Tugce Aktas @_taktas_ Twitter profile

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Tugce Aktas

5 months

Proudly presenting our new findings on how #RNA binding proteins (RBPs) may increase the tolerance of genomes to transposable element (TE) insertions. If you want to know more read this thread or our story @Nature

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Tugce Aktas

@_taktas_

11 months

Look, what I found! This card was issued a bit more than 16 years ago. Time flies ✈️

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Tugce Aktas

@_taktas_

2 years

Today marks 15 years since I moved to Germany to start my PhD at @embl . I'm glad that my scientific vision has been continuously supported. Special thanks to @maxplanckpress for the last ~10 years. Here is a photo of a young and excited PhD student 😊

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Tugce Aktas

@_taktas_

4 years

It’s my great pleasure to announce the first paper from our group. It’s a true team effort. If you are interested in biomolecular condensates, splicing and RNA biology read the thread👇. Especially if you have worked with SRSF2 or nuclear speckles. (1/9)

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Tugce Aktas

@_taktas_

1 year

A pretty image from today's microscopy (done by the postdoc). In orange you see the Nuclear Speckles, stained for SON & SRRM2. We are getting close to commercial style images 😉 Cell line credit @MMalszycki

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Tugce Aktas

@_taktas_

3 years

I just got the news that my first DFG @dfg_public application will be funded 🥳 stay tuned for job openings!

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Tugce Aktas

@_taktas_

9 months

Honored to be listed in @Tagesspiegel "The 100 most important minds in Berlin science 2023" together with Aydan @bulutkarslioglu The full list is here (with Aydan on the cover):

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Tugce Aktas

@_taktas_

2 years

Mass spec results just arrived and the RNA we used in this pull down seems to be an hnRNP heaven. It was only a preliminary experiment but now I can go through the list and start dreaming things 💭

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Tugce Aktas

@_taktas_

3 years

Our group is growing. I think we beat the photo of the German politicians from last week! #Wiehei ßtdieseBand?

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Tugce Aktas

@_taktas_

4 years

Good news, right before the end of the week! Our manuscript is accepted @eLife We're extremely happy with the revision process. Many thanks to eLife editors&reviewers, especially in these times. SON and SRRM2 are essential for nuclear speckle formation

SON and SRRM2 are essential for nuclear speckle formation

Re-characterization of the targets of a commonly used nuclear speckle marker unexpectedly leads to the discovery of the elusive core of the nuclear speckles.

elifesciences.org

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Tugce Aktas

@_taktas_

4 years

Getting to the core of nuclear speckles

Researchers have discovered two proteins that make up the scaffold that holds nuclear speckles together.

elifesciences.org

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Tugce Aktas

@_taktas_

3 years

Our state-of-the-art review on #NuclearSpeckles is out now @FEBSJournal . Many thanks to the editors and the reviewers! Reviewers were very helpful and they had great suggestions. Enjoy reading:

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Tugce Aktas

@_taktas_

1 year

Proud PI moment: First MSc student, Theresa successfully defended the thesis today🎉 We also took the opportunity to get a quick lab photo while the sun was momentarily shining (directly on to Theresa 🌟 )

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Tugce Aktas

@_taktas_

8 months

We are 5 years young! A shout out to former & current team members🌟 I am still enjoying this journey and looking forward to celebrating many more lab anniversaries.

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Tugce Aktas

@_taktas_

4 years

We are looking for a PhD student (see details of the project below). Apply at before 3rd of January, 2021 if you're interested. Max Planck Institute for Molecular Genetics - PhD project in the Aktas lab

Application

The graduate program IMPRS for Biology And Computation (IMPRS-BAC) provides an education for students at the interface of molecular life sciences and computational sciences. This is based on perspe...

www.molgen.mpg.de

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Tugce Aktas

@_taktas_

4 years

A western blot result I've been waiting since 6 months comes as we countdown to the closing of the institute. Last result needed to write the paper comes on the last day of work. Perfect timing 😊

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Tugce Aktas

@_taktas_

2 years

I wonder what they are talking about 🤔 #freezersoftheworldunite

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Tugce Aktas

@_taktas_

2 years

My new highlight on how transposons fuel evolution is now online

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Tugce Aktas

@_taktas_

3 years

My first PhD student gave an institute seminar today and it went all well. I felt strangely nervous, which is something I no longer have when I'm the one giving talks. I know one day they will fly the nest, but until then I'm protecting them.

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Tugce Aktas

@_taktas_

8 months

Winter arrived in #Berlin ❄️ We made a snow pig inspired by the cute mini pigs of @metzger_lab I challenge @MundlosLab to make a snow bat 🦇

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Tugce Aktas

@_taktas_

3 years

We are looking for a bioinformatics postdoc who has previous experience with analysis of CLIP-like datasets. Please spread the news. Max Planck Institute for Molecular Genetics - Postdoctoral Associate (f/m/d) | Computational Biology

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Tugce Aktas

@_taktas_

2 years

Our group dressing as the characters from #theoffice for our Halloween themed social hour. They planned everything and got me the wig. We got the second 🥈 place in the costume contest. Proud of you! @lisamartina_ @MMalszycki @PetarGlazar @omrysrq

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Tugce Aktas

@_taktas_

1 year

I never trash reagents. These membranes are probably 20 years old, left in one of our lab rooms, and today, we used them to test some RNA probes for Northern blots. It just works, I guess I can continue being a hoarder 🙃

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Tugce Aktas

@_taktas_

5 years

1st anniversary of Quantitative RNA Biology Lab. Last year had been amazing for me, and I am looking forward to having many more years like this with these talented team members.

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Tugce Aktas

@_taktas_

4 years

As of today, Aktas lab is 2 years old. It feels like just yesterday to me. Time flies when you're having fun!

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Tugce Aktas

@_taktas_

4 years

More speckles for the new year! My students gave me one of the most creative Christmas presents I've ever seen. I don't think we'd get tired of looking at nuclear speckles.

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Tugce Aktas

@_taktas_

2 years

3 years after starting my lab, I temporarily stopped doing bench work to finish some writing business. And now I realize; writing is so easy if I'm not doing experiments in parallel! Still not fun but at least I found out that I'm not as slow in writing as I once thought 🙂

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Tugce Aktas

@_taktas_

4 years

Sometimes as we make the libraries we have an indication that particular RNA binding protein is a good RNA-binder, as seen by the clumping beads 😁 (The one on the right is a negative control)

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Tugce Aktas

@_taktas_

2 years

Our new intern Ömer @omrysrq started working with us today. The original plan was for the summer of 2020 (I guess I don't need to explain what happened in 2020), but I'm glad that it eventually worked out. I wish Ömer lots of luck and success 🤞

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Tugce Aktas

@_taktas_

3 years

An extremely well conducted study on a rare disease identifies a non coding RNA which regulates a developmental gene. Congratulations @lila_allou and @StefanMundlos ! interested should also see the thread by Lila👇

Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator

Nature - The long non-coding RNA locus Maenli controls mouse limb development by regulating En1 activity, and the absence of the homolgous MAENLI locus is associated with severe congenital limb...

www.nature.com

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Tugce Aktas

@_taktas_

3 years

The relief after uploading the revised manuscript is indescribable 😊 now I can leave the office and go home

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Tugce Aktas

@_taktas_

2 years

Most important thing I learned from Asifa: "I don’t dwell on disappointments. Instead, I look forward to the new challenge ahead. You have to seize the moment. There are many times when I had setbacks, but I get up, try to see where my strengths are and move forward with those"👇

Max Planck Society

@maxplanckpress

2 years

“We need a cultural change to remain competitive”: interview with the utterly brilliant Asifa Akhtar, Vice President @maxplanckpress , about her engagement in a cultural change towards more diversity & inclusion @ Max Planck Society🤗 #DiversityDay @mpi_ie

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Tugce Aktas

@_taktas_

2 years

Very honoured to be among the rising stars ( with @LabBoke and @SinemKSaka1 ) and waiting impatiently

Gökhan Hotamışlıgil

@ghotamis

2 years

I am extremely excited to announce our 2023 "Metabolism & Life Symposium" with a terrific line up of speakers. Supported & organized by @sabriulkerctr & @SU_foundation the meeting will be on the waters of the Bosphorus. Mark your calendars for this scientific and cultural feast.

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Tugce Aktas

@_taktas_

4 years

My favorite 2 topics together in 1 publication 🤟 RNA & transposon biology combined. Congratulations @TChelmicki and @DeborahBourchis

m6A RNA methylation regulates the fate of endogenous retroviruses

Nature - A CRISPR screen in mouse embryonic stem cells shows that transcripts derived from endogenous retroviruses are destabilized by m6A RNA methylation.

www.nature.com

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Tugce Aktas

@_taktas_

3 years

You know you have too many meetings when... The postdoc ( @OlgaJasnovidova ) brings you a 3d printed door sign 😁

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Tugce Aktas

@_taktas_

3 years

A crazy afternoon! The MSc student said she has homozygous clones. Not one but 4. Now the postdoc says sequencing data are here for an experiment I've been impatient to see. The other postdoc tells me the mutants don't bind RNA. What's next? I'm becoming addicted to good news 🧿

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Tugce Aktas

@_taktas_

3 years

Lab of @EddaGSchulz identified a novel Xist-enhancing regulatory transcript; Xert! @RutgerGjaltema presented at our RNA Salon Berlin, I was fascinated by the quality of the work but also surprised to hear there are still so many unknowns of XCI. Read👇

Distal and proximal cis-regulatory elements sense X-chromosomal dosage and developmental state at...

Developmental genes such as Xist , the master regulator of X-chromosome inactivation (XCI), are controlled by complex cis -regulatory landscapes, which decode multiple signals to establish specific...

www.biorxiv.org

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Tugce Aktas

@_taktas_

2 years

Thank you @RNASociety for supporting our RNA salon application. Together with Marina @chekulae we continue bringing RNA enthusiasts in Berlin together. #RNAclubBerlin

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Tugce Aktas

@_taktas_

3 years

A perfect reminder for why I like my job. I love helping younger generation of scientists and I am very lucky to be surrounded by so many of the good ones. A beautiful surprise from Liza today🌺

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Tugce Aktas

@_taktas_

3 years

My science journey... (in Turkish) Bilimsel yolculuğumu konuştuğumuz güzel bir bilim sohbeti oldu. Çok teşekkürler @fesraoz

Esra Öz

@fesraoz

3 years

🙋‍♀️Esra Öz ile Bilim Sohbetleri devam ediyor 🧬Max Planck Enstitüsü’nden Dr. Tuğçe Aktaş, zıplayan genlerin neden olduğu genetik parmak eksikliği ve Alu transpozonlarının neden olduğu hücre ölümlerinin önüne geçen çalışmalarını anlattı. @_taktas_ 👇

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Tugce Aktas

@_taktas_

2 years

The first one of our joined efforts with @AlexandraBergf1 from Markus Wahl's lab at @FUBiochemistry is officially out. Our star🌟; Alexandra is now a postdoc at Yale and I hope we will have the chance to work together in the future again.

The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-in...

Abstract. Biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs) and their recycling after splicing require numerous assembly/recycling facto

academic.oup.com

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Tugce Aktas

@_taktas_

4 years

Thanks to the German system which makes us keep record of every genetically modified organism (FormblattZ), I know exactly how many cell lines we have generated in 1.5 years. We are almost at 100! I think we should celebrate the 100th cell line 🥳

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Tugce Aktas

@_taktas_

3 years

Almost ready for vacation starting in 2 days after preparing all the cell lines with treatments etc. to be sequenced while we're gone. The postdoc (also my significant other) consumed all his energy to turn these into 48 libraries. We'll have a drink to celebrate tonight 🥂

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Tugce Aktas

@_taktas_

3 years

I was virtually in #istanbul yesterday ❤️ Many thanks to @CytoLabKoc I had wonderful time talking to the top scientists in Turkey.

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Tugce Aktas

@_taktas_

9 months

At the closing event of @Tagesspiegel Aydan speaking about her team's efforts on understanding diapause 🤩

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Tugce Aktas

@_taktas_

3 years

This Thursday, together with @TazebayUygar we will be talking about transposable elements live on YouTube (unfortunately only in Turkish). Bu perşembe günü çekirdek konuşmalarına konuk oluyorum. Transpozonlar ve genom evrimi üzerine gerçekleştireceğimiz sohbete hepinizi beklerim.

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Tugce Aktas

@_taktas_

2 years

In Freiburg to teach a course tomorrow and had a reunion with @Iovino_Lab . It was a wonderful fun dinner with Nicola, but just too short. Next time we meet in Berlin😉

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Tugce Aktas

@_taktas_

1 year

I can't believe I'm saying this, but after spending the whole January writing and submitting a manuscript and a grant, committee meetings start to sound interesting.

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Tugce Aktas

@_taktas_

3 years

A beautiful present from @OlgaJasnovidova before she leaves our lab to start a new adventure at her home country. The #octopus represents someone who can do many things (has 8 hands working in parallel). I am trying my best but I don't think I am an octopus yet😄

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Tugce Aktas

@_taktas_

3 years

I'm almost crying & feeling proud at @cica_dups PhD defense. One of the best students I've ever worked with is rocking the stage now❤️

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Tugce Aktas

@_taktas_

1 year

Almost a year later, the reunion with @Iovino_Lab in Berlin this time. Very excited to host him for a seminar and hear about the latest adventures of team Iovino.

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Tugce Aktas

@_taktas_

2 years

Here comes the second one from @AlexandraBergf1 . This time also including the great support from Marco ( @pre_mRCO ) from the lab of Florian Heyd @FUBiochemistry . Happy to be part of this work 🥳

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Tugce Aktas

@_taktas_

2 years

The applications for our PhD program (IMPRS-BAC) are now open. We are recruiting in this round as well. Please forward to the interested and RT. Max Planck Institute for Molecular Genetics - PhD project proposals 2023

PhD projects 2024

www.molgen.mpg.de

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@_taktas_

3 years

I don't know if anyone did this already. For me the most obvious thing to type was "transposable elements" and this is how it looks: like gaps in genome assembly

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Tugce Aktas

@_taktas_

6 years

First experiment in the new lab. (Just bacteria transformation but that's something 😊)

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Tugce Aktas

@_taktas_

4 years

Trying to purify a protein we accidentally made hydrogels. At least it shows our hypothesis was correct 😁 image recognition thinks it's a freshwater snail. 🐌

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Tugce Aktas

@_taktas_

4 years

First time I saw TLS I couldn't believe how real they look. Finally the story is out. Congratulations @jvveenvliet @adrianobolondi @helenekretzmer Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites

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Tugce Aktas

@_taktas_

2 years

Our review has been online for a while, but the special issue with all the other reviews is definitely worth checking 👇

The FEBS Journal

@FEBSJournal

2 years

📜State-of-the-Art Review📜 Nuclear speckles: dynamic hubs of gene expression regulation ✏️By İbrahim Avşar Ilık and Tuğçe Aktaş from @MPI_MolGen 🔗 Part of our Special Issue on Organelle Homeostasis!

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Tugce Aktas

@_taktas_

5 years

Our latest paper together with @AsifaAkhtar1 @BackofenLab @dmaticzka is online. Have fun reading!

FLASH: ultra-fast protocol to identify RNA–protein interactions in cells

Abstract. Determination of the in vivo binding sites of RNA-binding proteins (RBPs) is paramount to understanding their function and how they affect differ

academic.oup.com

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Tugce Aktas

@_taktas_

2 years

Just a reminder: If you're requesting reagents from someone, make sure to remove the strange comment of your supervisor in your reply email. 😳

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Tugce Aktas

@_taktas_

4 years

I get frustrated when people tell me that I'm "lucky" to have this and that... Especially for things that I worked hard, planned and organized each step. My father told me when I was younger: You create your own luck!

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Tugce Aktas

@_taktas_

4 years

Welcome to our new lab member @OlgaJasnovidova . Olga will be working on revealing hidden potential of RNA binding proteins by introducing a few selected ones from various species into human cells.

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Tugce Aktas

@_taktas_

5 years

A proud PI moment😊 First student picking colonies of transgenic cell lines.

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@_taktas_

2 years

My colleague and good friend, Aydan @bulutkarslioglu summarized my feelings quite well. I believe it was a rare occasion to have two candidates from the same institute. We gave them a glimpse into the groundbreaking research done at @MPI_MolGen

Aydan Bulut-Karslioglu

@bulutkarslioglu

2 years

Day trip to Frankfurt for the Paul Ehrlich Prize symposium. Regardless of the outcome had a great day. Together with @_taktas_ strong showcase for @MPI_MolGen . Tomorrow off to the @MPI_MolGen retreat. Together with ERC preps, may I say I am TIRED

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@_taktas_

3 years

We continue with the fourth season of Berlin RNA club. Our beautiful crowd keeps on growing. Join us!

Marina Chekulaeva

@chekulae

3 years

Happy to announce the continuation of the Berlin RNA club in 2022, co-organized with @SamanthaMendon4 , @ILoedige , and @_taktas_ . We will meet every 2d Wednesday of the month at 5 pm. If you would like to join the club or present, let us know!

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@_taktas_

3 years

Nowadays, I often find myself discussing with my colleagues about things to change (or revolutionize) in academia. I believe the unexpected developments we experienced over the last year changed our mindsets dramatically. I hope we use these new ideas to change for the better.

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@_taktas_

1 year

It was a lot of fun to meet and interact with IMPRS for GS students. We mostly talked about career planning, (personal) definition of success and adaptive management styles. Smart students here ✨️

IMPRS for Genome Science

@IMPRS_GS

1 year

Retreat 2022 in Hann. Münden, three days on research, networking and career. Here Speed dating with the PIs. ⁦ @uniGoettingen ⁩ ⁦ @mpi_nat ⁩ ⁦ @yourUMG ⁩ ⁦ @DPZ_eu ⁩ ⁦ @thegoecampus ⁩

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@_taktas_

3 years

I'm preparing for that time of the year when I get asked if all the documents (Formblatt-Z) are up to date. This way I realize that we have more than 400 glycerol stocks and ~120 cell lines frozen. Not bad 😉

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@_taktas_

6 years

One step closer...

Aktas lab

www.molgen.mpg.de

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@_taktas_

9 months

Don't miss the chance to attend this interesting meeting in beautiful Freiburg! I will present our latest results on Nuclear Speckles

MPI of Immunobiology & Epigenetics

@mpi_ie

9 months

📅 Save the date! Don’t miss the 3rd Symposium on Medical Epigenetics by CRC992 MEDEP. 18-20 March 2024 in #Freiburg (Germany) Registration is already open:

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@_taktas_

3 years

Even though it was all virtual, I had a great day full of science in Dresden @CRTDpress . Thank you @MareikeAlbert for being a fantastic host! And also everyone else who spared their time to talk with me😊

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@_taktas_

2 years

@CytoLabKoc Years ago we got a similar reviewer comment and did nothing about it (because there was nothing to correct) but thanked the reviewer and said we now got the language checked in our response letter. The reviewer thanked and said the text was improved 😂

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@_taktas_

5 years

Why haven't you heard of multipartite viruses : “They’re everywhere, but because they’re mainly on plants, no one cares.” I think we should care about these very interesting new findings

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@_taktas_

6 years

Laboratory of Quantitative RNA Biology is also recruiting, see projects here: Apply before the deadline (Feb.14).

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@_taktas_

1 year

I am thrilled to participate in The Metabolism and Life Symposium. Let the countdown begin ⏳

Gökhan Hotamışlıgil

@ghotamis

1 year

The Metabolism and Life Symposium returns on May 9-10, 2023 and brings together expert scientists from around the world! #Sabri ÜlkerFoundation #MetabolismandLifeSymposium

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@_taktas_

3 years

My first animal handling was Parhyale hawaiensis at M.Gerberding's group at MPI in Tübingen in 2005 as a summer intern. So happy to see this paper which looks into Parhyale development in detail.

Dennis Sun (孙丹)

@Mezarque

3 years

The first preprint from my thesis work in the Patel Lab @Parflyale is out! We generated new functional genomic resources for our favorite emerging model crustacean, Parhyale hawaiensis, using a timecourse of Omni-ATAC-Seq and RNA-Seq. Thread below👇 1/n

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@_taktas_

2 years

Quick update: I ended up doing a spontaneous nuclear prep with @lisamartina_ today. I escape from writing whenever I can🙄

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@_taktas_

5 years

What is better than seeing other scientists following up your work? DHX9 levels seem to be the best correlating (99%) with circRNA levels and serves as an example! Expanded Expression Landscape and Prioritization of Circular RNAs in Mammals

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@_taktas_

6 months

I am looking forward to the 18th microsymposium on #RNA Biology in #Vienna Check the website and register👇

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@_taktas_

5 years

We just got this baby today. Super impatient to test it for protein purifications 😊

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@_taktas_

1 year

Thank you for inviting me. There is a lot of cool science happening at the IBC, and it is great to experience it first hand.

Prashant Rawat

@rawatravans

1 year

Great start to Day2 of #IBCRetreat2023 @ETH_en with super-fascinating talk from @_taktas_ @MPI_MolGen Condensates and IDPs make most sense in the light of evolution ✨️ a lot of food for thought 🤔 Looking forward to discussions following for next 1.5 days. @BioCondensates

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@_taktas_

4 years

I'm sometimes very impatient. I connected to our gel doc system from home to check the results of a western blot my student finished yesterday. Since she hasn't told me anything I thought the results were no good. It turns out she had 2 hom. out of 3 clones :) It's a good Sunday.

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@_taktas_

4 years

In light of our findings, nuclear speckles-related literature of the last 3 decades needs to be carefully re-evaluated. (9/9)

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@_taktas_

1 year

We are very happy to be part of this amazing work spearheaded by @RahaWeigert . See Raha's thread if you want to know more about the regulation of placental DNA & histone methylation.

Raha Weigert

@RahaWeigert

1 year

Ever wondered how the peculiar placental epigenome is regulated? We discovered a dynamic DNMT3B/Polycomb-antagonism that maintains it! Beyond thrilled to share my PhD work together with @hetzel_s published @NatureCellBiology . @MPI_MolGen #MeissnerLab (1/9)

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@_taktas_

2 years

I am one of the speakers on day1. Register for free before the tickets are all gone😉

German Scholars Organization e.V. (GSO)

@germanscholars

2 years

To be honest (tbh), navigating the career path in #academia & beyond is often based on informal knowledge, on watercooler conversations, or lucky coincidences. The #tbhconference is the place where such conversations take center-stage.➡️ Register here:

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@_taktas_

4 years

I'm so glad that it wasn't a stopover, she helped build other careers such as mine.

MPI of Immunobiology & Epigenetics

@mpi_ie

4 years

“A biologist from Pakistan thought Germany would be a stopover in her career. Twenty years later, she’s one of the most prominent researchers from abroad.” @maxplanckpress Vice President and @mpi_ie director @AsifaAkhtar1 in an interview with @zeitcampus

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@_taktas_

2 years

A normal day in the office for @lisamartina_ ☺️

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@_taktas_

3 years

Every scientist I know complains about things which are obviously not ideal and they also have some ideas on how to improve. But we all somehow fail to join forces to implement these changes. Talking about the problem is a good start but we also need to take actions.

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@_taktas_

1 year

It was a fantastic seminar by our guest @MariekeOudelaar today, including new methodoligies to functionally address genome architecture and in vitro re-constitutions. Co-hosting together with @EddaGSchulz as participants of @spp2202_dfg

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@_taktas_

2 years

@mpicbg We also have one coming to the pond behind our institute @MPI_MolGen (photo from August 2020)

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1 year

@der_bri @bulutkarslioglu @MPI_MolGen Looks amazing. Here a photo of my efforts from the last night.

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@_taktas_

2 years

My name (Tuğçe) is difficult to type on an EN keyboard and predatory journals don't put so much effort into this (or is this even on purpose to get our attention🤔). I have mostly seen versions with missing fonts (first photo) but this is new (second)😂

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@_taktas_

5 years

Role of Dhx9 in SMA. When I proposed a research of Dhx9 in disease I was told I'm "walking on thin ice", so nice to see my hunch was correct. Human Survival Motor Neuron genes generate a vast repertoire of circular RNAs

Human Survival Motor Neuron genes generate a vast repertoire of circular RNAs

Abstract. Circular RNAs (circRNAs) perform diverse functions, including the regulation of transcription, translation, peptide synthesis, macromolecular seq

academic.oup.com

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6 years

Finally got my official offer 😊 (I was waiting since April)

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@_taktas_

3 years

One more week left to apply! Dear Tweeps, please send the job ad. to the people who might be interested.

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3 years

We are looking for a bioinformatics postdoc who has previous experience with analysis of CLIP-like datasets. Please spread the news. Max Planck Institute for Molecular Genetics - Postdoctoral Associate (f/m/d) | Computational Biology

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6 years

Coolest leaving gift ever! Thanks @Feli_Bas @maria_sa__ @cica_dups Aline and Claudia

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4 years

I hope the re-evaluation of past research brings a positive outcome. Perhaps we will be able to understand things which didn’t make sense before or it will even lead to new discoveries. Such as ours: we identified the core of nuclear speckles

SON and SRRM2 form nuclear speckles in human cells

The nucleus of higher eukaryotes is a highly compartmentalized and dynamic organelle consisting of several biomolecular condensates that regulate gene expression at multiple levels ([1][1], [2][2])....

www.biorxiv.org

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5 years

Evolution in action! Alternative paths lead to the same destination. A great story on the evolution of fly dosage compensation. Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling

Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive...

Genome rearrangements that occur during evolution impose major challenges on regulatory mechanisms that rely on three-dimensional genome architecture. Here, we developed a scaffolding algorithm and...

www.biorxiv.org

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@_taktas_

4 years

The postdoc made the 96th sequencing library this week, perhaps I should ask him how he feels about the last 2 years 😉

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