RMD Open @bmj_rmdopen Twitter profile

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RMD Open

@bmj_rmdopen

3 months

⭐ Meet the @bmj_rmdopen SoMe editors 📱 ▶️ Cristiana Sieiro Santos ( @cristianasieiro ) is a Consultant Rheumatologist at @ReumaLeon and a clinical researcher at @unileon , Spain 🇪🇸 🔬 Her main research interests are: systemic sclerosis, SLE, pregnancy in RMDs, and #CV risk

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@bmj_rmdopen

13 days

🦶 Forefoot inflammation differences in ACPA-Positive vs Negative #RheumatoidArthritis ACPA(+): • More prevalent & severe inflamed forefoot tissues • Intermetatarsal bursitis associated with swelling & tenderness ACPA(-): • Synovitis associated with MTP joint swelling

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@bmj_rmdopen

23 days

🔬Cancer risk in #Scleroderma 🧬 20% cancer prevalence in SSc patients ⏫ Higher risk in elderly & anti-Ro52 or U3-RNP antibodies 📍 Cancer-associated SSc is linked to the absence of anti-centromere & topoisomerase-1 antibodies 🔓

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RMD Open

@bmj_rmdopen

2 months

⭐ Meet the @bmj_rmdopen SoMe editors 📱 ▶️ Shinji Izuka ( @IzukaShinji ) is a Rheumatologist at the Department of Allergy and Rheumatology, The University of Tokyo, Japan 🇯🇵 🔬 His main research interests are: SLE, myositis, auto-inflammatory disease and translational research

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@bmj_rmdopen

18 days

💻 Predictive model for cardiovascular & cerebrovascular events in #SLE 🔗 Clinical indicators 📌 Disease onset age >40 📌 β2GP1 📌 Smoking 📌 High dose of GC 📌 Male gender 📌 Hypertension 📌 HCQ 📌 Cutaneous 📌 Arthritis 📊 Model showed high accuracy (C index: 0.801) for

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RMD Open

@bmj_rmdopen

2 months

⭐ Meet the @bmj_rmdopen SoMe editors 📱 ▶️ Vincenzo Venerito ( @vincevenerito ) is an Assistant Professor of Rheumatology at the University of Bari, Italy 🇮🇹 🔬 His main research interests are: Spondyloarthritis, AI, Sinovial Histopathology, RA-ILD, Vaccines and Fibromyalgia

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@bmj_rmdopen

25 days

🔍 Real-world data on #LupusNephritis : achieving EULAR/ERA-EDTA therapy targets👥 140 LN Patients. Treatments: 51.4% CYC, 32.1% MMF ✅ 69.2% achieved renal response at 12 months -Response Rates: - 3 months: 72.6% - 6 months: 78.5% - 12 months: 69.2% 🔽 Increased

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RMD Open

@bmj_rmdopen

1 month

🚨 Immune-mediated thrombotic thrombocytopenic purpura and Sjögren’s disease (iTTP-SjD) iTTP-SjD patients vs idiopathic iTTP⤵️ ✅ Diagnosis with Sjögren's at a younger age 🔬 Higher rates of anti-SjS-related antigen A antibody positivity 🔺 Higher rates of xerostomia 💊

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@bmj_rmdopen

12 days

🏥 How to prevent hospitalisations in patients with Chronic Inflammatory Rheumatic Diseases? 🔍 Systematic Screening for Multimorbidities leads to: 👉 50% rise in dispensation of multimorbidity-preventing drugs: 💉Vaccines 🫀Lipid-lowering agents 🦴Antiosteoporotic

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@bmj_rmdopen

24 days

🔍 Persistent synovitis detected by ultrasound can predict #RheumatoidArthrits relapse/radiographic progression 🚨 50.4% of RA patients in remission had persistent Power Doppler-positive ultrasonography synovitis (PDUS) 🦴 Persistent PDUS predicted relapse or radiographic

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RMD Open

@bmj_rmdopen

22 days

From the history of interferon to the potential use of #anifrolumab in treating Type I interferonopathies. 📄 Editorial by @MLFremond , @crichez33 . 🔓

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RMD Open

@bmj_rmdopen

17 days

🫀 Frailty & Subclinical Cardiovascular Disease in #SLE 🗒️ 202 patients with SLE were examined for frailty and atherosclerotic plaques using carotid/femoral artery ultrasound 📊 SLICC-Frailty Index & cardiovascular risk class were associated with carotid & femoral plaques

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RMD Open

@bmj_rmdopen

2 months

📚 Explore the Most-Read Articles from the RMD Open 🧬 🔥 CAR T cells for treating autoimmune diseases 🔍 Colchicine in crystal-induced arthritis 🌐 Sinusitis & rheumatic diseases 👂 Hearing loss in Sjögren’s syndrome 💁‍♀️ Hormonal factors & rheumatoid arthritis Stay ahead

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RMD Open

@bmj_rmdopen

20 days

💉Bimekizumab, IL-17A/IL-17F inhibitor, improves patient-reported outcomes and health-related QOL in #PsoriaticArthritis 📊 Phase 3 studies show rapid pain, fatigue, physical function, and HRQoL improvements by week 4, sustained through week 16. 📉 Pain reduction (VAS):

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RMD Open

@bmj_rmdopen

2 months

💉 Sandy-2, a BAFF-blocking antibody, improved salivary function and reduced gland inflammation in mice with Sjögren's-like disease. 🔬 The treatment boosted regulatory T cells in salivary glands, potentially explaining its benefits. 📊 BAFF inhibition could be a promising

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RMD Open

@bmj_rmdopen

2 months

🔍 “Gout was like the boss”: How does gout affect work life? 😖 Pain, tophi & job demands influence work ability. 🛠️ Effective management = improved work participation. 📑 Discuss employment impacts with patients. 🔓

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RMD Open

@bmj_rmdopen

16 days

💊 Opioids & #fibromyalgia syndrome 🗒️ Population-based, propensity-weighted cohort study of 10 334 patients 🔎 Long-term opioid use (>90 days) is associated with increased risks of: 📈 Depression (HR: 1.58) 📈 Sleep disorders (HR: 1.30) 📍Suicidal ideation

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RMD Open

@bmj_rmdopen

10 days

🚨 Conception in women with primary Sjögren′s disease (pSS) ▶️ Assisted reproductive technology use does not seem much higher in women with pSS ▶️ Prospective and preconceptional follow-ups for cases and controls are needed 🔑 @GregoireMDF 🗝️

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RMD Open

@bmj_rmdopen

2 months

🔬Parotid gland in pediatric- vs adult-onset Sjögren’s disease 💧Ped SjD ⬆️ CD45+ cells ⏫ B & ⬆️ T cells ⬆️ CD21+ follicular dendritic cells ⬆️ Germinal centers 🔍 Distinct pathological features of pedSjD, compared to adults with similar ESSDAI. 🔓

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RMD Open

@bmj_rmdopen

7 days

🚨 Methotrexate treatment hampers induction of vaccine-specific CD4 T cell responses in patients with IMID 👉 Deep immune profiling of spike-specific B and T cells following messenger RNA vaccination in both MTX-treated and MTX-untreated 💉 MTX reduces vaccine-induced CD4 T

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RMD Open

@bmj_rmdopen

1 month

🚨 Multivariable prediction model for progression of systemic sclerosis-associated interstitial lung disease ▶️ Patients from SENSCIS trial who had early and/or inflammatory SSc and severe skin fibrosis 💡 Predictors of SSc-ILD progression over 52 weeks: ✳️ Lower DLco %

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RMD Open

@bmj_rmdopen

2 months

🚨 Significant decrease of osteoporosis and osteoporotic fractures in rheumatoid arthritis within 24 years: experiences of a single centre ⬇️ ⬇️ Osteoporosis and fractures in RA within 24 years ✴️ Biologicals should be considered in patients with a high risk of osteoporosis 🔑

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RMD Open

@bmj_rmdopen

1 month

🚨 Comparison of established and preliminarily proposed ASAS MRI working group cut-offs for inflammatory MRI lesions in the sacroiliac joints in radiographic and non-radiographic axial spondyloarthritis ▶️ Post hoc analysis of part A of the phase 3 open-label C-OPTIMISE study

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RMD Open

@bmj_rmdopen

2 months

🔔 Does therapy with immunosuppressive drugs improve GI symptoms in patients with #systemicsclerosis ? 🚹 209 SSc patients (82.3% ♀️ ) ✅ 40 (19.1%) dcSSc 💊 71 exposed to immunosuppressive therapies 🔺 Immunossuppresives ⬇️ GIT score and GI symptoms ⛓️

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RMD Open

@bmj_rmdopen

2 months

🔍 Sensitivity of 2019 EULAR/ACR vs 1997 ACR criteria in 737 #SLE patients in Norway 🇳🇴 ⬆️ 92% met 2019 EULAR/ACR at diagnosis (vs 77% for 1997 ACR) 👉 Higher sensitivity in adults, varying by age & ethnicity 📊 2019 EULAR/ACR can capture early-SLE. 🔓

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RMD Open

@bmj_rmdopen

2 months

🔔 bDMARD use influences the impact of major adverse iCVE events in #RA . ❤️ 26,534 patient-years, 239 MACE, 362 iCVE ➡️ DAS28-CRP linked to MACE risk in bDMARD non-users (HR 1.21) 💡 bDMARDs may reduce CV risk in RA. ⛓️ @AKarpouzas

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RMD Open

@bmj_rmdopen

5 days

🚨 Cardiovascular risk according to genetic predisposition to gout, lifestyle and metabolic health across prospective European and Korean cohorts 🫀 Individuals at high genetic risk for gout had a higher risk of incident CVD than those with low genetic risk across ancestry ▶️

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RMD Open

@bmj_rmdopen

1 month

🚨 Agreement between patient-reported flares and clinically significant flare status in patients with RA in sustained remission: data from the ARCTIC REWIND trials 📢 Patient-reported flare status aligns with clinically significant flares in RA patients in sustained remission

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RMD Open

@bmj_rmdopen

14 days

📈 Do clinical phenotypes of chronic back pain suspicious of #axSpA change? 👥👥 Four Clinical Phenotypes previously identified SPACE (+DESIR) cohort: 📍 Pure axSpA (‘axial’) 📍 axSpA with peripheral signs (‘inflammatory back pain + peripheral’) 📍 axSpA at risk 📍 No

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RMD Open

@bmj_rmdopen

2 months

🚨 Bimekizumab treatment in patients with active psoriatic arthritis and prior inadequate response to anti-TNF: 52-week safety and efficacy from the phase III BE COMPLETE study and its open-label extension BE VITAL 📽️ Check out the video abstract:

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RMD Open

@bmj_rmdopen

4 months

Evaluating the participation of junior members and patient and healthcare professionals representatives in EULAR task forces: results from an international survey

Evaluating the participation of junior members and patient and healthcare professionals represent...

Objective European Alliance of Associations for Rheumatology (EULAR) task forces (TF) requires participation of ≥2 junior members, a health professional in rheumatology (HPR) and two patient research...

rmdopen.bmj.com

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RMD Open

@bmj_rmdopen

1 month

🚨 Inflammatory biomarkers predicting long-term remission and active disease in juvenile idiopathic arthritis: a population-based study of the Nordic JIA cohort ⚗️ Serum biomarkers IL-1β, IL-6, and S100A9 ▶️ improve predictions of disease activity and remission status at 18

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RMD Open

@bmj_rmdopen

1 month

🚨 Safety, pharmacokinetics, biomarker response and efficacy of E6742: a dual antagonist of Toll-like receptors 7 and 8, in a first in patient, randomised, double-blind, phase I/II study in SLE ✔️ E6742 had a favorable safety profile and was well-tolerated 🔽 IL-1β, IL-6, and

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RMD Open

@bmj_rmdopen

2 months

🧪 New study highlights the potential of serum biomarkers in distinguishing GCA from PMR ⭐ GCA: ⬆️ serum sCD141 and CXCL9 ⭐ PMR: ⬆️ serum MMP-3 and IL-6 ▶️ Subclinical GCA: sCD141 and MMP-3/sCD141 with a high diagnostic accuracy 🔑

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RMD Open

@bmj_rmdopen

2 months

🧬 MicroRNAs reveal hidden cardiovascular risks in Sjögren's syndrome patients! 💡 On 199 patients, miR-92a-3p levels positively correlated with carotid intima-media thickness (r=0.148, p=0.040). 🔍 Potential biomarkers for subclinical atherosclerosis in Sjögren's syndrome? 🔑

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RMD Open

@bmj_rmdopen

14 days

Web-Based Ecological Momentary Assessment Tool — The Future of #Sj ögren’s Disease Clinical Practice? 📱 Daily ESSPRI Assessments ✅ High Usability 📊 Accurate Symptom Tracking 📉 Captures Significant Day-to-Day Variability 🔓

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RMD Open

@bmj_rmdopen

2 months

▶️ Impact of initiation of targeted therapy on the use of PsA treatments 📊 9,793 PsA patients ⭐ Targeted therapy ⬇️NSAIDs, prednisone, opioids, MTX, hospitalizations 🔺 TNF inhibitors show a slightly greater impact than IL17 & IL12/23 inhibitors. ⛓️

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RMD Open

@bmj_rmdopen

2 months

🔬 Acetylated bacterial proteins from the gut ➡️ Induction of anti-modified protein antibodies and may contribute to seropositive #RA 🦠 Acetylated E. coli proteins 👉 recognized by AMPA. 🔍 Immunization with these proteins 👉 cross-reactive AMPA. 🔓

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RMD Open

@bmj_rmdopen

1 month

⭐ Dual Success: Managing PsA and Cancer with IL-17/23 inhibitors and immune checkpoint inhibitor (ICI) therapy 🏥 Three male patients with pre-existing PsA received ICIs for cancer treatment. 💉The patients were effectively treated with either anti-IL-17A or anti-IL-23 to

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RMD Open

@bmj_rmdopen

5 months

Read one of our latest articles: Original research: Management of pregnancy in #autoimmune #rheumatic diseases: maternal disease course, gestational and neonatal outcomes and use of medications in the prospectiveItalian study

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RMD Open

@bmj_rmdopen

2 months

▶️ Autologous haematopoiesis stem cell transplantation (AHSCT) for refractory autoimmune diseases in children ❇️ 7 patients 🔸 4.2-year median progression-free survival 🌡️ 3 infections, 2 new secondary autoimmune diseases and 1 breast fibroadenoma 🔑

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RMD Open

@bmj_rmdopen

2 months

💡 Arrhythmia in patients with systemic sclerosis 🚨 SSc with 2x the risk of developing cardiac arrhythmia ❗ Highest risk in the first year after diagnosis ▶️ Male sex, index age and PAH were significant risk factors 🔑

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RMD Open

@bmj_rmdopen

2 months

💡 RF test targeting the T3-17 epitope predicts progression to arthritis in seropositive arthralgia ▶️ T3-17 RF + aCCP titres improve predictive power for the development of arthritis (HR=6.4 (4.7–8.7) vs HR=5.1 (3.9–6.8) 🔑

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RMD Open

@bmj_rmdopen

1 month

🔬This post-hoc analysis of RAPID-axSpA trial data examined relationship between objective inflammation measures and clinical outcomes in axSpA patients. 📊 After 12 weeks of certolizumab pegol, >50% of patients had ≥50% reductions in MRI/CRP inflammation, but <50% in

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RMD Open

@bmj_rmdopen

9 days

'Pre-arthritis stages of Rheumatoid Arthritis: from Pathology to Disease Prevention' We have calls for papers in your subject area. Discover our Topic Collection: 👈

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RMD Open

@bmj_rmdopen

5 months

Want to stay up to date with the latest developments covering #rheumatic and #musculoskeletal disorders ? You can sign up for our eAlerts here:

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RMD Open

@bmj_rmdopen

21 days

🌍 Real-world evidence of Ixekizumab (IL-17Ai) in 1192 #PsA patients ⚖️ Comparable joint response to TNFi & JAKi 📈 Better skin outcomes compared to TNFi & IL-12/23i and IL-23i in active #Psoriasis patients ⚡️ Rapid joint disease improvement similar to JAKi 🔓

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RMD Open

@bmj_rmdopen

2 months

💡 Results from CareAR2020 trial 💊 Adding etanercept for 6 months did not improve disease control over 104 weeks versus adding leflunomide first ▶️ Early etanercept use led to better short-term control and reduced b/tsDMARDs use at 2 years ⛓️

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RMD Open

@bmj_rmdopen

1 month

Love a good podcast? 🎧 BMJ has 20 different podcasts covering a wide range of topics. We produce over 150 episodes, with over 2 million downloads, each year. The RMD Open podcast should be the one for you. Find out more and subscribe today 👉

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RMD Open

@bmj_rmdopen

2 months

🔬 Presence of soluble immune complexes (sICs) with CD16 bioactivity in RA serum and synovial fluid (SF). 🧫 RA serum and SF ⬆️ CD16 bioactivity and SF showing much higher activity than serum in RA patients 💡 CD16 bioactivity in SF correlated with RF and ACPA levels 🔑

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RMD Open

@bmj_rmdopen

5 months

Join our online community for the latest content on #rheumatic & #musculoskeletal disorders. Follow us here:

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RMD Open

@bmj_rmdopen

5 months

Attending #EULAR2024 ? So are we. Come find us at stand S5 and learn more about our journal. Be sure to collect an APC discount card from the stand if you are thinking about submitting your research to a reputed journal. Find out more:

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RMD Open

@bmj_rmdopen

2 months

Love a good podcast? 🎧 BMJ has 20 different podcasts covering a wide range of topics. We produce over 150 episodes, with over 2 million downloads, each year. The RMD Open podcast should be the one for you. Find out more and subscribe today 👉

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RMD Open

@bmj_rmdopen

15 days

🧬 Transcriptomic profiles in temporal artery biopsies of #GiantCellArteritis Transmural inflammation shows upregulation of: ⬆️ TNF superfamily members ⬆️ Immune checkpoints ⬆️ Chemokines & chemokine receptors ⬆️ TLR ⬆️ Complement ⬆️ Fc receptors for IgG ⬆️

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RMD Open

@bmj_rmdopen

4 months

We're going to be at #EULAR2024 this year. Catch us at stand S5 to ask us all things about publishing your research and accessing our content.

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RMD Open

@bmj_rmdopen

3 months

What role do socioeconomic and clinical factors play in disease activity states in rheumatoid arthritis? Data from a large UK early inflammatory arthritis audit

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RMD Open

@bmj_rmdopen

3 months

📑 Don't miss out - register to receive access to this ebook on #vasculitis , with cutting-edge content from our leading titles. Stay ahead in your knowledge and practice! #rheumatology 👉

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RMD Open

@bmj_rmdopen

4 months

We're excited to be at #EULAR2024 this year 👋 Catch us at stand S5 to ask us all things about publishing your research and accessing our content.

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RMD Open

@bmj_rmdopen

4 months

Increased risk of cardiovascular events under the treatments with Janus kinase inhibitors versus biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: a retrospective longitudinal population-based study using the Japane...

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RMD Open

@bmj_rmdopen

3 months

Is there a role for novel supplements in the management of fatigue in rheumatic diseases?

Fatigue is a common symptom of rheumatic diseases and frequently persists even when patients are in a near-remission state. In seeking options to manage troublesome symptoms such as fatigue, comple...

rmdopen.bmj.com

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RMD Open

@bmj_rmdopen

5 months

Read this article related to #myositis : Pretreatment mortality risk prediction model in patients with polymyositis/dermatomyositis-associated interstitial lung disease

Pretreatment mortality risk prediction model in patients with polymyositis/dermatomyositis-associ...

Objectives Risk prediction for patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD) is challenging due to heterogeneity in the disease course. We aimed to...

rmdopen.bmj.com

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RMD Open

@bmj_rmdopen

28 days

🚨 Persistence of power Doppler ultrasonography-detected synovitis over 1 year of follow-up predicts poor prognosis in rheumatoid arthritis in clinical remission: the SONORE prospective longitudinal study 🔅 Ultrasound-detected synovitis (PDUS) persists in 50% of patients: 25.9%

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RMD Open

@bmj_rmdopen

4 months

Anti-dsDNA IgE: a potential non-invasive test for prediction of lupus nephritis relapse

Objectives Discontinuation or continuation of maintenance immunosuppressive therapy (MIST) after a severe lupus nephritis (LN) requires measuring the risk of relapse but reliable clinical and...

rmdopen.bmj.com

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RMD Open

@bmj_rmdopen

15 days

How to define poor prognostic factors for clinical practice in #RheumatoidArthritis ? 👉 Disease stage matters in defining RA prognostic factors 🕰️ Early phase: DAS28 remission & Radiographic progression 🕰️ Established phase: Patient self-assessments & PROs 🔓

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RMD Open

@bmj_rmdopen

18 days

Love a good podcast? 🎧 BMJ has 20 different podcasts covering a wide range of topics. We produce over 150 episodes, with over 2 million downloads, each year. The RMD Open podcast should be the one for you. Find out more and subscribe today 👉

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2

RMD Open

@bmj_rmdopen

2 months

▶️ Is there a role for novel supplements in the management of fatigue in RMDs? 🔑 @drhectorchinoy

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RMD Open

@bmj_rmdopen

4 months

Twenty-year trajectories of morbidity in individuals with and without osteoarthritis

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RMD Open

@bmj_rmdopen

5 months

Read this article on the detection of #hypophosphatasia in hospitalised adults in #rheumatology and internal medicine departments: a multicentre study over 10 years

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RMD Open

@bmj_rmdopen

5 months

If you’re publishing research with us, we know you’ll want it to be shared as wide as possible. Explore how BMJ helps to maximise your reach and achieve the impact that your research deserves. Find out more: #AuthorSupport

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RMD Open

@bmj_rmdopen

4 months

Are poor prognostic factors a realistic basis for treatment decisions in patients with rheumatoid arthritis? Lessons from the IMPROVED study

Are poor prognostic factors a realistic basis for treatment decisions in patients with rheumatoid...

The European Alliance of Associations for Rheumatology (EULAR) recommendations for the treatment of rheumatoid arthritis (RA) recommend the use of poor prognostic factors (PPFs) in treatment decisi...

rmdopen.bmj.com

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RMD Open

@bmj_rmdopen

5 months

Looking to submit your research to a reputed journal covering the full spectrum of #musculoskeletal disorders, #rheumatism & connective tissue diseases ? Here are 5 reasons to publish with us! Find out more:

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RMD Open

@bmj_rmdopen

4 months

Our top cited content is free to read 📰 Check out one here: "Waiting for JAK inhibitor safety data" #EULAR2024

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RMD Open

@bmj_rmdopen

5 months

Did you know our open access articles in #rheumatology have received more than 744,000 citations? Explore top open access content:

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RMD Open

@bmj_rmdopen

5 months

Read our top cited papers - published in 2022 and 2023

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RMD Open

@bmj_rmdopen

5 months

Severe enterovirus infections in patients with immune-mediated inflammatory diseases receiving anti-CD20 monoclonal antibodies

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RMD Open

@bmj_rmdopen

4 months

If you're at #EULAR2024 this year, drop by our booth (S5) and try your luck on spin the wheel! Our friendly staff will be around to answer any questions you have about our journal.

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RMD Open

@bmj_rmdopen

5 months

Urinary methotrexate dosage in rheumatoid arthritis, in patients treated for at least 6 months: a potential marker of adherence

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RMD Open

@bmj_rmdopen

4 months

#EULAR2024 starts tomorrow! Be sure to visit us at stand S5 to learn more about our journal. If you're looking to submit your research to a reputed journal, please speak to us and be sure to pick up an APC discount card.

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1

RMD Open

@bmj_rmdopen

5 months

Attending #EULAR2024 ? So are we. Come find us at stand S5 and learn more about our journal. Be sure to collect an APC discount card from the stand if you are thinking about submitting your research to a reputed journal. Find out more:

0

1

RMD Open

@bmj_rmdopen

5 months

Dysregulation of circulating collagen turnover markers in very early systemic sclerosis

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RMD Open

@bmj_rmdopen

5 months

MRI of shoulder girdle in polymyalgia rheumatica: inflammatory findings and their diagnostic value

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RMD Open

@bmj_rmdopen

3 months

📑 Don't miss out - register to receive access to this ebook on #vasculitis , with cutting-edge content from our leading titles. Stay ahead in your knowledge and practice! #rheumatology 👉

0

1

RMD Open

@bmj_rmdopen

5 months

Looking to submit your research to a reputed journal covering the full spectrum of #musculoskeletal disorders, #rheumatism & connective tissue diseases ? Here are 5 reasons to publish with us! Find out more:

0

RMD Open

@bmj_rmdopen

5 months

BMJ is committed to speaking to its authors to understand their challenges and changing needs within the research landscape. Through this, BMJ can be seen as an advocate for authors, championing them and their work. Find out more: #AuthorSupport

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RMD Open

@bmj_rmdopen

5 months

Exploring complement biomarkers in suspected axial spondyloarthritis

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