Nature - A study shows that epididymal spermatozoa are sensitive to preconception diet, identifies mitochondrial tRNAs and their fragments as sperm-borne factors and demonstrates epigenetic...

Nature Reviews Cancer - In this Roadmap, Boire et al. consider the immediate causes of mortality in patients with cancer, a topic not often considered in either preclinical or clinical research,...

Nature - Cell-type-resolved spatial proteomics of the skin from patients with toxic epidermal necrolysis reveals that it is driven by JAK/STAT signaling, leading to successful treatment of this...

Nature Cell Biology - Majewska et al. show that p16-expressing senescent cells enhance the stability of the immune checkpoint PD-L1 by downregulating its proteasome-mediated ubiquitin-dependent...

Zhang et al. revealed that stress triggers irritable bowel syndrome with diarrhea by raising systemic purine levels, which stimulates the proliferation of Lactobacillus in the gut and leads to...

During allergen challenge, degranulating mast cells re-route and trap living neutrophils in vivo, resulting in functional and metabolic alteration of the mast cell and the acquisition of neutrophilic...

Nature Biotechnology - Chromatin organization is measured in single cells using droplet microfluidics.

Nature - The spatiotemporal activation of phagocytosis by hair follicle cells is orchestrated by lipids released from surrounding apoptotic cells and retinoids released by healthy cells.

Nature - Two studies help to explain why colorectal and bladder tumours take a bigger toll on men than on women

Nature - Using single-cell and multi-omics data of fetal blood, a high-resolution molecular map of dysregulated haematopoiesis in Down syndrome is provided.

Nature - By using phylogenetic analyses of multiple microdissected samples from both cancer and non-cancer lesions, unique evolutionary histories of breast cancers harbouring a common driver...

Immune tolerance mechanisms are shared in cancer and pregnancy. B7-H4 is identified as an immune checkpoint molecule contributing to onco-fetal immune tolerance, whose expression is regulated by a...

Nature - Human TNF is required for respiratory-burst-dependent immunity to Mycobacterium tuberculosis in macrophages but seems to be largely redundant physiologically.

Calubag et al. review recent findings that suggest dietary composition plays an important role in regulating senescence. The authors discuss molecular mechanisms engaged by altered macronutrient...

Nature Reviews Molecular Cell Biology - Single-cell and spatial transcriptomics are transforming our understanding of cell plasticity and tissue diversity. This Review discusses technical and...

Though pathogen vaccines are immensely successful, cancer vaccines are largely clinically ineffective. Guasp et al. outline features of emergent RNA cancer vaccines that have achieved recent immuno...

Yang et al. reveal the mechanisms underlying the terminal differentiation of tumor cells in medulloblastoma (MB) and establish an unprecedent connection between thyroid hormone (TH) signaling and MB...

Nature Reviews Molecular Cell Biology - Integrin receptors connect cells to the extracellular matrix, mediating cell interactions, adhesion and signalling. This Review discusses integrin function...

Cancer-associated fibroblasts (CAFs) are heterogeneous and ubiquitous stromal cells within the tumor microenvironment (TME). Numerous CAF types have been described, typically using single-cell...

Nature - The authors use lineage tracing to map the fate of wild-type and Brca1−/−;Trp53−/− cells in the adult mouse mammary gland, identifying three layers of protection...

Nature - Post-fast refeeding increases intestinal stem cell function and tumour formation by augmenting protein synthesis via polyamine metabolism.

Nature Reviews Cancer - In this Review, Polak, Zhang and Kuo discuss the currently available and rapidly evolving 3D tumour organoid models that capture the tumour immune microenvironment. They...

Neuroimmune cross-talk participates in intestinal tissue homeostasis and host defense. However, the matrix of interactions between arrays of molecularly defined neuron subsets and of immunocyte...

Zhang et al. show that PTEN is secreted as a soluble protein by the TMED10-mediated unconventional protein secretion pathway into the extracellular space, where it exerts a cytokine-like role by...

Nature - Experiments in mouse models and histology of human head and neck squamous cell carcinomas show that TIMP1-mediated periosteal thickening in proximity to tumours acts as a barrier to cancer...

Nature - A study demonstrates that metabolic signalling and inflammatory cues associated with obesity selectively induce expression of PD-1 on tumour-associated macrophages to suppress anti-tumour...

Nature Reviews Molecular Cell Biology - Heterochromatin loss, telomere attrition and DNA damage induce cellular senescence by eliciting genome instability and innate immunity responses, thereby...

Gan et al. reveal distinct tumor architectures, stromal interfaces, and tumor-intrinsic mechanisms that are preferentially adopted by prevalent brain metastases during the initiation of colonization....

Nature Genetics - The Human Endometrial Cell Atlas integrates single-cell transcriptomic datasets from women with and without endometriosis. Novel and known cell types are registered using spatial...

Nature Medicine - Using ethnically and geographically diverse metagenomic data, the authors identify microbiota alterations associated with inflammatory bowel disease (IBD). They discover universal...

Genetically engineered mice survive with only autocrine but no paracrine TGF-β1 signaling. Structural and functional studies reveal a mechanism for TGF-β1 autocrine signaling driven by conformational...

Nature - An atlas of tumour vasculature shows that tumour angiogenesis is initiated from venous endothelial cells and extended towards arterial endothelial cells.

DNMT3A mutations associated with clonal hematopoiesis result in elevated osteoclast precursors in the bone marrow (BM) and osteoclastogenic macrophages in the periphery, along with aggravated...

Cancer cells often evade the host immune system, challenging the effectiveness of immunotherapy. In this comprehensive review, Galassi et al. summarize key mechanisms of immune evasion within the...

This study demonstrates that single-cell RNA sequencing count matrices, although valuable for biological research, can inadvertently reveal private information about individuals.

Reprogramming of tumor-infiltrating neutrophils drives their convergent differentiation within the tumor microenvironment.

How do neurons become electrically excitable during development? This study reveals that Schwann cells make and secrete the prostaglandin PGE2, which is critical for sensory neurons to express...

Nature - How healthy cells influence whether cancer spreads at a secondary site.

Nature - Chromatin-associated retrotransposon RNA 5-methylcytosine can be recognized by the methyl-CpG-binding-domain protein MBD6, which guides deubiquitination of nearby monoubiquitinated Lys119...

Chemically induced stem-cell-derived islets were transplanted beneath the abdominal anterior rectus sheath in one patient with type 1 diabetes, resulting in tolerable safety and promising restoration...

Nature Reviews Cancer - In this Perspective, Holder et al. discuss the limitations of current predictive biomarkers of response to immune checkpoint inhibitors and the need to further explore...

McIntyre et al. demonstrate in an analysis of 1,360 patients the key features of early-stage pancreatic ductal adenocarcinoma (PDAC), including an enrichment of KRASG12R disease that extensively...

Nature Reviews Cancer - Sex matters in metastasis, but it has received little attention in research. Here, we highlight the emerging and important roles of biological sex in metastasis and advocate...

Patho-DBiT enables spatial profiling of a range of RNA species (i.e., mRNA, microRNA, tRNA, splicing isoform, etc.) all at once in clinical formalin-fixed paraffin-embedded tissue with high sensiti...

Recycling of cholesterol-rich myelin debris by macrophages leads to the emergence of lipid-laden macrophages (LLMs) in glioblastoma. LLMs support glioblastoma malignancy through transfer of myelin-...

After antigen stimulation, naïve T cells display reproducible population-level responses, which arise from individual T cells pursuing specific differentiation trajectories. However, cell-intrinsic...

This review summarizes how various spatial omics (transcriptomics, genomics, proteomics, epigenomics, translatomics, metabolomics, etc.) technologies are used at different scales, including the...

Nature - Tumour cells adapt to anticancer drug treatments by a series of cellular state transitions, each inducing distinct gene expression programmes and leading to increased drug resistance.

Nature - Studying changes in the metabolic properties of kidney cancer in patients reveals an increased need for mitochondrial metabolism as tumors metastasize from the kidney to distant organs.

Mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) protein are highly prevalent in cancer. However, small-molecule concepts that address oncogenic KRAS alleles remain elusive beyond...

To delineate the mechanisms by which the ERK1 and ERK2 mitogen-activated protein kinases support mutant KRAS–driven cancer growth, we determined the ERK-dependent phosphoproteome in KRAS-mutant...

Nature - Whole-genome sequencing of 962 clear cell renal cell carcinomas from 11 countries shows geographic variations in somatic mutation profiles, including a mutational signature of unknown...

Nature - We combined human intestinal immuno-organoids and single-cell transcriptomics to investigate intestinal inflammation triggered by cancer-targeting biologics, which was associated with an...

Nature Reviews Cancer - In this Review, Arpinati et al. summarize how the extracellular matrix, produced primarily by cancer-associated fibroblasts, impacts tumour progression, metastasis and...

Nature - Whole-genome sequencing of more than 2,000 colorectal carcinoma samples provides a highly detailed view of the genomic landscape of this cancer and identifies new driver mutations.

Nature Genetics - Spot-based spatial transcriptomic analysis of paired primary and metastatic pancreatic cancers identifies cellular, metabolic and fibrotic changes in ecotypes associated with...

Nature - Myddosomes, in which MyD88 forms barrel-like scaffold structures for effector protein recruitment and activation, contain proteins that act at all stages and regulate all effector...

Nature Reviews Cancer - Clonal evolution is now a central theoretical framework in cancer research. In this Perspective, Laplane and Maley identify challenges to that theory such that some...

Yan et al. show the underappreciated role of lactate, a metabolite recognized as a cellular energy source, in conferring stress resilience under persistent exercise. Via modulating the lactylation of...

Tissue-resident memory T (TRM) cells patrol tissues after pathogen clearance, but how these cells contribute to immune responses in the tumor context remains ill defined. Masopust and colleagues...

To identify cancer-associated gene regulatory changes, we generated single-cell chromatin accessibility landscapes across eight tumor types as part of The Cancer Genome Atlas. Tumor chromatin...

Nature Reviews Cancer - In this Expert Recommendation, Faupel-Badger and colleagues present a conceptual framework to define precancer and advance our understanding of the earliest changes that...

During skin wound repair, the basal cell layer transitions from a solid-like homeostatic state to a fluid-like state that allows tissue remodeling during repair and then progressively returns to a...

Sarah-Maria Fendt highlights the history of the Warburg effect and how these findings have advanced our understanding of cancer metabolism.

Yan et al. reveal age-related changes in the rat mammary gland, identifying a unique aging-associated luminal progenitor population. Midkine treatment mimics the effects of aging and promotes mammary...

Nature - CRISPR–Cas9 screens in cultures of young and old neural stem cells (NSCs) and in vivo in old mice identify gene knockouts that can boost old NSC activation and neurogenesis, with...

Nature - Alterations in the tumour suppressor genes STK11 and/or KEAP1 can identify patients with advanced non-small-cell lung cancer who are likely to benefit from combinations of PD-(L)1 and...