Score!!🎉
Paper just accepted in NATURE PHYSICS!
@NaturePhysics
Using Stentor, we show that hydrodynamics could have been a key factor in evolution of multicellularity!If you are a postdoc candidate with background in biological fluid dynamics & like doing experiments -email!
📢Excited to share lab's first preprint and our first Stentor paper!
"Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular ciliate Stentor”
We asked "Can a simple unicellular organism mimic multicellularity?" 1/n
Thrilled to announce award of our 5 year $1.94M
@NIH
@NIGMS
R35 MIRA grant! Will fund our work on multicomponent mechanochemical molecular mechanisms underlying cellular actin dynamics. Huge thanks
@Emory_Physics
@BassellLab
@EmoryUniversity
2 postdoc positions open! pls RT!
📢(1/n) Please RT!
I am hiring a postdoc to work on exciting biophysics and biochemical projects in cytoskeletal mechanobiology in my lab at
@EmoryUniversity
, Atlanta, USA !! See lab website:
📢Lab’s first paper out in Science Advances.
We just discovered processive pointed end polymerization of actin filaments!!! Yes, you heard it right – FIRST EVER report of processive polymerization at the pointed end!
@ScienceAdvances
1/n
(1/5) Excited to start my lab as an Assistant Professor of Physics at
@EmoryUniversity
. I am also hiring postdocs and a technician. If you are Interested in the cytoskeleton, pls get in touch! We welcome Physicists, Biologists and Biochemists. Please RT. .
📢Lab's first paper just out in Nature Communications! Please RT.
Actin duels : twinfilin-formin-capping protein multicomponent ecosystem regulates actin assembly at filament barbed ends.
By
@Heidis_Cells
and Ignas Gaska.
@EmoryUniversity
1/n
📢(1/n) Please RT!
I am hiring a postdoc to work on exciting biophysics and biochemical projects in cytoskeletal mechanobiology in my lab at
@EmoryUniversity
!! See lab website:
📢(1/n) Please RT!
I am hiring a postdoc to work on exciting biophysics and biochemical projects in actin mechanobiology in my lab at
@EmoryUniversity
, Atlanta, USA!
See lab website:
📢Please RT!📢
I am hiring a postdoc to work on exciting biophysics and biochemical projects in actin mechanobiology in my lab at
@EmoryUniversity
, Atlanta, USA!
See lab website:
(1/n)
📢Excited to share lab's first actin preprint!
"Multicomponent regulation of actin barbed end assembly by twinfilin, formin and capping protein”
We asked "How do polymerases, blockers and depolymerases simultaneously control actin assembly?" 1/n
New Grant!! Excited to share that we have been awarded funds to purchase a new iLas-ring TIRF microscope!
More microscopes, more discoveries, happy lab members!
@NIH
@NIGMS
@emorycollege
@EmoryUniversity
📢Preprint alert – I present to you, the ⚡️swiss army knife of actin, CAP⚡️. The depolymerase of both actin ends, friend of formin and enemy of capping protein!
CAP - one ring to rule them all!
Interested in a postdoc? Come talk to me at
#cellbio2023
!
Image shows molecular mechanisms driving F-actin and G-actin turnover.
@BruceLaneGoode
, Eskin and
@sshekhr
review the molecular machinery and mechanisms employed in cells to drive the disassembly and turnover of actin networks.
#Cytoskeleton
Colored droplets in corn syrup seemingly blended together can be returned to their original state by reversing the direction of mixing, a form of laminar flow called "Stokes flow".
Credit: UNM Physics & Astronomy
Source:
F****** $11,390 publication fees.
And yes we scientists will pay. Why, because we are suckers.
We will review for free, edit for free and then pay to publish. Why?
Because we are suckers for impact factors. Yes, we all are.
In this scenario, the cost of publication is covered by an Article Processing Charge (APC) paid at the time of publication. The APC for Nature Neuroscience in 2022 is €9,500/US $11,390/£8,290.
Our recent
@NatureComms
paper is in news!! Here is a cartoon by first author
@Heidis_Cells
that beautifully summarizes her results on Multiprotein regulation of actin by a polymerase, depolymerase and a capper!
Lab's newest PhD candidate - Ekram! Congratulations on passing your qual with flying colors!!
@Emory_Physics
@Etowsif1
Just like actin, our lab is assembling one member at a time 😀
Speaking at the cytoskeleton seminar series coming Tuesday
@MBLScience
. Have seen some of the most inspiring scientists in the field present from this podium over the last five years. Honored. Come listen!
📢Please RT!
Apply by September 2nd!
I am hiring a postdoc to work on exciting biophysics and biochemical projects in cytoskeletal mechanobiology in my lab at
@EmoryUniversity
, Atlanta, USA !! See lab website:
ImageJ experts - I am looking for a plugin for identification and tracking of mobile single molecules. Any help would be greatly appreciated! Thank you!
📢📢New paper just out in European Journal of Cell Biology! 🎊
In 1950, Bruno Straub remarked:
“One great problem of actin chemistry remains still unsolved, and that is the mode of physiological depolymerization.”
70 years on, we are only now beginning to get some answers!
I second that, big meetings can be overwhelming, especially for the first timers! We all have our awkward stories!
A friend of mine once very innocently asked Tom Pollard : "Do you know anything about actin?". Its tough to beat that, so you will be just fine 😀
Nothing about meetings as a student or first-timer is easy. I have some really awkward stories myself 🤦🏽♀️. It gets better & mostly people aren’t awful. It might feel like you’re the only one hustling but many PIs are looking to recruit too. You might be that someone! Go get it!
@cytoskeletown
@Archaeon_Alex
Alex, sorry I disagree. I am pretty certain many of us (including myself) would not be where we are today, had all conferences been virtual. Human-human interactions matter. Just because some people don't have access to in-person conferences doesn't mean no one should.
📢Our discovery of FIRST EVER pointed end elongator is in news!!!!!
Great collaboration with
@KudryashovLab
! Our lab's first paper and that too with BOTH of my first grad students
@Heidis_Cells
and
@AnkitaYadavIN
!!
A simple Z-projection using flowtrace by
@wgilpin0
@Viveknprakash
and
@PrakashLab
showed beautiful vortices around Stentor's oral apparatus! And I was hooked! 3/n
A giant trumpet-shaped cell that skulks in the bottom of ponds has given scientists a new clue about how single-celled creatures may have taken the first steps towards evolving into multicellular ones, a key transition in the evolution of life
@sshekhr
@nature
group is inviting faculty members to a PAID workshop "to prepare early-career researchers to submit to top-tier journals".
So first we pay to "learn" how to submit to Nature, then we review for free, & then pay to publish and then pay again to read. We truly are suckers.
Using a stentor-pair as a model, we found that neighbors continuously change the separation between them! As the distance decreases, inner vortices fuse and the flow rate of the feeding flow increases! 5/n
Happy to present our lab’s first publication on the structure of 𝗮𝗰𝘁𝗶𝘃𝗲 𝗔𝗿𝗽𝟮/𝟯 𝗰𝗼𝗺𝗽𝗹𝗲𝘅 and bound to its nucleated actin filament at
@NatureSMB
Congrats
@Shaaban_cryoEM
(
@FulbrightAssoc
fellow), and a great collaboration with
@BradNolen2
Finally, someone reminding us that academic life is not so bad afterall! Its important that we tell the next generation about the good stuff of academia too!
Unfortunately, discourse on
#scitwitter
often gets too centered on self-flagellation.
PhDs can be challenging and public discourse tends to focus on the negatives.
To bring back some balance and positive momentum, this group of students sought to highlight the positive elements of the PhD experience.
#AcademicChatter
#PhDChat
Happy to receive an honorable mention award for my poster at EMBO workshop on Physics of Living Systems! Thank you
@sshekhr
@Sandeep_IMSc
for your consistent support & recommending me this conference. Learned a lot and made some new science friends.
#EMBOlivingsys23
@PoLDresden
'Proud' to announce $2278 as my new Referee Processing Charge (RPC). Assuming there are three reviewers, one editor and the person whose job it is to click to upload the pdf on the website - $11,390/5 = $2278
In this scenario, the cost of publication is covered by an Article Processing Charge (APC) paid at the time of publication. The APC for Nature Neuroscience in 2022 is €9,500/US $11,390/£8,290.
This model looks great, especially if you have cells with a really bundle-y leading edge. Can't wait to dive into the details of this preprint. Congrats
@DVavylonis
!
@jenheemstra
Interesting thought, in most European labs that I worked in, everyone including the PI was gone for Atleast three weeks for summer. And guess what? Everything was just fine, and the labs were just as productive as their non-vacationing counterparts.
New preprint from
@Viveknprakash
lab!
They have addressed one of the most fundamental question how left right patterning using fluid dynamics! If physics or dev bio aren't your thing, go see it for beautiful pictures!
📢Please RT! New Preprint Alert
@biorxiv_biophys
This is our latest work in collaboration with Prof. Takashi Mikawa’s lab at UCSF. We showed that cellular flows initiate L-R patterning prior to laterality gene expression in amniotes! 🐣😀
Actin ❤️
First ever successful internal tagging of actin. Works like magic, in budding yeast and in mammalian cell! Work done by
@koenvddries
and
@syncellbiolab
!
Having read many ERCstg success stories today, I am actually really glad that someone shared the other side - takes lot more courage to share "it didnt work out". Unfortunately, such beauty awards aren't solely about good science and how good your questions are!
Very sad to admit that I didn't get the
#ERCStG
. I'll need some days to move on from the disappointment. However, I still believe in my vision and project idea, and I'll find other ways forward! Thanks to the people who gave me their support despite the news. So... What's next?