Decades of research have validated pathways that extend the life span of short-lived organisms. By modeling muscle aging adjusting for metabolic and aerobic capacities, we demonstrate that these...

Author summary Functional enrichment analysis is a commonly used technique to identify trends in large scale biological datasets. In biomedicine, functional enrichment analysis of gene expression...

Transcriptome-wide molecular profiling of cells or tissue is used for multiple purposes including classification, pathway biology and drug repositioning. Replacement of microarray technology by...

Adipocytes increase energy expenditure in response to prolonged sympathetic activation via persistent expression of uncoupling protein 1 (UCP1)1,2. Here we report that the regulation of glycogen...

Metformin and exercise independently improve insulin sensitivity and decrease the risk of diabetes. Metformin was also recently proposed as a potential therapy to slow aging. However, recent eviden...

Background The efficacy of high-intensity interval training for a broad spectrum of cardio-metabolic health outcomes is not in question. Rather, the effectiveness of this form of exercise is at...

Optimising the use of transcriptomics enables screening of thousands of compounds and illustrates an approach that yields quantitative pharmacology at the single-gene and pathway level.

Background Simpson's paradox is sometimes referred to in the areas of epidemiology and clinical research. It can also be found in meta-analysis of randomized clinical trials. However, though readers...

IntroductionRegular physical activity (PA) can reduce the risk of developing type 2 diabetes, but adherence to time-orientated (150 min week−1 or more) PA gu...

Nature Reviews Drug Discovery - Physical activity has demonstrated positive effects in preventing and ameliorating a broad range of diseases, particularly central nervous system disorders....

Branched-chain amino acids (BCAAs) are essential for critical metabolic processes; however, recent studies have associated elevated plasma BCAA levels with increased risk of insulin resistance. Using...

Large individual differences exist in aerobic fitness in childhood and adolescence, but the relative contribution of genetic factors to this variation remains to be established. In a sample of...

Insulin infusion increases skeletal muscle microvascular blood flow (MBF) in healthy people but is impaired during insulin resistance. However, we have shown that eliciting insulin secretion via oral...

Scientific Reports - Whole transcriptome analysis and validation of metabolic pathways in subcutaneous adipose tissues during FGF21-induced weight loss in non-human primates

Sequencing the human genome empowers translational medicine, facilitating transcriptome-wide molecular diagnosis, pathway biology, and drug repositioning. Initially, microarrays are used to study the...

Our results suggest that short-term treatment of senescent myoblasts with reversine could restore insulin resistance, enhance glucose metabolism and oxidative phosphorylation, likely via reactivati...

Michael Mosley experiences his first session of High Intensity Training (HIT) on an exercise bike.

The biosynthesis of endogenous brain-derived neurotrophic factor (BDNF) has thus far been examined in neurons where it is expressed at very low levels, in an activity-dependent fashion. In humans,...

Sorry, boiled chicken bros.

Nature Human Behaviour - This umbrella review of meta-analytic evidence reveals that previously reported benefits of physical exercise on cognitive function may have been exaggerated. The authors...

SUMMARY The induction of cellular reprogramming by forced expression of the transcription factors OCT4, SOX2, KLF4, and C-MYC (OSKM) has been shown to allow the dedifferentiation of somatic cells and...

Nature Metabolism - This study reports and characterizes the impact of loss-of-function GDF15 variants in human individuals.

Scientific Reports - DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity

Optimising the use of transcriptomics enables screening of thousands of compounds and illustrates an approach that yields quantitative pharmacology at the single-gene and pathway level.

Transcriptome-wide molecular profiling of cells or tissue is used for multiple purposes including classification, pathway biology and drug repositioning. Replacement of microarray technology by...

Decline in skeletal muscle cell size (myofiber atrophy) is a key feature of cancer-induced wasting (cachexia). In particular, atrophy of the diaphragm, the major muscle responsible for breathing, is...

AbstractIntroduction. Ageing skeletal muscles become both insulin resistant and atrophic. The hormone glucagon-like peptide 1 (GLP-1) facilitates postprand

Nature Methods - This study introduces a method utilizing homotrimeric nucleotide blocks to achieve accurate counts of RNA molecules in both bulk and single-cell sequencing data.