Dan Tyrrell @danis1337 Twitter profile

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Dan Tyrrell

@danis1337

2 years

Currently reviewing a manuscript that was submitted in landscape orientation

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Dan Tyrrell

@danis1337

4 years

Just paid off my last student loan. Peace out 2020 ✌️ see ya never

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Dan Tyrrell

@danis1337

8 months

I write comments to myself on grant apps and manuscripts. does everyone do this?

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Dan Tyrrell

@danis1337

2 years

Okay! Here it is! all 15 years of the K99/R00 grant mechanism (2007-2022). Only K99s that successfully transferred to R00. File is too large for Twitter. I have a zoom-in-able SVG on my lab website: @biorxivpreprint :

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Dan Tyrrell

@danis1337

8 months

Excited to finally share this final product! Analysis of NIH K99/R00 awards and the career progression of awardees There is bias in faculty hiring networks! bottom line.

Analysis of NIH K99/R00 awards and the career progression of awardees

There is a significant disadvantage to receive a major grant (i.e., R01) for K99/R00 awardees that are women, those at lower funded institutions, and those with lower career mobility.

elifesciences.org

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Dan Tyrrell

@danis1337

2 years

I wanted a better way to show physical location of K99s (more coastal) are versus where R00s are (more distributed), so I plotted the data onto maps. This is from 2007-2022.

Dan Tyrrell

@danis1337

2 years

Okay! Here it is! all 15 years of the K99/R00 grant mechanism (2007-2022). Only K99s that successfully transferred to R00. File is too large for Twitter. I have a zoom-in-able SVG on my lab website: @biorxivpreprint :

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Dan Tyrrell

@danis1337

4 years

As a 4th year post-doc, I’m getting extremely worried about all of the hiring freezes around th country. For post-docs planning to look for jobs next year, what are you doing? Delay? Try anyway? #AcademicTwitter #AcademicChatter @AcademicChatter

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Dan Tyrrell

@danis1337

2 years

BTW, there was a 20.4% retention rate out of the 251 K99 in 2021 that transitioned to R00 in 2022, meaning 79.6% of postdocs packed their bags and left. Disclosure: I am in this dataset

Dan Tyrrell

@danis1337

2 years

Whole dataset with fixed colors. 2021 K99 to 2022 R00 holders. alphabetical for K99 institution

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Dan Tyrrell

@danis1337

5 years

It appears I’m the only person in the lab today. 🔬There is a lot of talk about toxic lab environments, but I really love what I do which is why I’m working today. The alternative is to be at home alone with the in-laws 😉 @AcademicChatter #AcademicChatter

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Dan Tyrrell

@danis1337

3 years

Super excited to announce that I’ll be joining @UABHeersink 🐉 and starting my lab in @UABPathology this summer! Focusing on vascular and immune mechanisms of neurodegeneration (also mitochondria 😅) DM or email if interested. Pls RT 😄

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Dan Tyrrell

@danis1337

3 years

Super excited to receive the notice of award for a K99/R00 from NIA today! I can’t thank my many amazing mentors, advisors, and referees enough! Guess what!? Its on aging and mitochondria and blood vessels and BRAINS 🧠

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Dan Tyrrell

@danis1337

3 years

@astrojessiem @AprajitaTripat5 My kid’s daycare teacher often dyed her hair various colors and told the kids it changed due to the fruit she ate 🍉 🍏 🍌 I thought that was very cool

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Dan Tyrrell

@danis1337

3 years

Negative data is data too. Just putting it out there.

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Dan Tyrrell

@danis1337

4 years

Got news that my paper was accepted today. Now to celebrate 🎉 🍻 by going through in detail with my wife and family. She’ll be thrilled and I’m sure the 3-yo will love it too. 🥰🤩🥳

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Dan Tyrrell

@danis1337

1 year

Sooo first PhD student signed to join my lab. This is getting real. Feeling very happy and some other feeling similar to grateful but mixed with nervousness. He already figured out flow!!!

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Dan Tyrrell

@danis1337

4 years

What is more satisfying than shooting a pippette tip into the trash?

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Dan Tyrrell

@danis1337

2 years

Took a look at the % of K99/R00 recipients that get an R01 and the time it took to get an R01 by those that stayed at the same institution for the K99/R00 versus those that moved to a new institution for the R00. Notice the pie charts look…similar

Dan Tyrrell

@danis1337

2 years

Okay! Here it is! all 15 years of the K99/R00 grant mechanism (2007-2022). Only K99s that successfully transferred to R00. File is too large for Twitter. I have a zoom-in-able SVG on my lab website: @biorxivpreprint :

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Dan Tyrrell

@danis1337

3 years

As a kid I was very concerned that the sun was going to burn out in 5 billion years.

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Dan Tyrrell

@danis1337

1 year

I've never done #fluorescencefriday before, but a technician in my lab (Chase Bolding) took this awesome Lightsheet image of the aortic root/arch this week. @zeiss_micro Zeiss Lighsheet 7. Inspired by @DrEMBahnson and his preprint and his visit to UAB

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Dan Tyrrell

@danis1337

1 year

No K99 award has been made to someone at an HBCU and only 2 R00 awardees have started labs at HBCUs.

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Dan Tyrrell

@danis1337

10 months

Really happy to have this one out in @NatureAging with @Gracedan10_99 @LabGoldstein . T cells change A LOT as you age. Subscription link and free readcube link:

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Dan Tyrrell

@danis1337

2 years

Also interesting in the NIH data are the top institutions that produce people with K99 versus those that recruit people with R00. Producers are who you would expect. Recruiting institutions may surprise (and provide insight into generous recruitment packages)

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Dan Tyrrell

@danis1337

2 years

Super excited to publish this article in @atvbahajournals The proteome in the aging human aorta (healthy and TAA)! With @LabGoldstein @Gracedan10_99 @umichCVC

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Dan Tyrrell

@danis1337

1 year

@NikiWoitowich , @science_SRH , @TaurVil , @JoelBabdor & I have examining biomedical faculty trends/outcomes There is a cumulative disadvantage to get an R01 for K99 awardees that stay at their K99 institution, are women, & are at R00 institutions with small NIH funding portfolios

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Dan Tyrrell

@danis1337

2 years

@BrockMSouth1 Negative. Just long long lines of text

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Dan Tyrrell

@danis1337

4 years

I'm proud of all of my skills

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Dan Tyrrell

@danis1337

4 years

I’m very excited to share this review in @NatRevCardiol where we tried to bring together #vascular and immune mechanisms of how #aging accelerates #atherosclerosis . Check it out 👇

Nature Reviews Cardiology

@NatRevCardiol

4 years

New Review online! Tyrrell and Goldstein discuss vascular intrinsic and extrinsic mechanisms by which #aging promotes #atherosclerosis @Gracedan10_99 @dantyrr @LabGoldstein @umichmedicine @umichCVC

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Dan Tyrrell

@danis1337

2 years

Looking at K99/R00 data a lot (TOO MUCH?) lately and 1 name haunts me! The 1st K99 was awarded to @byneuron at UCSF in 2006/2007 who was recruited by U of Michigan for R00 and has been v successful since. BTW I've updated the preprint. more updates coming:

Analysis of National Institutes of Health K99/R00 Transitions and Outcomes from 2007-2022

Postdoctoral research fellows are highly skilled and trained researchers within the academic biomedical research workforce. Those that aspire to continue academic research careers typically seek...

www.biorxiv.org

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Dan Tyrrell

@danis1337

4 years

3-yo got me good! Me: “you’re the best 3-year old I know” Him: “how old are you?” “32” “How old is mom?” “32” “She’s the best 32-year old I know”

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Dan Tyrrell

@danis1337

2 years

Hey that’s me! I’m excited to start this new position and grateful to all of my supporters, mentors, and new colleagues. View from the office and lab isn’t bad either!

UAB Pathology

@UABPathology

2 years

Daniel Tyrrell, Ph.D., joins the @UABPathology Division of Molecular and Cellular Pathology today as Assistant Professor. Read more: Welcome, Dr. Tyrrell! 🎊

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Dan Tyrrell

@danis1337

4 years

Omg past me labeled all the tubes for today me! Such a nice surprise

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Dan Tyrrell

@danis1337

1 year

Hey that me. Grateful for this support!

Nathan Shock Centers

@NathanShockCtrs

1 year

We are excited to highlight 2022 UAB NSC Pilot Awardee: @dantyrr ! Read his NSC Pilot Awardee Spotlight here: . #AgingResearch @NscUab

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Dan Tyrrell

@danis1337

2 years

Whole dataset with fixed colors. 2021 K99 to 2022 R00 holders. alphabetical for K99 institution

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Dan Tyrrell

@danis1337

9 months

Happy to contribute (a little) to this one just published @jclinicalinvest . Congratulations Jianrui! @LabGoldstein @Gracedan10_99 @LyssiotisLab

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Dan Tyrrell

@danis1337

2 years

Woohooo NOA! It’s only for R00 but still exciting. Especially because “Award of the R00 phase is not automatic” 🤷 😅

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Dan Tyrrell

@danis1337

5 years

Best way to start the weekend! Manuscript accepted! 3-years in the making. #Aging #Mitochondria #VascularBiology Paper should be online next week

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Dan Tyrrell

@danis1337

3 years

Today was the day. I knew this was coming. My 4-yo dropped the f-bomb at daycare. 😭🤐💀

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Dan Tyrrell

@danis1337

7 months

Yo! If you’re outraged about how un-surprising our findings are, you can help. Vote dammit! Congress literally controls most of this. We have a direct role in who gets grants. We review them. Support women, people with less mobility, and those at “less fancy” institutions!

Mike Feigin 🥯

@mike_feigin

7 months

From the “no fucking shit” department.

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Dan Tyrrell

@danis1337

2 years

@Jane_A_Allen Pretty good tbh

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Dan Tyrrell

@danis1337

3 years

If you’re re-using gloves, please don’t put your mouth on them. There’s a better way.

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Dan Tyrrell

@danis1337

2 years

Besides this, I have a basic science lab. We study impact of aging on cardiovascular disease & dementia in murine models. We use scRNAseq and spatial transcriptomics. I'm recruiting postdocs, so please DM or email if interested. I'd love to work with you 😅 we're fun 😁

Dan Tyrrell

@danis1337

2 years

I wanted a better way to show physical location of K99s (more coastal) are versus where R00s are (more distributed), so I plotted the data onto maps. This is from 2007-2022.

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Dan Tyrrell

@danis1337

4 years

I got that good good mRNA in the arm today and now I can’t sleep

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Dan Tyrrell

@danis1337

4 years

Happy to share our paper just published from @Gracedan10_99 & @LabGoldstein : Aging impair mitochondrial function and mitophagy in the cerebral vasculature 🧠🐭 @JAHA_AHA @umichCVC @umichmedicine

Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral...

www.ahajournals.org

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Dan Tyrrell

@danis1337

4 years

@wendy_bickmore As many have said. Post-docs are here and willing to review. If only we were asked.

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Dan Tyrrell

@danis1337

1 year

Histology is crazy. This is paraffin sectioned aortic root. No stain. No antibodies. No washing. Paraffin was is still all over this slide, yet you can see amazing tissue morphology. Have to learn to take advantage of autofluorescence

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Dan Tyrrell

@danis1337

6 months

We’re hiring! Looking for a lab manager! Despite how sterile the job posting is, we are a fun group! Doing cool science!! If interested, apply or send a DM! Plz share thx 🙏

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Dan Tyrrell

@danis1337

2 years

It begins

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Dan Tyrrell

@danis1337

4 years

I really like the days when it winters really hard and I’m the only one I’m the lab. I am an introvert.

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Dan Tyrrell

@danis1337

4 years

@OpenAcademics Mitochondria in the vasculature and how it changes with aging & disease! Mitochondria are thought to arise from Alphaproteobacteria which are animals, so here's my animal pic 🙌

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Dan Tyrrell

@danis1337

2 years

Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier: Neuron

Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier

Ayloo et al. reveal a mechanism of how blood-CNS barriers are actively maintained by the CNS microenvironment. They discovered that a ligand-receptor signaling between pericyte-secreted vitronectin...

www.cell.com

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Dan Tyrrell

@danis1337

4 years

@neubadah The 16 unread emails you leave in your inbox so you don’t forget to respond. For the people with thousands of unread emails I don’t know how you live with yourself. Don’t @ me.

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Dan Tyrrell

@danis1337

4 years

My 1-yr old kid's daycare in Ann Arbor costs more than tuition at Univ. of Michigan

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Dan Tyrrell

@danis1337

2 years

Update on the lab! Our Cytation C10 is set up (spinning disk confocal! 🔬 & fluorescent platereader) & testing flow panels on the core's BD FACSymphony A5 flow cytometer which easily runs our 15(!) color panels! 🤩🤩 This is only the 20X objective😎. We're rolling now

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Dan Tyrrell

@danis1337

2 years

2021 K99 holders who transitioned to R00 in 2022. Showing institutions with highest retention. Full set in next tweet. fixed colors. no particular order

Dan Tyrrell

@danis1337

2 years

For those curious where people with K99 end up for R00 and about retention. I took 2021 K99 holders who transitioned to R00 in 2022. This is a subset of 25 K99 prod. institutions with highest retention. Full set in next tweet. Sorry all "University of" names are same color

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Dan Tyrrell

@danis1337

4 years

What is your most mundane super power?

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Dan Tyrrell

@danis1337

11 months

busy 2 weeks. 2 grants submitted (1st big boy grant). 1 paper accepted. 1 paper submitted.

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Dan Tyrrell

@danis1337

1 year

Men have received more K99 awards every year of since the award mechanism began:

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Dan Tyrrell

@danis1337

2 years

fixed point size in the R00 graph and count scale to be consistent between the 2 for comparison.

Dan Tyrrell

@danis1337

2 years

I wanted a better way to show physical location of K99s (more coastal) are versus where R00s are (more distributed), so I plotted the data onto maps. This is from 2007-2022.

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Dan Tyrrell

@danis1337

2 years

getting there

Dan Tyrrell

@danis1337

2 years

It begins

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Dan Tyrrell

@danis1337

9 months

Proud of this review. Great effort from talented PhD student @Md_Ali_Akkas in the lab and colleagues and friends @RGRunPenguin , Dongli Yang, and @nadia_sutton !

Cardiovascular aging: spotlight on mitochondria | American Journal of Physiology-Heart and Circul...

Mitochondria are cellular organelles critical for ATP production and are particularly relevant to cardiovascular diseases including heart failure, atherosclerosis, ischemia-reperfusion injury, and...

journals.physiology.org

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Dan Tyrrell

@danis1337

4 years

What I’m like when I finally get back in the lab.

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Dan Tyrrell

@danis1337

2 years

@YesHunter Arial. They're shaking things up but they aren't monsters

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Dan Tyrrell

@danis1337

4 years

@Afro_Herper No I cannot. I swear there are only rocks and dust there.

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Dan Tyrrell

@danis1337

2 years

Wow 😳 Nuclear-embedded mitochondrial DNA sequences in 66,083 human genomes | Nature

Nuclear-embedded mitochondrial DNA sequences in 66,083 human genomes

Nature - A study examining DNA transfer from mitochondria to the nucleus using whole-genome sequences from 66,083 people shows that this is an ongoing dynamic process in normal cells with distinct...

www.nature.com

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Dan Tyrrell

@danis1337

3 years

Got this from the daycare today. Guess we have a problem.

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Dan Tyrrell

@danis1337

6 years

Today would have been my dad's 55th birthday He died 5 years ago during a track workout He appeared healthy. 9 months before he died, he won his age group in an Ironman (10:36:17) Even if you are an athlete, you are not immune to #atherosclerosis Get a checkup

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Dan Tyrrell

@danis1337

3 years

If 62% of people are vaccinated in Michigan, why are 100% of people at the grocery store not wearing masks?

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Dan Tyrrell

@danis1337

4 years

Lighter note for today, I'm officially 1 day into my 5th (omg) year of post-doc. Here is one skill I've learned. Not particularly useful. #AcademicChatter @AcademicChatter @OpenAcademics

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Dan Tyrrell

@danis1337

4 years

Goal this year is to do a little better at self-care and I want to read 12 books (excluding audiobooks which I listen to in lab) I started with a ~1200 page banger which is very good. I typically like fantasy/non-fic history but <1200 pg😅 Any recommendations out there?

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Dan Tyrrell

@danis1337

1 year

54% of all K99 awardees were at 10% of institutions. 46% of all R00 awardees were at 10% of institutions. R00 awards are much more geographically dispersed.

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Dan Tyrrell

@danis1337

3 years

The lab has 50mL falcon tubes again and we rejoice

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Dan Tyrrell

@danis1337

3 years

Kid is home from daycare so I’ve got him doing experiments. How many Cheerios can the balloon hold? Cat is is the lab manager

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Dan Tyrrell

@danis1337

5 years

Excited that my abstract for @AHAMeetings Scientific Sessions 2019 was accepted for an oral presentation! Come see what we’ve been doing on Nov 17 (Sunday) at 5:30pm room 126B to hear about how vascular mitochondria change with age and impact atherogenesis. See you at #AHA19 !

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Dan Tyrrell

@danis1337

2 years

On this day, November 14th 2022, our IACUC protocol is approved.

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Dan Tyrrell

@danis1337

1 year

This is v. cool

Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality

Nature Medicine - Organ-specific aging clocks for multiple brain and body systems show that the biological age of one organ system selectively influences the aging of multiple other systems via...

www.nature.com

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Dan Tyrrell

@danis1337

4 years

@jonykipnis Unfortunately this is the behavior that prevents people giving interesting talks at conferences etc for fear of being scooped. Sorry this happened to you.

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Dan Tyrrell

@danis1337

5 years

Excited to share our study out today! 🙌🔬🐭 How #aging links #inflammation to aortic mitochondrial function to accelerate #atherosclerosis in @CircRes @Gracedan10_99 @LabGoldstein @umichCVC @UMMicroImmuno @umichmedicine @UMich #VascularBiology

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Dan Tyrrell

@danis1337

4 years

My kid’s daycare teacher dyes her hair all different colors. She tells the kids it changes based on which fruit she eats. 🍓 🍊 🍏

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Dan Tyrrell

@danis1337

5 years

@ProfCoulson Mugs are good though. Keep those

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Dan Tyrrell

@danis1337

3 years

Woohoo! Exciting. That me. Vascular biologist trying to learn about the brain 🧠

U-M Alzheimer's Disease Center

@umichalzheimers

3 years

The final mentee in our class joins us from @UMIntMed . Dr. @dantyrr 's research investigates the contributions of mitochondria & inflammation on neurodegeneration, and also the role of amyloid beta on atherosclerosis. Welcome, Dr. Tyrrell and our full 2021-2023 mentorship class!

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Dan Tyrrell

@danis1337

7 months

@mike_feigin Pumped that your tweet is giving our paper so much exposure. Bahahah haha. There should be a section for “notable tweets” in academic CVs

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Dan Tyrrell

@danis1337

3 years

Going to conferences in person means you actually attend the sessions Attending conferences virtually means you feel guilty about not working

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Dan Tyrrell

@danis1337

4 years

My kid just dropped something on his toe and started crying and screamed that he needs an ice pack. Guess what he dropped on his foot?

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Dan Tyrrell

@danis1337

2 years

For those curious where people with K99 end up for R00 and about retention. I took 2021 K99 holders who transitioned to R00 in 2022. This is a subset of 25 K99 prod. institutions with highest retention. Full set in next tweet. Sorry all "University of" names are same color

Dan Tyrrell

@danis1337

2 years

Also interesting in the NIH data are the top institutions that produce people with K99 versus those that recruit people with R00. Producers are who you would expect. Recruiting institutions may surprise (and provide insight into generous recruitment packages)

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Dan Tyrrell

@danis1337

4 years

What is the coolest science super hero name? Wizard of white blood cells Lady of leukocytes Master of mass cytometry Queen of qPCR Warrior of western blots Baron of bioinformatics Princess of paraffin

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Dan Tyrrell

@danis1337

2 years

This is why I went into science.

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Dan Tyrrell

@danis1337

2 years

Think some people are misinterpreting this. By "retention" I mean by the same institution that they had the K99 at. Everyone in this list transitioned to an R00 which by default means they landed a faculty job somewhere. 20% stayed at their home institution. 80% went elsewhere

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Dan Tyrrell

@danis1337

3 years

What's a less meaningful GO term than "biological process"?

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Dan Tyrrell

@danis1337

3 years

Sciencing on hard mode

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Dan Tyrrell

@danis1337

5 years

@SenguptaLab @smd_phd I submitted 2 F31’s during the PhD. Both triaged. First one major weakness (in my 2nd year) was that I was too early on in my PhD. 2nd one major weakness (in my 3rd year) was that I was too close to the end. In retrospect, neither was that great but still.

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Dan Tyrrell

@danis1337

8 months

More K99s go to men than women. That has happened every year of the program. The gap may be narrowing in the last 3 years but we'll see.

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Dan Tyrrell

@danis1337

3 years

Next time relatives ask what I do at work

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Dan Tyrrell

@danis1337

2 years

Less than a month in Alabama and I caught my 5-yo saying “How y’all doing today”

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Dan Tyrrell

@danis1337

3 years

Just learned that eggs explode if you microwave them. Don’t ask

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Dan Tyrrell

@danis1337

4 years

@OpenAcademics 1) I’m studying vascular diseases, aging, and mitochondria! 2) 🇺🇸 3) yikes I need to take more pictures. Have a cool insect.

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Dan Tyrrell

@danis1337

3 years

Feast your eyes on this data visualization. Kudos to whoever had this idea. Brilliant.

Nature Aging

@NatureAging

3 years

NEW: During #aging the #immune system undergoes severe changes that impact health in many ways. Here, Krishnarajah et al. provide comprehensive immune cell profiling across twelve tissues from young and old mice. @burkhard_becher @Sindu_krishn @BecherLab

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Dan Tyrrell

@danis1337

4 years

Kids books were a bit different back in the day

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Dan Tyrrell

@danis1337

3 years

When the whole family became sick and tested positive for Covid-19 this week I thought it was inevitable for me also. Still no symptoms and testing negative! Actual footage of my immune system. I hope this tweet ages well

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Dan Tyrrell

@danis1337

2 years

My computer can handle gigabytes of sequencing data, but is brought to it's knees if I try to insert 1 reference through endnote

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Dan Tyrrell

@danis1337

3 years

My 4-yo child just taught me how to say welcome home in German (Willkommen zuhause) 😆

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