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Kristin Knouse Profile
Kristin Knouse

@kristinknouse

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Whitehead Career Development Professor @MITBiology @KochInstitute . Building tools to understand and modulate regenerative capacity across tissues.

Cambridge, MA
Joined January 2018
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@kristinknouse
Kristin Knouse
2 years
Thrilled to share our lab’s first paper in which we establish genome-wide CRISPR screening within a single mouse! We are so excited about the power of this platform to enable high-throughput genetic dissection of diverse phenomena within a living mammal.
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@kristinknouse
Kristin Knouse
3 years
That women and underrepresented groups manage to persist in science despite the numerous barriers thrown up in their faces speaks volumes to their qualifications.
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@kristinknouse
Kristin Knouse
3 years
I’m thrilled to announce I’ll be joining @MITBiology and @kochinstitute as an Assistant Professor! It’s a tremendous honor to return to the community that first inspired and fostered my scientific career. Seeking people to join us in the adventure ahead!
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@kristinknouse
Kristin Knouse
3 years
Excited to honor Angelika’s profound legacy of mentorship and discovery with the establishment of the Angelika Amon Young Scientist Award! This annual award will recognize 2 PhD students from outside the US who embody her infectious enthusiasm for biology.
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@kristinknouse
Kristin Knouse
4 years
We are thrilled to share our development of genome-wide CRISPR screening within a living mouse! Our approach is accessible to diverse phenotypes and we look forward to the many insights now achievable with high-throughput functional genomics in an organ!
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@kristinknouse
Kristin Knouse
2 years
The barriers and ramifications of reporting sexual misconduct are still prohibitively high. We will not see lasting change until the majority in positions of power—not just exceptional brave individuals—actively support and protect those harmed. Silence is part of the problem.
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@kristinknouse
Kristin Knouse
2 years
Nature affording optics despite the times
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@kristinknouse
Kristin Knouse
3 years
Seeing your trainees succeed >>>>> your own success
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@kristinknouse
Kristin Knouse
4 years
Angelika occupied a league of her own, with an infectious energy, brilliant mind, bottomless heart, and tenacious grit. Her loss is irreplaceable and far too soon, but may we all carry part of her legacy. Thank you, Angelika, for everything. Rest assured we will keep pipetting ❤️
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@kristinknouse
Kristin Knouse
1 year
Latest addition to our lab break room. While our samples spin, so can we 🚴🏼‍♀️
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@kristinknouse
Kristin Knouse
4 years
The visual and emotional appeal of a thawing Charles River
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@kristinknouse
Kristin Knouse
4 years
Our lab is hiring! Seeking post-docs and students interested in developing in vivo genome-wide screens and gene delivery tools to understand and modulate cell cycle states in the context of organ injury, regeneration, and cancer. Please spread the word!
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@kristinknouse
Kristin Knouse
3 years
I had so much fun talking to @MIT about how I fell in love with liver regeneration and how I hope it can inspire new therapies for organ injury and cancer. Check out this behind-the-scenes footage of our new lab!
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@kristinknouse
Kristin Knouse
2 years
I am incredibly honored to be named the Whitehead Career Development Professor. My deepest appreciation to the Whitehead family, @ScienceMIT , and the community for their ongoing support—it has made all the difference this past year.
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@kristinknouse
Kristin Knouse
2 years
We @kochinstitute are privileged to continue honoring Angelika’s deep legacy of mentorship with the second annual Angelika Amon Young Scientist Award! Please encourage any students outside the US who embody her infectious enthusiasm for biology to apply!
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@kristinknouse
Kristin Knouse
2 years
We are hiring for multiple positions, including a lab manager, research assistants, and post-doctoral fellows! Come join our interdisciplinary team as we unite technology development and biological discovery to understand and modulate organ regeneration!
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@kristinknouse
Kristin Knouse
5 years
Holiday survival meets TSA compliance 🥃✔️
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@kristinknouse
Kristin Knouse
2 years
Crossed a line item off the bucket list
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@kristinknouse
Kristin Knouse
5 years
Our lab owes ~50% of its non-consumable existence to Amazon Prime. Orders of magnitude cheaper than Fisher, VWR, etc.
@arjunrajlab
Arjun Raj
5 years
PSA: We’ve been buying DI water from Target for a while now instead of paying for a Millipore service contract. No problems so far, and saving considerable money.
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@kristinknouse
Kristin Knouse
3 years
We are hiring at multiple levels, including techs and post-docs! Great opportunity to work at interface of tool development and biological discovery in an energetic environment fueled by a meticulously maintained snack drawer. Please spread the word!
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@kristinknouse
Kristin Knouse
1 year
Enjoyed a few fantastic days on Cape Cod for our first ever lab retreat! Supplemented our science with excellent masterclasses, food, and nature and discovered fame at a karaoke bar (not pictured). So grateful for this amazing group and excited for what lies ahead!
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@kristinknouse
Kristin Knouse
4 years
To anyone else whose science (and self) have suffered from the poor parental instinct of B6 mice, I'm amazed by the extent to which adding shredded paper/ecobedding improves nest building and dramatically increases litter survival. At this point I’m tempted to try sleeping in it.
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@kristinknouse
Kristin Knouse
7 months
We are privileged to continue honoring Angelika’s inspiring legacy of mentorship and discovery with the third annual Angelika Amon Young Scientist Award! Please encourage PhD students outside the US who embody her infectious passion for biology to apply!
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@kristinknouse
Kristin Knouse
3 years
First lab meeting in our new home @kochinstitute and not the last time we do it over mimosas 😇
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@kristinknouse
Kristin Knouse
4 years
Jaw-dropping intravital imaging of mouse embryonic development at cellular resolution via abdominal windows. I am unceasingly amazed and inspired by the innovations to study mammalian biology in context. 🤯
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@kristinknouse
Kristin Knouse
6 years
Excited to share our work in @CellCellPress on the importance of tissue architecture for mitotic fidelity! A potential explanation for chromosome instability in cancer and a limitation of two-dimensional cell culture.
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@kristinknouse
Kristin Knouse
2 years
Apply to join us as a faculty member @kochinstitute and @MITBiology ! This unique interdisciplinary community of scientists and engineers provides an incredible environment to elevate and expand your science!
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@kristinknouse
Kristin Knouse
4 months
The inevitable backlash from those seeking to protect and enable ill-gotten and abused power is all the more reason why we cannot stop fighting for change.
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@kristinknouse
Kristin Knouse
3 years
If only it hadn’t taken me 10 years to discover that this is merely a 10 minute Uber from the city 😍
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@kristinknouse
Kristin Knouse
4 years
Great work from John Replogle and the late @AngelikaAmon toward resolving the paradox of aneuploidy in cancer! Cell cycle delays caused by chromosome imbalance suffice to confer resistance to chemotherapy. Treatment thus converts Achilles' heel into asset.
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@kristinknouse
Kristin Knouse
10 months
Happy Halloween from the Knouse Lab, where we're always down for a good mystery!
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@kristinknouse
Kristin Knouse
1 year
So grateful for this incredible group 🥳
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@kristinknouse
Kristin Knouse
1 year
Not-so-silver linings of springing forward
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@kristinknouse
Kristin Knouse
4 years
Excited to have our lab's vision featured alongside other emerging labs in @CellStemCell Voices! Thank you @CellCellPress for bringing visibility to young investigators in a time when traditional avenues are limited!
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@kristinknouse
Kristin Knouse
3 years
Honored to be chosen alongside these amazing women for the Future Founders Program! Grateful to ⁦ @snbhatia ⁩, ⁦ @SusanHockfield ⁩, and Nancy Hopkins for tackling gender inequity in entrepreneurship and excited to contribute to the next generation!
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@kristinknouse
Kristin Knouse
2 years
I admire @kaymtye for leading by example with her outspoken support and advocacy in this situation. We need more people like her.
@kaymtye
Kay M Tye PhD
2 years
No matter who we are, our roles as mandatory reporters is real. Disappointed in ⁦ @jonykipnis ⁩ Alleged sexual misconduct and support system failures cause graduate student to drop her WU PhD degree - Student Life
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@kristinknouse
Kristin Knouse
4 years
Cape Cod sky sitting pretty despite 2020
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@kristinknouse
Kristin Knouse
5 years
Celebrating the great character, brilliant mind, connoisseur of white wine, and queen of the dance floor that is @AngelikaAmon . Science wouldn’t be the same, and we would be nowhere in it, without you.
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@kristinknouse
Kristin Knouse
4 years
Sunset and windows of support over an empty Boston Common
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@kristinknouse
Kristin Knouse
5 months
Very well-deserved congratulations to our graduate student @TessFallon11 on her NSF Graduate Fellowship and our technician @SaritRadak on his graduate school acceptances! Your futures are so bright we had to wear eclipse glasses 😎
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@kristinknouse
Kristin Knouse
6 years
We are very honored and grateful to have support from @NIH_CommonFund as we begin to investigate quiescence and its applications to regenerative medicine. Seeking post-doctoral fellows to tackle new projects in this area! #NIHHighRisk
@WhiteheadInst
Whitehead Institute
6 years
Congratulations to Whitehead Fellow Kristin Knouse and other recipients of a 2018 NIH Director’s Early Independence Award. Read more . @NIH_CommonFund
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@kristinknouse
Kristin Knouse
2 years
Sun setting on summer
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@kristinknouse
Kristin Knouse
4 years
Petition to @WhiteHouse to allow international students to remain in the US even if instruction is online. We must support the appropriate use of remote learning and promote the inclusivity that has historically propelled innovation in our country:
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@kristinknouse
Kristin Knouse
4 years
I enjoyed sharing my reflections on MD-PhD training, how it has shaped my research career, and advice for the early stages of independence in this interview with @HarvardHHPR ! I hope these thoughts can be helpful for aspiring scientists or physicians.
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@kristinknouse
Kristin Knouse
4 years
After a decade of running in the city I finally rediscover what this trail running thing is all about 😍
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@kristinknouse
Kristin Knouse
4 years
#Boston looking a bit more quiet but no less beautiful
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@kristinknouse
Kristin Knouse
1 year
Those who say never meet your heroes haven't met women like these. Such a special night hearing @ngertner , Nancy Hopkins, and @snbhatia talk about the efforts that got us to where we are and what we must do to move further toward equity and inclusion in science ♥️
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@kristinknouse
Kristin Knouse
4 years
A very well-deserved and well-distanced congratulations to @KristinaELopez for being named a @NASEMFordFellow ! We are so proud of all you've overcome and accomplished and grateful for the unique perspective and creative solutions you bring to our lab and the scientific community.
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@NASEMFordFellow
Ford Foundation Fellowship Programs
4 years
Congratulations to 132 outstanding scholars who have been awarded fellowships in the 2020 Ford Foundation Fellowship Programs competition administered by the Fellowships Office of @theNASEM . Read more:
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@kristinknouse
Kristin Knouse
2 months
It is always a highlight of my summer to speak with the students from the @mit Summer Research Program. Their energy and ideas leave me so excited for this next generation of scientists!
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@kristinknouse
Kristin Knouse
6 years
Could not be happier to be starting my lab @WhiteheadInst , where we will use the mouse liver to investigate reversible cell cycle states and uncover novel approaches for regenerative medicine. Seeking post-doctoral fellows to join us in this effort!
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@kristinknouse
Kristin Knouse
4 years
In light of travel restrictions our lab will be Zooming across the worlds of whiskey and chocolate for the holidays. Cheers!
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@kristinknouse
Kristin Knouse
3 years
We are hiring a lab manager to help keep our growing lab ~on track~! Great opportunity to interface with trainees and facilitate projects spanning tool development, biological discovery, and therapeutic innovation. Please spread the word and apply!
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@kristinknouse
Kristin Knouse
5 years
Our lab is one year old and we’re pretty jacked up about it #labsfirstbirthday #labsfirstgymselfie
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@kristinknouse
Kristin Knouse
4 years
The bar is low
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@kristinknouse
Kristin Knouse
5 years
Our lab @WhiteheadInst is seeking post-doctoral fellows interested in developing and implementing in vivo approaches to understand reversible cell cycle states and regenerative capacity across organ systems. Please spread the word!
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@kristinknouse
Kristin Knouse
4 years
scRNA-seq of human embryos revealing mosaic, typically mitotic, aneuploidy in 80% (!!) of embryos, corroborating prior observations of high aneuploidy in development. It is remarkable how mitotic errors are so pervasive (and/or better tolerated) at such a formative stage!
@rajivmccoy
Rajiv McCoy
4 years
Our study of aneuploidy in human preimplantation embryos is now published in @genomeresearch . We combined signatures of chromosome-wide gene expression and allelic imbalance to discover meiotic and mitotic-origin aneuploidy in single-cell RNA-seq data:
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@kristinknouse
Kristin Knouse
4 years
The past few weeks have left me especially grateful for the constant support of some incredible friends and colleagues. In a year of unrelenting tragedy, it is reassuring to remember that humanity is equally relentless. There can never be too much kindness.
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@kristinknouse
Kristin Knouse
4 years
Sunset over the Brewster Flats making a literal watercolor
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@kristinknouse
Kristin Knouse
4 years
Just another Zoo meeting
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@kristinknouse
Kristin Knouse
2 years
Looking forward to highlighting the new directions in our lab @kochinstitute as part of this great series to share science with the community!
@kochinstitute
Koch Institute at MIT
2 years
Professor Kristin Knouse studies how tissues sense and respond to damage. Learn about the connections between regeneration and cancer at SCIENCE with/in/sight on October 13. Attend at MIT: On Zoom:
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@kristinknouse
Kristin Knouse
6 years
Not bad #foliage for not leaving #Boston city limits
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@kristinknouse
Kristin Knouse
4 years
Highly recommend watching @PictureaSciFilm ! Though sobering in its portrayal of past and present realities it’s very inspiring to watch our predecessors fearlessly fight battles of even greater magnitude as we continue to work toward a better enterprise.
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@kristinknouse
Kristin Knouse
4 years
After baking and consuming 15 chocolate lava cakes this past month I decided to diversify my domestic endeavors portfolio with some glass painting. Will serve well in the cocktail parties I throw for myself.
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@kristinknouse
Kristin Knouse
4 years
A transatlantic toast to celebrate the lab's second birthday, @dianabrgomes 's and @KristinaELopez 's fellowships, and that we're even smiling on a Zoom call at this point...! #its5oclocknowhere
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@kristinknouse
Kristin Knouse
4 years
Apparently seasonal change has also been cancelled
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@kristinknouse
Kristin Knouse
1 year
Congratulations to our graduate student @KristinaELopez for being named a @UofUBiochem Rising Star! Kristina's fearlessness and determination have forged exciting new frontiers in our lab and we are so proud of her for receiving this well-deserved recognition!
@roh_johnson_lab
Minna Roh-Johnson
1 year
We are looking forward to hosting the 2023 Graduate Student Rising Stars Symposium in 1 week, on Mon May 22. Join us as we hear from talented grad students from around the country! @UofUBiochem @uofunuip
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@kristinknouse
Kristin Knouse
5 years
The ancient city of Teotihuacán: where every day must’ve been leg day
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@kristinknouse
Kristin Knouse
5 years
Safari through the Ishasha savanna boasting a bit more biodiversity than the mouse room
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@kristinknouse
Kristin Knouse
6 years
Non-denominational and non-randomly distributed lab advent calendar. All secondarily aged in polypropylene casks for up to four weeks.
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@kristinknouse
Kristin Knouse
5 years
Successfully penetrated the Bwindi Impenetrable Forest
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@kristinknouse
Kristin Knouse
5 years
#Boston skyline as seen sitting on a stand up paddle board 🤙🏼
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@kristinknouse
Kristin Knouse
3 years
As a graduate student @kochinstitute I had the utmost privilege and pleasure of learning from the late and irreplaceable @AngelikaAmon . I will forever carry her lessons and inspiration with me and I owe so much of where I am today and what lies ahead to her incredible mentorship.
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@kristinknouse
Kristin Knouse
3 years
Looking forward to sharing our work to bring genome-wide CRISPR screening into mouse tissues with this community! We’re excited to help others adapt this tool to investigate diverse cellular phenotypes directly in the organism.
@mpswaffer
Matthew Swaffer
3 years
More Cell Size & Growth seminars coming up next week (Tuesday 24th August). Sign up and tune in on Tuesday to hear some awesome science about organ growth and cell size regulation from @kristinknouse and Sean Sun. Registration:
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@kristinknouse
Kristin Knouse
5 years
To fans of #mitosis , #meiosis , and all things up and downstream: registration is now open for this year’s BAMM meeting! We are thrilled to have keynote talks from @StearnsLab and @AngelikaAmon and many opportunities for trainees to present their work! 👉🏻
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@kristinknouse
Kristin Knouse
5 years
Thank you @mit_hst for the deep understanding of physiology and medicine that has forever shaped our investigation of even the most fundamental cellular processes.
@mit_hst
HST
5 years
For their research on oxygen biology and reversible cell cycle states respectively, @mit_hst alumni Isha H. Jain and @kristinknouse will receive up to $1.25M from the @NIH . Congratulations Isha and Kristin!
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@kristinknouse
Kristin Knouse
5 years
A wonderful start to #BAMM2019 with @AngelikaAmon delivering an energy-rich and conceptually deep opening keynote on over two decades of work on her true love—the MEN.
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@kristinknouse
Kristin Knouse
3 years
Pandemic prompted precocious arrival to crazy cat lady fate. Appears we’re on the same page.
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@kristinknouse
Kristin Knouse
3 years
Lab cephalopotluck! Portuguese octopus compliments of our multitalented post-doc @dianabrgomes 😋
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@kristinknouse
Kristin Knouse
3 years
Very happy to see @ScienceMIT prioritizing diversity, equality, inclusion, and justice and Jackie taking on this important role. She has long been a close listener and fierce advocate for myself and countless others. I look forward to tangible progress for our community! 💪🏼
@MITBiology
MIT Biology
3 years
Jackie Lees of @kochinstitute and @rebecca_saxe of @mitbrainandcog have been named associate deans @ScienceMIT ! They will both contribute to the school’s diversity, equity, inclusion, and justice activities, as well as career-development programs:
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@kristinknouse
Kristin Knouse
2 years
Detailed analysis of somatic mutagenesis across mammals supports inverse relationship between mutation rate and lifespan! Could explain why short-lived mammals still get cancer and begs question of how long-lived mammals better maintain their genomes.
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@kristinknouse
Kristin Knouse
4 years
It is exhausting until you stop caring. People are always going to talk. The more women (and men) we have leading by example to show that the capacity to think, do experiments, and be a good colleague is wholly uninfluenced by one’s appearance the quieter these voices become.
@stephenfloor
Stephen Floor
4 years
Incredible how thin the space is for women to just be themselves. Be put together, but not attractive. Speak up for yourself, but not too loud. Friendly, but not flirty. Send photos for a seminar, but not “the wrong photo” - or people will still say did it wrong. Seems exhausting
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@kristinknouse
Kristin Knouse
5 years
To #liver and other organophiles who have struggled with #immunofluorescence due to high autofluorescence: we've started using the quenching kit from @VectorLabsUS and it can really help increase signal:noise for diffuse antigens. An unpaid endorsement!
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@kristinknouse
Kristin Knouse
5 years
Very exciting talk from former ⁦⁦ @MIT ⁩ graduate student Katie Bouman on the massive group effort that led to the first-ever image of a black hole. A truly impressive feat of collaborative science.
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@kristinknouse
Kristin Knouse
4 years
Immune cells also partake in the ever popular phenomenon of liver zonation! Beautiful images and experiments by @anita__gola showing that macrophages concentrate near portal tracts to enhance capture of gut-derived bacteria and limit further dissemination.
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@kristinknouse
Kristin Knouse
4 years
Congratulations @KristinaELopez for being recognized by this wonderful initiative from @CellCellPress ! Your fearlessness and determination in developing new techniques have opened so many directions for our lab and we have such high expectations and excitement for your future!
@CellCellPress
Cell
4 years
We are delighted to bring you the @CellCellPress paper from #FacesOfCell Kristina Lopez @KristinaELopez “Chromosome Segregation Fidelity in #Epithelia Requires Tissue Architecture”
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@kristinknouse
Kristin Knouse
5 years
#Boston always manages to make winter worthwhile
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@kristinknouse
Kristin Knouse
4 years
Optimized remote office optics and for better or worse my phone overheats 30 minutes into any Zoom call
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@kristinknouse
Kristin Knouse
5 years
A comprehensive, cross-species study of how #quiescent cells maintain #centromere identity and proliferative capacity through prolonged dormancy in stark contrast to terminally differentiated cells. Beautiful work @ZakSwartz and @iaincheeseman !
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@kristinknouse
Kristin Knouse
5 years
#Jupiter and two moons through an iPhone through a telescope on Cape Cod
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@kristinknouse
Kristin Knouse
6 years
0 hour time point and global maximum of cleanliness #labsfirstphoto
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@kristinknouse
Kristin Knouse
5 years
Our lab @WhiteheadInst is seeking a research assistant to join our efforts to develop in vivo tools to understand and engineer organ #regeneration . Great opportunity to pursue an independent project and assist with lab management:
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@kristinknouse
Kristin Knouse
6 years
As amazing a scientist as she is a person. An extremely well-deserved congratulations to @AngelikaAmon . I am so fortunate to have been one of your trainees.
@MIT
Massachusetts Institute of Technology (MIT)
6 years
Angelika Amon wins 2019 @brkthroughprize in Life Sciences
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Kristin Knouse
4 years
Fantastic piece from Oceane Marescal and @iaincheeseman on the ubiquitous yet mysterious cell cycle state known as quiescence! This review captures our current understanding across contexts and highlights the many fundamental and fascinating unknowns.
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@kristinknouse
Kristin Knouse
4 years
I don't know of anyone mentally or physically stronger than my cousin Kyle, who by age 12 had become a two-time cancer survivor. A heartwarming reminder of the lifetimes that can be saved by commitments to basic research, blood drives, and beyond.
@PCFLV
PCFLV
4 years
Please check out Kyle's story at and re-tweet it. This young man is a 2-time survivor!
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@kristinknouse
Kristin Knouse
3 years
So long as they’re viewing you as an object, then can’t possibly be viewing you as an equal.
@AdamMGrant
Adam Grant
3 years
Sexual harassment isn't driven by a desire for women. It's motivated by a desire for power over women. Data: assertive women face more sexual harassment—especially in male-dominated workplaces. The problem is not self-control. It's a culture that normalizes control over women.
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Kristin Knouse
6 years
Apparently running a lab and following whiskey blogs has convinced the internet I’m a 40+ year-old man.
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@kristinknouse
Kristin Knouse
4 years
Very glad to add “being outside without a parka” to the sanity maintenance protocol
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