Shekhar lab @sshekhr Twitter profile

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Shekhar lab

10 months

📢New publication in Journal of Cell Biology! Our review on "Mechanisms of actin disassembly and turnover" just out in @JCellBiol ! Written jointly with one and only @BruceLaneGoode ! @EmoryUniversity @emorycollege @BrandeisU

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Shekhar lab

@sshekhr

3 months

Score!!🎉 Paper just accepted in NATURE PHYSICS! @NaturePhysics Using Stentor, we show that hydrodynamics could have been a key factor in evolution of multicellularity!If you are a postdoc candidate with background in biological fluid dynamics & like doing experiments -email!

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Shekhar lab

@sshekhr

2 years

📢Excited to share lab's first preprint and our first Stentor paper! "Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular ciliate Stentor” We asked "Can a simple unicellular organism mimic multicellularity?" 1/n

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Shekhar lab

@sshekhr

3 years

Thrilled to announce award of our 5 year $1.94M @NIH @NIGMS R35 MIRA grant! Will fund our work on multicomponent mechanochemical molecular mechanisms underlying cellular actin dynamics. Huge thanks @Emory_Physics @BassellLab @EmoryUniversity 2 postdoc positions open! pls RT!

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Shekhar lab

@sshekhr

1 year

Score! Lab's first solo paper just accepted in @NatureComms . My rockstar grad student @Heidis_Cells and Ignas who made it happen! @EmoryBCDB @EmoryUniversity

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Shekhar lab

@sshekhr

2 years

📢(1/n) Please RT! I am hiring a postdoc to work on exciting biophysics and biochemical projects in cytoskeletal mechanobiology in my lab at @EmoryUniversity , Atlanta, USA !! See lab website:

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Shekhar lab

@sshekhr

1 year

Celebrating Heidi's (& lab's!) first paper being accepted in @NatureComms ! @Heidis_Cells @EmoryUniversity

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Shekhar lab

@sshekhr

2 years

📢Lab’s first paper out in Science Advances. We just discovered processive pointed end polymerization of actin filaments!!! Yes, you heard it right – FIRST EVER report of processive polymerization at the pointed end! @ScienceAdvances 1/n

Pointed-end processive elongation of actin filaments by Vibrio effectors VopF and VopL

Vibrio VopF/L toxins challenge the classic actin treadmilling paradigm by promoting unconventional minus-end actin elongation.

www.science.org

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Shekhar lab

@sshekhr

4 years

(1/5) Excited to start my lab as an Assistant Professor of Physics at @EmoryUniversity . I am also hiring postdocs and a technician. If you are Interested in the cytoskeleton, pls get in touch! We welcome Physicists, Biologists and Biochemists. Please RT. .

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Shekhar lab

@sshekhr

1 year

📢Lab's first paper just out in Nature Communications! Please RT. Actin duels : twinfilin-formin-capping protein multicomponent ecosystem regulates actin assembly at filament barbed ends. By @Heidis_Cells and Ignas Gaska. @EmoryUniversity 1/n

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Shekhar lab

@sshekhr

3 years

📢(1/n) Please RT! I am hiring a postdoc to work on exciting biophysics and biochemical projects in cytoskeletal mechanobiology in my lab at @EmoryUniversity !! See lab website:

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Shekhar lab

@sshekhr

1 year

The lab that aliquots together, makes discoveries together!

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Shekhar lab

@sshekhr

2 years

New PI

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Shekhar lab

@sshekhr

1 year

📢(1/n) Please RT! I am hiring a postdoc to work on exciting biophysics and biochemical projects in actin mechanobiology in my lab at @EmoryUniversity , Atlanta, USA! See lab website:

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Shekhar lab

@sshekhr

1 year

Shekhar lab, 3 years on!

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Shekhar lab

@sshekhr

1 year

📢Please RT!📢 I am hiring a postdoc to work on exciting biophysics and biochemical projects in actin mechanobiology in my lab at @EmoryUniversity , Atlanta, USA! See lab website: (1/n)

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Shekhar lab

@sshekhr

1 year

📢Excited to share lab's first actin preprint! "Multicomponent regulation of actin barbed end assembly by twinfilin, formin and capping protein” We asked "How do polymerases, blockers and depolymerases simultaneously control actin assembly?" 1/n

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Shekhar lab

@sshekhr

3 months

Score!!🎉 Our spotlight on Actin-Microtubule crosstalk just accepted in JOURNAL OF CELL BIOLOGY! @JCellBiol . Written together with my brilliant student @Heidis_Cells ! @EmoryUniversity @emorycollege

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Shekhar lab

@sshekhr

3 years

#NewPI is hard, but starting a lab bang in the middle of the pandemic was something else! Bring it on 2022!

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Shekhar lab

@sshekhr

2 years

New Grant!! Excited to share that we have been awarded funds to purchase a new iLas-ring TIRF microscope! More microscopes, more discoveries, happy lab members! @NIH @NIGMS @emorycollege @EmoryUniversity

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Shekhar lab

@sshekhr

9 months

📢Preprint alert – I present to you, the ⚡️swiss army knife of actin, CAP⚡️. The depolymerase of both actin ends, friend of formin and enemy of capping protein! CAP - one ring to rule them all! Interested in a postdoc? Come talk to me at #cellbio2023 !

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Shekhar lab

@sshekhr

3 months

📢New publication in Journal of Cell Biology! Our spotlight "Profilin affects microtubule dynamics via actin" just out in @JCellBiol Written with my amazing student @Heidis_Cells ! @EmoryUniversity @emorycollege

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Shekhar lab

@sshekhr

2 months

Score!!🎉 Ankita's paper accepted in PRX Life! @PRX_Life With @Sandeep_IMSc , we combined theory & experiments to uncover multicomponent dynamics of 3 depolymerases that compete & collaborate on actin filament ends! @a_ankita1 @EmoryUniversity @emorycollege @Emory_Physics

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Shekhar lab

@sshekhr

2 years

Celebrating lab's first paper with my two grad students @AnkitaYadavIN @Heidis_Cells ! Stay tuned, this is going to be big, very big! Huge shoutout to our collaborators @KudryashovLab !

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Shekhar lab

@sshekhr

3 months

My graduate student Ankita @a_ankita1 just won the first prize in the poster competition at the @Warwick_CMCB - @VanderbiltU mechanobiology symposium! Yay!!

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Shekhar lab

@sshekhr

9 months

Our new paper in @JCellBiol !

JCellBiol

@JCellBiol

9 months

Image shows molecular mechanisms driving F-actin and G-actin turnover. @BruceLaneGoode , Eskin and @sshekhr review the molecular machinery and mechanisms employed in cells to drive the disassembly and turnover of actin networks. #Cytoskeleton

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Shekhar lab

@sshekhr

3 years

How it started a year ago vs how it's going! #NewPI

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Shekhar lab

@sshekhr

7 years

There is no translational research without basic research.

Irene Newton

@chicaScientific

7 years

From a $88,554 @NSF grant in 1966, we got PCR thanks to Thermus aquaticus - now ~$8B industry #basicresearchmatters

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Shekhar lab

@sshekhr

3 months

Shekhar lab in full strength at the @Warwick_CMCB - @VanderbiltU mechanobiology symposium! Thanks a lot @ZanicLab for having us over in Nashville! @a_ankita1 @Heidis_Cells

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Shekhar lab

@sshekhr

3 months

3 paper decisions in one day!!! One accept, one desk reject and one revise and resubmit! What a rollercoaster!

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Shekhar lab

@sshekhr

3 months

📢Paper accepted! Ekram's paper on multicomponent depolymerization of actin filaments just got accepted in European Journal of Cell Biology! Yay! Stay tuned for more on this! @etowsif2 @EmoryUniversity @emorycollege @Emory_Physics @EmoryBiochem

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Shekhar lab

@sshekhr

4 years

Low Reynolds number strikes again! One of the best demonstrations I have ever seen!

Wonder of Science

@wonderofscience

4 years

Colored droplets in corn syrup seemingly blended together can be returned to their original state by reversing the direction of mixing, a form of laminar flow called "Stokes flow". Credit: UNM Physics & Astronomy Source:

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Shekhar lab

@sshekhr

3 years

F****** $11,390 publication fees. And yes we scientists will pay. Why, because we are suckers. We will review for free, edit for free and then pay to publish. Why? Because we are suckers for impact factors. Yes, we all are.

Nature Neuroscience

@NatureNeuro

3 years

In this scenario, the cost of publication is covered by an Article Processing Charge (APC) paid at the time of publication. The APC for Nature Neuroscience in 2022 is €9,500/US $11,390/£8,290.

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Shekhar lab

@sshekhr

1 year

Our recent @NatureComms paper is in news!! Here is a cartoon by first author @Heidis_Cells that beautifully summarizes her results on Multiprotein regulation of actin by a polymerase, depolymerase and a capper!

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Shekhar lab

@sshekhr

1 year

Lab's newest PhD candidate - Ekram! Congratulations on passing your qual with flying colors!! @Emory_Physics @Etowsif1 Just like actin, our lab is assembling one member at a time 😀

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Shekhar lab

@sshekhr

5 years

Speaking at the cytoskeleton seminar series coming Tuesday @MBLScience . Have seen some of the most inspiring scientists in the field present from this podium over the last five years. Honored. Come listen!

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Shekhar lab

@sshekhr

2 years

📢Please RT! Apply by September 2nd! I am hiring a postdoc to work on exciting biophysics and biochemical projects in cytoskeletal mechanobiology in my lab at @EmoryUniversity , Atlanta, USA !! See lab website:

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Shekhar lab

@sshekhr

1 year

Our lab's very first undergrad Vishal Reddy just awarded @EmoryUniversity 's SURE fellowship!! @emorycollege @Emory_Physics

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Shekhar lab

@sshekhr

3 years

Looks almost like budding yeast! ❤️

Matt Tyska

@TyskaLabActual

3 years

ZO-1 staining in an #intestinal #organoid 🤩. The cells in that crypt bud are flexing some serious apical constriction.🔬: @DrChinowsky 🙌 #Enteroid #CellBiology #Microscopy #Biology @VUBasicSciences @VanderbiltCDB @VUBasicSciences

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Shekhar lab

@sshekhr

10 months

ImageJ experts - I am looking for a plugin for identification and tracking of mobile single molecules. Any help would be greatly appreciated! Thank you!

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Shekhar lab

@sshekhr

4 years

Amazing to see actual phagocytosis in 3D!

Nick Condon

@DrNickCondon

4 years

Lattice Light-sheet microscopy of phagocytosis reminds me of a certain classic film scene... Exciting imaging collaboration with @JennyStowLab and @themadscienti20 #FluorescenceFriday #Microscopy #StarWars @IMBatUQ @IMBmicroscopy

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Shekhar lab

@sshekhr

3 months

That's how we science in the Shekhar lab! Lab members presenting their exciting discoveries at the @VanderbiltU -Warwick Mechanobiology symposium! @TheVCoM @Warwick_CMCB @Heidis_Cells @a_ankita1

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Shekhar lab

@sshekhr

6 months

Looking forward to visiting @IiserMohali and talking Actin! Thanks to @Rakshits2016 and @SamratLabMohali for hosting me here!

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Shekhar lab

@sshekhr

3 years

Depolymerization - the forgotten child of actin dynamics! Come listen to my talk tomorrow @CellMigration !

Cell Migration Seminars

@CellMigration

3 years

Reminder: tune in tomorrow to hear from @sshekhr @JudeM_Phillip

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Shekhar lab

@sshekhr

5 years

Honoured to be awarded the Whitman Early Career Fellowship @MBLScience !

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Shekhar lab

@sshekhr

2 years

Lab that celebrates birthdays together, stays together! Surprise party by the lab - best lab members ever!!

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Shekhar lab

@sshekhr

3 months

📢📢New paper just out in European Journal of Cell Biology! 🎊 In 1950, Bruno Straub remarked: “One great problem of actin chemistry remains still unsolved, and that is the mode of physiological depolymerization.” 70 years on, we are only now beginning to get some answers!

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Shekhar lab

@sshekhr

3 months

Very excited to have been at @VanderbiltU for the Vanderbilt-Warwick Mechanobiology symposium! @TheVCoM @Warwick_CMCB

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Shekhar lab

@sshekhr

5 years

I second that, big meetings can be overwhelming, especially for the first timers! We all have our awkward stories! A friend of mine once very innocently asked Tom Pollard : "Do you know anything about actin?". Its tough to beat that, so you will be just fine 😀

Prachee Avasthi 🪷

@PracheeAC

5 years

Nothing about meetings as a student or first-timer is easy. I have some really awkward stories myself 🤦🏽‍♀️. It gets better & mostly people aren’t awful. It might feel like you’re the only one hustling but many PIs are looking to recruit too. You might be that someone! Go get it!

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Shekhar lab

@sshekhr

2 years

Actin ❤️

Eric Vitriol

@chillinwithpfn1

2 years

🤯

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Shekhar lab

@sshekhr

7 years

Profilin promotes microtubule growth! New paper from Goode lab in @CurrentBiology

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Shekhar lab

@sshekhr

7 years

Our paper in @CurrentBiology . How Actin filament dynamics define speed of cell movement.

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Shekhar lab

@sshekhr

2 years

@cytoskeletown @Archaeon_Alex Alex, sorry I disagree. I am pretty certain many of us (including myself) would not be where we are today, had all conferences been virtual. Human-human interactions matter. Just because some people don't have access to in-person conferences doesn't mean no one should.

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Shekhar lab

@sshekhr

2 years

Excited to present our research at IISc today and finally meeting @syncellbiolab !

Saravanan Palani

@syncellbiolab

2 years

Looking forward to @sshekhr 's talk on actin dynamics at the Biochemistry Lecture hall between 4-5 pm tomorrow @BICS_IISc @iiscbangalore #actin #cytoskeleton

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Shekhar lab

@sshekhr

2 years

📢Our discovery of FIRST EVER pointed end elongator is in news!!!!! Great collaboration with @KudryashovLab ! Our lab's first paper and that too with BOTH of my first grad students @Heidis_Cells and @AnkitaYadavIN !!

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Shekhar lab

@sshekhr

2 years

A simple Z-projection using flowtrace by @wgilpin0 @Viveknprakash and @PrakashLab showed beautiful vortices around Stentor's oral apparatus! And I was hooked! 3/n

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Shekhar lab

@sshekhr

1 year

Excited to be presenting tomorrow at Emory Biochemistry's seminar series! Thanks to @ebdraganova @EmoryBiochem for the invitation!

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Shekhar lab

@sshekhr

3 years

Guess who is going to have tons of money to pay for $11,000 per publication? Folks at Altos!

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Shekhar lab

@sshekhr

2 years

📢"Multicellular life may have begun with brief alliances between cells" Our recent work on Stentor is in news! With comments from @thibaut_brunet ! @EmoryUniversity @emorycollege @Emory_Physics @MBLScience

New Scientist

@newscientist

2 years

A giant trumpet-shaped cell that skulks in the bottom of ponds has given scientists a new clue about how single-celled creatures may have taken the first steps towards evolving into multicellular ones, a key transition in the evolution of life @sshekhr

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Shekhar lab

@sshekhr

2 years

#newPI

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Shekhar lab

@sshekhr

4 years

All the cytoskeleton folks take note: my guru and the actin disassembler in chief Bruce Goode has arrived on the twitter scene! @BruceLaneGoode

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Shekhar lab

@sshekhr

2 years

Actin ❤️

Slava Bobrov

@slava__bobrov

2 years

This is how cells in your body move: By SmartBiology

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Shekhar lab

@sshekhr

4 years

@nature group is inviting faculty members to a PAID workshop "to prepare early-career researchers to submit to top-tier journals". So first we pay to "learn" how to submit to Nature, then we review for free, & then pay to publish and then pay again to read. We truly are suckers.

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Shekhar lab

@sshekhr

2 years

Using a stentor-pair as a model, we found that neighbors continuously change the separation between them! As the distance decreases, inner vortices fuse and the flow rate of the feeding flow increases! 5/n

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Shekhar lab

@sshekhr

4 years

Structure of active Arp2/3 out, this is big!

The Chowdhury Lab

@saikatLab

4 years

Happy to present our lab’s first publication on the structure of 𝗮𝗰𝘁𝗶𝘃𝗲 𝗔𝗿𝗽𝟮/𝟯 𝗰𝗼𝗺𝗽𝗹𝗲𝘅 and bound to its nucleated actin filament at @NatureSMB Congrats @Shaaban_cryoEM ( @FulbrightAssoc fellow), and a great collaboration with @BradNolen2

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Shekhar lab

@sshekhr

2 years

Celebrating my grad student Heidi's PhD candidacy! Coat ceremony to mark the occaision! @Heidis_Cells @EmoryBCDB @emorycollege @EmoryUniversity

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Shekhar lab

@sshekhr

2 years

Lab dinner, postdoc candidate's presence is just an excuse 😜

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Shekhar lab

@sshekhr

2 years

Finally, someone reminding us that academic life is not so bad afterall! Its important that we tell the next generation about the good stuff of academia too! Unfortunately, discourse on #scitwitter often gets too centered on self-flagellation.

eLife - the journal

@eLife

2 years

PhDs can be challenging and public discourse tends to focus on the negatives. To bring back some balance and positive momentum, this group of students sought to highlight the positive elements of the PhD experience. #AcademicChatter #PhDChat

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Shekhar lab

@sshekhr

1 year

Extremely proud of my graduate student @a_ankita1 for her award at @PoLDresden 's #EMBOlivingsys23 meeting!

Ankita Arya

@a_ankita1

1 year

Happy to receive an honorable mention award for my poster at EMBO workshop on Physics of Living Systems! Thank you @sshekhr @Sandeep_IMSc for your consistent support & recommending me this conference. Learned a lot and made some new science friends. #EMBOlivingsys23 @PoLDresden

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Shekhar lab

@sshekhr

2 years

Actin? 😁

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Shekhar lab

@sshekhr

4 years

This is one movie you won't get tired of watching over and over again!

Needhi Bhalla 💅🏽

@NeedhiBhalla

4 years

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Shekhar lab

@sshekhr

2 years

Rabbit muscle actin prep! Done the good old way! What is there not to like?! @Heidis_Cells @AnkitaYadavIN @BiswasSudipta18

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Shekhar lab

@sshekhr

3 years

'Proud' to announce $2278 as my new Referee Processing Charge (RPC). Assuming there are three reviewers, one editor and the person whose job it is to click to upload the pdf on the website - $11,390/5 = $2278

Nature Neuroscience

@NatureNeuro

3 years

In this scenario, the cost of publication is covered by an Article Processing Charge (APC) paid at the time of publication. The APC for Nature Neuroscience in 2022 is €9,500/US $11,390/£8,290.

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Shekhar lab

@sshekhr

3 years

Now that's actin dynamics!

Eric Vitriol

@chillinwithpfn1

3 years

This model looks great, especially if you have cells with a really bundle-y leading edge. Can't wait to dive into the details of this preprint. Congrats @DVavylonis !

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Shekhar lab

@sshekhr

3 years

Excited to talk about our work on the actin cytoskeleton at the @buildacell seminar series this coming Monday at 11 am eastern time!

Kate Adamala

@KateAdamala

3 years

join us Mon, March 1 at 4PM GMT, for @buildacell synthetic cell engineering seminar Shashank Shekhar Building and remodeling the actin cytoskeleton, one molecule at a time @BaCSouthAmerica @fabrCELL @BaSyCresearch @EngBioRC #synbio @sshekhr

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@sshekhr

1 year

Microtubules ❤️

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@sshekhr

2 years

Three generations at the GRC! It all started with @BruceLaneGoode ! @AnkitaYadavIN @Heidis_Cells @EmoryUniversity @BrandeisScience

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Shekhar lab

@sshekhr

3 years

#GrantAdvice Kal likhe so aaj likh, aaj likhe so ab. Jaldi grant expire hogi, renew karega kab? 😁

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Shekhar lab

@sshekhr

3 years

Cell biologist looking for a faculty position? Come join us at Emory!

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Shekhar lab

@sshekhr

3 years

In-person conferences, I hope we can get back to them ASAP. For the sake of PIs and for the trainees.

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Shekhar lab

@sshekhr

6 months

Great visit today at @IISERPune and talking Actin, thanks to my host @AthaleLab ! Lots of great science and meetings!

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Shekhar lab

@sshekhr

5 years

@jenheemstra Interesting thought, in most European labs that I worked in, everyone including the PI was gone for Atleast three weeks for summer. And guess what? Everything was just fine, and the labs were just as productive as their non-vacationing counterparts.

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@sshekhr

4 years

Cell/molecular/developmental biologist? Looking to start your lab? Come join us at @EmoryMedicine !

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@sshekhr

4 months

New preprint from @Viveknprakash lab! They have addressed one of the most fundamental question how left right patterning using fluid dynamics! If physics or dev bio aren't your thing, go see it for beautiful pictures!

PrakashLab @ Miami

@Viveknprakash

4 months

📢Please RT! New Preprint Alert @biorxiv_biophys This is our latest work in collaboration with Prof. Takashi Mikawa’s lab at UCSF. We showed that cellular flows initiate L-R patterning prior to laterality gene expression in amniotes! 🐣😀

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@sshekhr

1 year

Actin ❤️ First ever successful internal tagging of actin. Works like magic, in budding yeast and in mammalian cell! Work done by @koenvddries and @syncellbiolab !

Saravanan Palani

@syncellbiolab

1 year

Yay! IntAct works in Yeast. Great collaboration with @koenvddries lab. Excellent job done @anubhav_dhar #actin #cytoskeleton #yeast #celldivision #imaging @_NanoTag_ @yeastgenome

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Shekhar lab

@sshekhr

7 years

Wouldn't it be useful if all papers come with a tweet size concise summary! Congratulations on the paper @goleylab !

Erin Goley

@goleylab

7 years

Take homes: FzlA structure solved, FtsZ binding surface ID’d; FtsZ-FzlA intrxn ess’l for division; mutants w weak binding constrict slowly.

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Shekhar lab

@sshekhr

3 years

Having read many ERCstg success stories today, I am actually really glad that someone shared the other side - takes lot more courage to share "it didnt work out". Unfortunately, such beauty awards aren't solely about good science and how good your questions are!

Anna Alemany

@annionna

3 years

Very sad to admit that I didn't get the #ERCStG . I'll need some days to move on from the disappointment. However, I still believe in my vision and project idea, and I'll find other ways forward! Thanks to the people who gave me their support despite the news. So... What's next?

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