Debbie Caswell @drmcaswell Twitter profile

Pinned Tweet

Debbie Caswell

9 months

I am excited to announce the publication of our manuscript out today, with @DrPhilippeGui , @CharlesSwanton , @SwantonLab , @BivonaLabUCSF , @Downwardlab , and @HarrisLabUTHSA ! 🧵 1/15

The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance

Nature Genetics - Analyses of in vivo models, cell lines and patient-derived samples show that apolipoprotein B mRNA-editing catalytic subunit 3B (APOBEC3B) not only restrains lung tumor initiation...

www.nature.com

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Last Seen Profiles

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Debbie Caswell

@drmcaswell

5 months

TFW someone posts your first author manuscript and all you can think is what’s missing from this picture?

Pulmonary Cell News

@pulmonary_news

9 months

A recent paper by scientists at @TheCrick and other institutions including Dr. Charles Swanton uncovers the multifaceted roles of A3B in NSCLC and identifies A3B as a potential target for more durable responses to targeted 🎯 cancer therapy.

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Debbie Caswell

@drmcaswell

5 years

I just joined the Liberal Democrats - join me here:

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Debbie Caswell

@drmcaswell

8 months

Lung cancer in patients who have never smoked — an emerging disease | Nature Reviews Clinical Oncology

Lung cancer in patients who have never smoked — an emerging disease

Nature Reviews Clinical Oncology - Lung cancer is a disease typically associated with tobacco smoking; however, lung cancer in individuals who have never smoked (LCINS) is estimated to be the fifth...

www.nature.com

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Debbie Caswell

@drmcaswell

1 year

Was so much fun to review this brilliant manuscript by @PeterMKWestcott @LabJacks with @JL_Reading and my mentor @CharlesSwanton . Cutting edge mouse model work highlighting the importance of tumor heterogeneity on immunogenicity in cancer!

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Debbie Caswell

@drmcaswell

5 months

@crispinhiley @JulianDownward @CharlesSwanton @BivonaLabUCSF That’s perfect thanks ☺️

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Debbie Caswell

@drmcaswell

2 years

Please checkout the updated version of our preprint, a result of a great collaboration with ⁦ @BivonaLabUCSF @HarrisLabUMN with my mentors @CharlesSwanton and⁩ @JulianDownward . Work done @TheCrick @SwantonLab #Downwardlab

The role of APOBEC3B in lung tumour evolution and targeted therapy resistance

Apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzymes are cytidine deaminases that play an important role in intrinsic responses to infection by viruses where they inhibit infection...

www.biorxiv.org

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Debbie Caswell

@drmcaswell

3 years

Very grateful to have been given the opportunity to write this review with my amazing colleague @WillHilliam and my wonderful mentor @CharlesSwanton . Please check it out:

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Debbie Caswell

@drmcaswell

2 years

Amazing to catch up with the best mentors and friends at #cshlcancer22

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Debbie Caswell

@drmcaswell

4 years

Please checkout our preprint, a result of a great collaboration with ⁦ @BivonaLabUCSF ⁩ ⁦ @HarrisLabUMN ⁩ ⁦ @JulianDownward ⁩ ⁦ @TheCrick ⁩ in ⁦ @SwantonLab ⁩ ⁦ @CharlesSwanton ⁩

Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

The clinical success of targeted cancer therapy is limited by drug resistance that renders cancers lethal in patients. Human tumours can evolve therapy resistance by acquiring de novo genetic...

www.biorxiv.org

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Debbie Caswell

@drmcaswell

3 years

Amazing time @CRUK_BI presenting my work and learning about all the impressive science being done at the institute. Thank you @DJMurphyLab1 for inviting me up. It was wonderful!

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Debbie Caswell

@drmcaswell

2 years

Very grateful to be giving a talk today in person at #AACR22 . Please come check it out.

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Debbie Caswell

@drmcaswell

2 years

So inspired by all the amazing talks and sessions with incredible scientists, clinicians, but most of all patients at #CRUKLung22 ! Back to lab in record time to keep driving the science forward. Thanks to @CharlesSwanton #CarolineDive @CRUKLungCentre and the organizers!

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Debbie Caswell

@drmcaswell

5 months

Thank you @crispinhiley for showing them how it’s done! 👏

Crispin Hiley

@crispinhiley

5 months

@BivonaLabUCSF @drmcaswell @JulianDownward @CharlesSwanton @DrPhilippeGui Maxing my IT skills this Easter weekend.

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Debbie Caswell

@drmcaswell

3 years

APOBEC3B, tumour initiation, and TKI resistance in EGFR driven lung cancer #AACR21 ! @swantonlab @TheCrick

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Debbie Caswell

@drmcaswell

1 year

Sometimes you just need to climb a mountain #Snowdon

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Debbie Caswell

@drmcaswell

4 years

Proud to be volunteering at the Vaccination Centre @TheCrick today!

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Debbie Caswell

@drmcaswell

3 years

Excited to talk about my work in collaboration with @BivonaLabUCSF tomorrow at the Crick Cancer Conference!

The Crick

@TheCrick

3 years

The 3rd Crick International Cancer Conference kicks off today! 🗨️ Follow along using #CrickCancerConf , and check out our website for the full programme ⤵️

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Debbie Caswell

@drmcaswell

4 years

@NewJournal Wonderful news. Thank you to @camdencyclists and @AdamDKHarrison for working so hard to push this through.

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Debbie Caswell

@drmcaswell

2 years

Hanging out in #NYC before heading to #cshl ! Very excited to attend.

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Debbie Caswell

@drmcaswell

2 years

Wonderful to be back in person @cshl for #CSHLcancer2022 ! Still as gorgeous as I remember it!

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Debbie Caswell

@drmcaswell

2 years

Very excited (as you can see in the photo 😂) to have been able to attend this fascinating talk by @theAliceRoberts @TheCrick !

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Debbie Caswell

@drmcaswell

3 years

Hello Twitter just wanted to do this to help and encourage others. I’m #BiInSTEM #LGBTQinSTEM 🌈 Must admit it is a bit scary. Have a good day!

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Debbie Caswell

@drmcaswell

3 years

Just off another vaccination shift @TheCrick . So pleased to be given the opportunity to help out.

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Debbie Caswell

@drmcaswell

2 years

Excited and privileged to have been able to contribute to this groundbreaking study from the @SwantonLab

Dr Maria Neira

@DrMariaNeira

2 years

Air pollution cancer breakthrough will rewrite the rules - BBC News

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Debbie Caswell

@drmcaswell

2 years

Hello Seattle!

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Debbie Caswell

@drmcaswell

1 year

Thank you so much to the organizers @SageJulien and @KevinHaigisLab for organizing such a great conference, #AMC23 ! It was inspiring to be a part of. Thanks to @Fusion_Conf for planning such a wonderful conference and to @NC3Rs and @Co_Biologists for their support.

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Debbie Caswell

@drmcaswell

3 years

Excited to present my work @CRUKLungCentre webinar next week!

Science and Innovation at Cancer Research UK

@CRUKresearch

3 years

Register now for the @CRUKLungCentre webinar on 17 June, where @Drmcaswell will present her research on targeted therapy resistance in EGFR mutant lung cancer, along with insights from four other early career researchers. #CRUKFutureLeaders Register now:

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Debbie Caswell

@drmcaswell

2 years

Wonderful lecture by @wmarybeard @TheCrick about Statue Wars! Such a privilege.

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Debbie Caswell

@drmcaswell

3 years

What do you give a dog who has been there for the entirety of your scientific career on her 14th birthday?

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Debbie Caswell

@drmcaswell

2 years

Such an important article highlighting our lab’s work at the Crick @SwantonLab done by brilliant scientists @LimEmilia @WillHilliam @DrClareWeeden as well as the critically important goal of cleaning up our air. Glad to have been able to help with this brillant research!

Adam Harrison

@AdamDKHarrison

2 years

Over the last year, nitrogen dioxide levels have fallen at 28 of Camden’s 40 monitoring sites. Find out more in my @HamandHigh about our journey to safer WHO #AirQuality levels!

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Debbie Caswell

@drmcaswell

2 years

Wonderful to have been given the opportunity to present my work at the #bacr 60th Anniversary Meeting in #Nottingham ! Thanks to my mentors @CharlesSwanton @JulianDownward for their incredible support. Check out our preprint to get more details on my work

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Debbie Caswell

@drmcaswell

1 year

Thanks for the opportunity!

CRUK Lung Centre

@CRUKLungCentre

1 year

The first talk is session 2 came from Debbie Caswell who gave a great talk on on the role of APOBEC3 in lung cancer evolution and therapy resistance

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Debbie Caswell

@drmcaswell

4 years

Amazing session on experimental therapeutics at #cshlcancer20 . Impressive work by @DrReuh , @CarminuzzoF and @AlanaWelm ! So impressed and honored to be able to participate. Thank you Elaine Mardis, @DrBenNeel , Martin McMahon, and Karen Vousden

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Debbie Caswell

@drmcaswell

2 years

Excited to be attending Deaminet 2023!!!

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Debbie Caswell

@drmcaswell

4 years

Looking forward to #cshlcancer20 conference starting today. Excited to talk about my work studying APOBEC mutagenesis in lung cancer on Thursday! Missing the beautiful scenery at #CSHL but hopefully we will all be there in person again in 2022.

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Debbie Caswell

@drmcaswell

2 years

Last day in San Francisco before heading to #AACR22

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Debbie Caswell

@drmcaswell

7 months

A beautiful talk by @DrClareWeeden

CRUKCOLcentre

@CRUKCOLcentre

7 months

How do never-smokers have lung cancer? Dr Clare Weeden @DrClareWeeden from @SwantonLab at the @TheCrick talks about her research which shows air pollution flips the switch and how that happens at the City of London Centre symposium.

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Debbie Caswell

@drmcaswell

3 years

This one loves when we work from home.

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Debbie Caswell

@drmcaswell

3 years

Happy to have been able to help with this work using new mouse models of lung cancer. Congratulations @MD_Venkatesan and @NnennayaKanu ! @SwantonLab

Mani Venkatesan

@MD_Venkatesan

3 years

Our paper is out: Induction of #APOBEC3 exacerbates #DNAreplication stress and chromosomal instability in early #breastcancer and #lungcancer #evolution @Samuel_Bakhoum @Bartek_Lab @NnennayaKanu @CharlesSwanton @SwantonLab @lungsforliving @HarrisLabUMN

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Debbie Caswell

@drmcaswell

2 years

Good morning #London

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Debbie Caswell

@drmcaswell

5 months

@JeremyFarrar Thanks very much!

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Debbie Caswell

@drmcaswell

2 years

London can be so beautiful #nofilter

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Debbie Caswell

@drmcaswell

4 years

Great collaboration with @BivonaLabUCSF @HarrisLabUMN @JulianDownward , @TheCrick in @SwantonLab @CharlesSwanton

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Debbie Caswell

@drmcaswell

1 year

Art inspiration on a Friday night

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Debbie Caswell

@drmcaswell

4 years

Fascinating work from ⁦ @sdecarne ⁩ ⁦ @jboumelha ⁩ and @JulianDownward ⁩ #APOBEC #KRAS

APOBEC3B expression generates an immunogenic model of Kras mutant lung cancer

Mutations in oncogenes such as KRAS and EGFR cause a high proportion of lung cancers. Drugs targeting these proteins cause tumour regression but ultimately fail to cure these cancers, leading to...

www.biorxiv.org

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Debbie Caswell

@drmcaswell

2 years

#AACR22 has been incredible so far. Lots of great talks and lovely catching up with old friends. My one complaint is I can’t find a cup of tea anywhere. Not at the convention center or at two different coffee shops I visited. Anyone have recommendations?

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Debbie Caswell

@drmcaswell

8 months

Thanks @CD_AACR for highlighting our work showing the complex and context dependant effect of APOBEC3B on lung tumor evolution and targeted cancer therapy resistance!

APOBEC3B Has Dual Roles During the Evolution of Non-Small Cell Lung Cancer

Major Finding: APOBEC3B inhibits early tumor growth but confers resistance to EGFR-targeted therapy in lung cancer. Concept: EGFR-targeted therapy induces APOBEC3B-associated mutations in genes that...

aacrjournals.org

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Debbie Caswell

@drmcaswell

5 months

Great review from Dr. Aaron Hata @MGHCancerCenter and Dr Mani Larijani @SFU on the importance of timing when targeting APOBEC enzymes in cancer:

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Debbie Caswell

@drmcaswell

4 years

40% of charity-funded early-career researchers have considered leaving medical research since #COVID19 hit the UK. Alongside @TheCrick and @AMRC , I’m asking @hmtreasury @RishiSunak to back charity-funded #ResearchAtRisk at the spending review.

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Debbie Caswell

@drmcaswell

2 years

Brilliant presentation by @RemiBuisson at #Deaminet2023

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Debbie Caswell

@drmcaswell

4 months

Check out this fascinating new preprint from @eriksahailab by @CultureOfCells !! Glad to have been able to contribute a small part to this brilliant work.

eriksahailab

@eriksahailab

4 months

Very pleased to share our latest preprint on MAPK dynamics and cell fate decisions in lung cancer . Does EGFR mutation mean MAPK is always on? NO, it shows dramatic pulses👇1/4

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Debbie Caswell

@drmcaswell

2 years

Old dogs are the best. This girl turns 15 today!

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Debbie Caswell

@drmcaswell

1 year

@CharlesSwanton @Nature @WillHilliam @LimEmilia @DrClareWeeden @SwantonLab Congratulations @WillHilliam @LimEmilia @DrClareWeeden !! So wonderful working with you on this, and exciting to see it out.

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Debbie Caswell

@drmcaswell

5 months

@WeitzmanLab @crispinhiley @JulianDownward @CharlesSwanton @BivonaLabUCSF Yes and all co-first authors

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Debbie Caswell

@drmcaswell

2 years

Back in beautiful San Francisco, #twinpeaks

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Debbie Caswell

@drmcaswell

4 years

Highlight of my career! @DrBenNeel just said my question was great @CharlesSwanton I can officially retire now :).

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Debbie Caswell

@drmcaswell

3 years

That Friday feeling

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Debbie Caswell

@drmcaswell

3 years

Weird and cool to see this paper knowing one of the samples is mine.

Emma Wall

@dremmacbw

3 years

Fantastic collaborative effort between @UCLHresearch and @TheCrick thank you to all the volunteers and staff in both institutions and support from @LabGandhi @CharlesSwanton @TimJaggard

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Debbie Caswell

@drmcaswell

2 years

Congratulations to @WillHilliam and @LimEmilia , @DrClareWeeden on this work from @SwantonLab , led by @CharlesSwanton ! Proud to have contributed.

Thom Yorke

@thomyorke

2 years

Cancer breakthrough is a ‘wake-up’ call on danger of air pollution | Cancer research | The Guardian

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Debbie Caswell

@drmcaswell

3 years

Rainy day hair

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Debbie Caswell

@drmcaswell

2 years

#blencathra

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Debbie Caswell

@drmcaswell

4 years

A Call to Action: Dismantling Racial Injustices in Preclinical Research and Clinical Care of Black Patients Living with Small Cell Lung Cancer | Cancer Discovery

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Debbie Caswell

@drmcaswell

2 years

😮

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Debbie Caswell

@drmcaswell

2 years

Great talk by @b_stefanovska at #Deaminet2023

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Debbie Caswell

@drmcaswell

5 years

Truly was an amazing talk @theAliceRoberts @TheCrick

Will Hill

@DrWilliamHill

5 years

Fantastic and inspiring talk today by @theAliceRoberts on generating complexity from simplicity #sciencegoals

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Debbie Caswell

@drmcaswell

4 years

Snow!

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Debbie Caswell

@drmcaswell

4 years

Happy Valentines Day!

Pablo J. Sáez

@pj_saez

4 years

Kiss & run between #cells ! They had to follow separate ways... #Actin dynamics (red) as observed under the 🔬 Preparing #SaintValentin , this movie is dedicated for #cytoskeleton & #CellMigration lovers #welovescience #scicomm #Saintvalentin2021 #scichat #science #CellsAtWork

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Debbie Caswell

@drmcaswell

2 years

Amazing talk by @abbygreenlab at #Deaminet2023 !!

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Debbie Caswell

@drmcaswell

9 months

Altogether our findings highlight the context dependent role of APOBEC3B in lung tumor evolution, and identify APOBEC3 family members as targets to restrict the emergence of resistance and thereby improve responses to targeted cancer therapy. 15/15

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Debbie Caswell

@drmcaswell

1 year

Super proud of this article highlighting my partners work: Code faster with Cursorless!!

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Debbie Caswell

@drmcaswell

5 months

@jdpereira Thanks for your message, really means more than you know. I’m privileged in so many ways: white, middle class, supportive partner, the list goes in. It’s so much worse for so many others.

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Debbie Caswell

@drmcaswell

2 years

Two brilliant scientists who I admire highlighted in this article @LimEmilia @DrClareWeeden ! Women in science, the future of science!

Upworthy Science

@upworthyscience

2 years

Lung cancer is the number one cancer killer worldwide—and contrary to what you might have heard, non-smokers can get it, too. Scientists are starting to understand more on why this happens. @RobinKD @TheCrick @CharlesSwanton @DrClareWeeden @LimEmilia

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Debbie Caswell

@drmcaswell

4 years

Exciting new paper from @PetrovADmitri @CharlesSwanton and Monte Winslow. Congratulations to Hongchen Cai and Su Kit Chew!

Elizabeth McKenna

@ElizSMcKenna

4 years

Now online in @CD_AACR : A functional taxonomy of tumor suppression in oncogenic #KRAS -driven #lungcancer by @PetrovADmitri @CharlesSwanton Monte Winslow and colleagues @StanfordMed @TheCrick @uclcancer

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Debbie Caswell

@drmcaswell

3 years

#ReclaimTheStreets #SarahEverad

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Debbie Caswell

@drmcaswell

4 years

Important paper by ⁦ @feebs ⁩ and Karishma Valand from ⁦ @JulianDownward ⁩

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Debbie Caswell

@drmcaswell

5 years

Can anyone guess when my tube rides were? @TfL @SadiqKhan thanks @Plume_Labs for developing this handy device!

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Debbie Caswell

@drmcaswell

3 years

@RishiSunak and @BorisJohnson your decision to renege on your original commitment to invest 2.4% of GDP on research and development will have devastating consequences for science in the UK for years to come. Please reconsider.

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Debbie Caswell

@drmcaswell

2 years

Wonderful catching up with friends from @LabWinslow at #AACR2022

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Debbie Caswell

@drmcaswell

1 year

It was a privilege to spend the week with you all!!

Giorgia Foggetti

@GiorgiaFoggetti

1 year

Privileged to meet, talk about #lungcancer research, and also dance with these outstanding scientists @rociosotillo , @drmcaswell , and @politikaterina at #AMC23 . Thanks so much to @Fusion_conf and the organizers @SageJulien and @KevinHaigisLab !!! @AIRC_it @lcrf_org @MyUniSR

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Debbie Caswell

@drmcaswell

4 years

@Keir_Starmer Thank you for showing your appreciation of all the hard work scientists do.

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Debbie Caswell

@drmcaswell

4 years

Super proud of @CharlesSwanton and the rest of the team working hard at COVID19 testing @TheCrick

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Debbie Caswell

@drmcaswell

2 years

Great to see it out, congratulations!

Dr. Bishoy M. Faltas

@FaltasLab

2 years

We‘ve made the cover of Cancer Research @CR_AACR 🎉 Thank you @CharlesSwanton and @drmcaswell for highlighting our paper on APOBEC3 #bladdercancer mouse models! Check out the paper and fantastic commentary ⬇️ @OncoAlert @WeillCornell

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Debbie Caswell

@drmcaswell

3 years

Wonderful work

Nuria Lopez-Bigas

@nlbigas

3 years

Whole-genome sequencing of 232 lung cancers in never smokers. Led by Teresa Landi @NCIEpiTraining @NatureGenet

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Debbie Caswell

@drmcaswell

2 years

Just want to say thank you to @NC3Rs and to @ERC_Research for making this research possible.

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Debbie Caswell

@drmcaswell

4 years

Incredible talk by @LauraSoucek at #cshlcancer20 ! Honored to have been able to see it.

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Debbie Caswell

@drmcaswell

5 years

Excited and extremely grateful to be recognized by @SerenaNikZainal , who has been a real a inspiration for me!

Serena Nik-Zainal

@SerenaNikZainal

5 years

Challenge accepted! Day 1 of the #FemScienceStar challenge and I wanna champion these amazing women: @xueqing_zou Jill Kucab @drmcaswell Samra Turaljic @MariamJHanjani I challenge @EllardSian to nominate 5 young women and nominate another to spread the 💕

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Debbie Caswell

@drmcaswell

4 years

Nice work!

John Maciejowski

@J_Maciejowski

4 years

Please consider reading our new preprint identifying the APOBEC3A deaminase as a main driver of mutational bursts in cancer cells. Work led by @MPetljak in collab with K Chu, @ALLIEgator__ , @PatrickMorgen , E Bergstrom, L Alexandrov, and M Stratton

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Debbie Caswell

@drmcaswell

6 months

Worth a read if you are interested in ecDNA!

Anton Henssen

@anton_gh

7 months

Beautiful review article on ecDNA in @NatureRevCancer by @HowardYChang @mischellab !! 🔥🔥👇🏻👇🏻

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Debbie Caswell

@drmcaswell

1 year

Yesss Team 4! We are SEXIER!!!

CRUK Lung Centre

@CRUKLungCentre

1 year

4th team… SEXIER! 🤣🤣🤣 The creativity level is matching the excellent science!

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Debbie Caswell

@drmcaswell

5 years

#IAmEmilia best play I have seen in ages @EmiliaThePlay

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Debbie Caswell

@drmcaswell

3 years

Wish I had been volunteering today!

Stefan Rousseau

@StefanRousseau

3 years

Photo du Jour: Labour leader @Keir_Starmer receives his first dose of the Coronavirus vaccine from midwife, Emily Malden at the Francis Crick Institute today. By Stefan Rousseau/PA

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Debbie Caswell

@drmcaswell

2 years

Fascinating preprint by @Aliciaadv

Alicia Alonso de la Vega

@Aliciaadv

2 years

I could not be happier and grateful today to share my work during these last 4 years. Want to give a special thank to @rociosotillo , @SotilloLab and @HarrisLabUMN for all the support given in this journey. Read more here 👉👉 Stay tuned, more to come!🐭🐭

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Debbie Caswell

@drmcaswell

3 years

@LabWinslow @WJGreenleaf Reminiscing about being the first graduate student in the Winslow lab. I recall that I could immediately show Monte my first ever western blot because his office was under construction so he was sitting next to me in lab! :)

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Debbie Caswell

@drmcaswell

2 years

Wonderful opportunity to join a great lab!

Giulia Biffi

@BiffiGiulia

2 years

‼️We are looking for our next PhD student 🤩‼️ If you are nice 😇, eager to join our lovely and diverse team ❤️ and excited about #fibroblasts , #PancreaticCancer and #MakingDiscoveries 🐭🧫, apply👉 Please RT. @CRUKCamPancCan @CRUK_CI @CRUKCamCentre

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Debbie Caswell

@drmcaswell

4 years

To have a president who respects science, and knows the importance of research is so important! Thank you @KamalaHarris and @JoeBiden we did it #voteforscience

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Debbie Caswell

@drmcaswell

4 years

Omg I could cry!

CBS News

@CBSNews

4 years

Kamala Harris says she feels a “certain kinship” with the new science team, as her mom was a scientist: “Science has a way of shaping how you think and way of life, and she instilled in me a fundamental belief in the importance of collecting and analyzing data. Facts.”

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Debbie Caswell

@drmcaswell

1 year

Congratulations, beautiful cover!!

Clare Weeden

@DrClareWeeden

1 year

Our research made the cover of Cancer Cell! Thanks to the stunning art of Amy Manson @WEHI_Research , demonstrating resident memory T cell 'sharks' enforce selective pressure for developing tumour octopi to become invisible. Read the article here:

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Debbie Caswell

@drmcaswell

3 years

Check out this fascinating paper from @sdecarne and @JulianDownward on RAS transcriptional activity and disease outcome!

Sophie de Carné

@sdecarne

3 years

Excited to share our preprint on #KRAS in #lungcancer . With @phileast , we show that oncogenic RAS transcriptional activity predicts outcome and response to chemotherapy in lung adenocarcinoma whereas KRAS mutational status does not! Please share 🙂

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Debbie Caswell

@drmcaswell

1 year

Exciting work!

Rémi Buisson

@RemiBuisson

1 year

New preprint from the lab! We find that APOBEC3B targets DNA hairpins, but are different from those recognized by APOBEC3A. Importantly, we show APOBEC3A and APOBEC3B can generate distinct mutations in tumors, driven by their unique substrate selectivity.

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