Matt Krisiloff Profile Banner
Matt Krisiloff Profile
Matt Krisiloff

@mattkrisiloff

7,690
Followers
588
Following
37
Media
1,614
Statuses

CEO @Conception (generating human eggs to help treat infertility) Started @SciFounders (helping scientists start companies)

San Francisco, CA
Joined April 2012
Don't wanna be here? Send us removal request.
@mattkrisiloff
Matt Krisiloff
10 months
As an original member of @OpenAI Nonprofit's founding team, I think the rest of the board should resign. Regardless of the details, the way today has been handled is such a disgrace.
54
248
4K
@mattkrisiloff
Matt Krisiloff
3 years
'Science Startups - Who's Hiring?' A lot of scientists have a hard time finding cool startup opportunities. Trying an experiment to help. Science startups -- reply with 1 tweet on your mission, roles looking for, and how to learn more. Everyone -- RT so more scientists see!
103
670
1K
@mattkrisiloff
Matt Krisiloff
4 years
Starting a fellowship program for early career scientists that want to start companies -- funding up to $400,000 along with mentorship from founders building science companies. Please RT so scientists can see!
44
679
1K
@mattkrisiloff
Matt Krisiloff
2 years
I learned yesterday there are four different teams making serious attempts to form artificial womb startups. Very cool times!
90
71
777
@mattkrisiloff
Matt Krisiloff
9 months
The charter for @OpenAI says "their primary fiduciary responsibility is to humanity." It's time for the board to listen to humanity and resign. As a founding member of OpenAI, I'm calling to please sign and share/RT this petition asking for resignation.
31
75
451
@mattkrisiloff
Matt Krisiloff
3 years
Opening a second round of applications for SciFounder Fellowship, a program to help scientists start companies. Teams receive $400,000 along with mentorship from founders building science companies. Please RT so scientists see!
9
172
300
@mattkrisiloff
Matt Krisiloff
3 years
Ginkgo Bioworks was started by graduate students, and 12 years later is still led by those same graduate students. Scientists, know you can start and lead transformational companies too.
3
28
266
@mattkrisiloff
Matt Krisiloff
10 months
If the last 24 hours is how @OpenAI 's board communicates, I have no confidence they would act appropriately in a situation of emergency AI safety. Unless evidence is shared that negligence was about to result in immediate societal harm, OpenAI's board needs to resign now.
@mattkrisiloff
Matt Krisiloff
10 months
As an original member of @OpenAI Nonprofit's founding team, I think the rest of the board should resign. Regardless of the details, the way today has been handled is such a disgrace.
54
248
4K
4
26
221
@mattkrisiloff
Matt Krisiloff
10 months
I always tell people Sam and Greg were the two people in my career I learned the most from. They are incredible operators, and I can’t imagine OpenAI will be nearly as effective without them. I don’t know what actually happened, but this all feels very unfair.
@gdb
Greg Brockman
10 months
After learning today’s news, this is the message I sent to the OpenAI team:
Tweet media one
2K
5K
36K
3
14
209
@mattkrisiloff
Matt Krisiloff
3 years
Announcing SciFounder Capital -- a new funding source to keep scientist founders in control of their companies. We're giving the voting rights from our investments to the founders -- this will help keep startups mission-focused on science. Please share!
6
48
212
@mattkrisiloff
Matt Krisiloff
4 years
We received 371 applications for Sci-Founder Fellowship. Reading through the apps feels inspiring -- almost every scientist wants to start a company that could save people's lives.
6
8
180
@mattkrisiloff
Matt Krisiloff
3 years
'Science Startups, Who's Hiring?' (June) Last month I made a thread to help scientists / others find cool roles at startups. Seemed helpful, so doing again! Science startups -- reply with 1 tweet on your mission + open roles. Everyone -- please RT so more people see! (🧵 1/2)
27
80
182
@mattkrisiloff
Matt Krisiloff
1 year
These five 🐭 pups, two dads each. Born just from cells from male mice. I hope one day soon it works for everyone. 👨‍👨‍👧‍👦
Tweet media one
6
24
185
@mattkrisiloff
Matt Krisiloff
2 years
I find that lot of the best scientists do not have PhDs. They often instead went into industry after college and learned excellent bench skills / critical thinking in a team-oriented setting. Companies should look out for these people and promote them -- they are strong assets.
7
15
156
@mattkrisiloff
Matt Krisiloff
3 years
I wrote a post on why more scientists should consider starting companies. Companies have two big advantages that make it easier to pursue many kinds of research.
5
35
150
@mattkrisiloff
Matt Krisiloff
1 year
The New Yorker spent a couple days with Conception and wrote about our company in depth:
3
42
146
@mattkrisiloff
Matt Krisiloff
3 years
We're hiring for many roles at Conception, where we're working on turning stem cells into human eggs. If developed safely, this technology could be a very big deal:
13
11
136
@mattkrisiloff
Matt Krisiloff
2 years
Interested in working at a cool science startup? We've put together a list of science startups that are currently hiring with great opportunities.
2
44
124
@mattkrisiloff
Matt Krisiloff
3 years
Also, started a program called Sci-Founder Fellowship to help early career scientists start companies. We give $400,000 + mentorship to scientists to help them get started. If have an idea for a company, check out .
1
15
104
@mattkrisiloff
Matt Krisiloff
3 years
At Ovid Research we're working on turning pluripotent stem cells into human eggs for fertility purposes. This could allow women to have children into their 40's and 50's, and potentially allow gay couples to have biological children of their own.
2
8
99
@mattkrisiloff
Matt Krisiloff
3 years
Postdocs-- I don't think enough of you realize you can 2x or more your salary by taking a job in industry. You don't have to give up on meaningful work -- there are many companies pursuing inspiring research. You deserve a respectful wage now -- not just in the future.
1
4
90
@mattkrisiloff
Matt Krisiloff
3 years
We're taking applications again for SciFounder Fellowship and now making applications always open and rolling! Scientists can apply any time at for $400,000 + mentorship from science founders to help start a startup. Please share so scientists see!
4
29
81
@mattkrisiloff
Matt Krisiloff
4 years
The hope is to inspire more scientists to start companies-- the right scientist can become a great founder, and companies are often the most effective way to develop research that can improve or save people's lives.
6
5
75
@mattkrisiloff
Matt Krisiloff
2 years
It's a good time for industry scientists to start startups. Most startups seem to be started by academic scientists, but industry scientists should take the idea of starting a company more seriously. 🧵
7
15
75
@mattkrisiloff
Matt Krisiloff
2 years
Human embryos will be made from blood samples by the thousands in our lifetimes. These will be screened for genetic disease risk, some even edited. Odds for future generations to have cancer, Alzheimer's, heart disease and more may be dramatically reduced.
13
9
68
@mattkrisiloff
Matt Krisiloff
11 months
Sending a cold email has been the start for almost every important career event in my life. (And for meeting my boyfriend too!)
1
1
73
@mattkrisiloff
Matt Krisiloff
3 years
Why are the vaccines not being reformulated and approved for new variants much faster? Is moving quickly with short trials really that big of a risk given the base versions are so safe?
12
8
71
@mattkrisiloff
Matt Krisiloff
2 years
Opening a new round of SciFounder Fellowship! If you're a scientist looking to start a company, we'll give you $400,000 + mentorship on how to get started. Deadline to apply is December 15th.
2
7
69
@mattkrisiloff
Matt Krisiloff
4 months
I feel like people in biotech can sometimes be more casually judgmental of each other's companies for trivial reasons. Worth staying positive! - everyone's working on hard/important things, and it can be unclear from the outside how things are progressing given long timelines.
7
5
69
@mattkrisiloff
Matt Krisiloff
3 years
This will be true for scientist-led companies too!
@qcapital2020
 Q-Cap 
3 years
Founder-led Stocks > Non Founder-led Source: Bain & Company
Tweet media one
45
287
1K
2
9
66
@mattkrisiloff
Matt Krisiloff
7 years
Want to fund scientists trying to engineer embryos/gametes from stem cells. Please email if know people! matt @ycombinator .com
9
17
63
@mattkrisiloff
Matt Krisiloff
1 year
Celebrated @Conception 's office warming last week with our remote team flying in too. I'm so excited for this year 🙂🥚🥚🥚
Tweet media one
1
14
64
@mattkrisiloff
Matt Krisiloff
4 years
The deadline to apply for Sci-Founder Fellowship is next Friday! If you're a scientist, get $250,000 or $400,000 along with mentorship from founders building science companies to start your own company.
4
17
55
@mattkrisiloff
Matt Krisiloff
2 years
The custom where startups pay the VC's legal bills for a round closing is so stupid!
3
1
57
@mattkrisiloff
Matt Krisiloff
2 years
We should make a world where hiring high skilled immigrants takes 2 weeks from hire offer to 🇺🇸 immigration approval. Disgusting on so many fronts that we have to turn away super qualified scientists and engineers just because getting a visa is hard.
3
6
56
@mattkrisiloff
Matt Krisiloff
4 years
Five Reasons Scientists Should Consider Starting Companies
Tweet media one
Tweet media two
Tweet media three
Tweet media four
2
14
57
@mattkrisiloff
Matt Krisiloff
2 years
Scientists at startups should care more about equity. Most scientists don't fully see the value of owning shares. That sucks for them, and it sucks for the startups they're at too. I wrote a post on this, and I hope we can change this.
6
13
50
@mattkrisiloff
Matt Krisiloff
9 months
I'm grateful humanity is in an era where many of the most ambitious fight over things like how to build AI, not feudal war or territorial conquest.
5
1
48
@mattkrisiloff
Matt Krisiloff
3 years
It feels like those who have come into crypto wealth are more interested than most in using their wealth to fund scientific progress. Would love to find a way to know who are the many crypto millionaires and billionaires that fit this mold.
6
3
47
@mattkrisiloff
Matt Krisiloff
4 years
Today at end of day is the deadline for applying for Sci-Founder Fellowship ($250-400k + mentorship for scientists that want to start companies). If you want to apply and need more time, please email hello @sci -founder.com
1
13
44
@mattkrisiloff
Matt Krisiloff
2 years
We just hired our 27th scientist at @Conception , and we want to bring on a few more! Especially looking for people with stem cell differentiation backgrounds -- come work with us to generate new viable human eggs.
2
19
43
@mattkrisiloff
Matt Krisiloff
10 months
@deanbphillips Thanks for giving this a shot - feels important to have an open conversation.
13
1
42
@mattkrisiloff
Matt Krisiloff
3 years
It is so crazy how hard we make it for high skilled international people to get work visas in the US. Who is working seriously to reform this?
4
4
43
@mattkrisiloff
Matt Krisiloff
2 years
New @Conception lab building coming together nicely! It will meaningfully expand our research capabilities - ready in September.
Tweet media one
3
9
43
@mattkrisiloff
Matt Krisiloff
1 year
Pursuing AI that exceeds human intelligence prompts a sobering thought: Will there be pressure to use genetic engineering and selection to help humans keep pace with AI? The moral challenges would be so tough to navigate.
Tweet media one
10
5
38
@mattkrisiloff
Matt Krisiloff
9 years
Almost done reviewing YCF apps! Excited to send out interview invites tomorrow 😀
3
1
38
@mattkrisiloff
Matt Krisiloff
2 years
Most investors seem to look at medical devices as more boring than therapeutics. I predict medical devices that combine software will become highly profitable, and after this economic cycle, become a new cool thing.
7
4
38
@mattkrisiloff
Matt Krisiloff
3 years
Yesterday my neighbor's bike was stolen out of our garage. Today my friend's car was broken into while we were at lunch. San Francisco is getting ridiculous :(
10
1
37
@mattkrisiloff
Matt Krisiloff
3 years
What are areas of life science research that will have a big impact one day but few people currently realize it?
14
2
39
@mattkrisiloff
Matt Krisiloff
3 years
The deadline for SciFounder Fellowship applications is August 15! For fledgling science companies, get $400k + mentorship from experienced science founders to help you get started.
0
12
37
@mattkrisiloff
Matt Krisiloff
1 year
Shout out to @LauraDeming , @sama , and Metaplanet for being great investors to Conception during the SVB crisis. All proactively offered financial support to help get us through it if we had needed it. They are investors you want on your cap table.
0
1
36
@mattkrisiloff
Matt Krisiloff
2 years
Science startups should think of recruiting as an operational expense just like anything else. It's worth spending money to find really excellent people.
4
4
36
@mattkrisiloff
Matt Krisiloff
2 years
Medical devices are still vastly underestimated in their startup potential. That is still a 'secret' where investors can make a massive return.
1
6
34
@mattkrisiloff
Matt Krisiloff
1 year
Many ambitious people I know work a lot less now, which also is inspiring their friends to want to do the same. Worried our culture may be losing some drive to pursue difficult things.
9
0
34
@mattkrisiloff
Matt Krisiloff
3 years
We're looking to hire a Scientist with iPSC differentiation experience at @Conception This role will work on making viable eggs from XY cell lines, demonstrating same-sex couples could have biological children together. Get in-touch if any interest!
0
16
33
@mattkrisiloff
Matt Krisiloff
2 years
The average SciFounder Fellowship application this cycle feels stronger than in previous cycles. It's clear a lot of strong scientists are increasingly planning to start their own companies.
0
2
34
@mattkrisiloff
Matt Krisiloff
2 years
Young scientists should start companies if they want funding.
@patrickc
Patrick Collison
2 years
Movies left, NIH right. 🤔 (From .)
Tweet media one
Tweet media two
50
87
913
0
5
34
@mattkrisiloff
Matt Krisiloff
11 months
Since getting a puppy, it's become easy for me to imagine how a pig, cow, or sheep could become a loving member of my family. So I'm trying to stop eating mammals! Hope I keep it up. 🐶🐮🐷🐑
5
0
33
@mattkrisiloff
Matt Krisiloff
2 years
So many of the good events in my life have come from reaching out to people cold - job at Y Combinator, finding a co-founder, even meeting my boyfriend @CRISPR_LuCas . Do have a specific reason for it, but don't be afraid to reach out to people you don't know!
1
1
33
@mattkrisiloff
Matt Krisiloff
9 years
Please don't get down if you don't get an interview. It's not the metric of success. Start your startup, keep going.
@sama
Sam Altman
9 years
We will continue to scale up YC, but for now, we're going to have to turn down a huge number of promising cos due to our own constraints :(
14
10
58
4
2
32
@mattkrisiloff
Matt Krisiloff
2 years
Definitely agree with @sethbannon Contrary to common belief, a lot of the times research intensive companies don't need business people for quite some time.
@sethbannon
Seth Bannon 🥥
2 years
Too many "accelerators" push PhD founders to team up with MBAs they just met as co-founders. Much better to co-found a company with someone you've known for a long time or worked with before. And all-PhD founding teams work perfectly well! No MBAs needed!
19
18
237
1
2
31
@mattkrisiloff
Matt Krisiloff
1 year
Incredible work from @KHAYASHILAB1 making viable eggs from male mice - gay couples could have kids this way. Dr. Hayashi predicts scientists will have proof of concept for this in human 'in the next 10 years.' I think it'll be a lot faster than that!
1
5
28
@mattkrisiloff
Matt Krisiloff
1 year
After spending a week in Japan I think there's potential for many more strong 🇯🇵startups - people there work extremely hard.
1
0
19
@mattkrisiloff
Matt Krisiloff
9 years
Less than an hour left to apply to YC Fellowship. Get your application in.
5
12
27
@mattkrisiloff
Matt Krisiloff
2 years
Hard tech fundraising is definitely getting harder in the current environment. @SciFounders is still actively funding companies -- if you are working on a science company and need funding, please reach out. We would love to try and help.
2
4
28
@mattkrisiloff
Matt Krisiloff
4 years
The deadline to apply for Sci-Founder Fellowship is coming up this Friday! If you're a scientist, get $250,000 or $400,000 along with mentorship from life science founders to help you start a company --
1
9
27
@mattkrisiloff
Matt Krisiloff
3 years
The deadline to apply for SciFounder Fellowship is this Sunday! The program is to help scientists start companies. Teams receive $400,000 along with mentorship from founders building science companies. You can apply with nothing more than an idea.
1
6
24
@mattkrisiloff
Matt Krisiloff
3 years
We're starting a Fellows program at Ovid -- we will teach experienced biologists from other fields on how to work with pluripotent stem cells. Come work for 1-2 years on our research to turn iPSCs into egg cells. Learn highly valuable, in-demand skills.
0
7
25
@mattkrisiloff
Matt Krisiloff
3 years
The deadline to apply for SciFounder Fellowship is two weeks away! If you’re a scientist, consider applying for $400k + mentorship from founders that have started science companies.
0
11
24
@mattkrisiloff
Matt Krisiloff
2 years
Founders doing fundraising should be extremely paranoid until money is wired. You should constantly plot on how to keep the ball moving. Many early founders treat bits of positive momentum too passively, and that can be the difference between a successful or failed raise.
0
3
25
@mattkrisiloff
Matt Krisiloff
1 year
I keep hearing about major tech layoffs continuing left and right. Dealmaking is in sharp decline - high interest rates hurt startups more. Silicon Valley is in a recession.
Tweet media one
2
1
19
@mattkrisiloff
Matt Krisiloff
3 years
We're hiring a Stem Cell Differentiation Scientist and a Senior Research Associate at Ovid Research. Our mission is to turn stem cells into viable human eggs for fertility purposes. It's a fascinating research problem, and we're making rapid progress.
0
12
23
@mattkrisiloff
Matt Krisiloff
3 years
Over 80 startups participating in this thread -- a lot of non-scientist roles needed at these companies too. If you want to explore working at a super impactful science company, take a look at this thread.
@mattkrisiloff
Matt Krisiloff
3 years
'Science Startups - Who's Hiring?' A lot of scientists have a hard time finding cool startup opportunities. Trying an experiment to help. Science startups -- reply with 1 tweet on your mission, roles looking for, and how to learn more. Everyone -- RT so more scientists see!
103
670
1K
1
3
24
@mattkrisiloff
Matt Krisiloff
9 years
YCF interview decisions will be released today by 1159 pacific daylight time. It will likely be sooner.
3
4
23
@mattkrisiloff
Matt Krisiloff
9 months
Never work with mercenaries - only work with people that are there for the mission.
2
0
22
@mattkrisiloff
Matt Krisiloff
2 years
A lot of fun at our @Conception retreat in Napa this weekend! We have a lot of role openings still which can be checked out at -- come join one of the best scientific startup teams that exist.
Tweet media one
Tweet media two
Tweet media three
0
6
23
@mattkrisiloff
Matt Krisiloff
3 years
Really awesome thing YC did that will help more research intensive companies get started! So great to see this.
@eperlste
Ethan Perlstein bio/acc
3 years
The new YC $500,000 Standard Deal will be a boon for biotech company formation. Can’t wait for future of 100+ bio newcos per batch! I’d have done unspeakable things to get uncapped MFN terms back in the day (2016). These are the new rules for seed stage
2
7
42
0
1
23
@mattkrisiloff
Matt Krisiloff
3 years
Scientists -- do you find it hard to find interesting job opportunities? If so, why?
10
2
22
@mattkrisiloff
Matt Krisiloff
3 years
*New* Scientists / others looking for roles -- fill out this form, and I will share responses with startups that reply on the thread. (Startups, DM me an email address so I can send a spreadsheet) Please do RT the top thread so more ppl can see! (🧵2/2)
3
4
22
@mattkrisiloff
Matt Krisiloff
2 years
@srikosuri You don't think there's a version where this could be done well? I could imagine it being a really great learning experience under the right circumstance (definitely wrong ones too...)
2
0
22
@mattkrisiloff
Matt Krisiloff
3 years
Interested in working at a science startup? Fill out the form in this tweet! Answers will be shared tomorrow with close to 30 very cool science companies.
@mattkrisiloff
Matt Krisiloff
3 years
*New* Scientists / others looking for roles -- fill out this form, and I will share responses with startups that reply on the thread. (Startups, DM me an email address so I can send a spreadsheet) Please do RT the top thread so more ppl can see! (🧵2/2)
3
4
22
0
7
22
@mattkrisiloff
Matt Krisiloff
1 year
Perhaps the recession will make it easier for the best startups to rise to the top. When things revert, those that survive might have less competition for team building and capital. The generational startups, not the incremental ones, would be the clear companies that matter.
@mattkrisiloff
Matt Krisiloff
1 year
I keep hearing about major tech layoffs continuing left and right. Dealmaking is in sharp decline - high interest rates hurt startups more. Silicon Valley is in a recession.
Tweet media one
2
1
19
0
1
14
@mattkrisiloff
Matt Krisiloff
2 years
Stem cell eggs and sperm will happen a lot lot faster than this
@jachaseyoung
Jordan Chase-Young
2 years
2028: >100 people with stem-cell-regenerated teeth, tooth enamel, or root canals 2029: >125 gene-edited babies 2030: Commercial supersonic flights return 2031: First eggs and sperm made from stem cells 2032: U.S. student-loan bubble pops 2035: First "strong" AGI
5
4
123
2
0
20
@mattkrisiloff
Matt Krisiloff
3 years
20 groups have reached out since Friday -- seeing some great scientist-led teams! Keep reaching out if we can be of help.
@mattkrisiloff
Matt Krisiloff
3 years
Announcing SciFounder Capital -- a new funding source to keep scientist founders in control of their companies. We're giving the voting rights from our investments to the founders -- this will help keep startups mission-focused on science. Please share!
6
48
212
0
2
20
@mattkrisiloff
Matt Krisiloff
9 years
Reminder: the application deadline for running YC Research's basic income study is next Monday.
0
10
20
@mattkrisiloff
Matt Krisiloff
4 years
Are you a scientist with a question about starting a company? Please ask, I’m happy to help.
5
2
20
@mattkrisiloff
Matt Krisiloff
8 years
We're hiring a Research Manager for the YC basic income study -- see here:
1
23
20
@mattkrisiloff
Matt Krisiloff
6 years
More 'non-technical' people should start companies with scientists -- a lot of scientific work is people coordination and logistics; there's a lot to do there to make research go faster.
1
0
20
@mattkrisiloff
Matt Krisiloff
3 years
One of the most valuable things I learned working at Y Combinator is how to do a 10 minute candidate interview. I still interview most job applicants this way-- it lets me meet way more people, it's still very information rich, and if upfront about the length, people don't mind.
2
1
19
@mattkrisiloff
Matt Krisiloff
3 years
Many recent college grads pursuing life science careers have been very hurt by Covid -- a lot missed out their chance to learn how to operate in a laboratory. Any ideas to help them catch up?
2
0
18
@mattkrisiloff
Matt Krisiloff
2 years
Valuable single product medical device companies: Intuitive Surgical: $93 billion market cap Dexcom: $44 billion Insulet: $20 billion
@mattkrisiloff
Matt Krisiloff
2 years
Medical devices are still vastly underestimated in their startup potential. That is still a 'secret' where investors can make a massive return.
1
6
34
0
3
18
@mattkrisiloff
Matt Krisiloff
3 years
The hope is to inspire more scientists to start and lead their own companies -- companies can be great vectors for pursuing important research, and more scientists can make for great leaders than currently try. We have so far funded 5 teams, and would love to fund many more.
0
0
19