A copper-catalyzed regio- and enantioselective hydroboration of 1-trifluoromethylthio(SCF3)-alkenes with H-Bpin has been developed. The enantioselective hydrocupration and subsequent boration...

A general haloform coupling reaction for the synthesis of esters from methyl ketones is reported using one equivalent of alcohol. Detailed kinetic modelling studies demonstrate that the key interme...

Dialkylchlorophosphines are among the most versatile building blocks for tertiary phosphine ligands, but their synthesis relies on the nucleophilic substitution of PCl3, leaving substituents that...

The introduction of secondary amines at the aryl iodide ortho position by the palladium/norbornene (Pd/NBE) catalysis has been developed, which leads to versatile synthetic applications, such as...

The truxillates constitute a large class of dimeric natural products featuring a central, highly substituted cyclobutane core. In principle, these structures could be efficiently synthesized via [2 +...

Sulfurimidoyl difluorides (RNSOF2) are excellent multidimensional SuFEx hubs, however their preparation from the scarcely available thionyl tetrafluoride (SOF4) gas limits this chemistry. Here, we...

Nature Chemistry - Phenols and their derivatives are ubiquitous in nature and important within the chemical industry. Their properties are linked to their substitution patterns, but meta-isomers...

An unprecedented caged 2H-benzo-dioxo-pentacycloundecane framework was serendipitously obtained in a single transformation via triple-dearomative photocycloaddition of chromone esters with furans....

We described an unprecedented iron-promoted hydrogen atom transfer (HAT) to gem-difluoroalkenes in reversed regioselectivity for the generation of difluoroalkyl radicals. Hydrogenation and halogena...

Three-component diene carboaminations offer a potent means to access synthetically valuable allylic amines with rapid molecular complexity escalation. The existing literature primarily discloses...

Fluoroalkylated N-heteroarenes are efficiently synthesized from fluoroalkyl 2-azaheteroarylsulfones via Grignard reagent-promoted formal SO2 extrusion reaction. The reaction proceeds through the...

With increasing interest in constructing more three-dimensional entities, there has been growing interest in cross-coupling reactions that forge C(sp3)–C(sp3) bonds, which leads to additional...