A more mindful approach to science can help scientists to handle negative and positive emotions better.

Nature - Fumarate metabolism regulates the innate immune response through a mechanism in which high levels of fumarate result in the generation of mitochondrial-derived vesicles and the release of...

Nature Communications - Mitochondrial quality control is critical for cellular homeostasis and survival. Here, the authors identify that defective mitochondria can be eliminated via secretion in...

Nature Cell Biology - Organic acidurias are inherited disorders that can severely affect mitochondria. A study in Caenorhabditis elegans suggests that binding of a toxic metabolite to a factor...

Nature Cell Biology - Diehl et al. show that imbalance among nucleotide species is not sensed by canonical metabolic regulatory pathways, causing excessive cell growth despite a DNA replication...

The Tricarboxylic Acid Cycle (TCA) cycle is arguably the most critical metabolic cycle in physiology and exists as an essential interface coordinating cellular metabolism, bioenergetics, and redox...

On the many things nobody told me when I decided to move abroad for a postdoc.

During a postdoc many of you will be asked whether you want to become a Principal Investigator (PI) – an academic position of financial and intellectual independence, with direct responsibility for...

To assess the distribution of metabolites between mitochondria and the cytosol, we developed a rapid fractionation procedure. We take mouse heart/liver and within ~ 30 s stabilise the distribution...

Modulating mitochondrial electron flow improves tumor immune response.

Alongside hypoxia, acidosis is a chemical signature of many solid tumors. By performing a genome-wide CRISPR-Cas9 screen, Michl et al. find that cancer cells require NDUFS1 and other OXPHOS genes for...

Nature Communications - Primary and metastatic tumours have different metabolic phenotypes due to changes in nutrient availability. Here the authors perform multi-omic analyses of primary and...

Global methylation changes in aging cells affect cancer risk and tissue homeostasis

Nature - This study highlights the role of mitochondrial complex I-dependent NAD+ regeneration in directing lung epithelial cell fate during postnatal alveolar development by preventing...

Nature Reviews Drug Discovery - Despite the link between metabolism and oncogenes, very few metabolism-based drugs for cancer have been successfully developed. This Review covers the setbacks and...

Nature - CRISPR screening and protein–protein interaction networks identify components and mechanisms of nutrient-dependent mTORC1 signalling in regulatory T cells and reveal how mTORC1...

Nature Chemical Biology - Aerobic glycolysis is a hallmark of fast-growing cells, but it is unclear whether glycolysis was selected for its speed. Glycolysis produces ATP slower than respiration...

Nature Reviews Molecular Cell Biology - Metabolites are generally viewed as intermediates or products of metabolism. However, many metabolites are also signalling molecules that regulate metabolic...

Multi-omic analyses reveal a connection between the integrated stress response and the regulation of redox and amino acid metabolism when the TCA cycle is impaired.

Rogerson et al. profile the open and active chromatin in an in vitro model of hereditary leiomyomatosis and renal cell cancer (HLRCC). Through various multi-omic approaches, they identify FOXA2 as an...

Nature - Pathologically activated neutrophils, termed myeloid-derived suppressor cells, in the tumour microenvironment spontaneously undergo ferroptosis, which negatively regulates anti-tumour...

Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we combined...

A review discusses how epigenetic stochasticity can connect mutations and environmental perturbations to cancer progression and treatment.

Nature Biotechnology - An open invitation to the Understudied Proteins Initiative

Sarah-Maria Fendt highlights the history of the Warburg effect and how these findings have advanced our understanding of cancer metabolism.

Small cell size preserves the function of hematopoietic stem cells (HSCs); HSC enlargement during aging causes their dysfunction.

Abstract. In the summer of 2021, we held a community workshop at the International Congress of Arabidopsis Research (ICAR) aimed at early career researcher

Nature Reviews Cancer - This Review outlines how the profound intertumoural heterogeneity in immune landscapes of tumours is shaped by cancer cell-intrinsic alterations and highlights how the...

Light: Science & Applications - HBmito Crimson has the ability to localize specifically on the inner mitochondrial membrane and emit light, while its superior photostability enables STED imaging.

Pilic et al. describe an unexpected function of hexokinase (HK1) in forming rings that constrict mitochondria during energy stress. The assembly and disassembly of HK1-rings regulates mitochondrial...

Wenes et al. show that lactate oxidation via pyruvate conversion and mitochondrial import may sustain antitumor function of cytotoxic T cells in the tumor microenvironment. In contrast, short-term...

Nature - Inhibition of the fatty acid oxidation metabolic pathway through inactivation of Cpt1b enhances cardiomyocyte survival and proliferation and allows heart regeneration in adult mice.

Nature Communications - The spatial signature of metabolic remodeling in tumours remains to be explored. Here, the integration of mass spectrometry imaging-based spatial metabolomics and lipidomics...

Nature Communications - How cells adapt to glucose starvation is still elusive. Here, Levy et al. show that the mTOR substrate 4EBP1 protects human, mouse, and yeast cells from glucose starvation...

Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the role of metabolism during metastasis has been limited by the development of robust and sensitive technologies...

Evidence for UTP as a phosphate donor for thiamine pyrophosphate formation is found.

Degradation of hyaluronan in the extracellular matrix leads to mitochondrial remodeling, activation of mitochondrial stress responses, and augmented immune signaling.

Aerobic glycolysis is associated with proliferation in many biological contexts, yet what drives this phenotype has not been fully explained. Luengo et al. show that cells engage in aerobic glycoly...

Nature Medicine - As another clinical trial of a mitochondria-targeting cancer therapy faces failure, it calls for a thorough re-evaluation of the strategy; the time has come to go from the bedside...

Clear cell renal cell carcinoma (ccRCC) tumours develop and progress via complex remodelling of the kidney epigenome, transcriptome, proteome, and metabolome. Given the subsequent tumour and inter-...

Mitochondria, special double-membraned intracellular compartments or ‘organelles’, are popularly known as the ‘powerhouses of the cell’, as they generate the bulk of ATP used to fuel cellular...

We need to shift the focus of aging research to aging itself

Nature Communications - The authors showed that, in C. elegans, inhibition of translation or mTORC1 increases ATF-4 expression independently of ISR signalling. ATF-4 promotes longevity by...

Nature Cell Biology - Shapiro, Chang, et al. identify a conserved role for the iron-binding histone demethylase KDM3B in sensing iron levels and regulating mTORC1 through transcriptional repression...

Mitochondrial dysfunction induces a strong adaptive retrograde signaling response; however, many of the downstream effectors of this response remain to be discovered. Here, we studied the shared...

Nature Communications - Methods for the analysis of metabolites in cells often require sample disruption and lack spatio-temporal resolution. Here, the authors show that Raman spectroscopy can...

Nature Metabolism - Reactive oxygen species (ROS) have important roles in health and disease, but are chemically complex and difficult to measure accurately. This consensus statement proposes...

Nature Metabolism - Subcellular quantitative analysis has been a long-standing goal of mass spectrometry imaging, but was originally thought to be unattainable. However, recent advances have made...

Serine is traditionally viewed as a nonessential amino acid that plays vital roles in various biological processes, including nucleotide and lipid metabolism and the production of one-carbon units to...

Ye et al. develop and apply a dead-guide RNA-based genome-wide gain-of-function CRISPR activation screen, which identifies PRODH2 as an enzyme that reprograms proline metabolism in CAR-T cells to...

Nature Metabolism - In 1923, Otto Warburg published his landmark study , in which he described his seminal observations related to metabolic shifts in cancer, often referred to as the Warburg...

Nature Cancer - Papagiannakopoulos and colleagues discuss the roles of reactive oxygen species in cancer and the ways in which redox mechanisms may be exploited for cancer therapy.