DO GLP-1 Agonists Really Cause Eye Disease
There has been a huge amount of press about a report showing an association between the use of GLP-1 agonists and Nonarteritic anterior ischemic optic neuropathy (NAION)
Because of it being heavily promoted by
Responded to a passenger with syncope on Monday-I suggest keeping this card on your smartphone and reviewing it instead of the safety information at the start of the flight (everyone knows that stuff). You may need to help a passenger some day....
The same thing happened with the University of California. They canceled their Elsevier contract and were expecting a huge backlash. After about a year, one of the librarians told me that they were surprised that almost nobody complained.
When I was at JAMA, we did a survey of
What happened when MIT stopped paying Elsevier? Not much except they are saving a lot of money. "MIT is interested in collaborating with other libraries to reinvest these funds in community-controlled open publishing initiatives..."
@EricTopol
@EnigmaCosmic
We interviewed one of our surgical residents who got
#COVID
and was sick for a very long time. The long-term consequences can be very problematic and this problem has not received much attention
My son just finished the first year of medical school – it’s astonishing how much they made him learn that has nothing to do with the actual practice of medicine
Backchannel discussion of having clinicians teach only clinically relevant basic science in med school 👀
I'm in the 'Ummm, no...' camp on that proposal.
A picture is worth a thousand words-In this case 2 pictures! Determining How Public Health Measures Might Be Slowing COVID-19 Using the Reproduction Number (Rt)
@T_Inglesby
@JAMA_current
I had a similar experience with Dr Fauci when I interviewed him for
@JAMA_current
clinical reviews when we produced our show on the discovery of
#AIDS
. Washington DC was shutdown for a severe snow storm-He showed up to do our interview and was the only person in the NIH building
13 years ago, I emailed Dr. Fauci out of the blue to ask if I might interview him for my undergrad thesis. He invited me to his office, where he answered all my questions. When I sent him the thesis, HE READ THE WHOLE THING (see his overly effusive review below). Who does that?!
Does ECMO work? It depends on how strongly you believe it should. Really good explanation of how to use
#Bayesian
theory to understand how to use results of clinical trials by
@RogerJLewis
and Derek Angus
@JAMA_current
@PittCCM
To me, how single-payer will be administered is the Achilles heel of the concept. It is a great idea but not one that can be implemented. I say this after a 28-year career in the VA, many years of which I was in leadership positions. It just does not work...
@dhume
Not exactly a superpower. The number of papers published means little. Most of it reports very low quality science. I can say this as someone who has worked a great deal with Chinese investigators trying to help them publish acceptable science.
@EladSharonMD
@NIH
Now that I am no longer with JAMA, I can now say that the behind the pay wall journal model is dying. The future is an open access and pre-print servers followed by discussion of findings in blogs, etc.
better to have feedback from many people on the Internet than just a few
I cannot imagine how this will be administered. Current state agencies like the DMV are completely dysfunctional. How will they manage healthcare delivery? Incredibly bad idea...
CA takes first step to create single-payer health that would eliminate employer-provided insurance & Medicare. Single-payer rations care severely, incl patients waiting so long for imaging tumors double, & denial of cataract surgery.
,
@HooverInst
Here is something I don’t understand.
The founders of Ben & Jerry’s take great pride in their social activism.
However, the gains in longevity in the Western world attributable to reduction and smoking are now being reversed because of obesity.
The ice cream product of Ben &
#COVID19
in 1 hospital: Most common comorbidity HTN (n = 164, 43.5%). 166 patients tested for influenza A/B or respiratory syncytial virus (44.0% of the cohort), none positive. Bilateral infiltrates on CxR in 63.4% (n = 239).
@JAMA_current
Hip fracture can be a devastating complication in older adults. What you need to know to prevent it: Hip Fracture Prevention in Older Adults in 2019
@JAMA_current
Evaluation and Management of Penicillin
#Allergy
-Important new review-endorsed by 3 societies. Toolkit to help evaluate penicillin allergy, podcast, video
@JAMA_current
Did you know that very few people are actually allergic to
#penicillin
?
Very interesting trial-took CT-confirmed appendicitis patients and randomized to abx v no-abx and NO SURGERY - patients did OK-treatment failure was 20-23% - similar to
@JAMA_current
APPAC trial -Is surgery for appendicitis needed?
The FDA has to do something so OK. But without a placebo comparator cannot say there is a 35% improvement. Lots of reasons comparing high to low antibody levels in the serum could yield spurious results.
Plasma transfusion can reduce mortality rate by as much as 35%.
“Patients who received plasma...are under the age of 80 and not on mechanical ventilation benefited the most, with a 35% improvement in survival 30 days after receiving the transfusion.”
"Propensity score methods are used to reduce the bias in estimating treatment effects and allow investigators to reduce the likelihood of confounding when analyzing nonrandomized, observational data" All you need to know - in 2 pages!
@RogerJLewis
Evidence clearly shows that
#flu
vaccination can reduce disease severity and prevent hospitalizations—critical considerations at a time when the health care system is burdened by
#COVID19
#VaccinesWork
Walking around, I see many people who seem to be ignoring the risk of
#COVID__19
- They need to know that if they get it, the long term effects can be devastating: Long-term Health Consequences of COVID-19 via
@JAMA_current
part of
@JAMANetwork
.
@JAMA_current
Clinical Evidence Synopsis:
#Clopidogrel
+ASA: Reduced risk for MI and ischemic stroke-Increased risk for major bleeding compared with aspirin alone. Combined therapy is NOT associated with lower mortality.
“Dr. Livingston said he had long been known as a “curmudgeon” who was reluctant to make claims about the long-term health benefits of weight-loss surgery”. Yup- I said that....
via
@nytimes
Conserving Supply of Personal Protective Equipment—A Call for Ideas - Now up to more than 150 comments- Lots of good ideas for how to address the
#PPEShortages
-Reminds me of
#apollo13
-Need
#Engineers
to find creative solutions
#Vaccinated
! Sincere thank you to the scientists, vaccine trial participants, and the always-amazing
@NorthwesternMed
team! Please step up and get your vaccine when the time comes!
(Just wish I had been working out the guns a little more before my vaccine selfie!) 🤣
And if you are a clinician and flying-load up the pdf in the supplement for this
@JAMA_current
article on your smartphone or tablet-Its a
#checklist
for what to do when responding to
#medical
#emergencies