Shannon Macauley @macauleylab Twitter profile

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Shannon Macauley

3 years

Thrilled to be part of NPR’s Science Friday with @iraflatow this afternoon to discuss metabolism as a major player in the development of Alzheimer’s disease! @scifri @wakeforestmed @WakeGeriatrics @WakeADC

Untangling Alzheimer’s Connection To Insulin Resistance

New research finds that the brains of Alzheimer’s patients are less able to obtain energy from glucose.

www.sciencefriday.com

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Shannon Macauley

@macauleylab

2 years

7/1/22. It’s really weird to wake up today and officially be an Associate Professor with Tenure. … as a woman … with a family … in science … who failed Cell Bio in college … 5 yrs after starting my lab Mind blown. 🤯

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Shannon Macauley

@macauleylab

6 years

20 yrs ago, I failed cell bio in college & was told science was a bad fit for me. 5 yrs later, a grad school said my GPA/GREs weren't good enough for admission. Today, I have my own lab & serve on the same admissions committee that rejected me. If you want it, dig deep & fight.

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Shannon Macauley

@macauleylab

3 years

I am both humbled and thrilled to find out I got promoted to Associate Professor with Tenure! Many thanks for my lab, mentors, and colleagues for their support. I couldn't have done this without you.

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Shannon Macauley

@macauleylab

1 year

!!!Big lab news!!! Macauley lab is moving to the University of Kentucky! @ResearchKY Excited to join the Dept of Physiology. Thanks to @alan_daugherty for making this possible! So grateful for my time at Wake. Looking forward to conquering all things re: brain metabolism! 🧠

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Shannon Macauley

@macauleylab

3 years

Why do people studying metabolism use GAPDH as the "control" for westerns/qPCR/etc? Pssst, if ya modulate glucose, ya might modulate glycolytic protein levels, and it might not be a good control... especially in a disease state....

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Shannon Macauley

@macauleylab

1 year

And like that, one chapter ends and a new one begins. Hello, University of Kentucky!!! @universityofky 🤩🤩🤩🤩🧠🧠🧠💕💕💕

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Shannon Macauley

@macauleylab

8 months

New paper from the lab! We are the first in the world to collect extracellular vesicles from the brains of live mice w/ in vivo microdialysis. Female APP/PS1 mice ⬆️ amyloid plaques, ⬇️ plaque associated microglia & ⬇️diverse microglial EV-ISF proteome.

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Shannon Macauley

@macauleylab

3 years

Tenure calls for breaking open the good stuff. Cheers!

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Shannon Macauley

@macauleylab

4 years

Ever have those days where it looks like your hypothesis is unequivocally true and your data passes the “eyeball test”? Me neither. Until today. Plaques, meet no plaques. Happy 🦄 day to us.

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Shannon Macauley

@macauleylab

2 years

Some days I wonder what I could really do as a PI if I wasn’t worrying about budgets, reimbursement, editorial responsibilities, roof leaks…. Boy I miss just doing science.

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Shannon Macauley

@macauleylab

2 years

Oh my goodness. LACTATE and GLIA! Radial glia shift rely on aerobic glycolysis and lactate production for neuronal differentiation and vasculature development.

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Shannon Macauley

@macauleylab

1 year

11 yrs ago, coating ELISA plates on a Saturday in the Holtzman lab, one baby in my arms, the other incubating in my belly. Oh the places we’ll go…. @Momademia

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Shannon Macauley

@macauleylab

1 year

Our paper is out @JCI_insight ! 1/n 🧵 Key findings: ☑️Elevated blood glucose drives production & aggregation of amyloid-beta in mice. ☑️ Neuronal KATP channels couple metabolism & abeta. ☑️Brain KATP channel expression is altered in human AD brains.

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Shannon Macauley

@macauleylab

4 years

Coming off reviewing grad school applications for two programs at Wake Forest. Here are my PERSONAL opinions on applications in biomedical research if you are prepping for next year . #academictwitter #phdlife A thread:

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Shannon Macauley

@macauleylab

2 years

Best. Email. Ever. 🤩🤩🤩

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Shannon Macauley

@macauleylab

2 years

Y’know who’s amazing? This woman! @C_M_Carroll submitted her PhD thesis today. I can’t wait to see her defend next month! Seriously. A new PI only dreams of finding fantastic students to anchor their lab. Our labs 1st R01 was 100% due to her. Congrats, Caitlin! @WakeNeuroGrad

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Shannon Macauley

@macauleylab

2 years

RIP my beautiful friend. For 14 yrs, you’ve been my loyal & trusted companion. Always by my side- training for half marathons, epic road trips, hiking, kayaking, swimming, long nights writing grants, even longer nights feeding & soothing babies. I feel lost w/o my “helper” dog.

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Shannon Macauley

@macauleylab

1 year

Now this is cool. Mitos are secreted in EVs during lysosomal impairment. EVs w/ mitos are taken up by macrophages but not degraded.

Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired

Nature Communications - Mitochondrial quality control is critical for cellular homeostasis and survival. Here, the authors identify that defective mitochondria can be eliminated via secretion in...

www.nature.com

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Shannon Macauley

@macauleylab

1 year

Best. Email. Ever. 😍 I’m not sure what’s harder these days- doing the work and writing the paper or passing all the formatting hoops to finally get published! Big thanks to @ncons95 for helping get this over the finish line!

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Shannon Macauley

@macauleylab

1 year

Wonder how extracellular vesicles (EVs) change, in the brain, in LIVE mice, due to path? So did we!! @MorganPait developed a new method for collecting EVs from the brain's interstitial fluid (EV-ISF) & found changes in microglial EV proteome due to Aβ.

Novel method for collecting hippocampal interstitial fluid extracellular vesicles (EVISF) reveals...

Brain-derived extracellular vesicles (EVs) play an active role in Alzheimer’s disease (AD), relaying important physiological information about their host tissues. Circulating EVs are protected from...

www.biorxiv.org

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Shannon Macauley

@macauleylab

4 years

1/4 Sub the N for T and what do you get??? NOGA! NOGA! NOGA!!!!! Macauley Lab's 1st R01 is officially funded! @wakeforestmed @wakehealth @WakeADC

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Shannon Macauley

@macauleylab

3 years

When your awesome postdoc bakes the most amazing apple treats for your bday, you know you’re a lucky PI! Thanks, @smd_phd !!!!

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Shannon Macauley

@macauleylab

4 years

Very excited to announce that our @_BrightFocus proposal entitled, "KATP channel inhibition as a modifier of tau pathology in Alzheimer’s disease" was selected for funding! We are thrilled to work with the Bright Focus Foundation to complete this work!

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Shannon Macauley

@macauleylab

1 year

Moving a lab and family is absolutely exhausting. The End. That’s my TED talk.

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Shannon Macauley

@macauleylab

1 year

Super excited for this! NIH awards $10.6 million to UKy for CNS metabolism research!!! 🧠💕

NIH awards $10.6 million for central nervous system metabolism research center at UK

The goal of the new multidisciplinary CNS-Met COBRE is to create a strategically designed framework that promotes leading-edge research on the role of metabolic mediators of brain function and...

uknow.uky.edu

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Shannon Macauley

@macauleylab

2 years

Interested in METABOLISM? SLEEP? US TOO!👇 1) We describe the relationship between ISF glucose & lactate based on intrinsic oscillations, diurnal rhythms, & sleep/wake cycles. 2) We explored how hyper- & hypo-glycemia change brain metabolism, neuronal activity, & sleep.🧵1/N

bioRxiv Neuroscience

@biorxiv_neursci

2 years

Acute hyper- and hypoglycemia uncouples the metabolic cooperation between glucose and lactate to disrupt sleep #biorxiv_neursci

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Shannon Macauley

@macauleylab

8 months

This is the elephant in the room. Yes let’s pay postdocs & students more!!! 💯 But how? Budgets are slashed on R01s, NIA paylines just tanked. Where does the $ come from? And if $ goes to salaries, what’s the cost to the science? Unis have to support salaries for PIs & trainees.

Julie S Di Martino and Co

@julieSdimartino

8 months

NIH suggests to increase postdoc salaries👍🏻R01 Modular budgets are still capted at 250k per year👎🏻 PIs are responsible for a big chunck of their own salaries👎🏻 Lab supply prices skyrock👎🏻 So are we supposed to hire postdocs and provide no supplies to do experiments?🤷

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Shannon Macauley

@macauleylab

4 years

Day 19 #ArtAdventCalendar . Neurons and alcohol inks.

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Shannon Macauley

@macauleylab

9 months

Happy Friday to us! Our paper is accepted! 🤩🤩 "A novel method for collecting hippocampal interstitial fluid extracellular vesicles reveals sex dependent changes in microglial EV proteome in response to Abeta pathology" Big congrats to @MorganPait & collaborator Gagan Deep!

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Shannon Macauley

@macauleylab

3 years

Glucose, lactate, KATP channels, Abeta- on my! Another labor of love from my lab! Started as my K01 work w/ @holtzman4 , then continued by my fantastic postdoc, Dr. John Grizzanti. A 🧵about the role of neuronal KATP channels in Alzheimer's disease.

bioRxiv

@biorxivpreprint

3 years

Kir6.2-containing KATP channels are necessary for glucose dependent increases in amyloid-beta and Alzheimer's-related pathology #bioRxiv

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Shannon Macauley

@macauleylab

1 year

Wow. True to my experience. Attacks always come from mediocre scientists, while the true super stars are generous and supportive.

Claudia Gonzaga-Jauregui

@cgonzagaj

1 year

"Bullying is a means for mediocre scientists to rise to the top. Some star academics reached their position because they are bullies, not in spite of it." - Excellent piece about bullying in academia (and really any other professional environment).

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Shannon Macauley

@macauleylab

4 years

I am beyond THRILLED to brag about my dear friend and colleague @karchlab who was just promoted to Associate Professor with tenure @wustl @WUSTLdbbs !!! So well deserved. I love to see awesome science ladies absolutely crushing it!

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Shannon Macauley

@macauleylab

1 year

It’s all about lactate!!! 😍 “Lactate oxidation, not glycolysis, occurs at a comparable pace with the tricarboxylic acid cycle (TCA), supporting lactate as the primary fuel. “

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Shannon Macauley

@macauleylab

8 months

I always feel the need to paint this time of year. Eastern bluebird. Watercolor. Remembering fondly our back porch visitors in NC.

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Shannon Macauley

@macauleylab

6 years

D5, #ArtAdventCalendar . Watercolor Fishies!! Painted, with gratitude, for my PhD advisor. @bulldawginmo

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Shannon Macauley

@macauleylab

4 years

How to have a socially distanced 10th BDay: 1) Build 8 ft sling shot 2) Bake & individually wrap 49 cupcakes, 11 Rice Krispie treats, 15 brownie balls. Safety first. 3) Invite neighbors to catch treats 4) Sling shot 75 treats down block to awaiting children 5) Laugh. A lot.

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Shannon Macauley

@macauleylab

5 years

R01 submitted!!! Couldn’t decide between a celebratory beer, bike ride, cathartic cry, or sleep... then I saw lobster. And with a side of tuna. And an avocado. Now comes 🚲 🍺 😴 #lobsterdogsFTW

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Shannon Macauley

@macauleylab

2 years

NIA statement on amyloid beta protein dementia research

Read the NIA Director's statement on amyloid beta protein dementia research

www.nia.nih.gov

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Shannon Macauley

@macauleylab

2 years

My latest creation, gifted to Dr Caitlin Carroll, so she can finally relax after 5yrs of hard work and crushing it!

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Shannon Macauley

@macauleylab

1 year

Here’s a picture of my dog in case you need it. After this week, I need lots of pictures of doggos. Or goats. Goats are hilarious.

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Shannon Macauley

@macauleylab

4 years

@JessicaLTami Failed Cell Biology in college. F on transcript (more Cs then I can remember) and every fellowship I ever applied for dinged me for it. Eventually, I was awarded F31, F32, K01, and just landed a fundable score on an R01. 🤞🤞 Don't give up. You got this. Grit>2Cs.

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Shannon Macauley

@macauleylab

3 years

The Macauley Lab turned 4 years old today! It’s so rewarding to see the growth and accomplishments of my team. Forever grateful for their hard work and truly giddy for all the stories we’re ready to tell! Bring on the manuscript submissions!

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Shannon Macauley

@macauleylab

3 years

I am absolutely THRILLED to announce that @MorganPait received the NOGA for her F31 entitled, "Dissecting the role of hippocampal exosomes in Alzheimer's disease pathogenesis". Congratulations, Morgan, on all your hard work!!! #proudPI @wakeforestmed @WakeIPP @WakeGeriatrics

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Shannon Macauley

@macauleylab

3 years

Some see a beautiful sunset through the trees, but us neuroscientists know it’s neurons.

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Shannon Macauley

@macauleylab

7 months

What a couple weeks. So thankful to the MDs & nurses in the Yale ICU who cared for my dad. End of life decisions are so challenging. Grateful they treated him w/ dignity & honored his wishes. Love you, Dad. Hopefully you’re on a lake somewhere in your trusted unwinder. @YNHH

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Shannon Macauley

@macauleylab

2 years

And just like that, the Macauley Lab turns 5 yrs old! Many thanks to my amazing group, @C_M_Carroll @MorganPait @smd_phd @ncons95 @rirmen59 @Dr_GrizzJM @gironda_stephen Sarah Kaye, Ryan Pettit-Mee, Zhen Lin, & the incomparable, Andy Snipes. Lucky to tackle Alzheimer’s w/ you!

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Shannon Macauley

@macauleylab

4 years

3 yrs ago today, I left Wash U after 14 yrs to run my own lab. Seems like yesterday and a lifetime ago.

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Shannon Macauley

@macauleylab

4 years

10 yrs ago today, my water broke in the middle of lab in a rather heroic fashion, scaring the daylights out of both me & my PI, as I scrambled to finish an experiment before maternity leave. Spoiler: the paper can wait but shockingly my daughter couldn’t. Best surprise ever. 🥰

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Shannon Macauley

@macauleylab

2 years

Congratulations Dr Carroll!!!! @C_M_Carroll @WakeNeuroGrad

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Shannon Macauley

@macauleylab

3 years

Science twitter- there's a cool website where you enter your abstract to get ideas on journal possibilities. Anybody know what it is? Thanks!

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Shannon Macauley

@macauleylab

3 years

Overheard from morning carpool: 9yo neighbor: Friday’s are so easy. We get spelling tests with bonus points for hard words. My 8yo daughter: Like what words? Microscope? Army crawl? Microglia? I have nothing left to teach my children. I’ve peaked as a parent.

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Shannon Macauley

@macauleylab

3 years

Interesting in sleep, metabolism, and Alzheimer's disease? We're hiring! DM me if interested. Link to my website:

Research | macauleylab

www.macauleylab.com

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Shannon Macauley

@macauleylab

2 years

Day 10, #ArtAdventCalendar : Himalayan Blue poppy, watercolor. Painted from a photo my father in law took while traveling in France. Thinking of him and my mother in law today. 💕

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Shannon Macauley

@macauleylab

4 years

You know what’s fantastic? When your Chair puts up the list of 2020 faculty promotions for your Geriatrics Section and it’s composed of alllllll LADIES!!!!!! Amazing women scientists no less!!!! 😍😍 @wakeforestmed @WakeGeriatrics @WakeADC

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Shannon Macauley

@macauleylab

4 years

Beaming with gratitude and hope. Thanks to @pfizer for the hard work to develop this life saving vaccine. Thanks to @wakeforestmed @wakehealth for the quick roll out to vaccinate. First dose and I’m feeling great. 💪🏻👍🏻

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Shannon Macauley

@macauleylab

3 years

I didn’t get any awards this week, publish any papers, get any grants, or accomplish anything spectacular… so I did the next best thing and made my house SPOOKTACULAR! 👻 🎃 Dad jokes, they get me every time. In case you’re in need of something silly….👇🏻👇🏻

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Shannon Macauley

@macauleylab

2 years

Being a PI mom typically means dropping all the balls in a heroic fashion- eg, home at 8pm, missed dinner, way behind on SS reviews due to covid. But then, your amazing 11yo shows you the speech she wrote for her 5th grade graduation & despite it all, you’re doing ok. @Momademia

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Shannon Macauley

@macauleylab

2 years

Life long dream accomplished- I got to swim with sea turtles! 🐢 💕

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Shannon Macauley

@macauleylab

1 year

3 days, 57 pavers, 11 gallons of paint, 2 plumbers, 1 floor guy, and the Kentucky house is starting to look a bit more like “our home”. We, however, are exhausted... 😴 @rrambach

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Shannon Macauley

@macauleylab

5 years

Well deserved! Grateful to have such a fantastic mentor in translational neuroscience.

WashU Medicine

@washumedicine

5 years

WashU neurologist David Holtzman has received the August M. Watanabe Prize in Translational Research from @IndianaCTSI for his work uncovering the causes of #Alzheimers and translating an understanding of its basic biology into potential therapies.

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Shannon Macauley

@macauleylab

1 year

What a day! Tremendous honor to hood my 1st PhDs @C_M_Carroll & @MorganPait and Master student extraordinaire @rirmen59 !🥳 Humbled to receive the Faculty Excellence Award at Commencement. Honored to be nominated by my mentees. Grateful to share it w/ my family. 🥹

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Shannon Macauley

@macauleylab

4 years

Day 10 #ArtAdventCalendar . Himalayan blue poppy. Watercolor. Monet’s garden, France. Painted from a photograph taken by my FIL, Steve Rambach.

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Shannon Macauley

@macauleylab

4 years

Day 17, #ArtAdventCalendar . A rare mix of art and science. Metallic markers and alcohol inks. Little neuron doodles... or are they glia?

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Shannon Macauley

@macauleylab

6 months

So excited! Macauley Lab’s latest uploaded to biorxiv tonight! Big congrats to @ncons95 on getting his first 1st author pub out the door!! Stay tuned if you like glycolytic flux, sleep, arousal, and KATP channels…

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Shannon Macauley

@macauleylab

2 years

Wow. Summary statements are a special kinda “ouch”. Nothing like being called “unproductive” for taking 5 yrs to build a research program, in a pandemic, while getting R01++ funding, investing in trainees, b/c the number of senior author pubs is lower than what we’d all like.

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Shannon Macauley

@macauleylab

2 years

R01 #1 submitted.✅ R01 #2 submitted.✅ RPPR routed.✅ Dishes are done.

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Shannon Macauley

@macauleylab

4 years

Hit the pause button on science for a moment to engage the other half of my brain... Day 1, #ArtAdventCalendar : Painting of my girls in Francis Park, St Louis, MO.

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Shannon Macauley

@macauleylab

3 years

Thanks so much to @LJohnsonLab for hosting me at University of Kentucky! A fantastic couple days talking metabolism, glia, and all things Alzheimer’s disease. Nothing better than great science and a ton of laughs. Thanks @Morganti_Lab @UKY_Sunlab Until next time!

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Shannon Macauley

@macauleylab

2 years

M: Mom, can I lift with you? Me: yes, always yes. Mom wipes single tear from her eye and realizes amongst the mayhem of home-academia, she’s doing something right. 😢 @Momademia Cheers to the small wins. 🎉

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Shannon Macauley

@macauleylab

4 years

Not sure there’s anything better then getting a $4000 piece of functional equipment off eBay for $140. 😍😍

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Shannon Macauley

@macauleylab

3 years

Interested in metabolism, aging, cognitive impairment, and Alzheimer's disease? We are launching a new research topic through Frontiers in Aging Neuroscience. Check it out. 👇👇👇 Editors: Raymond Chuen-Chung Chang, Tao Ma, Shannon Macauley

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Shannon Macauley

@macauleylab

2 years

Been in my science teacher hubby’s classroom a million times. Always loved that his walls are covered w/ pictures of diverse scientists & world leaders. Spied for the 1st time today that he cropped me into the “history of women in science” poster. All the feels. @rrambach

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Shannon Macauley

@macauleylab

3 years

11 yrs ago today, I thought I absolutely had to finish that last experiment for a paper prior to maternity leave. My daughter had other plans. BTW- wanna know what makes a lab full of dudes super uncomfortable? Amniotic fluid.

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Shannon Macauley

@macauleylab

5 years

Ya know what's fun? Adding Figures to Microsoft Word. Seamless integration every time. Every. Damn. Time.

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Shannon Macauley

@macauleylab

11 months

This is fascinating. “For every 50% reduction in Aβ42/Aβ40, there was a 2-fold increase in risk of epilepsy (adjusted subhazard ratio 2.30, 95% CI 1.27–4.17).” Interesting to consider how anti—beta abs will play into this.

Neurology Journal

@GreenJournal

11 months

According to this study, a reduction in plasma Aβ42/Aβ40 is associated with an increased risk of subsequent #epilepsy : #NeuroTwitter

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Shannon Macauley

@macauleylab

3 years

Made it home from Cali to kiss kiddos good night✅ Submitted grant with 54 minutes to spare ✅ Finalized proposal due tomorrow... and within page limit no less ✅ Time for a beer? ✅✅

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Shannon Macauley

@macauleylab

4 years

Giddy for my new T! Not only does it support #blackinneuro but it’s made by talented students from my alma mata @wustl . As a former Neuro retreat organizer and MC, this is the best tshirt I’ve seen to date!!

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Shannon Macauley

@macauleylab

2 years

So proud of @rirmen59 who rocked her talk on “Tau pathology alters sleep & metabolism”. Not only is she one of the most talented Master’s students I’ve had the pleasure to mentor, she just got accepted into Wash U’s PhD program in Neuroscience! Way to go, Riley! @WakeNeuroGrad

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Shannon Macauley

@macauleylab

1 year

“Scientists should embrace their humanity rather than pretending that they are a bunch of automatons who instantly reach perfectly objective conclusions.” I love this. Scientists are humans. Science is never perfect. Give space to evolve.

It matters who does science

www.science.org

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Shannon Macauley

@macauleylab

1 year

The gangs all here! So excited for the next chapter of our lab @ResearchKY @UKYMedicine !! So grateful to have this team by my side. @rirmen59 @ncons95 #andysnipes

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Shannon Macauley

@macauleylab

1 year

Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation

Nature Communications - Despite a wealth of knowledge on astrocytes, their contribution to cerebrovascular maturation is less known. Here, the authors identify a molecule produced by astrocytes...

www.nature.com

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Shannon Macauley

@macauleylab

4 years

Can a rigorous scientist have a moment to believe in magic? Lost a friend to cancer, MIL diagnosed w/ breast cancer, dad septic in hospital, all this week. Kinda need to believe my darling E is drumming up rainbows, fairies, and pixie dust to bring us all good fortune in 2021.

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Shannon Macauley

@macauleylab

1 year

Tonight an adult called by 10yo daughter fat. The daughter that will change the world. The daughter whose eyes light up a room, whose warmth & magic is indescribable. The daughter who is strong AF. To that person I say fuck you. To society I say 1000x fuck you. Do better.

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Shannon Macauley

@macauleylab

3 years

Our work investigating the role of vascular KATP channel activity in Alzheimer’s disease is on biorxiv! This labor of love 6+ years started while I was a postdoc w/ @holtzmand @wustl and continued in my own lab @wakeforest . A thread 1/n

bioRxiv Neuroscience

@biorxiv_neursci

3 years

Sulfonylureas target the neurovascular response to decrease Alzheimer's pathology #biorxiv_neursci

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Shannon Macauley

@macauleylab

3 years

I’m so proud of my trainees. They are the best. That is all. That’s the tweet.

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Shannon Macauley

@macauleylab

2 years

If the bourbon’s in a brain etched whiskey glass, it makes the grant sound smarter, right?

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Shannon Macauley

@macauleylab

2 years

What a great visit to @uab_neurology @UAB_Alzheimers ! Fantastic bonus - meeting those virtual/Twitter friends in real life! Great to visit @constanza343 !!

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Shannon Macauley

@macauleylab

4 years

The Macauley Lab turns 3 years old today! Proud of all we’ve accomplished. Such gratitude to @MorganPait @C_M_Carroll @smd_phd Khadijah Winkey, Dave Rubinow, Andy Snipes, for all their hard work in lab. Thankful to my @wakeforestmed colleagues for collaboration and support!

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Shannon Macauley

@macauleylab

2 years

Excited to have our work showcased by @NeuroscienceNew Alcohol consumption liked to acceleration of Alzheimer’s Disease @smd_phd @gironda_stephen @jlweiner1 @wakeforestmed @WakeGeriatrics @WakeADC @WakeNeuroGrad @WakeIPP

Neuroscience News

@NeuroscienceNew

2 years

Alcohol Consumption Linked to Acceleration of Alzheimer’s Disease Even modest consumption of alcohol can accelerate brain atrophy and increase amyloid plaque formation. The findings reveal alcohol consumption can accelerate Alzheimer's disease

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Shannon Macauley

@macauleylab

2 years

2 yrs I’ve avoided this by maniacally masking and being super diligent. Loosened up for one week and boom, I’m part of the club.

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Shannon Macauley

@macauleylab

2 years

Very excited for our collaborative work with @jlweiner1 entitled "Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice" to be online! Congrats to co-1st authors @smd_phd and @gironda_stephen !! Most later!

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Shannon Macauley

@macauleylab

6 months

Lactic acid as an immunosuppressant in macrophages

Lactic acid induces transcriptional repression of macrophage inflammatory response via histone...

Lactic acid is emerging as a prominent immunosuppressive metabolite. Shi et al. reveal that lactic acid acts as a primary fuel source for the TCA cycle to promote H3K27 acetylation. This histone...

www.cell.com

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Shannon Macauley

@macauleylab

2 years

The more I mentor, the more I appreciate the basics: 1) show up 2) be consistent 3) be responsive 4) be passionate 5) know your "why" The rest is gravy.

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Shannon Macauley

@macauleylab

1 year

Excited for our work on extracellular vesicles to be highlighted in @alzforum !! Congrats to @MorganPait for leading this effort in lab! @WakeIPP

Alzforum

@alzforum

1 year

Scientists sampled extracellular vesicles in the brain fluid of living mice, unveiling microglial messages in response to amyloidosis. @wakeforestmed

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Shannon Macauley

@macauleylab

1 year

#InternationalWomensDay Thanks to my lady army that inspires and supports me on this crazy journey. I see you.

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Shannon Macauley

@macauleylab

1 year

Finally finished a little congratulatory “doodle” for my PhD student @MorganPait ! So proud of all she accomplished during her time in lab. Can’t wait to hood her and @C_M_Carroll today!!! 👏 🥳 EVs on the brain, watercolor, pen & ink.

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Shannon Macauley

@macauleylab

6 years

Seal posing on rock. Watercolor painted from a picture my sister @kkmacauley took while vacationing in Peru. #artadventcalendar

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Shannon Macauley

@macauleylab

2 years

Yknow the best way to celebrate the last day of your postdoc??? PAPER ACCEPTED!!!!! Congrats to @smd_phd & co first author @gironda_stephen ! Great collab w/ @jlweiner1 studying alcohol use disorder & Alzheimer’s disease! @WakeIPP @WakeNeuroGrad Actual footage of me this am👇🏻

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