprising role for HERV-K during hPSC-derived cortical neuron and organoid differentiation. It was exciting seeing the story develop - moving forth and back across the Atlantic.
@HelmholtzMunich
@sloan_kettering
It’s published! Excited to share our publication in Cell Stem Cell. Vidya did an amazing job. 4 years of hard work... worth every single weekend we spent in lab. Many thanks to our great collaborators.
@HelmholtzMunich
@sloan_kettering
@studerl
@HadianKamyar
Great shout-out especially to
@gabriele_ciceri
and to
@ejhergenreder
who led the respective studies in huge efforts over the last few years, and thanks to the many outstanding collaborators who made the work possible.
Only 2 days to deadline ! Excited to consider your applications for faculty positions at CSCB & DB program
@sloan_kettering
. Join amazing colleagues working on basic stem cell questions all the way to pioneering clinical application of hPSCs. for details
Open search for new faculty positions at the Center for Stem Cell Biology and the DB program
@sloan_kettering
. Deadline for applications is October 15, 2021. For more info see or contact me directly at studerl
@mskcc
.org.
Looking very much forward to tomorrow’s
#VISION2030
discussion organized by
@ISSCR
. This is a very interesting time for our efforts in Parkinson’s disease with
@BlueRockTx
and for the field in general.
#VISION2030
will feature
@BlueRockTx
Scientific Founders,
@studerl
and Viviane Tabar, and President/CEO Emile Nuwaysir. Interviewed by Arnold Kriegstein, these execs will share their predictions for engineered
#celltherapies
in the decade ahead.
Congratulations to Scott Callahan
@GSKGradSchool
for his successful thesis defense. Leading our lab's foray into cancer biology and melanoma modeling. Lot of fun co-mentoring Scott with
@whitefishlab
using both hPSCs and zebrafish for this project.
Our 3rd Ph.D. from the lab!
@GSKGradSchool
student Scott Callahan, co-mentored by
@studerl
. An impressive body of work, now on to new horizons!
#zebrafish
If you are excited about work aimed at the translation of hPSC-derived oligodendrocytes for repair of radiation-damage and other CNS applications, this is an excellent postdoc opportunity in the Tabar lab here
@sloan_kettering
. For more info:
For additional information on the work directed at a broader audience see the “in the news” piece from Ian Demsky
@MSKCancerCenter
directed to a broader audience on “Hacking Neuron’s Internal Clocks..”–
Human Schwann cells for modeling Charcot Marie Tooth from either patient specific iPSCs, hESCs or via direct reprogramming. Congratulations to Gabsang for a story which started more than 10 years ago… For full text see:
Big congrats to Marius ! Just noticed that this in now official..
Marius Wernig Awarded the 2018 Ogawa-Yamanaka Stem Cell Prize by the Gladstone Institutes .
#stemcells
#ogawa
-yamanaka #
Visionary effort from Roche
@HansClevers
&
@TheLutolfLab
to push the frontiers in organoid research
@IHB_Research
. At interface of fundamental discoveries, human translation, drug discovery & precision medicine. This will be a very exciting place to make true progress!
Super excited to share that we will be expanding our ambitions to advance
#organoid
research with a translational goal at
@IHB_Research
! Stay tuned for our latest discoveries in the exciting fields of human model systems and human biology.
👉Learn more:
Thanks to
@harschnitz
for putting together this excellent (and timely) review
@NatRevImmunol
and for leading our work in the lab on the many exciting applications of hPSC-based models on this topic.
I'm delighted to share this
@NatRevImmunol
review in which
@studerl
& I discuss how hPSC-models can help study host-virus interactions in the CNS. We discuss the latest insights into viral CNS disease using hPSC models (incl
#SARSCoV2
), & what challenges lie ahead.
#immunology
Only 6 days before I will ride with Team DB - MSK SKI
@Cycle4Survival
event to raise money for rare cancers, an amazing cause to bring better treatments to patients everywhere. If you want to support the ride, you can make a tax-deductible donation at
Yes, another fun collaboration with
@casanova_lab
& co. with a particular shout out to Fabien,
@harschnitz
&
@ShenYingZhang1
. Quite amazing that a small nucleolar RNA protects CNS neurons from HSV-1 infection, and likely just one of many more surprising pieces to the HSE puzzle.
In our new preprint by Ryan Samuel et al. we used hPSCs to find developmental sources of heterogeneity in human melanocytes. Signature genes in melanocytes that emerge from the Schwann cell lineage promote metastasis in melanoma.
For enthusiasts of the enteric nervous system, an updated protocol for deriving human ENS lineages from pluripotent stem cells. Big shout-out to
@FaranakFattahi
and her new team at UCSF. One step closer towards a cell therapy for Hirschsprung's disease?
A belated congratulations to
@NoopurKhobrekar
being selected for the
@NYSCF
Druckenmiller Postdoctoral Fellowship - very well deserved.. I can’t wait to see the results from this exciting project!
Thanks to all the amazing postdocs and students in the lab and the many collaborators that made the work possible recognized here. I had a wonderful time in SF.
Exciting study from
@khuranalab
in Cell (
@CellCellPress
) describing unexpected role of alpha-synuclein in P-bodies and on RNA stability in experiments from yeast to fly to PD-iPSCs and patient brains. Congrats to Vik,
@ehallacli
et al. - with partial support from
@ASAP_Research
Thanks to Madolyn for the detailed discussion in
@alzforum
of our recent
@NatureNeuro
paper for work led by
@sudhavallii
in the lab, and thanks to the interesting comments by the community in response.
A triculture system of human neurons, microglia, and astrocytes reveals how glial cells cooperate to boost inflammation in
#alzheimersdisease
.
@sloan_kettering
Less than 2 weeks left to Oct 17 deadline!
If you are looking for tenure track positions in stem cell biology don’t miss this opportunity
@MSK_CSCB
@MSKCancerCenter
– outstanding environment for studies ranging from basic stem cell biology to actual human translation.
Exciting opportunity in stem cell biology! The Center for Stem Cell Biology
@MSK_CSCB
@MSKCancerCenter
has an ongoing search for new tenure track faculty. Deadline is October 17, 2022. For more info see or contact me directly at studerl
@mskcc
.org.
Extremely grateful to receive a NARSAD Young Investigator Award! Many thanks to
@BBRFoundation
for providing this opportunity, and to my mentor
@studerl
for his support. Looking forward to all the exciting science yet to come!
Congratulations to Shen-Ying
#CasanovaLab
for her new Cell paper on DBR1 mutations in primary brain stem encephalitis. -- Now, we really have to push forward with the iPSC model on this.
Congrats to
@harschnitz
for being selected as a Warren Alpert 2021 Distinguished Scholar. Very well deserved for all his amazing work on modeling encephalitis in human stem cells and with exciting future discoveries to come.
Please join us in congratulating
@harschnitz
who was just named a Warren Alpert 2021 Distinguished Scholar, a highly competitive national program to advance
#neuroscience
training! 👏
@HarvardMed
See below for other awards recently given to our MSK employees.
Impressive team at the bench as well as in Central Park. Congratulations to all the runners and thanks to Angela for getting this organized. Hopefully, I won’t miss the opportunity to participate in the next race as well..
Great morning in Central Park running with a big group of
@studerl
lab mates!! No amount of rain slowing us down today... plus the post-run brunch was a strong motivator ;)
It’s incredible to receive the Christopher Marshall award 🎉!
Thank you to the
@SocietyMelanoma
, the
@whitefishlab
, and the
@studerl
lab for all your support along the way 🌟🌟🌟
So much looking forward to SMR meeting in Edinburgh
#SMR2022
!
Interesting and very timely forum piece from
@TabarViviane
and Roger Barker
@CellStemCell
on the role of sham surgery in the development of PSC-based CNS cell therapies.
A possibly controversial perspective as we look forward to the next decade of
#stemcell
therapies.
Sham surgery for the trialing of cell-based therapies to the CNS may not be necessary: Cell Stem Cell
@harschnitz
@sloan_kettering
It was truly awesome to have
@harschnitz
in the lab and see your growth a scientist / colleague who told me a lot about neurovirology. It will be exciting to hear about all the amazing work that will come from your own lab – and yet another great reason to visit Milan!