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John Speakman Profile
John Speakman

@JohnSpeakman4

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Scientist working in China and the UK. Studies energy balance: esp #obesity and #ageing . Likes #photography #wildlifephotography . Co-EiC: @lifemetabolism2

Shenzhen, Beijing and Aberdeen
Joined July 2016
Don't wanna be here? Send us removal request.
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@JohnSpeakman4
John Speakman
1 year
Red whiskered bulbul (Pycnonotus jocosus) shenzhen. May 2023.
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@JohnSpeakman4
John Speakman
4 years
One thing I hate is when you have a really great idea. But then someone steals it and publishes it in 1995.
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@JohnSpeakman4
John Speakman
2 years
Everyone has heard of people who are extremely lean and seem able to eat what they want because they burn it all off. We have now characterized the lifestyles and metabolism of underweight people @Cell_Metabolism The results are unexpected 1/n
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@JohnSpeakman4
John Speakman
4 years
Recent reviewer comment. A high proportion (35%) of the cited papers in this manuscript are from before 2010. Call me old fashioned but isn't it better to cite the first person who described something than the last person to repeat it.
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@JohnSpeakman4
John Speakman
5 years
Some advice for PhD students. Pick your favourite scientist. The person you think is the best in your field. Know this. They get their grants rejected. They also get their papers rejected. When it happens to you, all you are doing is following their footsteps.
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@JohnSpeakman4
John Speakman
5 years
I don't think there is a shred of evidence that fat shaming reduces obesity. But even if it did, even if it was super effective. even if there were 10 RCTs and a meta-analysis, I still don't think it is justified. There are some things as decent human beings we just shouldn't do.
@GMB
Good Morning Britain
5 years
@piersmorgan @susannareid100 @CharlotteHawkns ‘The more we fat-shame, the more people will keep their mouths shut and stop overeating’ - @dannilevyfit Can fat-shaming help cure obesity? @piersmorgan | @susannareid100 | #GMB
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@JohnSpeakman4
John Speakman
5 years
It's nice to see this in @nature . But dont get misled. @nature will never ever publish your replication study. Ever. No matter how important they say doing this is. They will not even review it. Ever.
@NaturePortfolio
Nature Portfolio
5 years
Editorial: Replication studies are important. But publishing this work is not always a priority for researchers, funders or editors — something that must change.
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@JohnSpeakman4
John Speakman
2 years
@Nature Nature has a board of 38 editors. How many of those have degrees from universities in the Global South? Zero.
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@JohnSpeakman4
John Speakman
2 years
At the moment however it seems that this phenotype is an urban myth 9/9
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@JohnSpeakman4
John Speakman
2 months
Watching the all Ireland hurling final for the first time ever and its the most exciting sports event I ever saw. Super exciting and full of bits of minor violence and not one person rolling on the floor with a fake injury. Even the referee got blood drawn!
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@JohnSpeakman4
John Speakman
5 years
The truth about eggs and health.... Given the confusion about eggs and health I searched the internet for the definitive answer. here it is.....
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@JohnSpeakman4
John Speakman
5 years
scientist: Fat in diets makes mice fat. twitter: Ha. We can ignore that then. Don't you know mice arn't little humans. They tell us nothing about human nutrition. also scientist: Keto diets stop mice getting flu also twitter: I knew it. Such a great study.
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@JohnSpeakman4
John Speakman
3 years
Friday the 13th is supposed to be really unlucky….except of course when it’s the day @ScienceMagazine choose to publish your paper. Out in print today.. here are the main points. Daily energy expenditure through the human life course | Science ()
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@JohnSpeakman4
John Speakman
1 year
Very happy to distribute here the latest paper from the @IAEANA DLW database published in @NatMetabolism which concerns the decline in energy expenditure over the last 3-4 decades in the USA and Europe. 1/
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@JohnSpeakman4
John Speakman
2 years
In Shenzhen they have a park called the Talent Park where they have statues of famous scientists like Newton, Darwin et al. Plus they have a bridge with poles on it celebrating lesser scientists who have contributed to Shenzhen. Last night I got my pole!!!
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@JohnSpeakman4
John Speakman
2 years
@ProfKarolSikora If there was an injection available to cure cancer would you have the same attitude. That it undermines personal responsibility, and send the wrong message? For info, cancer and obesity have about the same balance of genetic and environmental causality.
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@JohnSpeakman4
John Speakman
6 years
Great news. My lab just voted for me to renegotiate with Nature about that paper they rejected. They have outlined what they don't like about the rejection and given me a clear mandate to go back and let Nature know what we need them to do. They voted 7 to 5 against no acceptance
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@JohnSpeakman4
John Speakman
6 years
I admire the fact that you lost a lot of personal weight. But its a mistake to think that in so doing you simultaneously became an expert in nutrition and medical science. Sugar is NOT every bit as deadly as tobacco.
@tom_watson
Tom Watson
6 years
Refined sugar can be every bit as deadly as tobacco. We banned tobacco adverts and changed the packaging regulations. Now we need to change the culture around sugary cereals to deal with the twin obesity and dental crisis. #getthatmonkeyoffourpacks
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@JohnSpeakman4
John Speakman
1 year
Who would have guessed that the most populous country on earth would also have the most people living with diabetes. Also note they have the most people without diabetes as well at 1.3 billion. low meat, high carb, high seed oil for the win?
@SBakerMD
Dr Shawn Baker 🥩
1 year
India, the most diabetics in the world, just crossed the 100 million diabetics threshold!! Low meat, high carb, high seed oil diet!!
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@JohnSpeakman4
John Speakman
4 years
Thanks for your views. I give lots of talks on obesity and I would say at about 50% of them the 'isn't it just willpower' question arises. Generally the people asking are slim and have deluded themselves into thinking their body weight is a result of their superior willpower 1/3
@matthewsyed
Matthew Syed
4 years
Here I say that some obese people could lose weight with willpower - more exercise, less food. I explicitly exclude those with thyroid & other conditions. That this has caused offence underlines my point: we've seen a collapse in individual responsibility
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@JohnSpeakman4
John Speakman
4 years
hahaha..when Fox news do Science. check out the Y-axis
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@JohnSpeakman4
John Speakman
5 years
Cancer scientist: we found some things related to cancer. Public : oooo.. you're so clever Nutrition scientist: we found some things controlling body weight Public: don’t give me that shit. Obesity is caused by ….(insert idea here) as detailed in the tweets I just read
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@JohnSpeakman4
John Speakman
2 years
in case you want to bookmark for future reference, here are the links to the three days of streamed content for the #RScausesobesity meeting. day one day two and day three
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@JohnSpeakman4
John Speakman
3 years
So much of the discussion on nutrition twitter revolves around good and bad foods. is meat good or bad, are eggs good or bad..blah blah. Here is an idea. There are NO good or bad foods. Just good or bad quantities.
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@JohnSpeakman4
John Speakman
1 year
Today my son and his wife both picked up their PhDs at the University of Edinburgh in the stunning McEwan hall. And I couldn't be more happy or proud.
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@JohnSpeakman4
John Speakman
2 years
Second surprise was that they ate about 12% less than the normal people. We may think they can eat whatever they want, but it seems what they actually want is less than what normal people want. 5/n
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@JohnSpeakman4
John Speakman
6 years
Did you know fast food restaurant meal servings on average have about 30% less calories than meals at full service restaurants - across the globe. Our latest work now out at @bmj_latest
@bmj_latest
The BMJ
6 years
Calories in popular restaurant chain meals are “excessive” and this is a global problem, not confined to the US, finds new research #XmasBMJ @JMHNRCA @johnspeakman4
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@JohnSpeakman4
John Speakman
5 years
Carbohydrate insulin model makes 5 predictions. We tested IN MICE. Two partially supported (and hence partially not supported). Other three were not supported. We conclude the CIM does not explain the impact of dietary macronutrients on adiposity in mice.
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@JohnSpeakman4
John Speakman
2 years
Very happy to have been inducted today (unfortunately in absentia) to the US National Academy of Sciences. Many thanks to my groups in the UK and China, past and present, who make this sort of accolade possible.
@theNASciences
National Academy of Sciences
2 years
In recognition of his contributions to energetics, John R. Speakman of the Chinese Academy of Sciences is being inducted into the National Academy of Sciences. Watch the #NAS159 livestream:
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@JohnSpeakman4
John Speakman
2 years
Delighted to announce on behalf of myself and co-organisers @KevinH_PhD David Allison and Thorkild Sorensen that the talks for the RS causes of obesity meeting are now online as individual talks you can access on youtube. Go to the site to get access
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@JohnSpeakman4
John Speakman
2 years
I don't
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@JohnSpeakman4
John Speakman
4 years
On Monday I was elected to the US National Academy of Sciences. I just want to say thanks to the people who nominated me, the people who have said congratulations, and most of all to my amazing groups in Aberdeen and Beijing past and present that made it possible. THANKS
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@JohnSpeakman4
John Speakman
3 years
I will shortly have a PhD position available in my shenzhen lab. If you are interested to work on a 'fatally flawed paradigm that has derailed obesity science' then this is the opportunity for you. contact me via email j.speakman @abdn .ac.uk with CV if interested.
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@JohnSpeakman4
John Speakman
3 years
For those of you asking why this recent @ScienceMagazine paper on metabolic rate through the lifecourse with @HermanPontzer and many others wasn't open access I'm very glad to say it now is. You can get it here for free.
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@JohnSpeakman4
John Speakman
3 years
Six years ago we published a paper in @ScienceMagazine on the remarkable low metabolism of the giant panda. Now we extended this work in an interesting way... full story follows.
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@JohnSpeakman4
John Speakman
11 months
Very happy to be awarded the Dale medal from the Society for Endocrinology today and present our work on very low protein diets. #SfEBES2023 Many thanks to all my group who make this sort of thing possible.
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@JohnSpeakman4
John Speakman
4 years
Want to know the cause of obesity? Very happy to announce the Royal society is hosting a meeting of 24 world experts on 15-17th February 2021 to explore different ideas. Organised by @johnspeakman4 @KevinH_PhD David allison and Torkild Sorensen. Free to register and attend.1/n
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@JohnSpeakman4
John Speakman
1 year
We are currently expending about 220 kcal/d less for males and 122 kcal/d less for females than people of our age and body composition were in the late 1980s. These changes are sufficient to explain the obesity epidemic in the USA. @KevinH_PhD 7/
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@JohnSpeakman4
John Speakman
2 years
I dont understand the referee/editor critique that 'this study is just an incremental advance'. That's literally how the best science works. Building slowly on solid foundations.
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@JohnSpeakman4
John Speakman
2 years
GENETICS and OBESITY. I heard a lot recently about how genes can’t change in 60 years. If you envision this as gene mutations happening and then spreading then its true. But there are other mechanisms by which allele frequencies can change. And they can happen rapidly. 1/
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@JohnSpeakman4
John Speakman
4 years
In fact people with obesity often show enormous willpower to overcome these physiological drives. Something that people who were lucky in the genetic lottery (probably like you) never have to do. Your willpower is not superior to theirs. 4/3
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@JohnSpeakman4
John Speakman
5 years
Interesting that in the big lancet study on deaths due to bad diet the diets causing the lowest mortality were 'high in red meat' = lowest mortality! and 'high in sugar sweetened beverages' = 4th from lowest. Yet all the focus in reports was on increasing veg and fruit?
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@JohnSpeakman4
John Speakman
2 years
We also measured their resting metabolic rates. Third, surprise was they had much higher metabolic rates than predicted from their body composition and that was associated with elevated levels of circulating thyroid hormones, particularly T3, T4 and fT4. 6/n
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@JohnSpeakman4
John Speakman
2 years
Short review on the impacts of different macronutrients on appetite, intake and adiposity.
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@JohnSpeakman4
John Speakman
2 years
Interestingly despite being less active they had lower TGs, higher HDL and lower LDL, suggesting being lean trumps activity for biomarkers of heart health. Or their diet helped both the leanness and the lipid profile 7/n
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@JohnSpeakman4
John Speakman
10 months
Thats good. Our recent paper in Nature metabolism (link below) shows body temperature likely a key indicator for lifespan extension. Would be better to know your 24h profile than a point measure though.
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@JohnSpeakman4
John Speakman
4 years
@NatureNews For some reason I'm not getting a big rush of joy at this announcement. It doesn't seem a big win for Open access science.
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@JohnSpeakman4
John Speakman
4 years
@prizzotweet Why is someone so young as you even asking. This is my ex-student Ian (John) Forsyth. He graduated his PhD in 2012 aged 82. Sixty years after getting his BSc.
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@JohnSpeakman4
John Speakman
2 years
Obesity is currently costing the US alone 210Bn$ a year. If the US gov invested ten billion dollars on research to work out why it happens and how to solve it, and that work halved its costs - that investment would pay itself back in just over month. #RScausesobesity
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@JohnSpeakman4
John Speakman
5 years
Breakfast IS the most important meal of the day... if you are a cereal manufacturer.
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@JohnSpeakman4
John Speakman
1 year
@kevinnbass China did though - a lot. Not on your chart.
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@JohnSpeakman4
John Speakman
4 years
well that's something interesting I didn't know. Mitochondria can migrate between cells... @Cell_Metabolism !
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@JohnSpeakman4
John Speakman
3 years
@davidasinclair I think you missed out 'if you are a mouse'. Correct me if I am wrong but there is no incontrovertible proof in humans.
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@JohnSpeakman4
John Speakman
2 years
Such a great pleasure to organise this special issue of Molecular metabolism with Christoffer Clemmensen. 1/
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@JohnSpeakman4
John Speakman
5 years
Elsevier: someone has sent us a book proposal. It's 5 pages long. Will you review it for us? Me: Elsevier made 9.8 Bn dollars profit last year, some of it charging me to publish papers. Will you be paying me for this book review service? 2 weeks later - still waiting for reply.
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@JohnSpeakman4
John Speakman
4 years
I am a native English speaker who moved to China 9 years ago. As soon as I started publishing papers with lists of Chinese students as authors I started to get comments from reviewers that my English was poor and would benefit from being proofread by a native speaker.
@JohannesTextor
Johannes Textor
4 years
Are native English speakers privileged in academia?
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@JohnSpeakman4
John Speakman
2 years
First surprise was they were not highly active. In fact their activity measured by accelerometry was about 23% less than people with normal BMI. This was true in both males and females. Their activity was lower throughout the whole day. 3/n
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@JohnSpeakman4
John Speakman
4 years
It is well established that obesity is driven by elevated appetite mostly down to genetics expressed in an obesogenic environment. Your appetite at 5pm is probably what a person with obesity deals with all the time. 3/3
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@JohnSpeakman4
John Speakman
5 years
wow...very pleased and honored to have been awarded the Osborne and Mendel basic research award from the American Nutrition Society!! Thanks to all my group past and present for making it possible.
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@JohnSpeakman4
John Speakman
2 years
Of course its still possible there are people that have the super thin phenotype that got there by eating what normal folks eat and then burning it off with excessive exercise. Just none of the people who volunteered for our study came anywhere near to that phenotype. 8/n
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@JohnSpeakman4
John Speakman
5 years
@ramencult more importantly why are they still using POUNDS..! what is this medicine update for the year1742? Get some SI units in your life.
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@JohnSpeakman4
John Speakman
4 years
Remember the show 'The biggest loser'? Ethically questionable but if there was an inverse show called 'The biggest gainer' - what strategies would you advise the contestants use to gain body fat? Should be easy right? I'll start. I don't think the winner will be eating fruit.
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@JohnSpeakman4
John Speakman
6 years
Did you know under food restriction the gut gets larger? Our review paper on how food supply and changes in energy demand are related to growth of the alimentary tract is now out at obesity reviews.. enjoy
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@JohnSpeakman4
John Speakman
6 years
how about calling it that failed model that fits almost none of the data but was heavily promoted by a group of people with no nutrition training who wrote a ton of books on it for the public theory.....
@DoctorTro
DoctorTro
6 years
Let’s stop calling it the carbohydrate-insulin model (CIM), let’s call it the hormonally driven model for obesity. Insulin Adiponectin Inflammation Cortisol Thyroid Leptin Grehlin NPYY NPY CCK Henceforth, I present to you the HDM...
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@JohnSpeakman4
John Speakman
2 years
Live cold, die old. Our paper in @NatMetabolism last month on how hot body temperatures shorten lifespan in mice and hamsters has been the subject of a @NatureAging highlight. Thanks to Anna Kriebs for writing it.
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@JohnSpeakman4
John Speakman
1 year
Last october @KevinH_PhD David Allison, Thorkild Sorensen and I organised a 'causes of obesity' meeting at the Royal Society in London. The discussion and debate prompted us to write this article in @ScienceMagazine about 'unanswered questions'.
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@JohnSpeakman4
John Speakman
6 years
@MrsSasser the very first lecture I gave (physiology) I ended with 'any questions?' an older guy at the front said 'yes, last summer I was sailing on the west coast and two basking sharks swam past. where were they going?' . I didn't ask again for 2 years!
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@JohnSpeakman4
John Speakman
3 years
I finally started to read 'Sapiens'. Already on page 3 I'm disappointed. It says a single ape 6 million years ago had two daughters one of whom was the ancestor all humans and the other the ancestor of all chimpanzees. Really? I'm pretty sure that's not how evolution works.
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@JohnSpeakman4
John Speakman
5 years
Hey twitter. This is Emem Udoh. Today she did her PhD viva and she passed. Hooray! But because of the virus we cant celebrate it with our usual group cake/champagne. She isnt on twitter - but please consider sending her an email to say "congrats on your PhD". e.udoh @abdn .ac.uk
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@JohnSpeakman4
John Speakman
3 years
Very happy today to be among the prize winners for the best papers published in 2021 in the Institute end of year ceremony - for our paper in Science @HermanPontzer
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@JohnSpeakman4
John Speakman
7 months
check out our latest work here. key points. mice increase their food intake before gaining weight disproving the reverse causality idea. Plus they eat much more than expected from passive overconsumption. hedonic overdrive fits these data best.
@ObesitySociety
The Obesity Society
7 months
HOT OFF THE PRESS @johnspeakman4  et al. tested 3 models of why mice experience high-fat diet-induced obesity. Using 240 mice exposed to 12 high-fat diets, they found the hedonic overdrive model fits the data best compared to passive overconsumption and reverse causality.
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@JohnSpeakman4
John Speakman
2 years
amazing first day at the causes of obesity meeting at the RS in london. Here are the speakers at the speakers dinner this evening.
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@JohnSpeakman4
John Speakman
5 years
I got to thinking about all these keto bods and the need to peel off your shirt to show how good your diet is. Yet I cant help thinking a massive confound here is going to the gym. So is there anyone out there who has just done keto without gym work? If so show us your pecs mate
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@JohnSpeakman4
John Speakman
6 years
Our new review on genetics of physical activity "Genetic factors associated with human physical activity: Are your genes too tight to prevent you exercising?", has just been accepted in Endocrinology. Main message is PA has high heritability, but no so much you cant intervene.
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@JohnSpeakman4
John Speakman
1 year
Ever speculated on why Japanese people may be so thin. here is me yesterday with a main course chicken and chips.
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@JohnSpeakman4
John Speakman
4 years
I have been offline for 7 days with no home internet and hence no twitter - moving house. In the meantime it was announced I won the TOPS award from the obesity society. Thanks everyone for your kind comments and congratulations. Sorry for delay in acknowledging!
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@JohnSpeakman4
John Speakman
1 year
This past weekend my son and daughter-in-law celebrated their marriage with a traditional ceremony in China.
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@JohnSpeakman4
John Speakman
2 years
You don't see this very often. Me in a suit and tie....! out to dinner at the Leverhulme Trust this evening. Now back at the RS preparing my talk for tomorrow. is 70 slides too many for 15 mins I wonder?? #RScausesobesity
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@JohnSpeakman4
John Speakman
10 months
Thanks to my lab for the surprise birthday cake containing more calories than I dare to count...
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@JohnSpeakman4
John Speakman
4 years
Look at this almost a perfect correlation. Except China. oh and Argentina. and the UK. and all the European countries. But otherwise its almost r = 1.0, or 0.1 close anyway to being somewhere between 0 and nearly not 0, so that completely proves it.
@drcateshanahan
Cate Shanahan, MD
4 years
Vegetable oil kills. The most common high PUFA oil is soy. Worldwide equation: Soy oil consumption = high COVID-19 death rate. Very little of either in Africa & S America besides Brazil. (China is an outlier unless consumption/infection by province correlates better) #FATBURNfix
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@JohnSpeakman4
John Speakman
2 years
By measuring their Total energy expenditure using Doubly-labelled water and their weight change in the measurement period we could objectively measure their food intake averaged over a period of 2 weeks. 4/n
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@JohnSpeakman4
John Speakman
2 years
Just 5 days until the Causes of obesity meeting in London @royalsociety organised by @KevinH_PhD David Allison, Thorkild Sorensen and myself. I am really excited about the meeting and cant wait for it to start. You can still join us in person or online.
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@JohnSpeakman4
John Speakman
4 years
so here is a little obesity-willpower experiment you can do. Tomorrow when you get up skip your breakfast. Then skip your lunch. Then around 5pm lets think about how great your willpower is to overcome your appetite. 2/3
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@JohnSpeakman4
John Speakman
4 years
The classic interpretation of the effects of caloric restriction on lifespan is the disposable soma hypothesis. In this perspective I propose a novel idea that I have called the 'clean cupboards' hypothesis. Read it here. Very happy to have comments.
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@JohnSpeakman4
John Speakman
6 years
Here is my signature in the @royalsociety charter book along with most of the 'class of 2018'. Great culmination to an amazing 3 days. Glad I didnt blot the velum or fall off the stage. Incredible to be listed in the same book as Darwin and Newton.
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@JohnSpeakman4
John Speakman
5 years
@charliekirk11 to have a correlation you need two variables.
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@JohnSpeakman4
John Speakman
2 years
but wait... since 1993. number of dentists up 30% obesity up 90%
@kevinstock12
Kevin Stock, DDS
2 years
Over the last 50 years: • Red meat consumption down 40% • Obesity up 300%
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@JohnSpeakman4
John Speakman
2 years
Since I am in London I popped down to downing street this pm to see if any jobs were on offer. I mean the bar seems to have dropped so low you never know what could happen.
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@JohnSpeakman4
John Speakman
2 years
We recruited 150 people with BMI <18.5 living in Beijing, and compared them to 173 normal weight individuals (BMI 21.5 to 25). We screened out people with eating disorders, those living with HIV and individuals who had lost weight due to prior disease. 2/n
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@JohnSpeakman4
John Speakman
5 years
@JamesMelville for me this is exactly what sums it up...
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@JohnSpeakman4
John Speakman
18 days
Back in April I should have attended the APS summit in LA to get the Solomon Berson award. But due to some visa issues I couldn't attend. Today it arrived in the post. Its very nice and weighs a ton. Many thanks to the APS for choosing me.
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@JohnSpeakman4
John Speakman
1 year
@kevinnbass I think what you mean is it doesn't fit your narrative, so you are going to call it unreliable. If you had lived it, been tested everyday for months on end, locked down if a case within 1 km, you would be less dismissive.
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@JohnSpeakman4
John Speakman
2 years
Our paper from the IAEA DLW database on effects of ambient temperature changes on human energy expenditure is now online at @iScience . Here is some background on the study, what we found and its implications. 1/16
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@JohnSpeakman4
John Speakman
2 years
Today is thanksgiving – and not coming from the US I am mostly giving thanks for our paper in Science published today on human water turnover. 1/ Variation in human water turnover associated with environmental and lifestyle factors | Science 10.1126/science.abm8668.
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@JohnSpeakman4
John Speakman
1 year
The first batch of papers from the causes of obesity meeting held in London last year will be released on Monday. Second batch coming in oct/nov. @KevinH_PhD
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