Erik Reinertsen @erikrtn Twitter profile

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@Pathfinders__

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@stwmaniax

@Tante_Binal69

@DuncanBarr27184

Erik Reinertsen

@erikrtn

5 years

1/ Why is lactate elevated in sepsis or septic shock? @dolan_russell & I explore this common #ICU pimp question via #tweetorial . We're taught that ↓O2 revs up anaerobic metabolism causing ↑ lactate. But wait, there's more... #medtwitter #FOAMed #meded #FOAMcc #criticalcare

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Erik Reinertsen

@erikrtn

2 years

Dear all bioinformatics vendors, we don't want "no code", "low code", or a UI. We want more code, better code, CLIs, and clear documentation.

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Erik Reinertsen

@erikrtn

9 months

What I learned leading a data science & software team in biotech You You are a technical leader at a biotech startup. Your title is Director, or VP of Data Science / Machine Learning / Engineering, or CTO / CDO. Your remit is to develop a "platform" or "engine", an exciting

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Erik Reinertsen

@erikrtn

5 years

I'm joining @MIT @MGHMedicine @HarvardMed as a postdoctoral researcher! Will work on machine learning for physiological time series data w/ Profs Aaron Aguirre, Brandon Westover, & Collin Stultz. Excited to learn about data science, cardiology, & critical care in Boston.

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Erik Reinertsen

@erikrtn

2 years

For many early stage biotechs doing bioinformatics, bottleneck turns out to *not* be how many samples their RNASeq pipeline concurrently processes. Rather, speed enabled by simple data infra, well-documented APIs, & self-service tools for users. In other words, good engineering.

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Erik Reinertsen

@erikrtn

9 months

My 2024 predictions for biopharma software platforms: 1. Fewer new bioinformatics SaaS cos will be founded, funded, or alive by EOY. Customers and investors are saturated with many undifferentiated competitors. Slapping a GUI on top of an EC2 VM with a few ready-to-go RNASeq

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Erik Reinertsen

@erikrtn

5 years

12/ To summarize, ↑ lactate in sepsis septic shock is 2/2: + ↓ O2 extraction 2/2 inflammation, microcirculatory & mitochondrial dysfx + β2 adrenergic stim. & hypermetabolic state, shunting pyruvate → lactate + Thiamine deficiency (maybe) Thanks @tony_breu for inspiring!

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Erik Reinertsen

@erikrtn

10 months

@wangzjeff brilliant. now imagine scaling this to its logical endpoint. a vehicle with large capacity, frequently traveling on a popular route, made inexpensive per rider due to up front capex and scale economies. most major cities in europe and asia have this amenity :)

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Erik Reinertsen

@erikrtn

9 months

@ashleyruba_phd a PhD in French literature can be helpful to someone interested in a career teaching French literature

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Erik Reinertsen

@erikrtn

6 years

In this @NatureMedicine paper, @matkomorowski @FaisalLab @agordonICU apply reinforcement learning to automate fluids & pressors in sepsis This closer look by @point85_ai (not me) raises concerns I summarize in this thread

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Erik Reinertsen

@erikrtn

3 years

What are the best blog posts on product management in life science (or tech ∩ biotech)*? cc'ing people who I bet know the best PMs @kulesatony @MichaelRetchin @zavaindar @ImranSHaque @sk_leung *not health care, care delivery, medical devices, etc.

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Erik Reinertsen

@erikrtn

4 years

Excited to announce new role as Director of Data Science & Engineering at @PrometheusBio , the first co using precision medicine & ML to create better medicines for patients w/ GI disease. Will finish projects at MGH/MIT and transition in coming weeks. Excited for next chapter!

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Erik Reinertsen

@erikrtn

6 years

Data quality, infrastructure, and clinician workflow are FAR more important for machine learning in healthcare vs. developing better neural networks.

Louie Mantia, Jr.

@Mantia

6 years

What‘s something that seems obvious within your profession, but the general public seems to misunderstand?

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Erik Reinertsen

@erikrtn

5 years

Related: amazing BST mode (cc @gradydoc ) talk by @maxhockstein at #CCS19 on five causes of lactic acidosis. Elevated lactate is not always sepsis! Check out @SummitCritCare , hopefully talks will be uploaded to YouTube.

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Erik Reinertsen

@erikrtn

5 years

Which VC firm has the best website? Ideally tasteful, informative, tells founders what they invest in / why, who is on team, etc. No fluff. I like @NEA @GVteam cc @vcstarterkit ("how can I be helpful?" RT!) @WillManidis @sk_leung @nikillinit #vctwitter

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Erik Reinertsen

@erikrtn

3 years

Any tech + bio VC firms looking for a rock star intern? Asking for friend: incredible MD/PhD student at @UCLA / @Caltech , background in cell-based cancer dx & tx tools, synthetic bio. cc @JeffreyLowMD @kulesatony @sk_leung @ShahramSN @zavaindar @zebulgar @SaraNayeem @nxpatel

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Erik Reinertsen

@erikrtn

5 years

Risk models can predict death or stroke after ACS, but do not perform well for *all* patients. Stultz Lab @MIT , @IBMResearch , & @UMassMedical developed “unreliability score” to determine if model’s results can be trusted for given patient cc @EricTopol

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Erik Reinertsen

@erikrtn

4 years

MGH ACLS is now live on the App Store! This app was created to help MDs, PAs, NPs, & EMTs improve the efficiency & effectiveness of running codes - and ultimately save more lives. Made by @MGH_HTL in collab w/ @EMRES_MGHBWH @MGHMedRes @American_Heart .

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Erik Reinertsen

@erikrtn

6 years

Working in the newborn nursery. Epic does not allow user to simultaneously view mother's and baby's chart. Have to close one completely to view other or write note. Have to print one of them on paper to work. The year is 2018.

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Erik Reinertsen

@erikrtn

2 years

List of early stage investors (VCs & angels) active in AI / software ∩ bio Compiled by @ad_am_ara & the @bitsinbio community cc @nlarusstone

Investors AI/Software & Bio - TechBio | Notion

A curated list of investors in the AI/Software & Bio and TechBio space. The aim of this list is to have investors that understand the space and the new breed of companies that are coming into this...

pitch-hugger-7ec.notion.site

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Erik Reinertsen

@erikrtn

6 years

@reepRN @cacace_frank Also, nice for students / trainees of all fields to just hang out together. Social event with MD, RN, PT, RT, PA students > sitting for hours in big lecture hall getting talked at about “leadership”, “teamwork”. Teamwork is built on relationships.

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Erik Reinertsen

@erikrtn

5 years

Collin Stultz, MD, PhD ( @RLEatMIT @MITEECS @MIT_IMES MGH) giving talk on “clinically useful ML” at AI Research Week @MITIBMLab @IBMResearch @IBMWatsonHealth #AIRW2019 Key q’s: 1. Does model make physiological sense? 2. Does model apply to my patient? 3. What are failure modes?

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Erik Reinertsen

@erikrtn

5 years

6/ Other causes of ↑ lactate in the cirrhotic patient: + Lactated Ringers + Albuterol or other β2 adrenergic stimulation (seen in asthmatics or pt on epi drip; h/t @ASundaralingam ) + Metformin, especially in setting of renal impairment; rare

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Erik Reinertsen

@erikrtn

5 years

@raj_mehta @venkmurthy @f2harrell @ADAlthousePhD Naive question from a trainee: the 95% CIs include 1.0, so why is it incorrect to conclude there was not a statistically significant benefit? Trying to learn so I can more rigorously evaluate papers like this. Thanks in advance!

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Erik Reinertsen

@erikrtn

5 years

Next @MIT Computational Medicine Seminar () is Mon 11/4 1-2 pm at E25-401 @JFutoma ( @hseas ) will talk about "Assisting with Sequential Clinical Decision Making Using Machine Learning" Please RT & spread the word! cc @RLEatMIT @MITEECS @MIT_CSAIL @MIT_HST

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Erik Reinertsen

@erikrtn

6 years

Next few years will be formative for AI drug disc/dev. Key event will be if these tech x bio cos (like @recursionpharma ) get candidates past milestones toward clinic, resulting in licensing or acq by big pharma → repeat a few times → $BB platform acq → every pharma buys AI.

Eric Topol

@EricTopol

6 years

By many metrics, overall research productivity and biopharma innovation are slowing down. Can #AI rev it up? @DavidRotman explores, with many worthy examples, @techreview @AtomwiseInc @deepgenomics @KebotixInc

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Erik Reinertsen

@erikrtn

5 years

9/ In sepsis, systemic inflammation and endothelial activation causes microcirculatory and mitochondrial dysfunction: Also, despite high CO and low SVR, peripheral O2 extraction is low. These factors shunt pyruvate into lactate.

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Erik Reinertsen

@erikrtn

5 years

10/ β2 adrenergic stimulation → ↑ aerobic glycolysis in skeletal muscle, shunting excess pyruvate into lactate (c/w sepsis = hypermetabolic state): and This also explains the ↑ lactate in patients given albuterol or epi drip!

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Erik Reinertsen

@erikrtn

9 months

Biotech and Tech people use different vocabulary and mental models Biotechs employ scientists, accountants, manufacturing specialists, lab managers, lawyers, medical affairs specialists, software developers, etc. It is a naive mistake to think everyone shares an understanding of

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Erik Reinertsen

@erikrtn

5 years

4/ Hepatocytes metabolize 70% of lactate via gluconeogenesis & to a lesser extent, oxidation. Outside of the liver, mitochondria-rich skeletal & cardiac myocytes & proximal tubule cells remove the rest of the lactate by converting it to pyruvate. Ref:

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Erik Reinertsen

@erikrtn

10 months

@dr_alphalyrae people seem to give all sorts of advice, confidently, without access to firsthand experience, context, counterfactual information realizing this as early in one’s career as possible is both concerning and useful

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Erik Reinertsen

@erikrtn

1 year

@saranormous Sucks for the customer, I've lived the experience. My team would simply not engage further if the vendor pushed for a live call or mentioned a multi-week implementation process. This status quo = low-hanging opportunity for new entrants. Self-serve with clear pricing is the way.

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Erik Reinertsen

@erikrtn

2 years

@ai__pub @IsomorphicLabs @RecursionPharma @benevolent_ai @insitro @generate_biomed @exscientiaAI @Schrodinger @AtomwiseInc @cellaritybio @ValoHealth and other @FlagshipPioneer cos

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Erik Reinertsen

@erikrtn

5 years

@kdpsinghlab @venkmurthy @GSCollins @MaartenvSmeden @Richard_D_Riley @ADAlthousePhD @f2harrell @ESteyerberg @NavTangri Some of your followers (e.g. me) know something is wrong, but are still learning methods. Made me think of @david_sontag 's paper on RNNs for multivariate time series with missing values Intro describes various approaches to address missing values:

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Erik Reinertsen

@erikrtn

5 years

8/ ↑ lactate often does not correlate w/ traditional indicators of perfusion, nor does it diminish with ↑ O2 delivery: and

Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue...

OBJECTIVE. The purpose of this study was to quantitate the derangements in intermediary carbohydrate metabolism and oxygen use in severely septic patients in comparison with healthy volunteers....

www.ncbi.nlm.nih.gov

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Erik Reinertsen

@erikrtn

11 months

Any biotechs hiring computational biologists? An acquaintance is looking for new opportunities at Principal / Sr Principal level. Background in genetics, bioinformatics, and biostatistics. Ideally remote-first processes and culture. Experience spanning immunology, oncology, and

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Erik Reinertsen

@erikrtn

3 years

New preprint! "Patient Contrastive Learning: a Performant, Expressive, and Practical Approach to ECG Modeling" arxiv github Outstanding work w/ @MGHHeartHealth @MITEECS @broad_ml4h @broadinstitute led by Nate Diamant & @gpbatra

Patient Contrastive Learning: a Performant, Expressive, and...

Supervised machine learning applications in health care are often limited due to a scarcity of labeled training data. To mitigate this effect of small sample size, we introduce a pre-training...

arxiv.org

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Erik Reinertsen

@erikrtn

5 years

3/ The liver is responsible for ~70% of lactate metabolism. Patients with hepatic dysfunction can have ↑ lactate 2/2 ↓ clearance or ↑ production. Also, cirrhotics are more prone to hyperlactatemia in setting of sepsis. Diving deeper, how does the liver metabolize lactate?

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Gluconeogenesis

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Oxidation

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Erik Reinertsen

@erikrtn

8 months

I think we’re in a bubble

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Erik Reinertsen

@erikrtn

3 years

@moorejh Recommend the highly accessible by James, @daniela_witten , Hastie, and @robtibshirani . "An Introduction to Statistical Learning provides a broad and less technical treatment of key topics in statistical learning."

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Erik Reinertsen

@erikrtn

7 years

@careyjans @MargaretAxelrod @MDPhDToBe @MadPhud22 @MedicalRedhead @babbymd @BrianMSweis @back2brains @jonatlin @runDRG @MDPhDinProgress @nnebeluk @AlexSilverMSTP @AimeeVester @heydavemathews finally, don't forget your memes Marvel: "Infinity War is the most ambitious crossover event in history" NIH:

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Erik Reinertsen

@erikrtn

3 years

Exciting work led by the incredible @daphneschles ( @mit_hst ) is out in #JACCAdvances ! A Deep Learning Model for Inferring Elevated Pulmonary Capillary Wedge Pressures From the 12-Lead ECG Great collaboration w/ @MIT @MGHHeartHealth @gpbatra @broad_ml4h

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Erik Reinertsen

@erikrtn

6 years

@DShaywitz Health IT is a gigantic pile of technical debt.

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Erik Reinertsen

@erikrtn

6 years

Acad med training ❤️ basic science. Great - but translation more than "bench to PDF"! Includes entrepreneurship, commercialization, implementation. Best leaders build culture that values work w/ industry, policy, etc. cc @ReedOmary @atulbutte @zakkohane @RichDuszak @DShaywitz

Eric Topol

@EricTopol

6 years

So much invaluable biomedical research sits in journals, without actualizing its potential to improve human health. Lost without translation.

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Erik Reinertsen

@erikrtn

3 years

Who is building @capiche for biotech / techbio / comp bio / bioinformatics? How much time does the industry cumulatively spend (waste?) comparing Latch vs Seven Bridges vs DNANexus vs. X? cc @nikillinit @nterminus

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Erik Reinertsen

@erikrtn

7 years

Wonderful talk on the bedside exam in the age of tech by @cuttingforstone @stanfordmed25 . On spending 2 hrs charting per hr w/ patient: “I’m disappointed in the associations that represent us. Students & residents have a voice and must use it” #medicine

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Erik Reinertsen

@erikrtn

1 year

Recent @NatureMedicine on #AI -designed drugs All FDA Cleared or Approved Companion Diagnostic (CDx) Devices look at DNA or one-target protein exp. Multi-omics CDx good in theory, but tough cost & logistics. Who is working on this?

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Erik Reinertsen

@erikrtn

5 years

11/ Thiamine (vit B1) deficiency can shunt pyruvate to lactate, and may play a role. B1 can be deficient in sepsis: Giving B1 *may* improve lactate clearance: ...but this RCT suggests it does not help:

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Erik Reinertsen

@erikrtn

9 months

Biotechs care about scientific or clinical results, not platforms You care about your platform. The potential impact and efficiency of scaling the same analyses across multiple scientific programs is obvious. Unfortunately, everyone else at your biotech is most likely

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Erik Reinertsen

@erikrtn

9 months

if you are organized, brief, and responsive via email, you are in the top 25% of professionals if you RSVP to events, send an agenda ahead of time, and follow up after, top 10% if you actually do what you say you will do, on schedule, top 1% this does not seem to be taught in

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Erik Reinertsen

@erikrtn

5 years

5/ Patients w/ hepatic dysfx have ↑ lactate 2/2 ↓ clearance or ↑ production. Why? ↑ lactate may be 2/2 accelerated glycolysis in the splanchnic region: Also, cirrhotics are more prone to hyperlactatemia in setting of sepsis.

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Erik Reinertsen

@erikrtn

5 years

MD++ is a community of #NYC -based med students interested in entrepreneurship, tech, & innovation . Great initiative by @sk_leung ! cc @sarah_zweifach @HalleTecco @kanavjain @suchisaria @nikillinit Does Boston need something similar?

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Erik Reinertsen

@erikrtn

6 years

Proud of these brilliant peeps. Strong MD/PhD #MatchDay for class of 2019: @NYULangone Surgery @HopkinsBayview Medicine @EmoryDeptOfMed Medicine @EmoryPRSurgery Plastics @NURadiology Rads @EmorySurgery Surgery @DukeSurgery Surgery @CoxHealth Fam Med @WeillCornell Medicine

Emory MSTP

@EmoryMSTP

6 years

Happy Match Day!! Congratulations to our @EmoryMSTP M4s and to all graduating M4s! We wish you the best at the next stop in your journey and can’t wait to see all achieve!! #doubledocs #MatchDay2019 @EmoryAlumni @EmoryMedicine

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Erik Reinertsen

@erikrtn

9 months

@La_calderone the applicant who is authentic about their interests and does not do research to pad the CV is virtuous, and this should be lauded instead of punished by the gatekeepers of medical education

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Erik Reinertsen

@erikrtn

2 years

It seems much harder to teach computational biologists about version control, code review, unit tests, etc. than to teach a software engineer some bioinformatics methods. May have to do w/ culture, incentives, critical path in tech vs biotech. Any tips that help? cc @jejomath

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Erik Reinertsen

@erikrtn

9 months

Build? Buy? Some of both? Your decision to build versus buy depends on how your firm generates value, what you promised your investors, who you hired (and who you have to work with but didn't hire), the culture at your firm, and what tools are available. We built a lean, focused

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Erik Reinertsen

@erikrtn

1 year

@mbrkhrdt Can a SaaS expert tell me why it would be bad to offer everyone atomic pay per GB used that scales up to a huge ceiling most users never reach, like 1000TB?

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Erik Reinertsen

@erikrtn

3 years

Machine learning models predict operative mortality for cardiac surgical procedures without STS scores Happy to publish our work in #JTCVS w/ Chin Siang Ong @SunHaoqi @philmoonsamy @NayaMohanMD @aaguirreMD @BrighamThoracic @HopkinsCTSurg @MGHHeartHealth

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Erik Reinertsen

@erikrtn

7 years

Predicting glioma cancer outcomes from histology & genomics using convolutional neural networks clinically actionable results via #deeplearning ! @pooya_msy @lee_ad_cooper @DanielJBrat @emorybmi @georgiatech @PNASNews #precisionmedicine #machinelearning

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Erik Reinertsen

@erikrtn

9 months

Conduct monthly retrospectives with your team to reflect and learn Every month, my team met (over Zoom) to hold a retrospective (retro, for short). We covered three topics: 1. Rose - what is going well? 2. Thorn - what is going poorly? 3. Bud - what should we change? I opened

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Erik Reinertsen

@erikrtn

5 years

@rasbt @ErikTheSimpson Good point. Flipped classroom model can be remote: 1 - "aysnch" recorded lectures, readings, exercises 2 - "sync" office hours via video chat to provide interactive learning and discussion

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Erik Reinertsen

@erikrtn

9 months

Background In early 2021 I joined Prometheus Biosciences, a small biotech startup, as an early employee and the head of data science and software engineering ("DSE"). Our mission was to develop precision therapeutics for autoimmune disease, with an initial focus on inflammatory

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Erik Reinertsen

@erikrtn

5 years

7/ Let’s return to sepsis. We are taught that lactate rises as a result of ↓O2 delivery, hypoperfusion, tissue hypoxia, and anaerobic glycolysis: Unfortunately, this may be an oversimplification. What are other causes of ↑ lactate in sepsis?

Microcirculatory dysfx

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β2 adrenergic stimulation

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Thiamine deficiency

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All of the above

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Erik Reinertsen

@erikrtn

9 months

Track work in a single source of truth We used (and grew to love!) @NotionHQ for documentation, meeting notes, onboarding, etc., and @GitHub Issues for tracking technical work. Tasks were categorized into TODO, In Progress, and Done. Every two weeks we opened the board, groomed

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Erik Reinertsen

@erikrtn

2 years

@Dereklowe Love the biochem background you expand upon in your post, but disagree with statement that this paper reports a “very strong correlation”. I generally concur with the 🧵 another person shared in response to your tweet; key item here:

Iceman

@ColdOneder

2 years

The effect is small. Here is the main plot. The one that this entire claim hinges on. I've circled the SIDS death group: 24/

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Erik Reinertsen

@erikrtn

9 months

@MBurt34 if only there was a simple number to capture quality of research instead of quantity

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Erik Reinertsen

@erikrtn

6 years

Just published review paper on monitoring neuropsychiatric illness with smartphones & wearable devices! Applications in depression, bipolar, schizophrenia, PTSD, Alzheimers, Parkinsons. @GariClifford @EmoryMedicine @EmoryBMI @EmoryMSTP @GeorgiaTech

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Erik Reinertsen

@erikrtn

6 years

Boston’s density of intellectual firepower in life science is unparalleled and so much fun to be in midst of. Only day 2 of work but am already so impressed by industry’s level of scientific sophistication and emphasis on genuinely impacting patient care.

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Erik Reinertsen

@erikrtn

9 months

@NotionHQ @github Build an advisory board There are many smart, experienced, and supportive people with expertise in data science and software engineering within the context of biotech. Maybe you report to the CTO and have a board member or collaborator with a storied history at the intersection

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Erik Reinertsen

@erikrtn

5 years

Paper in @JAMACardio using deep learning to screen hyperkalemia from EKG Prevalence <5%, so AUROC not useful. Precision-recall more appropriate for imbalanced classes. Did I miss something? cc @venkmurthy @ethanjweiss @DrLukeOR

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Erik Reinertsen

@erikrtn

4 years

We evaluated 1198 adult patients dx #COVID19 at MGH and found RDW significantly associated w/ mortality, adjusted for age, D-dimer, absolute lymph count, and common comorbidities. Outstanding work led by Brody Foy, postdoc in Higgins Lab .

MGH Center for Systems Biology

@MGHCSB

4 years

Elevated RDW is Associated with Increased Mortality Risk in COVID-19 @MGH_RI #MGH #medRxiv #covid19

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Erik Reinertsen

@erikrtn

6 years

Wellness is stepping away from reviewer no. 2 comments and UWorld beatings, marveling at some scenery, and waiting an hour in line for brunch.

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Erik Reinertsen

@erikrtn

5 years

2/ In homeostasis, lactate is continually produced and metabolized; serum concentration is at steady state. Which of the following organs is responsible for the majority lactate consumption and metabolism?

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Heart

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Erik Reinertsen

@erikrtn

5 years

Next @MIT Computational Medicine Seminar is 2/19, 1:30 pm in 36-428 Speaker: @MelaniePradier , postdoc @HSEAS @harvard_data @HCRCS Title: Are you exploiting your assumptions? Towards effective priors for biomarker discovery & functional predictions Site:

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Erik Reinertsen

@erikrtn

5 years

Interested in a part-time #VC role? + 15 hrs/wk from Oct 2019-2020 + fund focuses on oncology (tx, dx, digital health) and is stage-agnostic + based in Boston, MA + for 3rd year MD/MBA or MD/PhD students DM me for details.

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Erik Reinertsen

@erikrtn

1 year

@mikpanko If I used a GUI instead of version-controlled code, I would worry about reproducibility, precision, scale, lack of modularity, and inability to apply logical operators.

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Erik Reinertsen

@erikrtn

7 months

Character Biosciences () is hiring an Associate Director / Director of Data Science! This is a unique opportunity to work with an outlier team at an early stage on a promising techbio platform that will have enormous impact. About Character Biosciences -

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Erik Reinertsen

@erikrtn

5 years

Sleep can be accurately staged from ECG and respiratory signals with #deeplearning . New preprint by @SunHaoqi @wolfganglberger @MGHCDAC @MGHNeurology @MGH_RI 7,208 patients is 150x larger than prior sample sizes in this literature!

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Erik Reinertsen

@erikrtn

6 years

Wonder if this can be used to get blood glucose home logs into the EMR. Most patients I saw on primary care used paper. Same for other logs such as pain, diet, etc.

The Verge

@verge

6 years

Microsoft Excel now lets you convert photos of data tables into a fully editable table

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Erik Reinertsen

@erikrtn

1 year

@dr_alphalyrae From past experience as a customer, "first" was totally irrelevant to the decision to buy something. Perhaps this is too cynical, but many startups that self-describe as "techbio" fall into one of two uninteresting buckets: 1. No or low-code UI slapped on EC2 & S3 to "help

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Erik Reinertsen

@erikrtn

2 years

@patricksmalone +1. To say another way: best case, you can go from target discovery to drug discovery to lead opt to preclinical dev faster and cheaper, but the time and cost savings are still trivial vs the bottleneck steps.

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Erik Reinertsen

@erikrtn

8 months

biotech version of this is "x therapeutics" or "y biosciences". all you are doing is making your domain name and email addresses longer and harder to type.

Nikhil Krishnan

@nikillinit

8 months

idk who needs to hear this, but they’ll know you’re a healthcare company even if you don’t put health in the name I promise you

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Erik Reinertsen

@erikrtn

2 years

Interested in building better software/technology for biology? @ClarkPolner generously sponsoring a @bitsinbio meetup in Boston on evening of Tue May 3 cc @nlarusstone @MorseCell @jejomath @kulesatony #software #techbio

BiB May Meetup

Join the BiB community for an IRL event; find others interested in SW+Bio intersection.

www.eventbrite.com

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Erik Reinertsen

@erikrtn

9 months

Close friend is looking for applied ML roles. Ideally West Coast, SoCal preferred, healthcare or biotech nice to have. PhD in ECE from top 5 institution. Currently research scientist at top academic medical center. Leads dev and deployment of DL models across multiple health

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Erik Reinertsen

@erikrtn

6 years

New paper in Physiological Measurement is 1st study using machine learning trained on *interactions* between physiology & behavior to discriminate patients w/ schizophrenia from controls @GariClifford @sprajw @EmoryMedicine @GeorgiaTech #digitalhealth

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Erik Reinertsen

@erikrtn

3 years

Incredible work by talented @BenGlicksberg on ML, ECG, EHR data to screen PE! 1. Clinical criteria (even Wells!) abysmal; AUCs of 0.50-0.58, even in pts w/ moderate- to high-suspicion 2. ECG model surprisingly bad (AUC 0.59) 3. Rigorous comparison vs multiple criteria, subgroups

European Society of Cardiology Journals

@ESC_Journals

3 years

Development of a #MachineLearning model using #electrocardiogram signals to improve acute pulmonary embolism screening #EHJDigital #cardiotwitter @BruiningNico @rafavidalperez @pauldub67 @ACVCPresident

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Erik Reinertsen

@erikrtn

3 years

@MichaelRetchin @WillManidis @kulesatony @CelineHalioua @MattZschwartz What are your go-to blog posts, articles, and learning resources on: - regulatory - FDA approval - clinical trials - HIPAA for folks new to biotech / pharma? (or could just follow @nikillinit for a few yrs)

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Erik Reinertsen

@erikrtn

5 years

Next @MIT Computational Medicine Seminar is Mon 10/21, 1-2 pm at E25-401 Michael Lu, MD ( @MGHImaging @HarvardMed ) will talk about deep learning to assess mortality from CXRs Paper: New seminar website:

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Erik Reinertsen

@erikrtn

6 years

Rockstar @EmoryMedicine students prepared excellent qbank & radiology review to prepare their classmates for exam. Love the culture of #MedEd & team players here. cc @StefanTigges @brainbanker @EmoryRadiology

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Erik Reinertsen

@erikrtn

9 months

@ron_alfa senator warren wants to take down big sandwich yet allows this to happen? outrageous

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Erik Reinertsen

@erikrtn

3 years

Our paper is now out in @PLOSCompBiol

Patient contrastive learning: A performant, expressive, and practical approach to electrocardiogram...

Author summary ECGs are a rich source of cardiac health information. Many recent works have shown that deep learning can extract new information from ECGs when there are a sufficient number of...

journals.plos.org

Erik Reinertsen

@erikrtn

3 years

New preprint! "Patient Contrastive Learning: a Performant, Expressive, and Practical Approach to ECG Modeling" arxiv github Outstanding work w/ @MGHHeartHealth @MITEECS @broad_ml4h @broadinstitute led by Nate Diamant & @gpbatra

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Erik Reinertsen

@erikrtn

6 years

This is the patient experience I’d want for myself and my family, but I don’t want to pay $$$ to @onemedical @goforward for what should be default everywhere in the USA. This is also the patient experience I want to provide in the future. Big fan of the brand consistency.

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Erik Reinertsen

@erikrtn

5 years

Nice overview of ways to visualize data. But *raincloud plots* are still the most beautiful & statistically valid approach. GitHub (R, Matlab, Python): Paper: Creators: @micahgallen @kirstie_j @TomRhysMarshall @rogierK

Circulation

@CircAHA

5 years

#Primer : Reveal, Don’t Conceal: Transforming Data Visualization to Improve Transparency #AHAJournals @T_Weissgerber @questbih @WHMayoClinic

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Erik Reinertsen

@erikrtn

6 years

Latest paper from @GariClifford lab out in @IEEEBigData ! We use smartphone data to estimate quality of life in patients with heart failure Preliminary study; bigger to follow! cc @AmitJShah79 @EmoryBMI #informatics #digitalhealth #cardiology

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Erik Reinertsen

@erikrtn

6 years

@nikillinit Erroneous upcharging is absolutely part of their business model.

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Erik Reinertsen

@erikrtn

9 months

john is smart + successful biotech leader, positive intent, points make sense. however, also good counter-arguments. another lens to consider: which habits, cultures, and behaviors do people learn in big biotech / pharma that impede success at a startup? which are helpful?

John Maraganore 🇺🇦🇮🇱

@JMaraganore

9 months

Do NOT jump from an MBA to try to start your own biotech company. Do NOT jump into a small start up. Do NOT skip experience in a big biotech (where you will learn from great people) and think you can develop drugs when you’ve never seen it done. 🧵7

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Erik Reinertsen

@erikrtn

6 years

*UPDATE* The authors of original paper finally released their code at @point85_ai @ShamimNemati @sprajw also released their code used in the blog post:

GitHub - point85AI/Policy-Iteration-AI-Clinician: This is the companion GitHub repository for the...

This is the companion GitHub repository for the point85 blog post on using Policy Iteration to treat sepsis. - point85AI/Policy-Iteration-AI-Clinician

github.com

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Erik Reinertsen

@erikrtn

10 months

What's wrong with showing your MVP to potential customers and validating your product idea? Turns out humans are excellent at recognizing patterns and inferring causes for the phenomena around them. This also means we are not being good at finding that there is no pattern.

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Erik Reinertsen

@erikrtn

4 years

Is it better to: 1. Run one #COVID19 test per specimen? or 2. Pool many specimens & use one test on all? Read how the concept behind the power of binary search algorithm could improve testing capacity by order of magnitude. cc @balajis @michaelmina_lab @zachweinberg @rtnarch

Donald Reinertsen

@DReinertsen

4 years

I've posted a more technical explanation of how Sample Pooling could provide a 40x improvement in Covid-19 Testing productivity. It's a big opportunity.

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Erik Reinertsen

@erikrtn

5 years

Residents, fellows, junior faculty interested in healthcare innovation & implementation science, apply to 2020-21 @MGH_HTL Fellowship in Healthcare Innovation! Great opportunity to enhance care & interact w/ leaders at @MassGeneralNews @HarvardMed

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