Tim Stearns @StearnsLab Twitter profile

Last Seen Profiles

@khwater2030

@bokeplokalmalam

@BlessingDBless

@mae_chave

@smoothiejakee_

@bokeplokalmalam

@JohnParede38961

@Thumdelyna

@twinkywinky0_0

@FreeWillAstro

@bigsteper_

@qiqinmo

@MStidd78885

@sotwecom

@CatogEly

@jessie_pack29

@Liliana82795257

@LordFairfaxPTK

@indielabrva

@hepofi

@ThunderElite_OK

@sakamotoh

@scotthamm88

@fjiXvZ6MxQaiGas

@ddeuyaZZang

@regalogura

@MarkAvery

@penyukastw21

@Willowinski

@olegnovok

@Revan_Sahputraa

@ToddFallesen

@koro_lid

@dikiboy360

@Pegos19

Tim Stearns

@StearnsLab

4 years

In 1720 Marseille allowed a ship from plague-ridden Cyprus into port, under pressure from merchants who wanted the goods and didn’t want to wait for the usual quarantine. More than half the population of Marseille died in the next two years.

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Tim Stearns

@StearnsLab

3 years

Parsley flowers doing their anaphase A of mitosis imitation

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Tim Stearns

@StearnsLab

2 years

And we keep science twitter going why, exactly?

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Tim Stearns

@StearnsLab

5 years

I am sad and angry about the murder of Suzanne Eaton. Sad because she is someone I’ve known and admired for 25 years. Angry because every woman has to think about this happening to her every time she walks alone in the world. This has to change.

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Tim Stearns

@StearnsLab

3 years

Technical replicate.

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Tim Stearns

@StearnsLab

2 years

Nobody likes journal clubs that are just a march through the figures of a paper that most haven’t read. But there are many better ways to engage with the literature in lab groups or classrooms! Add your own examples below.

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Tim Stearns

@StearnsLab

2 years

Reading two nice new papers in Nature, but: Paper 1: submitted January 2020, published May 2022 Paper 2: submitted June 2020, published June 2022 Neither available as a preprint. Why do we still allow journals to hold up dissemination of science? We need a preprint mandate.

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Tim Stearns

@StearnsLab

4 years

As we prepare to inject millions with an mRNA-based vaccine, it’s worth remembering that mRNA wasn’t even known to exist 60 years ago. The historic 1961 review by Jacob and Monod proposed its existence and it was isolated soon after (pg. 349).

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Tim Stearns

@StearnsLab

1 year

Extraordinary news in a preprint on condensed matter physics: Lee, et al. claim to have made the first material that is a superconductor at ambient temperature and pressure. If true, will change the world.

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Tim Stearns

@StearnsLab

6 years

I'm happy to report that Stanford Biology will not require the GRE for PhD admissions this year. Late to the game, and not without some heated discussion, but the right thing to do, I think. #GRExit

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Tim Stearns

@StearnsLab

4 years

Rosalind Franklin, reanimated by running through Deep Nostalgia. She wants her DNA x-ray image back, Jim Watson. #WomenInSTEM

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Tim Stearns

@StearnsLab

6 years

In the interest of promoting an understanding of the history, this scathing letter from Crick to Watson in 1967 is a remarkable document. Crick lays out a detailed criticism of the draft of Watson's "Double Helix" (provisionally titled "Honest Jim" here).

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Tim Stearns

@StearnsLab

4 years

If the Republican leadership had any guts they would be in the Oval Office now, telling the President he has two options: resign now or be impeached and removed.

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Tim Stearns

@StearnsLab

4 years

It's 1955, and Rosalind Franklin, already a renowned structural biologist, has to beg her supervisor for a raise equal to her position. Surprising to no women in academia today.

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Tim Stearns

@StearnsLab

4 years

20 years after the announcement of the "working draft" of the human genome, we have the first complete assembly of a human chromosome. It's hard work to chase down every last base!

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Tim Stearns

@StearnsLab

1 year

Re: the history of the DNA structure, see this blistering 1967 letter from Crick to Watson objecting to the draft of Watson’s book on their work. “...it shows such a naive and egotistical view of the subject as to be scarcely credible.”

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Tim Stearns

@StearnsLab

4 years

Gregor Mendel, reanimated by running him through the Deep Nostalgia algorithm. Would definitely have a beer in the abbey with him.

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Tim Stearns

@StearnsLab

5 years

Huge coenocytic alga, also known as “sailor’s eyeball.”

💀 tttlllrrr 💀

@_tlr_

5 years

Valonia ventricosa - largest known single cell organism. This is one cell, you can hold it in your hand.

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Tim Stearns

@StearnsLab

2 years

A better title for this article would be “Huge demand for PhD scientists leads many to land high-paying jobs in the biotech sector”

‘The tipping point is coming’: Unprecedented exodus of young life scientists is shaking up academia

Faculty are struggling to hire postdocs, delaying research projects and pressuring universities to consider improving salaries and benefits as endowments are shrinking.

www.statnews.com

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Tim Stearns

@StearnsLab

4 years

Today was my last day as chair of the Stanford Biology department. After six years, my last official act was to send out faculty offer letters to two awesome young scientists who we want to bring here. Saving the best for last!

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Tim Stearns

@StearnsLab

4 years

I worked in a genetics lab in Bradfield Hall when I was an undergrad at Cornell. The building is devoid of windows except for a small seating area at the end of each floor. Eleven stories of basement.

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Tim Stearns

@StearnsLab

1 year

Congratulations to Karikó and Weissman! The 2005 paper that is the basis for the award has a simple hypothesis - that modified bases prevent the immune response to exogenous RNA - which is then tested by well-designed experiments. A classic.

The Nobel Prize

@NobelPrize

1 year

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

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Tim Stearns

@StearnsLab

5 years

We're starting a new postdoc program in the natural sciences at Stanford! 3 year appt, stipend of $83,000/year, plus research funds, strong interest in enhancing diversity. Apply by Nov. 1. Please RT!

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Tim Stearns

@StearnsLab

2 years

DALL-E 2, make a painting in the style of Gustav Klimt of a scientist with a microscope.

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Tim Stearns

@StearnsLab

6 months

Why are ~10% of humans left-handed? (🙋‍♂️) Exome-wide association study of rare variants in UK Biobank identified alleles of the beta-tubulin gene TUBB4B. Could be related to cilia function, which has been linked to other left-right asymmetries.

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Tim Stearns

@StearnsLab

5 years

I’ve admired David Goodsell’s brilliant structure visualization work for years, and now you can create a Goodsell-like image from any PDB file, at his web site! . Just made this one of the histone octamer, 1AOI.

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Tim Stearns

@StearnsLab

4 years

A large group of Stanford faculty signed a letter calling attention to misrepresentations of science by Scott Atlas, adviser to the White House. Lawyers for Atlas threatened to sue. Our letter in response reaffirms our points:

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Tim Stearns

@StearnsLab

2 years

“Happy to announce…” thread coming soon!

Rockefeller University

@RockefellerUniv

2 years

Tim Stearns ( @StearnsLab ) will become Rockefeller’s new dean of graduate and postgraduate studies on Sept 1. Welcome, Tim! In this Q&A, he shares his vision for the university’s educational programs:

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Tim Stearns

@StearnsLab

5 years

The beautiful new Bass Biology Building at Stanford has a dramatic 4 story-high pergola. Why are seemingly random slats in the structure missing? Because the very creative architects saw images of electrophoresis gels, and they ran with it.

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Tim Stearns

@StearnsLab

4 years

FOMO when you’re not important enough to have your account deleted by Twitter so you have to do it yourself. via @statnews

Scott Atlas, controversial former Trump adviser, deletes Twitter account

Scott Atlas deleted his Twitter account, saying the site "mainly inflames extreme thinking and disseminates distortions."

www.statnews.com

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Tim Stearns

@StearnsLab

4 years

Tony Fauci at 1:10, saying what all scientists (should) know: "peer-reviewed" ≠ "good science."

Elliot Tapper

@ebtapper

4 years

Best journal club ever

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Tim Stearns

@StearnsLab

2 years

Next @NIHDirector should address basic research funding issues as a top priority. Increase min salaries for postdocs, raise max modular R01, and reduce max PI salary on grants. Yes, this will result in fewer grants and faculty hired. We need more $ for basic research.

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Tim Stearns

@StearnsLab

3 years

I'm troubled by talks in which the speaker doesn’t make note of recently published, closely related work from others. And I see it much more often now. Giving credit is important, but even more important is putting your results in the context of current knowledge.

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Tim Stearns

@StearnsLab

5 years

I love stamps featuring scientists, especially when they have the actual science in tiny form. If you understand this stamp, you understand Mendelian genetics.

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Tim Stearns

@StearnsLab

2 years

I’m all ears for what current postdocs are saying would make their experiences better.

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Tim Stearns

@StearnsLab

2 years

When I started teaching at Stanford almost thirty years ago, nobody told me how to grade or what kinds to tests to give to gauge student knowledge. I didn’t really know what I was doing, but I did know that if most students failed my course, it would be my fault. 1/4

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Tim Stearns

@StearnsLab

2 years

It’s ornamental cabbage season in NYC, so a reminder that it and all of these vegetables are the same species and are the product of human selection and the remarkable plasticity of Brassica oleracea development.

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Tim Stearns

@StearnsLab

4 years

Pfizer plans to have 1.3B doses of their mRNA-based COVID vaccine available through 2021. Assuming a 30 µg dose, thats 40 kilograms of synthetic RNA.

How Pfizer Plans to Distribute Its Vaccine (It’s Complicated) (Published 2020)

Success will hinge on an untested network of governments, companies and health workers.

www.nytimes.com

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Tim Stearns

@StearnsLab

5 years

Likely explanation for loss of smell (anosmia) in #COVID19 patients - olfactory sensory neurons (OSN) don’t express receptor, but infection of supporting cells causes damage in the olfactory epithelium resulting in disruption of OSN function.

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Tim Stearns

@StearnsLab

3 years

Nobody I know believes you “need” a CNS paper or a K99 to get a faculty position. But everybody knows that they help - just look at those interviewing for positions at your institution. A paper about the faculty job market that ignores that is not helpful.

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Tim Stearns

@StearnsLab

6 years

We're packing up the Stearns lab to move into the new Bass Biology Building @Stanford ! Pulled this off the shelf, dusted it off and fired up Microsoft Word 1.0. 1984 is in the house.

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Tim Stearns

@StearnsLab

2 years

This graph plots the annual average number of authors per paper in four journals. Simple, and says a lot about how science has changed. I've run a small-shop lab my whole career, but is that a viable approach for people entering science now?

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Tim Stearns

@StearnsLab

5 years

To the students starting grad school this year, your enthusiasm for science and excitement about everything new is what makes a life in academia worthwhile. Don’t be shy about sharing it with everyone around you!

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Tim Stearns

@StearnsLab

6 years

It’s faculty salary-setting time at many universities. As a department chair, I always keep this important monkey-lesson in mind!

neuro.social.self

@neurosocialself

6 years

US: When two monkeys were offered unequal pay for the same task .. | Classic from Franz de Waal at Yerkes | TedTalks |

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Tim Stearns

@StearnsLab

3 years

Astounding case of rapid, life-saving genome sequencing and diagnosis of a 5 month old child with a metabolic disease. 10 years earlier his sibling died of the same condition.

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Tim Stearns

@StearnsLab

2 years

Cell biology often has a strong “feeling an elephant in the dark” vibe because of the focus on testing individual parts of very complex systems. We know much about these parts, but little of how they work together. Systems biology was supposed to address this problem. Has it?

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Tim Stearns

@StearnsLab

4 years

The Stanford Faculty Senate today voted to condemn the behavior of Scott Atlas, adviser to the White House, saying that it “violates the core values of our faculty”

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Tim Stearns

@StearnsLab

3 years

Anyone who has been on a faculty search committee knows this is not true.

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Tim Stearns

@StearnsLab

6 years

A great paper title: "A square bacterium" Nature 283:69 (1980). By A.E. Walsby, after whom Haloquadratum walsbyi is named. It grows as very thin square cells in 5M salt. First sentence: "I have come across a bacterium which has the form of a thin square sheet."

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Tim Stearns

@StearnsLab

5 years

Important new paper showing sites of #COVID19 viral shedding and timing vs. symptoms. Mainly throat and lungs, with very high virus titers, and seroconversion after 7 days. Also in GI tract. Throat swabs likely sufficient for testing.

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Tim Stearns

@StearnsLab

8 months

UMAP dimensionality reduction was designed to help visualize relationships in high-dimensional data. But, most users don’t know how it works, and therefore can’t usefully interpret the graphs. This is a great UMAP description, with interactive sliders!

Understanding UMAP

UMAP is a new dimensionality reduction technique that offers increased speed and better preservation of global structure.

pair-code.github.io

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Tim Stearns

@StearnsLab

4 years

Remarkably rapid work determining crystal structure of the viral protease, virtual screening to identify inhibitors and high-throughput actual screening of candidates. The power of modern molecular biology. #COVID19 .

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Tim Stearns

@StearnsLab

1 year

Great to see the people at DeepMind behind AlphaFold get the recognition of a Lasker Award! But award committees, don’t forget that David Baker at UW has been pushing this field forward for years, all in an open academic setting.

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Tim Stearns

@StearnsLab

2 years

I start as dean at @RockefellerUniv this week, and I expect my arrival will be less dramatic than that of my uncle Donald Stearns who in 1949 was arrested outside the gates of Rockefeller after leading police on a guns-blazing, high-speed car chase across Manhattan.

Tim Stearns

@StearnsLab

2 years

“Happy to announce…” thread coming soon!

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Tim Stearns

@StearnsLab

3 years

Stentor, colossus of the ciliate world, meets its match

Slava Bobrov

@slava__bobrov

3 years

Hungry flatworm attacks and eats a single-celled organism: #biology

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Tim Stearns

@StearnsLab

3 years

$25/plasmid for full sequence and annotation. @plasmidsaurus

Sebastian S. Cocioba🪄🌷

@ATinyGreenCell

3 years

Just got my plasmid sequencing results back from @plasmidsaurus and the insert is perfecto. Even fixed some legacy mis-sequencing from looong ago. Only 3 SNPs after 10 years of use. I *highly* recommend their services and for everyone to sequence their *entire* construct.

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Tim Stearns

@StearnsLab

1 year

It would be nice if the Nobel Prize Foundation wasn’t a source of misinformation about aging.

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Tim Stearns

@StearnsLab

2 years

The Nobel lecture of Alexander Fleming, discoverer of penicillin, has a section at the end where he considers personal responsibility and infectious disease. Still relevant.

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Tim Stearns

@StearnsLab

2 years

Cell biology: 150 years of single-cell analysis

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Tim Stearns

@StearnsLab

6 years

We really should not be giving Jim a public forum for his views, as they have not been based in real science for many years. He had a central role in the origins of molecular biology, but the cult of personality that continues to surround him is corrosive.

NYT Science

@NYTScience

6 years

James Watson's latest pronouncements on race and genetics already have brought censure: “It is disappointing that someone who made such groundbreaking contributions to science is perpetuating such scientifically unsupported and hurtful beliefs.’’

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Tim Stearns

@StearnsLab

4 years

Amazing stories of cells working together this week: 1) Cardiomyocytes discard defective mitochondria, which macrophages clear. 2) APCs donate their telomeres to T cells, transferring them through a vesicular intermediate(!)

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Tim Stearns

@StearnsLab

3 years

Why is Uli Laemmli’s 1970 paper describing SDS-PAGE - one of the most cited molecular biology papers of all time - still behind a paywall? Free the papers.

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Tim Stearns

@StearnsLab

2 years

Kudos to @NIH for providing $2500/yr in childcare costs to grad students and postdocs on training grants. It doesn’t cover the full cost, but it helps.

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Tim Stearns

@StearnsLab

2 years

For a class, you can hand out a printed abstract of a paper, then have students work in groups to answer “what must the authors have done to be able to write this abstract?” At the end, get together to compare the group outcomes with what they actually did in the paper.

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Tim Stearns

@StearnsLab

2 years

Mendel wrote a personal statement when he was 28 and applying to complete his degree. Writing in the third person, he described his failures and dashed hopes in academia. Becoming a monk was the escape that gave him the freedom to do research. #Mendel200

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Tim Stearns

@StearnsLab

3 years

Dali’s iconic surrealist painting “Waiting for the centrifuge door to open”

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Tim Stearns

@StearnsLab

2 years

When Stanford substantially raised its minimum postdoc salary, faculty short of funds to cover it could apply for assistance. Chairs, deans and provosts are there to facilitate research, and UC leaders must step up to keep the best public research univ. in the world going strong.

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Tim Stearns

@StearnsLab

4 years

Here’s what goes in your arm: alpha-globin 5’-UTR, a signal sequence, codon-optimized spike protein coding sequence (w/two mutations to keep it in the desired conformation), and a poly-A tail. All U’s replaced with ψ’s. Looking forward to getting it when my turn comes around.

Mark Budde 🦕🏆

@markwbudde

4 years

Here is the full sequence of the Pfizer vaccine, courtesy of the WHO. 4284 nucleotide, 1273 amino acids. All U are 1-methyl-3'-pseudouridine. PolyA has strange structure, is broken up with GCAUAUGACU.

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Tim Stearns

@StearnsLab

6 years

The serendipity of science - it’s all right there in the first paragraph of Fleming’s paper. Contaminated plates leads to discovery of penicillin.

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Tim Stearns

@StearnsLab

3 years

New professor me to David Botstein (many years ago): “Why did you choose to work on Salmonella when everyone else was working on E.coli?” Botstein: “When you’re on the side of the road it is easier to move fast and not get run over”

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Tim Stearns

@StearnsLab

1 year

My platform: Peace, Prosperity, Open Access and no change to the NIH bio page format for four years.

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Tim Stearns

@StearnsLab

4 years

Fixed it: Scientists ECSTATIC as Joe Biden wins tight US presidential election

Scientists relieved as Joe Biden wins tight US presidential election

Nature - The new president has the opportunity to reverse four years of anti-science policies — but he also inherits a nation divided.

www.nature.com

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Tim Stearns

@StearnsLab

5 years

Dept. chairs, check on your faculty after this first week at home and ask if they need to reassess what they are able to contribute during this crisis. Focusing completely on home and health will be the only realistic option for some and that should be OK.

Dr. Kirsten Read

@K_ReadLab

5 years

i. just. can't. i can't homeschool a 4, 8 and 10yo, teach 2 college classes online, remotely run my lab, concentrate on manuscripts and grant proposals, and innovate. while i'm also just worried all the time about my 76-yo mom who lives alone on the other side of the country.

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Tim Stearns

@StearnsLab

5 years

Excellent thread. The science you do will likely be forgotten in relatively few years, or, at best, anonymously remembered. True no matter who you are or how well-known at the moment. What lives on are the people you have taught and mentored. Do it for the people.

Tanentzapf Lab

@TanentzapfLab

5 years

1. One of formative experience of grad school for me was when our lab moved across the hallway to a bigger space & I realised my research didn’t really matter in the grand scheme of science & that this actually made me love science even more. So here is a thread about that.

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Tim Stearns

@StearnsLab

5 years

Superstar turnout for Katie “Black Hole” Bouman at Stanford! #WomenInSTEM

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Tim Stearns

@StearnsLab

2 years

Ten-year cell transfer experiment in mice shows that T cells have the ability to divide over many mouse lifetimes, without an apparent Hayflick limit. They do acquire markers associated with “exhaustion” but keep on going.

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Tim Stearns

@StearnsLab

2 years

So, professors, we have moved from requiring that students recall information to requiring that they synthesize information, since all information is easily accessible. With #ChatGPT and future successors able to synthesize information, what will we now ask of students?

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Tim Stearns

@StearnsLab

10 months

For those who run PhD programs or admissions committees, did you have a big increase in applications this year? We have a ~25% bump over last year, which is huge.

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Tim Stearns

@StearnsLab

2 years

Some replies suggesting that science twitter is an important and effective counter to the musk-ox. Could be, although it also gives legitimacy to the site and feeds their advertising machine, the main source of income.

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Tim Stearns

@StearnsLab

4 years

Brilliant: The. Endowment. Is. Not. For. You.

A University President Responds to Those Who Have Suggested the School Should Dip Into the Endowment

To the esteemed members of our faculty and staff, As president of this University, there is nothing more important to me than the health and safety...

www.mcsweeneys.net

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Tim Stearns

@StearnsLab

2 years

This completely at odds with how we engage with our research communities, for which we have meetings large and small and attendees from all over the world. Why aren’t we - professors at major research univ’s - more serious about teaching as a discipline? 4/4

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Tim Stearns

@StearnsLab

3 years

Summer lectures at Woods Hole in 1894

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Tim Stearns

@StearnsLab

8 months

Who were Gilson and Rainin? How many tips does the typical grad student use during their PhD? This and more in this history of the micropipette. .

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Tim Stearns

@StearnsLab

3 years

We’re losing species faster than we can keep track of right now, in the Anthropocene. Couldn’t we get smart, ambitious people interested in reversing that trend rather than the much more complex alternative of bringing them back after they’re gone?

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Tim Stearns

@StearnsLab

4 years

This is a wonderful response by @AOC . And, she was an Intel science prize winner for a worm project on oxidative stress and aging. Model organism of future congresswomen.

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Tim Stearns

@StearnsLab

4 years

Seeing younger women scientists find their social media voice is part of what makes science Twitter great. Seeing them harassed off the platform is what makes it not great. Let's eliminate the latter.

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Tim Stearns

@StearnsLab

3 years

Good advice on making slides for science presentations.

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Tim Stearns

@StearnsLab

2 years

DALL-E is amazingly good at creating images from simple input text. Input: A woman scientist with microscope 1) in the style of Matisse 2) in the style of a Diego Rivera mural 3) in the style of an Orozco mural Putting graphic artists out of work, or another tool for them?

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Tim Stearns

@StearnsLab

4 years

I am thrilled that @cobarnes27 and @naimagsharaf will be joining @Stanford Biology and @Stanford_ChEMH ! They will bring strong structural biology expertise and we look forward to seeing them on campus in person, next year. Students, they’ll be great thesis advisors!

Tim Stearns

@StearnsLab

4 years

Today was my last day as chair of the Stanford Biology department. After six years, my last official act was to send out faculty offer letters to two awesome young scientists who we want to bring here. Saving the best for last!

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Tim Stearns

@StearnsLab

4 years

“Rise up” against perfectly reasonable public health measures in a resurgent pandemic? This @HooverInst senior fellow is an embarrassment to the institution, a danger to the public and a sad reflection of the ineffectual White House COVID task force.

White House Coronavirus Task Force - Wikipedia

en.wikipedia.org

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Tim Stearns

@StearnsLab

4 years

Letter from @JoeBiden to @eric_lander , his new science advisor, laying out five big science questions.

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Tim Stearns

@StearnsLab

3 years

Need more evidence that journal impact factors are meaningless? This journal published 6 articles in 2020. Each is an assessment of cancer statistics, which tend to be highly cited. For comparison, the impact factor of Science is 42.

CA: A Cancer Journal for Clinicians

@CACancerJournal

3 years

CA is pleased to announce that the Impact Factor for 2020 has increased to 508.7. We express our sincerest thanks to our editors, authors, reviewers, and readers for helping us achieve this significant milestone.

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Tim Stearns

@StearnsLab

10 months

Finding a good mentor in grad school.

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Tim Stearns

@StearnsLab

3 years

For 20 years the reference human genome has had gaps and missing sequences. PacBio, Oxford Nanopore and a haploid human cell line to the rescue in the first complete human genome assembly! @aphillippy and a cast of many.

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Tim Stearns

@StearnsLab

2 years

Klimt’s “Portrait of Adele Bloch-Bauer” is astounding up close, at @NeueGalerieNY . But I can’t stop seeing cells migrating in the ventricular zone looking at her dress!

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Tim Stearns

@StearnsLab

10 months

Preprint reports predicted mega-proteins in bacteria of more than 85k aa. At a rate of translation of 18 aa/sec, it would take about 1.5 hours to make such a protein. Amazing to think of how processivity of transcription/translation is maintained!

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Tim Stearns

@StearnsLab

7 months

Susumu Tonegawa’s Nobel lecture from 1987 about the genetic basis of antibody diversity is a great example of technology driving discovery. Each new molecular biology advance - cloning, Southern blots, sequencing - enabled the next discovery.

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Tim Stearns

@StearnsLab

4 years

Good thread on what the "new normal" is likely to look like.

Andy Slavitt 🇺🇦

@ASlavitt

4 years

COVID Update July 7: I spent the last 24 hours with 3 scientists, all of whom have seen vaccine data, 2 of whom are former regulators, all of whom have opinion. Will 🧵 soon if interested.

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Tim Stearns

@StearnsLab

3 years

Excellent summary of what we know about how #SARSCoV2 gets into cells and takes over. Lots of interesting cell biology.

How the coronavirus infects cells — and why Delta is so dangerous

Nature - Scientists are unpicking the life cycle of SARS-CoV-2 and how the virus uses tricks to evade detection.