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Deirdre Tobias, ScD

@deirdre_tobias

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(DEER-druh) Obesity & Nutrition Epidemiologist, Methods | Assistant Professor @BrighamWomens @HarvardChanSPH @HarvardMed | Editor @AJCNutrition

https://t.co/9jSfBogyts
Joined March 2019
Don't wanna be here? Send us removal request.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 years
🥚Eggs and CVD🥚 Could there BE a more classic single food nutritional epi example? I submit that there is not! When another egg paper recently popped up in @CircAHA I jumped at the chance to walk through some of my favorite fundamental issues with single food analyses.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
Sorry I had to: the nutrition science lit of coffee ☕️
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
1 year
“Obesity is genetic” If you were just triggered, then this thread is for you. If “but the human genome can’t evolve in a generation!” has passed your lips in the past few months, then this thread is for you. 🧬This is why obesity is genetic. And the environment is to blame.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
1 year
Meta-analysis of meta-analyses of RCTs: dietary interventions to modify macronutrient composition still irrelevant for weight loss in patients with type 2 diabetes. No more low-carb vs. low-fat weight loss trials. It’s over. No difference. Move on.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
5 years
Randomized my 1st subject for my 1st trial today. I’ve been an epidemiologist for 10yrs and never met a participant behind the data. Totally perception-changing. TY to anyone who’s ever participated in a study in any way. Public health research cannot exist w/o you. #epitwitter
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
4 years
Dr. Fauci personally vaccinated Santa Claus himself and he is good to go. Here's the interview clip you can share with the kiddos!
@CNN
CNN
@CNN
4 years
Santa Claus will be coming to town this year, Dr. Anthony Fauci says. “I took care of that for you,” he says. “…I took a trip up there to the North Pole; I went there and I vaccinated Santa Claus myself. I measured his level of immunity, and he is good to go.” #CNNSesameStreet
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
1 year
Damn. The @CDCgov @BRFSS just released its annual state-level obesity prevalences. US obesity worsened again in 2022, with dramatic increases in many states in just 1 year. The US is completely off the rails. All the data, maps, subgroups here:
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Deirdre Tobias, ScD
@deirdre_tobias
1 year
Iodine is from the sea. Land animals are not naturally iodine rich. So why is dairy a good source of iodine? Because standard dairy cow feed is fortified with iodized salt. The cow takes the supplement for you. Read more about iodine here:
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Iodine

Iodine is an essential trace mineral not made by the body so must be obtained by food or supplements. It is found naturally in some foods and is added to supplements and some salt seasonings. Iodin…

nutritionsource.hsph.harvard.edu
@bigfatsurprise
Nina Teicholz, PhD
@bigfatsurprise
1 year
Vegan diets don't supply sufficient iodine. Another sign that this is not your natural human diet. If it were meant for humans, it would supply all the nutrients you need, naturally.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
4 months
As the obesity prevalence climbed in the US and globally, epidemiologists kept an eye on Japan. Despite an initial upward trend like the rest of the world, obesity in Japan quickly leveled off and came back down to <5%. Here's why...
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The Land That Doesn't Need Ozempic

Some 43% of Americans are obese, compared with just 4.5% of Japanese people. What explains this gap?

time.com
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
💣It's LDL results time! 1/
@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
📉Cholesterol-lowering therapies like statins are a cornerstone of preventing cardiovascular disease since the 1990s. So with that, please join me in an epidemiologic adventure as we address an emerging alternative viewpoint that refutes the role of LDL (bad cholesterol) in CVD.
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Deirdre Tobias, ScD
@deirdre_tobias
3 years
📉Cholesterol-lowering therapies like statins are a cornerstone of preventing cardiovascular disease since the 1990s. So with that, please join me in an epidemiologic adventure as we address an emerging alternative viewpoint that refutes the role of LDL (bad cholesterol) in CVD.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 years
Just published in @NEJM and presented @AHAScience Aggressive lowering of triglycerides in pts with T2D had no reduction in CVD. LDL remains king for causal lipid hypotheses.
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Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM

High triglyceride levels are associated with increased cardiovascular risk, but whether reductions in these levels would lower the incidence of cardiovascular events is uncertain. Pemafibrate, a se...

www.nejm.org
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
1 year
BREAKING: WHO to recommend a low-fat diet -- because **WEIGHT LOSS** 👻 😱🤯 What's happening over at the WHO lately? Is everyone there OK? 😬
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Deirdre Tobias, ScD
@deirdre_tobias
1 year
Lots of comments about whether BMI, self-reported or otherwise, is useful... I give a lecture on this, and can share a few slides. Monitoring population level trends is *exactly* what BMI does best. Here's why...
@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
1 year
Damn. The @CDCgov @BRFSS just released its annual state-level obesity prevalences. US obesity worsened again in 2022, with dramatic increases in many states in just 1 year. The US is completely off the rails. All the data, maps, subgroups here:
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 years
I have some news to share! 🪩
@USDANutrition
USDA Nutrition
@USDANutrition
2 years
🎉We’re excited to announce the members of the 2025 Dietary Guidelines Advisory Committee! The Committee looks at the relationship between diet and health — and informs nutrition guidance everyone can use. Learn more: #DietaryGuidelines
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Deirdre Tobias, ScD
@deirdre_tobias
2 years
The @usda MyPlate serves as the primary educational tool for the Dietary Guidelines for Americans. 📊New CDC report: how many Americans have even heard of MyPlate? And how many tried to follow its guidance? 💣Are you ready for this? 🍽️1
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
4 years
Ahhhh! It's official! Ahhhh! I just received my first ever R01! I'm actually going to be the PI of my dream substitution weight loss trial! This feels foreign...what do I do now? How do I not have this creepy grin for the rest of my zoom calls today??
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Deirdre Tobias, ScD
@deirdre_tobias
4 years
"We rigorously adjusted for all potential confounders"
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Deirdre Tobias, ScD
@deirdre_tobias
2 years
🥹 Floored, honored, SO grateful! Colleagues and I @MassGenBrigham @HarvardChanSPH were just awarded a U01 by @theNCI to investigate mechanisms of obesity & cancer. The best part of this program is the collaborations it builds across the funded centers. I cannot wait to begin!
@NCICancerCtrl
NCI Cancer Control
@NCICancerCtrl
2 years
Dr. Deirdre Tobias ( @deirdre_tobias ) et al will be decoding mechanisms underlying metabolic dysregulation in #obesity and digestive cancer risk @BrighamWomens #GICSM
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Deirdre Tobias, ScD
@deirdre_tobias
3 years
📜This comprehensive thread by lead author @KevinH_PhD on our new paper of what the modern Energy Balance Model (EBM) of obesity *is* and *is not* is a *must read*. However - I want to emphasize a few points from the epi/population health P.O.V. that underscore the biology: /1
@KevinH_PhD
Kevin Hall
@KevinH_PhD
3 years
I was honored to lead an international team of renowned obesity scientists (including @Farooqi_Lab @StephenORahilly @DrLeanneRedman @JohnSpeakman4 @deirdre_tobias ) to address widespread misunderstandings about modern obesity science in @AJCNutrition :
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
11 months
Walmart knows ozempic Rx fillers purchase less food…but how? How isn’t there a firewall to pharmacy data? Or was this an IRB approved research endeavor? For internal sales meetings, let alone public announcements, it is unsettling that patient data can be mined like this…wut?
@BevTchangMD
Beverly G. Tchang, MD
@BevTchangMD
11 months
#Ozempic Is Making People Buy Less Food, Walmart Says
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Deirdre Tobias, ScD
@deirdre_tobias
4 years
How I feel about scientific journals requiring graphical abstracts, in the form of a graphical abstract:
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Deirdre Tobias, ScD
@deirdre_tobias
4 years
@pnatarajanmd P=0.051
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
7 months
Dietary fat ≠ body fat levels. Dietary cholesterol ≠ fasting blood cholesterol levels. Dietary carbohydrate ≠ fasting blood glucose levels. If you still think otherwise, please re-take Liver 101 at Homeostasis University.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
5 years
👇This supp. fig waterfall plot from DIETFITS. It represents so much untapped potential to understanding long-term weight loss. Can we back-burner carbs/fat for a sec and focus on drivers of adherence? Also, if u have past trial data, can you plz send me a waterfall plot, I❤️them
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 years
This is huge. You know how epi is ugh and short-term interventions are meh? May I present to you, the *UNICORN OF NUTRITION SCIENCE* 🌠RCT of cocoa-flavs and multi-vits 🌠Placebo-controlled 🌠Blinded 🌠21,000 adults 🌠3.6 yrs follow-up 🌠INCIDENT CVD! 🌠ALL CAUSE MORTALITY!!!
@BrighamResearch
Brigham and Women’s Research
@BrighamResearch
2 years
In @AJCNutrition : @HowardSesso , Dr. JoAnn Manson of @BWHDPM @BrighamWomens & colleagues report the main findings of the first ever randomized trial of a cocoa flavanol supplement on cardiovascular disease endpoints and (1 of 5)
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Deirdre Tobias, ScD
@deirdre_tobias
4 years
Congrats to Dr. Willett on 40 years (!) teaching the Nutritional Epidemiology course at HSPH. Honored to serve as co-instructor, I still learn something new every year.
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Deirdre Tobias, ScD
@deirdre_tobias
1 year
Regular sugary beverage intake causes weight gain in kids and adults. CAUSES. <-Not a typo @AJCNutrition @BWHDPM
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Deirdre Tobias, ScD
@deirdre_tobias
3 years
🧵 When it comes to diet/disease studies how well do the bodies of evidence: -RCTs- and -observational epi- agree? @lschwinshakl et al tackled this oft-raised question with an impressively expansive systematic review @BMJ . Here's a thread about *all of that*:
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
4 years
Country-level correlation studies like the "lettuce will kill you" preprint provide epidemiologists with a good laugh-cry, & I want to be sure everyone understands why. So why are diet/disease correlations (AKA ecologic studies) less than useful for deriving causality? 1/
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
7 months
We're hosting a symposium Mar 6 (in-person @BrighamWomens & virtual) to bring you a line-up of brilliant nutrition colleagues & epidemiologists to discuss methods and works in progress addressing some of diet research's biggest challenges. To register:
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Deirdre Tobias, ScD
@deirdre_tobias
3 years
Do you have a cohort with *baseline diet* and 20-30 yrs of observational follow-up? Are you pondering an analysis of hi vs. lo (insert food/nutrient) intake to see whether its related to (insert dx) decades later? Don't do it! Follow me for more quality nutritional epi tips!
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Deirdre Tobias, ScD
@deirdre_tobias
8 months
Can you imagine having your research study followed by a Netflix documentary crew?! 😱🤯 Dr. Gardner is unparalleled at making nutrition science look so much fun -- I highly recommend bingeing this for the pop-sci (and then check out the real manuscript for all the gritty deets)
@GardnerPhD
Christopher Gardner
@GardnerPhD
8 months
Omnivore vs Vegan Diet Study Among Identical Twins Study was fun to design & run - thrilled it was published in @JAMANetworkOpen 👇 Certainly a new & unique experience to have the conduct & findings featured on Netflix! #3 since released on 1/1/24 🎥🤣
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 years
🇺🇸It is an absolute honor to serve on the US #2025DGAC . I am blown away by the federal coordination, dedicated staff, and 19 brilliant colleagues. Learn more about our daunting but critical road ahead and follow along:
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Deirdre Tobias, ScD
@deirdre_tobias
1 year
If the main source of monounsaturated fats in the US diet is beef, and commercial cattle feed is processed grains soy corn and sunflower, does this mean steak is our main source of seed oils?
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
7 months
Our latest publication📰is out with @rik_epi and co-authors: We derived a novel metabolomics score so strongly related to future risk of T2D, that honestly it is an embarrassment of odds ratio riches...
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
4 years
The DPP: $Huge NIH-funded trial (N=3200) in the 1990s. Conclusion: randomized diet/lifestyle significantly reduced T2D more than metformin or placebo. Big 58% reduction. The diet? Reduce total fat as much as possible. Be hypocaloric and lose weight. Exercise.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
Everyone! Gather around! I am SO excited for this @AJCNutrition paper that just came out. But first, Nutrition Science, I want to introduce you to my good friend, Causal Inference. CI is this niche of epidemiologic methods (paradoxical, I know). /1
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
11 months
This RCT presents a fantastic deep dive into modulators of weight loss Factors w/ *NO* DIFFERENTIAL EFFECTS on 12wk WL: - High carb vs. high fat (yet again) - Predicted "carb" or "fat" responder genotype (a la DIETFITS) - Insulin & IR - Insulin on high-carb - Insulin on high-fat
@MichelleCardel
Michelle Cardel, PhD, MS, RD
@MichelleCardel
11 months
Interested in personalized nutrition? Our new pub examining whether weight loss differs between genotype-concordant and genotype-discordant diets was published in @NatureComms and is featured as an Editors’ Highlight. A thread on findings below. Link:
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Deirdre Tobias, ScD
@deirdre_tobias
6 months
Thank goodness! Time to expose blueberries as the toxic glucose spike bombs that they truly are, once and for all!!!☠️🫐🥴
@DanielJDrucker
Daniel J Drucker
@DanielJDrucker
6 months
Dexcom announces over the counter CGM Stelo has been cleared by the ⁦ @US_FDA ⁩ #diabetes
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Deirdre Tobias, ScD
@deirdre_tobias
9 months
The hypocrisy of the mud slinging from the low-carb community every time a meat/vegan study makes headlines is truly the most bizarre form of non-scientific discord. Literally *everything* they chuck in attempt to discredit research(ers), applies to their own low-carb evidence.
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Deirdre Tobias, ScD
@deirdre_tobias
2 years
If your research was important enough to be done in the first place then it literally doesn't matter whether your results are null or significant. Report results with honesty & integrity. Don't marry your hypothesis. An important well-powered null is a beautiful thing.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
OMG Nutrition Twitter, look! Mutual respect 👊 and total disagreement can co-exist after all! 🤯
@TamarHaspel
Tamar Haspel
@TamarHaspel
3 years
@deirdre_tobias @marionnestle You are my new favorite scientist. I disagree about a lot of this, and I'll give it a closer look tomorrow (I just got in and saw it all), but I cannot tell you how much I appreciate your jumping in here and talking about all this in public. Thank you.
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Deirdre Tobias, ScD
@deirdre_tobias
2 years
One of the first things taught in introductory *epidemiology* textbooks is that correlation *could be* causation... ...and that it's your job to know how likely that is for a given set of experiments & observations.
@Cell_Onion
Cell Onion
@Cell_Onion
2 years
@CharlesMBrenner @deirdre_tobias “One of the first things taught in introductory statistics textbooks is that correlation is not causation. It is also one of the first things forgotten.” ― Professor Thomas Sowell
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Deirdre Tobias, ScD
@deirdre_tobias
2 years
Sad that $8/month doesn’t come with a Fact Checker 😢
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Processed and Unprocessed Red Meat and Risk of Colorectal Cancer: Analysis by Tumor Location and...

Although the association between red meat consumption and colorectal cancer (CRC) is well established, the association across subsites of the colon and rectum remains uncertain, as does time of...

pubmed.ncbi.nlm.nih.gov
@SBakerMD
Dr Shawn Baker 🥩
@SBakerMD
2 years
Why would Harvard refuse to publish a study on nearly 1 million people that shows that red meat does NOT CAUSE CANCER?🤔🤔🤔
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Deirdre Tobias, ScD
@deirdre_tobias
7 months
I thoroughly enjoyed this episode of @PlantChompers sitting down with first author of the HSPH red meat/diabetes paper, Xiao Gu. The nutritional epi methods discussion does not disappoint. Their dismantling of sloppy blogger and YouTube hot takes is 🏆A+.
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HARVARD: Red Meat Raises Diabetes Risk 62%. INTERNET: Nope.

Harvard's paper, red meat = diabetes, launched 100 headlines, all positive. And 20 YouTubes, all negative. Who got it right?PAPERS:Red meat intake and risk o...

www.youtube.com
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
4 years
Precision Nutrition will be a fascinating scientific journey. No doubt we’ll learn a TON about internal mechanisms. And, if $150 mil later, it leads us to finally acknowledge that the *external* food environment is actually the bigger issue, it will have been worth every cent.
@DrSherryPagoto
Sherry Pagoto
@DrSherryPagoto
4 years
NIH is investing $150M in a study to figure out the "best diet" for people. Meanwhile, the food industry will continue to churn out cheap ultraprocessed junk food that we'll all eat instead.
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Deirdre Tobias, ScD
@deirdre_tobias
6 months
In case you missed it -- our Causal Inference & Nutritional Epidemiology symposium recording is now available online!
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Symposium Causal Inference and Nutritional Epidemiology Symposium -...

The Symposium Casual Inference and Nutritional Epidemiology Symposium was held at Brigham and Women's Hospital on March 6th, 2024. Learn more about Nutrition...

www.youtube.com
@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
7 months
We're hosting a symposium Mar 6 (in-person @BrighamWomens & virtual) to bring you a line-up of brilliant nutrition colleagues & epidemiologists to discuss methods and works in progress addressing some of diet research's biggest challenges. To register:
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Deirdre Tobias, ScD
@deirdre_tobias
1 year
I am hiring a postdoc for nutritional epidemiology! Come research with me in Boston @bwh_postdocs ! *please share with your friends and colleagues* Details and to Apply Online: .
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Deirdre Tobias, ScD
@deirdre_tobias
3 months
Time to update your lecture slides…and your public health research priorities. ⚠️Over half a billion globally (6.1%) are living with diabetes.
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Deirdre Tobias, ScD
@deirdre_tobias
10 months
This whole article from last month lit a fire in me, I'm still enraged. This hot mic quote from the @KelloggsUS CEO, he's so cavalier about the US obesity epidemic -- food industry monitors and will "mitigate" successful weight loss strategies because they threaten sales. Gross.
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@business
Bloomberg
@business
11 months
Walmart says it’s already seeing an impact on shopping demand from people taking the diabetes drug Ozempic, Wegovy and other appetite-suppressing medications.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
1 year
Anyone claiming obesity is genetic 🧬isn’t wrong. It explains between-person differences in BMI and why weight gain propensity is similar to our parents. Anyone claiming obesity is environment🍩 isn’t wrong. It explains where our society has ended up in a short few decades.
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Deirdre Tobias, ScD
@deirdre_tobias
5 months
We were so much healthier back then on our unadulterated ancestral diets...
@fasc1nate
Fascinating
@fasc1nate
5 months
Causes of death in London, 1632. Anything stand out?
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Deirdre Tobias, ScD
@deirdre_tobias
4 months
“Nutritional epi is garbage, self-reported diet is useless” is my absolute favorite hot take❤️ Thanks @NutritionDanny for providing a safe space to discuss evidence and this poorly informed sentiment. Take a listen! But⚠️ it gets deep, you can't be any geek off the street
@NutritionDanny
Danny Lennon
@NutritionDanny
4 months
New episode with @deirdre_tobias , discussing the criticisms of, and misconceptions about, the food frequency questionnaire (FFQ). Find on all podcast apps or via the link:
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 months
New perspective piece @AmJEpi ! We lay out what makes dietary interventions/exposures inherently complex, and why all researchers (yes, YOU) *REALLY* need to stop ignoring this reality… “Improving nutrition science begins with asking better questions”
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Improving nutrition science begins with asking better questions

Abstract. A priority of nutrition science is to identify dietary determinants of health and disease to inform effective public health policies, guidelines,

academic.oup.com
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 months
Revealed! My personal daily Protocol: 1️⃣Tumble out of bed and stumble to the kitchen 2️⃣Pour myself a cup of ambition 3️⃣Yawn and stretch and try to come to life 4️⃣Jump in the shower & the blood starts pumpin 5️⃣Out on the street, the traffic starts jumpin 6️⃣On the job from 9 to 5
@hubermanlab
Andrew D. Huberman, Ph.D.
@hubermanlab
3 months
I’m excited to share some big news. I've been working on a book for quite some time — more than five years, in fact — though it's really based on more than three decades of research and experience. Today, I am thrilled to share that my new and first-ever book, Protocols: An
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
1 year
This week's coverage of the latest alcohol/mortality paper was disappointing. Most missed the point of this issue entirely. In cased you missed it, the hot takes were all like: "THINK THAT NIGHTLY PINOT IS YOUR FOUNTAIN OF YOUTH? NEW SCIENCE SAYS THINK AGAIN, SUCKERS☠️"
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
8 months
@DrNadolsky @SBakerMD I thought the take-away was that the person's keto diet was so horrendously bad for their LDLc that even cookies were healthier in contrast. 🤷‍♀️
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Deirdre Tobias, ScD
@deirdre_tobias
3 years
15/ I think this is the main take-away. It's striking how consistent the relationship between LDL and all-cause mortality is. Women with higher baseline LDL were more likely to die during follow-up. Regardless of their HDL and TG (or age, BMI, smoking, etc.).
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Deirdre Tobias, ScD
@deirdre_tobias
2 years
I ❤️THIS: “Unlike politics, when it comes to science there is no ‘two sides,’ “Scientific evidence is a process of critically evaluating data in a systematic and rigorous way and interpreting that data,” she said. Unlike politics, it’s based on facts, not feelings. - @DBelardoMD
@DBelardoMD
Danielle Belardo, MD
@DBelardoMD
2 years
Spoke to the @LosAngelesBlade this week about how @DrOz & @drmarkhyman are both a symptom of broader & more systemic problems in our healthcare system. We need to hold physicians accountable who are profiting off of pseudoscience & misinformation
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 years
Sweat equity and persistence paid off 🥹 long-time passion project is finally funded! Thank you @AmDiabetesAssn ! So excited to work with Drs. @LajousMartin & Dalia Stern on cutting-edge causal inference methods for nutritional epidemiology and T2D prevention. More to come...
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
This podcast on nutritional epidemiology with Danny and Alan was so much fun to record. If I sound way too excited geeking out on methods, it's because I was. We didn't talk about keto once and I even got to drop "triangulation of methods" ❤ My happy place.
@NutritionDanny
Danny Lennon
@NutritionDanny
3 years
It was an honor to talk to @deirdre_tobias about all things nutrition epidemiology. If you like nerding out on nutrition science, you'll enjoy this. Link: Or find Sigma Nutrition Radio on all podcast apps.
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Deirdre Tobias, ScD
@deirdre_tobias
1 year
“What the US kids needs now, more than ever, is another line of sweetened beverages marketed as fun and healthy!” - Said no one ev… 😳
@WSJLive
WSJ Live Journalism
@WSJLive
1 year
. @MichelleObama announced yesterday the launch of her food-and-drinks company Plezi. Packaged in colorful bottles that look like typical sugary energy drinks, PLEZi drinks retail for $3.89 for a pack of four and are intended to be less sweet than other children’s beverages.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
1 year
Can we use observational data to emulate randomized dietary intervention trials? Come find out! #ASN2023 Monday session for the nutrition research methods nerds out there…
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
6 months
📔 New clinical nutrition med school textbook is out soon & available for pre-order! "Essentials of Clinical Nutrition in Healthcare" I'm proud to have co-authored the chapter on *Popular Diets* with the one and only @KCKlatt Pre-order:
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
If a car leaves Boston going 60mph at 7:00am to retrieve child's shoes left in Rhode Island 60 miles away, and camp starts at 8:00am, and at 7:30am you realize the only pair of back-up shoes are in the same car on its way to Rhode Island, then how much coffee do you need?
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 years
It’s important clinically to understand RR *and* absolute risk reduction. But for the 👏LOVE 👏OF 👏SCROD the minuscule cumulative incidence of CVD from a 3-yr pharma trial is 👏NOT the same thing as your 👏PATIENTS’ 👏LIFETIME 👏RISK. HEART DISEASE IS THE #1 CAUSE OF DEATH.
@KCKlatt
Kevin C. Klatt, PhD, RD (he/him)
@KCKlatt
2 years
You can tell the TwitterDiet zealots have never been involved in any clinical nutrition research bc they're constantly in mentions about drug trials with disease endpoints whining about absolute vs relative risks, things you can't even calculate for their fav diet alternative..
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
11 months
It was an absolute honor to contribute to the development of this consensus report, years in the making, and to work alongside such impressive colleagues and legends. Where does the evidence stand for clinical uptake of precision medicine in diabetes?
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@NatureMedicine
Nature Medicine
@NatureMedicine
11 months
A new Consensus Statement from the Precision Medicine in Diabetes Initiative outlines the milestones that must be achieved for broad clinical implementation of #precisionmedicine in #diabetes care. #EASD2023 @lunduniversity @harvardmed @novonordiskfond
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
Just in case you don't read beyond the ominous headline, artificially-sweetened beverages were *NOT* associated with breast cancer.
@nutritionorg
American Society for Nutrition
@nutritionorg
3 years
Sugar-sweetened beverages or artificially sweetened beverages: Is there a better choice when it comes to breast cancer risk?
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
@AJCNutrition Editorial by me, Frank Hu, and Clemens Wittenbecher comments on mis-suse of systematic reviews/meta-analyses in nutrition research and where improvements can and must be made. 1/
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 years
I enjoyed writing a For Debate perspective for @diabetologia in defense of *Systematic Reviews and Meta-Analyses*. Their place atop evidence hierarchies is questionable and the method is far from perfect. So why should we continue to publish them?
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
Why anecdotes are not data: When you say "my patients did amazingly well with this diet" All I hear is "8 dentists reccomend Crest toothpaste " Denominators matter. A lot.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
A few words of caution for those who debate the causes of obesity using food/nutrient time trend data... Firstly, total population level availability data, like sugar in the 20th century, say nothing about how sugar is being consumed.
@DoctorTro
DoctorTro
@DoctorTro
3 years
Need to bring this out again
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
Commentary I wrote w/ @Riudecanyenc just published in @NatureMedicine on some methodological issues to consider in causal interpretation of Mendelian randomization & dietary exposures. Thread later this week but please read and share in the meantime ✌️
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
5 years
Below are the familiar overweight and obesity prevalence trends for US adults. See the inflection point at mid-1970s? Accepted hypothesis: Obesity epidemic not due to change in genetics. My wild hypothesis: ALSO NOT DUE TO A SUDDEN COLLECTIVE ABANDONMENT OF WILLPOWER.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
17/ I came into this project genuinely unattached to any outcome. These data are very clear. Women with higher LDL, regardless of so many other metabolic traits and factors, were more likely to die during follow-up.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
9 months
Although it's been said, many times, many ways: Case series of Diet X for change in some health intermediate (weight, lipids, etc.) aren't useful to anyone but the individual. No denominator. No comparator. No causal inference. No public health gains.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
If you think epi methods are some done-deal established set of tools finalized in a text book somewhere, you would be wrong. There is SO much methods work to be done, especially for nutrition science. It just doesn't get funded. better methods = better science = better health
@EpiEllie
Dr Ellie Murray, ScD
@EpiEllie
3 years
@PWGTennant @NoahHaber @pablogerbas @MariaGlymour @harlingg @elliecaniglia My kingdom for a hard-money funded epidemiologic methods institute!!
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
1 year
@AdamPrihoda Relevant opinions are welcome but your ugly language is not 👎
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
@statsepi Was kinda looking forward to it tbh
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 years
It's getter harder to blame obesity epidemic exclusively on our passive existence in an obesogenic environment. The crap food environment clearly evolved to tap into something biological, not just societal/economic.
@MichelleCardel
Michelle Cardel, PhD, MS, RD
@MichelleCardel
2 years
Double-blind, randomized, placebo-controlled trial, adolescents (n=201) w #obesity randomized to receive weekly subcutaneous semaglutide (2.4 mg) or placebo for 68w, plus lifestyle program. #BMI change at wk 68 was −16.1% w semaglutide & 0.6% w placebo.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
I say this with love: Free-living diet/lifestyle intervention trials are observational cohorts with lipstick on.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 years
*Clinicians* and *public health* often use different tools to address a common problem. Let's say a building was on fire 🔥 One quickly puts out fire with water. One investigates & improves electrical wiring standards. We want both tools. Both are good. Remember this.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 years
And the big kicker -- only 8% of US adults report ever having attempted to follow its dietary guidance. LESS THAN 10% HAVE TRIED TO FOLLOW THE DIETARY GUIDELINES. And if we're convinced pts over estimate their healthiness, then 8% is likely an OVERestimate. 🍽️6
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Deirdre Tobias, ScD
@deirdre_tobias
8 months
Open data has many upsides, but access w/o prerequisites sparked a concerning trend in retraction-worthy analysis errors. Glad to see the original trialists point out the glaring mistakes in this mss using their data, but that doesn’t always happen and is prob too late anyway.
@KevinH_PhD
Kevin Hall
@KevinH_PhD
8 months
A paper by @AdrianSotoMota @nicknorwitz @davidludwigmd et al. reanalyzed data from our previous study, claiming to have invalidated our primary findings, & concluding that our data support the carbohydrate-insulin model (CIM) of obesity. Our response:
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
A handful of requests for posthoc redefinition of "metabolically healthy" -- to define a healthy hba1c as <5.5 instead of 6.5%. Here. Stratified on "met healthy". LDL & all-cause mortality. Crude incident rates & fully adjusted HRs. Interpret as you will. In the folder.
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@foodbeforepills
Food Before Pills
@foodbeforepills
3 years
@DukeRamze @deirdre_tobias Genuinely curious. Can someone run the data on pop hBA1c below 5.6? Most doc would agree that above 5.7 is unhealthy. If I read the results as it stands, it tells me "high LDL in an unhealthy pre-diabetic population" is not a good thing.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
Found the missing chamber under the food pyramid that holds all the secrets to diet and health but I'm not telling where it is even though I'm dedicating my life's work to reversing the obesity epidemic w/o personal financial gain b/c I'm an establishment researcher.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 months
Seems legit.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
4 years
Reminder: The gap that your research question is addressing is what makes your manuscript "a novel contribution to the field", NOT the results.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 years
Let me first remind you of "Is everything we eat associated with cancer? A systematic cookbook review" and its scathing illustration published a decade ago now by Prof Ioannidis. Take-away: Everything is good. Everything is bad. Nutritional epi get your act together. Noted.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
5 months
THE most impactful proponent of Mendelian randomization methods has pumped the breaks, acknowledging his concerns that MR can generate spurious relationships & overstated causal conclusions, especially in nonlinear associations. TLDR: 🤌obesity still not protective for mortality
@mendel_random
george davey smith
@mendel_random
5 months
1/n In 2019 @BMJ_latest published a non-linear Mendelian randomization (NLMR) paper with the conclusion that gaining weight would reduce mortality risk in many people. The NLMR method produces spurious findings MR's credibility calamity in this 🧵
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
1 year
Chandler’s genome didn’t change. The environment did. So it’s environment. But Chandler gained less than many of his peers over that same time period, despite living in the same city, education, and job status. So it’s his genetics. It’s both.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
2 years
Old Navy marketing intern: Ok hear me out…
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Deirdre Tobias, ScD
@deirdre_tobias
3 years
All ask is that your dietary exposure is a well-defined dose-response isocaloric substitution with a distribution representative of actual intake in the population ascertained via repeated diet assessments validated against objective biomarkers, why is this so hard?
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
3 years
Friendly reminder that it's fine to eat fruit, in case you were questioning that.
@sguyenet
Stephan J. Guyenet
@sguyenet
3 years
Not going to pick on anyone in particular here, but it's a misconception that fruit were only available for a brief period of the year, historically.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
9 months
I'm hiring a postdoc in 'omics & obesity epidemiology! A strong analytic skillset is desirable. Come join our #NCI funded research @MeDOCResearch investigating the role of obesity in cancer @BWHDPM in Boston!❤️ Link to apply:
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
1 year
You cannot be a nutrition scientist without knowing who Dr. Willett is -- a true pillar of nutritional epidemiology. Definitely adding this episode to my To-Do list:
@theproof
Simon Hill MSc, BSc (Hons)
@theproof
1 year
My conversation with Walter Willett, PhD is now out. Was an honour to sit down with him in Boston a few weeks ago. Mastering the Art of Healthy Eating: Diet Tips and Nutrition Research |... via @YouTube
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
1 year
A gene-environment interaction is exactly how we can see massive population shifts in BMI over time due to environmental changes, and still explain statistical heterogeneity and heritability with genetics.
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
1 year
I made it through without a GIF @Dr__Guess
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@deirdre_tobias
Deirdre Tobias, ScD
@deirdre_tobias
5 months
What an inspiring week of Precision Nutrition science in beautiful Copenhagen 🇩🇰 It was great seeing many old friends and current colleagues in person
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@MartaGuasch1
Marta Guasch, PhD
@MartaGuasch1
5 months
We are starting the #PNF2024 , stay tuned!!!
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