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Matt Cooperberg Profile
Matt Cooperberg

@dr_coops

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Urologic oncology & epi, focus on #prostatecancer @UCSFcancer @UCSFurology . GU Chief @SFVAMC . All views strictly personal. RT≠E. #🟦

San Francisco, CA
Joined September 2010
Don't wanna be here? Send us removal request.
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@dr_coops
Matt Cooperberg
18 days
I'm thrilled to be able to share this report from the symposium CAncer or Not Cancer?: Evaluating and Reconsidering GG1 prostate cancer (CANCER-GG1?), out today @JNCI_Now When is prostate cancer really cancer?
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@dr_coops
Matt Cooperberg
3 years
New update @NCCN #prostatecancer : #activesurveillance once again "preferred" for most low risk disease. Very glad to see this update! Great news and clarity for patients. Quick work by @EdwardSchaeffer @wandering_gu @urogeek et al.
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Matt Cooperberg
6 years
Hot of the press @AmericanCancer 2019 #cancerstats : Prostate cancer mortality up for 1st time since early 1990s, likely due at least in part to plummeting screening rates. Incidence ticking back up a bit, so maybe we're finally heading toward a "smarter screening" consensus...?
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Matt Cooperberg
3 years
Another urologic sequela of #covid19 : massive calcified coronavirus obstructing an Indiana pouch :) ⁦ @HeikoYang ⁩ ⁦ @KShee11
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Matt Cooperberg
2 years
Trends and Variation in Use of #Activesurveillance for Low-risk #Prostatecancer , now out in @JAMANetworkOpen . Data from over 20K men in the @AmerUrological #AQUARegistry : Nat'l rates of AS up from 26% to 60% since 2014, but variation remains extreme:
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Matt Cooperberg
5 years
Breaking news: neoadj chemoADT improves OS for high risk #prostatecancer #suo19 PUNCH trial CALGB 90203 #pcsm
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Matt Cooperberg
5 years
Critical #prostatecancer terminology. ⁦ @declangmurphy ⁩ Know your acronyms! #pcsm @MartiniKlinik
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Matt Cooperberg
3 years
I was just sent this from a patient - omg for anyone who thought "prostatectomy comedy" is an oxymoron, give this the next 2.5 minutes of your full attention! Phenomenal. Many thanks @MarshSongs . #pcsm #prostatecancer #UroSoMe via @YouTube
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Matt Cooperberg
5 years
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Matt Cooperberg
2 years
@UCSFUrology
UCSFUrology
2 years
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Matt Cooperberg
2 years
ProtecT 15 yr: ⁦ @Freddie_Hamdy ⁩ taking on misconceptions, and conclusions. #eau23 Thoughts #pcsm ??
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Matt Cooperberg
5 years
I'm pretty sure this is, by a wide margin, the most thoughtful and best-researched article I've read yet on #coronavirus #covid19 . Big HT @tomaspueyo 🙌 Coronavirus: Why You Must Act Now by
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Matt Cooperberg
2 years
ICYMI @AmerUrological just dropped the new 2022 #prostatecancer guideline just in time for #AUA22 . Lots to like despite outdated risk groups persisting. But “very low risk” is GONE! Active surveillance now preferred for ALL low-risk tumors. 🎉🙌
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Matt Cooperberg
3 years
We can already anticipate the (aging) objections, but the idea of re-branding at least a subset of GS6 seems to be picking up momentum. Feels like the right side of history :) @uroegg ⁩ ⁦ @aleberlin2 ⁩ ⁦ @VickersBiostats @journotwit
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Matt Cooperberg
3 years
New @nccn #prostatecancer guideline. AS no longer "preferred" for low-risk?! 🤦‍♂️ #whiskytangofoxtrot #pcsm @wandering_gu @DrSpratticus HT @DanLinMD for noticing this...
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Matt Cooperberg
5 years
I’m thrilled to be launching a new Center of Excellence on @urotoday focused on localized #prostatecancer . Opening blog is now live, and lots more content to come soon. #pcsm
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Matt Cooperberg
7 years
Wegelin: 665 patient RCT shows zero advantage for MRI-fusion TRUS bx or in bore MRI biopsy over MRI and 'cognitive fusion' #eau18
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Matt Cooperberg
3 years
More evidence that "cognitive" fusion may be just about as good as software-based platforms for MRI-guided biopsy for #ProstateCancer patients. #wsaua21 @JJLiuMD #pcsm
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Matt Cooperberg
7 years
30% of women urology resident applicants asked re family plans during interviews. #aua17 Seriously??
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Matt Cooperberg
2 years
For anyone who can't get past the NEJM paywall for ProtecT 15 year:
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@dr_coops
Matt Cooperberg
2 years
Thank you to all who joined us for a truly all-star, multiD, int'l conference at @ucsfcancer during #GU23 to discuss nomenclature for GG1 #prostatecancer . Incredibly high yield afternoon and hopefully a path forward. @uroegg @adamkibel_uro @aleberlin2
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Matt Cooperberg
5 years
Large, prospective, multi-center #PASS study finds no benefit or utility for @oncotype_pca #GPS test in predicting outcomes on #prostatecancer #activesurveillance . Back to drawing board for next-gen markers! #pcsm @danlinmd @ASCO_pubs @CanaryFound
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Matt Cooperberg
5 years
Brought in by a VA pt. So misleading I think it crosses the line into lies. Show me ANY study proving CLINICAL superiority 🦗Shame on ⁦⁦ @nyulangone ⁩! ⁦This is proton-level false claims 🙄 @LoebStacy ⁩ ⁦ @daviesbj ⁩ ⁦ @DrSpratticus
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Matt Cooperberg
6 years
Cher Paris, Nous sommes vraiment désolés pour l'incendie a #NotreDame . Et aussi pour cet imbécile complet. 🤦‍♂️-EUA
@realDonaldTrump
Donald J. Trump
6 years
So horrible to watch the massive fire at Notre Dame Cathedral in Paris. Perhaps flying water tankers could be used to put it out. Must act quickly!
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Matt Cooperberg
3 years
So great to see our ⁦ @UCSFUrology ⁩ uro-onc alums back in SF from two coasts and three continents! #gu22 @pcarroll_ ⁩ ⁦ @SimaPorten ⁩ ⁦ @Uro_Max ⁩ ⁦ @SamWashUro ⁩ ⁦ @mdallera @RenuEapen ⁩ ⁦⁦ @mleapman @PeterLonergan ⁩ ⁦ @CChuMD
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Matt Cooperberg
2 years
🤦‍♂️ This ‘could’ be the understatement of the decade… History will judge this moment. Please do better 🙏.
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@dr_coops
Matt Cooperberg
3 years
Really fantastic talk from @thomashopemd on game-changing #PSMA PET at #SUO21 . Clinical pearl I haven’t seen summarized before re: when to think possible false pos:
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@dr_coops
Matt Cooperberg
4 years
Found a big ol’ coronavirus in a patient’s bladder with ⁦ @domesypantsx3 ⁩ yesterday. Add bladder cancer to the #covid19 syndrome list! 😆 #blcsm #UroSoMe
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Matt Cooperberg
4 years
Burned off my post-victory euphoria geeking out over some national data. Here's county level #covid19 deaths per capita since Sept as a function of how the county voted for Trump v. Biden. Adjusted analyses to come soon... I'm not judging I'm just sayin'! #MedTwitter
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@dr_coops
Matt Cooperberg
4 months
ICYMI: This paper from @JaneNguyen44 and Jesse McKenney on rethinking Gleason grading is a really big deal. Splitting all patterns into "favorable" and "unfavorable" amounts to the best biomarker I think I've ever seen for #prostatecancer .
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@WileyOnc_Hem
Wiley Oncology & Hematology
4 months
New from @Histo_Journal : Proposal for an optimised definition of adverse pathology (unfavourable histology) that predicts metastatic risk in prostatic adenocarcinoma independent of grade group and pathological stage ➡️ @BritishDivIAP @JaneNguyen44
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@dr_coops
Matt Cooperberg
6 years
Reiter: Even at UCLA center of excellence, MRI misses 20% of GS 8, 20% of >2cm tumors. MRI is a good adjunct to, NOT replacement for TRUS bx. PIRADS is still just inadequate. Go ahead & chuck tomatoes! #historywillbeonmyside #urs18 #pcsm
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Matt Cooperberg
1 year
ICYMI (I did): very important study from @thomashopemd @CalaisJeremie finding very high false-positive rate for "low-volume metastatic" disease on bone scan, using PSMA PET as gold standard. Meaning STAMPEDE H may be wrong, and studies of M1 local tx MUST be repeated in PSMA era.
@thomashopemd
Thomas Hope
1 year
If you thought PSMA PET always led to stage migration, you might want to think again. At initial staging over half of patients with bone mets on bone scan were negative on PSMA PET. Sometimes increased accuracy leads to fewer mets! Check it out from JNM:
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@dr_coops
Matt Cooperberg
6 years
The conclusion says it all: MRI is a good adjunct to, NOT a replacement for, systematic TRUS-guided biopsy. #pcsm
@TheLancetOncol
The Lancet Oncology
6 years
New Article online: Use of #prostate systematic and targeted #biopsy on the basis of multiparametric #MRI in biopsy-naive patients—the paired #diagnostic MRI-FIRST study
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@dr_coops
Matt Cooperberg
7 years
Here's the 2018 update ( @AmericanCancer super on-the-ball this year!): Likely gratis, @USPSTF prostate cancer incidence down to 1970s levels, and it's back up to #2 source of male cancer mortality. #pcsm #prostatecancer
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@dr_coops
Matt Cooperberg
4 years
So much unbridled love for prostate MRI throughout @socroboticsurg #SRS2020 . Role is clearly rising, but no one's talking about this: @acw_rad
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@dr_coops
Matt Cooperberg
4 years
@Bob_Wachter @nytimes And why is his mask down??
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@dr_coops
Matt Cooperberg
4 years
Letter to the editor re: PSA screening, from @SigridCarlsson , @jimhumd , and me in response to last month's editorial . No love from @nejm - so here it is for all you Urotwitterati! #pcsm The future of modern PSA screening is still bright (1/a few)
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@dr_coops
Matt Cooperberg
3 years
Active surveillance: Very much “preferred” for low-risk prostate cancer @JUrology Thanks @uroegg @wandering_gu @DanLinMD @ChapinMD @RonaldChenMD #pcsm #prostatecancer
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@dr_coops
Matt Cooperberg
5 years
Don't skip the history sessions at #aua19 ! Bedwetting alarm c.1900: tie a toad to the penis. Can't make this stuff up. Where's the visual abstract?? 🐸🍆🚫🛌🌊
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@dr_coops
Matt Cooperberg
2 years
Please tell me everyone at #GU23 would offer this man active surveillance at least as an option!? ⁦ @Scarps_kristen
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@dr_coops
Matt Cooperberg
3 years
50% rise in #testiscancer incidence AND mortality among Hispanic men since 2000 — no clues yet exactly why. #gu22 @AmerCancerCEO
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@dr_coops
Matt Cooperberg
2 years
“M1 low volume is the new high risk localized” - Gerhardt Attard #EAU23 . Will Rogers phenomenon in action!
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@dr_coops
Matt Cooperberg
4 years
End of an era today... my, and @anobelodisho 's, last cases on the @IntuitiveSurg Si! I don't usually get nostalgic for machines that aren't cars, but this has been a workhorse since @pcarroll_ brought it in when I was a resident. 1000s of pts have passed under it, it'll be missed
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@dr_coops
Matt Cooperberg
2 years
First look at use of #activesurveillance for low-risk #prostatecancer using ⁦ @AmerUrological ⁩ gold standard #AQUAregistry . Rates overall continue to rise rapidly but major local variation persists. #aua22
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@dr_coops
Matt Cooperberg
3 years
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@dr_coops
Matt Cooperberg
7 years
What #PIVOT really showed: RP= 37% less CSM, 16% less overall mortality; not stat sig because accrual was <40% of target. #pcsm #nejmfail
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@dr_coops
Matt Cooperberg
6 years
The Diverse Genomic Landscape of Clinically Low-risk Prostate Cancer @EUplatinum @pcarroll_ @felixfengmd @Davicioni @UCSFUrology @JuneChanScD @UCSFCancer
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@dr_coops
Matt Cooperberg
5 years
MRI has a role to play, but reports of the imminent demise of systematic biopsy have been greatly exaggerated! Huge kudos @michaelahdootmd et al on this one. @nejm #pcsm MRI-Targeted, Systematic, and Combined Biopsy for Prostate Cancer Diagnosis
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@dr_coops
Matt Cooperberg
2 years
@AmerUrological One thing I’ll say is how happy I am to see so many urology _residents_ speaking up here including our crew @ucsfurology . YOU are the future of urology and this organization. Get loud, be heard! #UroRes #urotwitter
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Matt Cooperberg
5 years
#prostatecancer at the turn of the decade: incidence "recovering" as screening policy seeks a rational middle ground. Mortality rates fortunately seem to be at a plateau rather than continuing to rise... #pcsm @AmericanCancer
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@dr_coops
Matt Cooperberg
2 years
One of the most important statements I’ve seen so far at #gu23 !
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@dr_coops
Matt Cooperberg
7 years
Single PSA at 45 can reduce #prostatecancer mortality ~20%--and with a <1% overdiagnosis rate #cisnet
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@dr_coops
Matt Cooperberg
5 years
Only ⁦ @declangmurphy ⁩ names a trial with a hashtag! But this is very cool. Sign us up when #LuTectomy goes int'l :) @DrMHofman ⁩ ⁦ @PeterMacCC
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@dr_coops
Matt Cooperberg
4 years
Latest/greatest annual 2021 data from @AmericanCancer , hot off the press. Sharp uptick in #prostatecancer incidence, mortality flat as lung and colorectal continue to fall. 2021 is a great year to work toward #smarterscreening ! #pcsm
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@dr_coops
Matt Cooperberg
2 years
Long term QOL data from ProtecT data also out today: #EAU23
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@dr_coops
Matt Cooperberg
2 years
Cancer statistics 2023 are out - thank you @ACSNews . #prostatecancer rates up sharply, partly due to rising screening, but the % of advanced dz at diagnosis is also rising. Mortality still flat, hopefully will begin falling again with smarter screening.
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@dr_coops
Matt Cooperberg
7 years
Finally a framework to evaluate max TURBT + chemo as legit option for carefully selected pts with T2 bladder cancer #gu18 #bcsm
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@dr_coops
Matt Cooperberg
2 years
What a city! Thanks so much again ⁦ @Uroweb ⁩ for the chance to join you at #EAU22 . It was a fantastic meeting, and SO good to see so many old and new friends in person. Hope to meet you in Milan next time :)
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@dr_coops
Matt Cooperberg
6 years
@DrAndreaKoko @daviesbj Don’t forget us uro oncs! 🔊🍑📸🦀 TRUS 🔭🍆👀🦀 cysto 🔪🦀🆎 open surgery 🔪🦀🤖 robot asst surgery ⚡️🦀💰 IMRT ⚡️🦀🏦 proton beam tx ❄️🦀 cryotx 👀🦀⏱ active surveillance 🔊🦀💥😫 HIFU
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@dr_coops
Matt Cooperberg
3 years
Taplin: Neoadjuvant space before prostatectomy getting more and more exciting #gu22
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@dr_coops
Matt Cooperberg
6 years
PSMA vs. fluciclovine (Axumin) PET/CT for recurrent prostate cancer. There's a pretty clear winner here. #pcfretreat18 @PCF_Science
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@dr_coops
Matt Cooperberg
1 year
Massive congratulations to the 2023 ⁦ @PCF_Science ⁩ ⁦Young Investigator Award winners! The future of research in #prostatecancer looks very bright. #PCFretreat23 @PCFnews
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Matt Cooperberg
4 years
Excellent review of the #proPSMA trial #suo20 . And as always @declangmurphy sets a VERY high bar for video production quality!
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@dr_coops
Matt Cooperberg
3 years
Deborah Kaye @DukeUrology presents a strong defense of TRUS biopsy #suo21 :
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@dr_coops
Matt Cooperberg
11 months
@DGlaucomflecken Seriously? You really don't know better? The violence is not "toward" medical facilities and patients. The violence is _because_ craven Hamas builds missile launchers and ammo depots in hospitals and hides behind the patients. And sometimes blows up their own hospitals.
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@dr_coops
Matt Cooperberg
2 years
Testing contemporary #prostatecancer screening in a fantastic population based RCT #ProScreen @auvinen_anssi #eau23
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@dr_coops
Matt Cooperberg
7 years
Heddy Hricak, one of absolute global leaders in prostate MRI, makes clear that MRI can improve biopsy performance but *cannot* replace biopsy for elevated PSA or in early active surveillance. #probase18 #pcsm
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@dr_coops
Matt Cooperberg
5 years
P<0.05 was never meant to be a indicator of 'truth,' 'importance,' publishability, or action. #suo19 @SHaneuse ⁩ ⁦ @gorejohn
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@dr_coops
Matt Cooperberg
1 year
Great to catch up with @mrsprostate #aua23 , and to see “personalized” coffee orders taken to a whole new level 😁
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@dr_coops
Matt Cooperberg
7 years
Here's the inevitable outcome of prostate MRI-mania -- a "Prostate center" run by a radiologist taking cash for all kinds of unproven tx, with no urologist anywhere in sight 🙄 HT @uroegg #pcsm
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@dr_coops
Matt Cooperberg
1 year
Memory lane - how you know you’ve been in the outcomes research game for a while!
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@dr_coops
Matt Cooperberg
6 years
This is at 10 years. Risk prob increases further at 20+ yrs, so caveat re primary RT for men in their 50s/early 60s
@EUplatinum
European Urology
6 years
External Beam Radiotherapy Increases the Risk of #BladderCancer When Compared with Radical Prostatectomy in Patients Affected by #ProstateCancer : A Population-based Analysis @UroMoschini
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Matt Cooperberg
2 years
More evidence at #aua22 (from PRIAS) that confirmatory biopsy is important early in #activesurveillance even if MRI is negative (esp if PSAD high). Validates ⁦ @CChuMD ⁩ paper last year in ⁦ @EUplatinum
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Matt Cooperberg
7 years
SO TRUE! Someone needs to PROVE that *community-based* PIRADS is more reliable than a well-done TRUS. Till then we're just wasting $millions. mpMRI may be biggest naked emperor in urology right now. #imho #pcsm
@geoffsonn
Geoffrey A. Sonn, MD
7 years
The extent of variation in prostate MRI interpretation across radiologists is alarming. Uros should know how your radiologist(s) performs, work with them to improve, and learn to read our own prostate MRI. via @urotoday @EurUrolFocus
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Matt Cooperberg
1 year
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@dr_coops
Matt Cooperberg
4 years
Proof that urologists make the best public-facing epidemiologists 😆 #UroSoMe
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@dr_coops
Matt Cooperberg
6 years
Huge +1! Time to right a big wrong. @US_FDA @SGottliebFDA
@EricKleinMD
Eric Klein
6 years
A long time ago in a galaxy far,far away it was asserted that finasteride use in PCPT would be bad cuz it caused high grade cancer. New 18yr data shows it ain’t so: fin users had better OS. Thx to SWOG for truth. FDA 5ARI black box warning should disappear
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Matt Cooperberg
7 years
Hadaschik: mpMRI NPV for GS3+4 cancer only 69%. MRI is a good adjunct, NOT replacement for systematic #siu17 #siu2u
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Matt Cooperberg
4 years
Now out in @EurUrolFocus : How Often Does Magnetic Resonance Imaging Detect Prostate Cancer Missed by Transrectal Ultrasound? Spoiler alert: sometimes, but not very often! Great work @aherlema and Maya Overland @UCSFUrology #pcsm
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@dr_coops
Matt Cooperberg
7 years
Briganti: increasingly common example of major stage migration effected by PSMA PET. Growing management challenge. #EAU18
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@dr_coops
Matt Cooperberg
6 months
An al fresco journal club ⁦ @UCSFUrology ⁩— warm SF spring evening and fantastic literature insights from ⁦ @spsutkaMD ⁩ as she wraps up a too-short visit to SF :)
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@dr_coops
Matt Cooperberg
7 years
Abi or enza? Efficacy is a wash, choose based on AE profile, comorbidity @OncLive @charlesryanmd
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Matt Cooperberg
6 years
Seems like @ASCO #gu19 pretty severely lowballed expected interest in data interpretation controversies session 🙄. It’s covering critical topics, should have been a main session! (Or at least a double room) @jenniferrrider
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Matt Cooperberg
1 year
Dontcha wish your section was Western like ours? So great to catch up for a spectacular afternoon at #WSAUA23 @palisadestahoe ⁩ with ⁦ @UCSFUrology ⁩ alums ⁦ @BogdanaSchmidt ⁩ ⁦ @IanMetzler ⁩ ⁦ @selmasic
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@dr_coops
Matt Cooperberg
5 years
Noel Clarke: The 7 stages of conducting clinical trials. 😂 truth #pcsm @MartiniKlinik ⁩ ⁦ @ChapinMD ⁩? ⁦ @DanLinMD ⁩?
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Matt Cooperberg
7 years
Well at least there's good news in NMIBC! #gemcitabine #AUA17 Practice changing SWOG trial.
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Matt Cooperberg
4 years
Pre-caffeinated question: We're >2 months into #COVIDLockdown . Who still joins a group Zoom and doesn't know to mute??! 🤬 Ok, micro-rant over ;)
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Matt Cooperberg
4 years
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@dr_coops
Matt Cooperberg
11 months
Beautiful to see tens of thousands packing the Mall plus more on-line, standing against #antisemitism and in support of the hostages still in Gaza. Unlike the displays on the other side, no violence, no calls for murder or genocide. #BringThemHome #HamasisISIS #IStandwithIsreal
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@dr_coops
Matt Cooperberg
4 years
I know this doesn’t change anything today, and that still we have long hard months in front of us. But this 0.5cc of hope feels like the turning of the tide. Huge, heartfelt thanks to ⁦ @moderna_tx ⁩, ⁦ @CDCgov ⁩, and especially everyone at ⁦ @SFVAMC ⁩!
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@dr_coops
Matt Cooperberg
4 years
Happy Halloween 🎃 (HT @anobelodisho )
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@dr_coops
Matt Cooperberg
5 years
By the way, the view outside the conf rm #banffGU2019 :
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@dr_coops
Matt Cooperberg
3 years
Richly deserved @pcarroll_ : the 2021 @UroOnc Whitmore Lectureship. (Live now )
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@dr_coops
Matt Cooperberg
3 years
The Impact of the #COVID19 Pandemic on Urologic Care Delivery in the United States 🙌 @dleeGU Unique data on trends and disparities from the #AQUAregistry @AmerUrological @veranahealth , now out in @JUrology : Updates to come,as this is far from over...
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@dr_coops
Matt Cooperberg
6 years
Martin Gleave, exceptionally deserving of the ⁦ @Uro_Onc ⁩ Huggins Medal. Unbelievable career—so far! #suo18
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