Michael Higley 🧠🌈🔬 @mjhigley Twitter profile

Last Seen Profiles

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@pixxarmom__

@yeuriferct

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@Candle_IRIAM

@fob_team

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@ok_Danka

@BiDjeba65910

@kontfeen

@etra_farm

@Supergta67

@Theerealku

@DavidLaney12

@saucetw12

Michael Higley 🧠🌈🔬

@mjhigley

4 years

Ten years, one month, and twenty days after opening my lab, just found out I have received tenure @YaleNeuro ! Thanks to so many friends, colleagues, mentors, and mentees who have supported and shared this journey!

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

Very excited and honored to receive an NIH Pioneer Award (DP1) from @NIH_CommonFund and @NatEyeInstitute 😃! We’re finally going to explore the dynamics of synaptic strength in behaving animals!

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

Our latest hugely collaborative effort to understand functional connectivity of cortical networks is finally out! Simultaneous 2photon/mesoscopic imaging. 1/3

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Michael Higley 🧠🌈🔬

@mjhigley

4 months

Ok, 14 years after starting my lab, promoted to full professor! So @jess_cardin , time for a vacation?

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Michael Higley 🧠🌈🔬

@mjhigley

2 months

Bit of a straw man... We and many others have found this and even noted on Twits. No reason to ever inject 10^13 AAV directly into brain. Dilute down to low-mid 10^12 for good expression and minimal toxicity.

eLife - the journal

@eLife

2 months

Evidence of artefactual calcium microwaves during calcium imaging of neurons in the hippocampus.

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Michael Higley 🧠🌈🔬

@mjhigley

7 years

just heard- my first competitive R01 renewal got funded! drinks on me!

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

Wondering about the cellular and molecular mechanisms driving the diversity of GABAergic synaptic plasticity? Check out our new review, with Chiayu Chiu and Andrea Barberis!

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

We're looking to recruit a long-term technician/research associate to work on molecular bio and viral prep work- senior applicants welcome! Synaptic neuroscience, gene editing, imaging... Opportunities to take lead on projects! DM if interested.

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Michael Higley 🧠🌈🔬

@mjhigley

4 years

1/ New study from (not on tw) Alka Puscian and Hadas Benisty! Ever wonder whether V1 neurons represent both sensory information and trial outcome on a visual detection task?

NMDAR-Dependent Emergence of Behavioral Representation in Primary Visual Cortex

Puścian et al. show that pyramidal and parvalbumin-expressing neurons in mouse visual cortex predict single-trial performance on a visual detection task. Prediction accuracy emerges with learning, is...

www.cell.com

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Michael Higley 🧠🌈🔬

@mjhigley

3 months

1/ Ever wonder how visual information becomes encoded by the brain's navigation systems? New work led by @ODubanet shows robust representation of simple visual stimuli by the medial entorhinal cortex (MEC).

Retrosplenial inputs drive visual representations in the medial entorhinal cortex

Dubanet and Higley show that single neurons in the mouse medial entorhinal cortex show robust, time-locked responses to simple visual stimuli. Visually driven cells are located primarily in layer 3...

www.cell.com

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

1/ Really excited to share some cool new findings, led by (not quite yet on tw) Hadas Benisty, collaboration with Andrew Moberly, @SweytaLohani , @dgbarson , @gmishne , Raphy Coifman, and @jess_cardin .

Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior

Experimental work across a variety of species has demonstrated that spontaneously generated behaviors are robustly coupled to variation in neural activity within the cerebral cortex[1][1]–[9][2]....

www.biorxiv.org

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

After a 2-year gap, super excited to be back in Woods Hole @MBLScience teaching for both NS&B @NSB_MBL and Neurobiology @MblNeuro with the incomparable @jess_cardin !

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Michael Higley 🧠🌈🔬

@mjhigley

4 years

Widefield “mesoscopic” imaging is rapidly becoming a key method for investigating large-scale network dynamics. With @jess_cardin and @MCrair , we’ve summarized the ins and outs of this powerful approach and highlighted some cool recent findings!

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

I’d like to share our new lab logo, created by the amazing @stellatecomms and @caitvw ! It symbolizes our efforts to bridge cellular and systems neuroscience. Time to get some lab swag!

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

New work from Lan Tang, amazing 4+ years of effort! Activity in corticopontine (but not corticostriatal) circuits in layer 5 of mouse V1 predicts and is necessary for performance on a visual detection task (eyeblink conditioning).

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Michael Higley 🧠🌈🔬

@mjhigley

4 years

Latest from our lab, led by Chiayu Chiu and Tom Morse! Tonic GABA paradoxically facilitates dendritic Ca2+ signals. Modeling implicates deinactivation of Ca2+ channels.

Tonic GABAergic activity facilitates dendritic calcium signaling and short-term plasticity

Brain activity is highly regulated by GABAergic activity, which acts via GABAARs to suppress somatic spike generation as well as dendritic synaptic integration and calcium signaling. Tonic GABAergic...

www.biorxiv.org

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

Wow! Today marks the ten-year anniversary of the Higley Lab at Yale! April 1st always seemed like an auspicious day to start the lab. I am incredibly thankful for all the people who have contributed so much to the group since that day, it’s been a privilege to work with you all.

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Michael Higley 🧠🌈🔬

@mjhigley

7 years

Our newest work is out! NMDARs selectively drive LTP at GABAergic synapses formed by SOM-INs.

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Michael Higley 🧠🌈🔬

@mjhigley

4 years

Really excited about an awesome collab with @jess_cardin , led by PDs @SweytaLohani and Andrew Moberly! Dual-color mesoscopic imaging reveals spatiotemporally heterogeneous dynamics of ACh and calcium in the awake mouse cortex.

Dual color mesoscopic imaging reveals spatiotemporally heterogeneous coordination of cholinergic...

Acetylcholine (ACh) is associated with the modulation of brain activity linked to arousal, attention, and emotional valence. We performed dual-color mesoscopic imaging of ACh and calcium across the...

www.biorxiv.org

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Michael Higley 🧠🌈🔬

@mjhigley

2 years

Latest work from the lab, collab with @jess_cardin , led by @SweytaLohani and tw-less Andrew Moberly, also with @HBenisty and @yulonglilab , dual color mesoscopic imaging of calcium and ACh dynamics in awake mouse cortex 1/

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

Maybe the cortex is good for sensory processing after all! Check out our latest-Layer 5 circuits in V1 differentially control visuomotor behavior. All the work of amazing student Lan Tang.

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Michael Higley 🧠🌈🔬

@mjhigley

2 years

New review out with @jess_cardin - we discuss the complementary benefits of electrophysiology and mesoscopic imaging for investigating network dynamics!

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

We are looking for postdocs to apply dual 2-photon/mesoscopic imaging to investigate functional connectivity in cortical networks during perceptual learning and in models of autism! Please DM if interested! (see )

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

Why do reviewers insist that VIP-INs only target other interneurons, when work from our lab as well as the Trachtenberg and Staiger labs show clear anatomical and functional inhibition of pyramidal cells?!?!

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Michael Higley 🧠🌈🔬

@mjhigley

11 months

Super cool new work from lab led by @HBenisty and @dgbarson . Time-varying cross-correlations between cortical areas/cells provide unique info about fluctuations in mouse behavior, similar or greater than that present in activity fluctuations. 1/

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

Excited to announce our latest from postdocs Alka Puscian and Hadas Benisty. Accurate representation of behavioral output emerges in the activity of V1 PNs and PV-INs (but not SOM- or VIP-INs) during task acquisition, and this requires functional NMDARs!

NMDAR-dependent emergence of behavioral representation in primary visual cortex

Neocortical sensory areas are generally thought to faithfully represent external stimuli. However, a growing body of evidence suggests that cortical networks exhibit considerable functional plastic...

www.biorxiv.org

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

@jiwandeepkohli @GDunnArt Jablonski diagram!

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

Little touch-up on my pyramidal neuron, courtesy of katrina and @LuckySoulTattoo

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

Watched the final presentations of MBL Neurobiology students today- the future of science is in safe hands! @MBLScience

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

New collaboration with @jess_cardin , Mike Crair, Todd Constable, headed by @dgbarson - dual 2-photon/mesoscopic imaging reveals heterogeneous cortical networks!

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

Huge congrats to @dgbarson who successfully completed his defense of an amazing PhD! Co-mentored with @MCrair , really proud of his accomplishments and tireless contributions to the lab and the community!

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

Awesome new study from the lab of former postdoc @gyorgy_lur now at UC Irvine! Stress alters specific circuits in mouse parietal cortex.

Repeated Exposure to Multiple Concurrent Stresses Induce Circuit Specific Loss of Inputs to the...

Severe loss of excitatory synapses in key brain regions is thought to be one of the major mechanisms underlying stress-induced cognitive impairment. To date, however, the identity of the affected...

www.jneurosci.org

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

Want to use cutting edge 2p/mesoscopic imaging and novel viral CRISPR/Cas9 tools to study mouse behavior in ASD-models? In collaboration with @jess_cardin we’re looking for postdocs to join a new @SFARIorg -funded project! Pls r/t and DM for more info!

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Michael Higley 🧠🌈🔬

@mjhigley

4 years

This has been an amazing large-group collaboration providing a great example of how spatiotemporal scales can be spanned using an array of imaging modalities, hopefully also providing a framework for linking human and non-human studies at a cellular-mechanistic scale!

Todd Constable (find me here @toddc.bsky.social)

@constable_todd

4 years

This is a companion paper to work linking 2-photon optical imaging to meso-scopic Ca2+ whole cortex imaging. @dgbarson @MCrair @mjhigley @jess_cardin

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Michael Higley 🧠🌈🔬

@mjhigley

11 months

Cardin/Higley Labs out for dinner! Some folks missing, but awesome to hang out away from work!

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

First round of Yale Neuro faculty interviews: 4 men, 4 women one of color. All fantastic scientists!

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

Awesome collaborative effort from Yale labs, showing links between Ca2+ and BOLD signals in mice!

bioRxiv Neuroscience

@biorxiv_neursci

6 years

Spanning spatiotemporal scales with simultaneous mesoscopic Ca2+ imaging and functional MRI #biorxiv_neursci

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

Totally psyched to be starting up the imaging cycle @MBLScience , Neurobiology 2019! Mesoscopic mouse brains with @dgbarson .

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Michael Higley 🧠🌈🔬

@mjhigley

7 years

latest from our lab- molecular heterogeneity of GABAergic synapses -> input-specific plasticity of inhibition:

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

Just got these awesome new stickers, sponsored by @YaleNeuro !

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Michael Higley 🧠🌈🔬

@mjhigley

4 years

Part 1 in our plan to entertain the kids without camp this summer, with @jess_cardin

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

Really excited to announce a new collaborative project, with @biedererlab , @MXHend , @DaniSBassett , and Elena Gracheva, using a combination of molecular, synaptic, and systems neuro approaches to understand cellular and circuit vulnerability in Parksinson’s!

Aligning Science Across Parkinson’s

@ASAP_Research

3 years

Excited to announce that 14 new teams will be joining the ASAP Collab Research Network ( #ASAP_CRN ) with a focus on #circuitry and brain-body interactions connected to #Parkinson 's. Meet the #ASAPGrantees !

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

Psyched to be back in Woods Hole teaching for the MBL Neurobiology course! So many memories, can’t wait to make some new ones!

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Michael Higley 🧠🌈🔬

@mjhigley

4 years

Shot #1 (Pfizer) in the bag... well, arm...

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Michael Higley 🧠🌈🔬

@mjhigley

8 months

Awesome convergence of in vivo and ex vivo data showing functional development of SST-INs in visual cortex!

Jess Cardin

@jess_cardin

8 months

Now on bioRxiv, a long-term collaboration between @AlexWang955 and @kt_ferguson on somatostatin interneuron development, with gorgeous synaptic data from @mjhigley and Jyoti Gupta. SST cells in 🐭V1 have a unique developmental window right after 👁️opening!

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

@jiwandeepkohli @GDunnArt and my layer 2/3 pyramidal neuron!

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

"last day of summer" for our lab!

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

In honor of #WomenInScienceDay , I’d like to acknowledge Drs. Chiayu Chiu, @mkannan3112 , Kacey Rajkovich, Alka Puscian, @Nouronal , Jyoti Gupta, Hadas Ben Esti, and Lan Tang (PhD pending). Outstanding scientists who have been fundamental contributors to our lab. Thank you!

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

We also developed a powerful approach for whole-brain viral infection via neonatal AAV9. More on this from Ali here:

Transverse sinus injections: A novel method for whole-brain vector-driven gene delivery

A major challenge in neuroscience is convenient whole-brain delivery of transgenes, especially early in postnatal development. Recent advances demonstrate whole-brain gene delivery by retro-orbital...

www.biorxiv.org

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

For those of you working on ANNs, is there a useful, searchable, curated repository of models across labs? Any thoughts from @KordingLab or @tyrell_turing ?

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Michael Higley 🧠🌈🔬

@mjhigley

7 years

new R01-fnded PD spot to stdy development of GABAergic inh in cortx- joint cardin/higley lab adventure! plz RT

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

Ever wonder about the spatiotemporal constraints on cholinergic signaling in the cortex? Check out a new review by Anita Disney and I, part of the J. Neuroscience dual perspectives series.

Diverse Spatiotemporal Scales of Cholinergic Signaling in the Neocortex

ACh is a signaling molecule in the mammalian CNS, with well-documented influence over cognition and behavior. However, the nature of cholinergic signaling in the brain remains controversial, with...

www.jneurosci.org

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

@jess_cardin Incredibly well-deserved. I'm privileged to share this adventure with you!

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

@anne_churchland @sheacshl @polybiotique @cllantz @jess_cardin honestly, for anyone trained as a synaptic/cellular physiologist, the dependence of neuronal activity on the kinetics of the opsin have always been obvious, but it’s really important to bring these issues to light in the systems communities.

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

had probably the last thesis comm mtg for one of my students, Lan Tang- very bittersweet, but she has totally rocked it! stay tuned for her upcoming manuscript!

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Michael Higley 🧠🌈🔬

@mjhigley

2 years

Interested in combining adaptive optics with multiphoton imaging in vivo? Apply for a @WuTsaiYale Postdoctoral Fellowship to work with Cristina Rodriguez @crisrodtsou and I in a super collaborative environment!

Postdoctoral Fellowships | Wu Tsai Institute

wti.yale.edu

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

Thank you so much to the LouLouFoundation! Can’t wait to get started on this collaboration with @jess_cardin !

Krzysztof Potempa

@BRAINCURES

3 years

@MamadOmar5 @findacure_fdn @eurordis @dliu_ccb @JohnSinnamon @SilaUltanir @mb470102 @journodave @CNSdrughunter @CDKL5Alliance @PatientIntv @CDKL5USA @davidrliu @CDKL5Cad @ArtForHLC @CDKL5UK @AAledo @CdklFr @Cdkl5ireland @AmitR_nyc @ORDR @CORareAdvocate @RareDiseases @NHGRI_Director @julianhalmai @cureangelman @fastercures @MilkenInstitute @GlobalGenes @CureFA_org @SonyasStory @cdkl5_nl @RareRevolutionM @EEpicare @MDBRide4Rare @RickSThomp @DavidFajgenbaum @rksemple @akorsunska @CureCastleman @PurposefulDR @IvoTimmermans @PlecoTx @LovettRosie @charleneson @Purrfectly_Rare @pulseinfoframe @Nick_Sireau @TorieRobinson10 #InternationalCDKL5Day 2021 CDKL5 Pilot Grant Program Awardees Michela Fagiolini Victor Faundez “Systems Analysis of the #CDKL5 -Deficiency Disorder (CDKL5-DD) Cerebrospinal Fluid Proteome” Michael Higley @mjhigley Peter Jackson Christopher McGraw Dolan Sondhi #RareDisease #SDG3

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Michael Higley 🧠🌈🔬

@mjhigley

8 years

Woot! Newly minted Associate Professor!

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Michael Higley 🧠🌈🔬

@mjhigley

2 years

an hour off the plane, sitting with rum and pork mofongo in old san juan! life is good!

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

New collaboration with @jess_cardin !

Simons Foundation Autism Research Initiative

@SFARIorg

6 years

SFARI intends to fund 36 grants (15 Pilot Awards & 21 Research Awards) in response to the 2018 Pilot and Research Awards RFA. More than $20 million in funding is intended to be awarded to 42 investigators as part of this program: #autism #research #grants

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

@KordingLab I understand Sutton's point, but I think one has to first decide if you want to understand the human (or mammalian) brain, or design a computational system that can match it's performance. I appreciate both goals, but I am personally only interested in the former.

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

Excited to be in beautiful Champery, Switzerland talking about neuromodulation!

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Michael Higley 🧠🌈🔬

@mjhigley

2 years

Gordon was welcoming, willing to teach, more importantly willing to learn. He was wonderfully able to appreciate links between theory and experiment. And he was endlessly curious. We'll miss him.

Jess Cardin

@jess_cardin

2 years

Gordon was the most generous and gracious colleague one could have. He was incredibly welcoming when I arrived at Yale, and a wonderful neighbor. We will miss his thoughtful presence at the weekly joint lab meetings with the @mjhigley lab.

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

@KordingLab @shadlen The Shadlen/Movshon perspective (and also Bill and Mike's older work) doesn't include dendritic heterogeneities, where synchrony may be amplified considerably. I think computational systems neuroscience world could benefit from cell biology and membrane biophysics a bit more.

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

Awesome dinner out with the lab! #toomuchfood

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

I'm off to Shanghai and Fudan University- first trip to China! 😁

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Michael Higley 🧠🌈🔬

@mjhigley

1 year

@lukesjulson Funny, I think I'm a card-carrying synaptic physiologist and this doesn't bother me that much- would be great for showing to my mom or a similar lay-person. I agree about the errors, but their importance is audience-specific.

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

Just had an awesome birthday break from rabid grant writing - lunch with the always amazing @jess_cardin !

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Michael Higley 🧠🌈🔬

@mjhigley

4 years

@NUro_science @NUneurobio Congrats!! (just found out that our board voted yesterday, so i'm official too!)

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

so excited i got to hang out with the awesome dr. griffith this summer!!

Dr. Theanne Griffith 🇧🇧👩🏾‍🔬🇭🇷

@doctheagrif

3 years

I’m so happy to finally share that I was invited to co-write the companion non-fiction book for the highly anticipated Ada Twist, Scientist @netflix series, exec prod by @MichelleObama and @BarackObama ! It’s been a blast working with you @andreabeaty ! 1st book Releases 12/14!

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

@S_Grella @jmcin9 AAV is remarkably stable for quite a while. It’s the freeze-thaw that causes the biggest titer drops (in our hands).

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

psyched to be heading to Zurich for 3 days of GABAergic signaling and plasticity!

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

@polybiotique @cllantz @sheacshl yep - take a look at earlier work on this topic from @jess_cardin

Activation of Distinct Channelrhodopsin Variants Engages Different Patterns of Network Activity -...

Several recently developed Channelrhodopsin (ChR) variants are characterized by rapid kinetics and reduced desensitization in comparison to the widely used ChR2. However, little is known about how...

pubmed.ncbi.nlm.nih.gov

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Michael Higley 🧠🌈🔬

@mjhigley

2 years

New review with @EvelynMRLake on multimodal brain imaging strategies, including mesoscopic imaging and fMRI!

Building bridges: simultaneous multimodal neuroimaging approaches for exploring the organization of...

Brain organization is evident across spatiotemporal scales as well as from structural and functional data. Yet, translating from micro- to macroscale (vice versa) as well as between different...

www.spiedigitallibrary.org

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Michael Higley 🧠🌈🔬

@mjhigley

8 years

Postdoc available in the Higley lab to study GABAergic synapses + role in behavior! We use ephys and opto in slice and in vivo! Please RT!

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

@jess_cardin Think you've seen tough audiences at seminars? Wait til the 5-year-olds come for you!

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

@KordingLab if you consider a precisely timed output as true, E alone gives a large burst, I alone nothing, E+I a precision output, not a perfect example, but easy to do experimentally

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

@anne_churchland The actual seminar is only a minimal part of the entire visit. There are no friendly conversations or nascent collaborations born out of long-distance skype talks.

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Michael Higley 🧠🌈🔬

@mjhigley

8 years

Our new study "Potassium channels contribute to activity-dependent scaling of dendritic inhibition" on bioRXiv...

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

@Labrigger We can also confirm, the objective works great for 2p dendritic calcium imaging! Spines and all- thanks to the group!!!

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Michael Higley 🧠🌈🔬

@mjhigley

2 years

Excited to announce, now former PD @HBenisty is a new Assist. Prof at the Technion, Israel! Also check out her work @CosyneMeeting tomorrow, "Rapid fluctuations in multi-scale correlations of cortical networks encode spontaneous behavior" [II-73]. She's recruiting!

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Michael Higley 🧠🌈🔬

@mjhigley

4 years

here you go!

Turrigiano Lab

@TurrigianoLab

4 years

@jess_cardin video or it didn't happen!

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

Here's a nice writeup from @Yale , @YaleMed ,

Yale Scientists Capture Dynamic Brain in Action

Researchers at Yale University have developed a way to employ a pair of microscopic technologies to provide a glimpse of the entire brain at work in real time.

medicine.yale.edu

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

@marius10p @TPVogels @markdhumphries @cian_neuro @ulisespereirao @neurograce @computingnature @bitking69 @CousinAmygdala @michael_okun @HSompolinsky @shadlen @SachaNelsonLab @sprekeler the idea of accurately assessing E and I in vivo with voltage clamp is laughable.

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Michael Higley 🧠🌈🔬

@mjhigley

7 years

@amysutton31 @HuShuLab @CarolineEBass @NeuronRoot @DavidBarker_PhD @ssimms21 as the significant other of Dr Cardin, I can point out that Atasoy et al did publish first and the idea should really be Flex not DIO

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

@bita137 Agreed- multiple postdoc babies in my lab and no issues AT ALL! We all accommodate, no loss of productivity, and lots of cute baby pics!

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Michael Higley 🧠🌈🔬

@mjhigley

3 months

@KordingLab @pwlot to whom? i think the original post was meant as a "look, the brain is braining, isn't that cool", not a specific take on which patterns of activity in which cells mediate decisions. we need more people to be awed by our ability to watch stuff happen in vivo.

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

@yusterafa @adilgkhan nice work rafa- but i should point out, we also used stimulation of som-ins, confirmed with 2p uncaging, to show inhibition in spines- maybe S1 versus PFC diffs

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

@KordingLab @brendon_hoch @nplareau but then you’re demanding that the data generator develop and build the “$100 2p system”. As mentioned by others in the thread - the cost of learning and porting code to python is seriously non-negligible.

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

Day 3, #7booksilove , another classic, tagging @MichaelHoppa !

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Michael Higley 🧠🌈🔬

@mjhigley

4 years

@mattlark Very cool! Similar to our findings in visual cortex.

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Michael Higley 🧠🌈🔬

@mjhigley

5 years

@andpru Funny, the more senior I get, the shorter my discussion sections get. I usually feel like saying "here are the results, please digest as you like".

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

lol, yup! @jess_cardin

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Michael Higley 🧠🌈🔬

@mjhigley

1 year

Incredibly excited to be part of Andrew’s awesome career trajectory! Stay tuned for his upcoming findings!

Yale Neuroscience

@YaleNeuro

1 year

For today's #TraineeTuesday , please welcome Andrew Moberly, PhD, a postdoc in the labs of @mjhigley & @jess_cardin ! Andrew was recently awarded a K99/R00, marking a significant step in his journey toward running a research lab 😮👏 Let's find out what he's been up to! [1/5]

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

Andes from 38,000 feet.

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Michael Higley 🧠🌈🔬

@mjhigley

2 years

Note, this work only took three years longer than than the "just a few months" we initially told the post docs! 😄😜😆

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

@JasonSynaptic check out @cris_niell lab's work on octopi visual system!

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Michael Higley 🧠🌈🔬

@mjhigley

7 years

@Jessrw_NYC @christlet I don’t think the point is to “model autism”, but rather use a system with some common cellular and circuit features to understand links between ASD-associated genes, cells, systems, and behavior

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Michael Higley 🧠🌈🔬

@mjhigley

3 years

If you’re interested in pushing the limits of in vivo imaging (2-photon, meso, ??) or understanding how synapses “work” in the intact brain, please DM! We’re looking to hire postdocs or research scientists for this project.

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Michael Higley 🧠🌈🔬

@mjhigley

6 years

@Nouronal @superkash remember that it is much more about how your grant resonates with 1-3 random people- it could get a completely different result under other circumstances- this is just the process, not a reflection of you. also, we ALL stress out anyway.

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