Steven Brem @StevenBremMD Twitter profile

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Steven Brem

9 months

Excited to be working with @NdukaAmankulor to announce the 11th Penn Brain Tumor CME on 1.26.2024, with keynote talks by Dr. Shawn Hervey-Jumper @HerveyJumper @NeurosurgUCSF and Dr. Evanthia Galanis @MayoClinic . Registration is open now

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Steven Brem

@StevenBremMD

2 years

Delighted that the Editorial Board of @NeurologyToday , the news source of the AAN, @AANmember , selected our dendritic cell vaccine trial, led by Dr. Linda Liau, as one of the "Best Advances of 2022." #immunotherapy @PennNeurology @PennNSG @PennCancer

Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival...

ClinicalTrials.gov Identifier: NCT00045968.

pubmed.ncbi.nlm.nih.gov

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Steven Brem

@StevenBremMD

11 months

Dr. Kati Kariko speaks from the heart as she relates the surprise at the 3:40 am call, tears in her eyes, how she started the seminal work on mRNA in the Dept. of Neurosurgery @PennNSG , the advocacy of David Langer, @drdavidlanger , "Neurosurgery needs a molecular biologist", the

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Steven Brem

@StevenBremMD

2 years

Kudos to Muskaan Aggarwal! With an interest in immunology + oncology, she summarizes the science behind the Phase 3 trial, led by Dr. Linda Liau, @UCLANsgy , @JAMAOnc , "Dendritic Cell Vaccines: A New Frontier of Treatment for #GBM " @PennNSG #immunotherapy

Dendritic Cell Vaccines: A New Frontier of Treatment for Glioblastomas

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www.youtube.com

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Steven Brem

@StevenBremMD

1 year

Pleased to see our paper on #dendriticcell #Vaccine published by our Neuroradiology team in @JNeurooncol using a novel, multiparametric #MRI -prediction model @PennNSG @PennCancer #Immunotherapy #Immunology @drsuyash @SanjeevCha75528 #Glioblastoma

Assessment of treatment response to dendritic cell vaccine in patients with glioblastoma using a...

Multiparametric MRI-based prediction model can assess treatment response to DCVax-L in patients with glioblastoma.

pubmed.ncbi.nlm.nih.gov

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Steven Brem

@StevenBremMD

1 year

The FUTURE OF NEUROSURGERY is in the hands of our medical students. Here are the Spectacular Seven, 5.14.2023, at their #commencement . All are headed to elite neurosurgical programs, destined for greatness. In the center, our chair, @DanielYoshor , prioritizing education.

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Steven Brem

@StevenBremMD

2 years

Great dinner last night with Dr. Linda Liau, with food for thought on the bright future of immuno-oncology for treatment of #glioblastoma . Pictured (left to right) are Yi Fan, @DrLeeBrainSurg , Linda Liau, @NdukaAmankulor , @DanielYoshor , @StevenBremMD . Await @NeuroOnc in Tampa.

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Steven Brem

@StevenBremMD

2 years

@NeuroOnc Currently, in (chilly) Philly, the temp = 42 degrees, Tampa = 75. Can't wait for the amazing meeting. Excited to be part of the Penn Brain Tumor Center team. Much attention on CTIM-27 (Liau LM...et al. Dendritic Cell vaccine) >2,000 views so far. Looking forward to our PVI-CME.

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Steven Brem

@StevenBremMD

9 months

What a day for Dr. Sabrina Heman-Ackah as she successfully matched to Harvard's Skull Base Surgery Fellowship, led by Timothy R. Smith, MD, PhD, MPH @BWHNeurosurgery , @MassgeneralB !! Kudos to @harvardmed for this great selection. #neurosurgery #skullbase surgery @PennNSG

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Steven Brem

@StevenBremMD

2 years

Superb lecture 10.27 by Dr. Linda Liau on targeting treatment-induced resistance in glioblastoma, organized by @PennRadOnc [Yi Fan], and @PennNSG [ @DanielYoshor ], elucidating the science behind the UCLA SPORE, glioblastoma treatment resistance, and exciting future clinical trials

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Steven Brem

@StevenBremMD

2 years

@RS_Preprints This is highly anticipated, supportive data —under review—by the team of Suyash Mohan, Sanjeev Chawla, and the work of Laiz de Godoy using a multiparametric (mp) MRI approach independently reporting increased survival using a separate U. Penn externally matched data base to show

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Steven Brem

@StevenBremMD

2 years

Kudos to @Ali_Nabavizadeh , Stephen Bagley and our superb team @PennCancer @PennNSG @PennRadiology for publication of 18F-Fluciclovine #PET scan to distinguish progression vs. pseudoprogression of recurrent #GBM : fulfilling an unmet need in neuro-oncology.

Distinguishing Progression from Pseudoprogression in Glioblastoma Using 18F-Fluciclovine PET -...

Accurate differentiation between tumor progression (TP) and pseudoprogression remains a critical unmet need in neurooncology. 18F-fluciclovine is a widely available synthetic amino acid PET radiotr...

pubmed.ncbi.nlm.nih.gov

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Steven Brem

@StevenBremMD

11 months

Breaking news 10/2/2023. @ScienceNews & @PennNewsToday confirm that our colleagues, Katalin Kariko, @kkariko adjunct professor of #neurosurgery @PennNSG and Drew Weissman @WeissmanLab @PennMedicine are indeed the 2023 recipients of the Nobel Prize in Medicine & Physiology!!!👏👏

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Steven Brem

@StevenBremMD

2 years

@PennNSG The exciting results of this Phase I/II study support and extend the findings of our large Phase 3 study, published @JAMAOnc , led by Dr. Linda Liau, Keyoumars Ashkan, MD, Dr. Marnix Bosch and the #DCVax team.

Adjuvant Vaccination with Allogenic Dendritic Cells Significantly Prolongs Overall Survival in...

Immunotherapy for cancer treatment has gained increased attention in recent years. Recently, our group reported the case of a patient with glioblastoma who underwent vaccination based on dendritic...

www.mdpi.com

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Steven Brem

@StevenBremMD

2 years

A quick preview of CTIM-27, abstract published 11.14 in #NeuroOncology dendritic cell vaccine improves survival...results of a phase 3 trial. (Liau L, Ashkan K, Brem S... Bosc M, et al), scheduled for Sunday, 8:20 to 8:30 a.m. presented by Dr. Linda Liau. #immunotherapy #vaccine

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Steven Brem

@StevenBremMD

2 years

The complexity, heterogeneity of the overlapping pathways (redundancy) as well as the mutational drift (oncoplasticity) contribute to glioblastomas being resistant to therapy. Excited that the #dendritic cell vaccine could be part of the future solution.

Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival...

Is treatment with autologous tumor lysate-loaded dendritic cell vaccination (DCVax-L) associated with improved overall survival (OS) for patients with newly diagnosed glioblastoma (nGBM) and recurr...

www.ncbi.nlm.nih.gov

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Steven Brem

@StevenBremMD

2 years

Wonderful to meet again with @MichaelLimMD , good friend and neurosurgical superstar, Penn's 27th Annual Sandra Altman Lecturer, on the timely topic of "Immunotherapy of Brain Tumors". @PennNSG #immunotherapy #glioma #Neurosurgery @PennMedicine

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Steven Brem

@StevenBremMD

2 years

There's still time to register for the CME, , developed in partnership with ABTA, Thursday, 11.17.22, 5:15 PM, dinner, Ballroom D, Tampa Convention Center, organized by @PeerView , featuring @BrainTumorDoc and Suriya Jeyapalan. Will preview CTIM-27, DCVax

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Steven Brem

@StevenBremMD

3 years

🎆🎇7/1/2021: Penn Neurosurgery rolls out the red (and blue) carpet for Dr. Brian Jankowitz, who now leads our Cerebrovascular Surgery Division. In addition to extraordinary surgical skills, he has >190 articles (PubMed) and led many groundbreaking trials. @BrianJankowitz

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Steven Brem

@StevenBremMD

1 year

Looking forward to the White House Moonshot Forum on Brain Cancer in one hour (1:00 PM E.T.) Rumor has it that our own Dr. Donald M. O'Rourke from the Penn Brain Tumor Center will be in attendance, as well as potential speakers, @MichaelLimMD and Shawn-Hervey-Jumper, MD.

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Steven Brem

@StevenBremMD

1 year

The validation of the mp-MRI based prediction model to differentiate pseudoprogression from true progression is described in the current issue of the Journal of Translational Medicine. Ongoing work was presented this week @TheASNR

Validation of multiparametric MRI based prediction model in identification of pseudoprogression in...

Our multiparametric MRI based prediction model may be helpful in identifying PsP in GBM patients.

pubmed.ncbi.nlm.nih.gov

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Steven Brem

@StevenBremMD

2 years

Penn Brain Tumor Center welcomes Dr. Christina Jackon, @Dr_CJackson , combining extraordinary background in #skullbasesurgery with innovative immunotherapy, a protégé of @MichaelLimMD & @dpardol1 , recipient of a F32 NIH fellowship: changing neoantigen landscape of #rGBM @PennNSG

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Steven Brem

@StevenBremMD

2 years

In addition, the all-important "tail" of the survival curves, 7/37 patients (5/7 GBM) were still alive at the time of publication. Long-term survivorship, and the other data, support the continued development of dendritic cell vaccines in the treatment of high-grade gliomas.

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Steven Brem

@StevenBremMD

1 year

A major unmet need in #neurooncology is the ability to differentiate progression from pseudoprogression. Using histopathology as the "ground truth", there was an overall concordance rate of 76.5%.

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Steven Brem

@StevenBremMD

2 years

Analysis reported independently by Amy A. Pruitt, MD, FAAN, William N. Kelley Professor of Neurology, University of Pennsylvania, an esteemed colleague, master clinician, an extraordinary educator, and a true pioneer in neuro-oncology. Kudos! #Neurology #Pennneurology

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Steven Brem

@StevenBremMD

1 year

@NeuroOnc Superb review article that places the recent DCVax study in perspective.

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Steven Brem

@StevenBremMD

2 years

At 30M, survival was 11.1 vs 5.1% (controls). The study is deemed important because: i) addition of DCVax to SOC resulted in clinically meaningful and statistically significant extension of survival compared to matched, contemporaneous, external controls receiving SOC alone.

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Steven Brem

@StevenBremMD

1 year

Historic day today, 3.21.23, marking the 50th anniversary of the founding of the American Brain Tumor Association, @theABTA by Susan Kramer. Kudos to other members of the Scientific Advisory Council, seeking a cure. Meet Hope Head On. H https://www.youtube.com/watch?v=K-v5xrZ93eA

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Steven Brem

@StevenBremMD

2 years

Kudos to Saba Haile Tegegne! With an interest in immunology, for her capstone project as a medical student in @PennNSG , she summarizes the recently published work of a Phase I/II #clinicaltrial of allogeneic #dendriticell #vaccine targeted

Glioblastoma and Dendritic Cell Vaccines: Phase I/II trial using...

null

www.youtube.com

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Steven Brem

@StevenBremMD

2 years

The article notes Median OS for 232 patients with nGBM on DCVax = 19.3M from randomization (22.4M from surgery) vs 16.5M from controls; Survival at 48 M = 15.7% vs 9.9%; mOS at 60M, 13.0M vs 5.7%. Survival for 64 patients with rGBM =13.2M vs. 7.8 M, controls. At 24M, 20.7 vs 9.6%

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Steven Brem

@StevenBremMD

7 months

The 11th Neuro-Oncology #braintumor Symposium. We have attendees From Around the World, 16 countries and 30 states. It is still possible for you to register and receive our educational materials for up to one year. Click below to register.

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Steven Brem

@StevenBremMD

2 years

ii) noteworthy tails of long-term survivors; iii) novel elements including: a) trial design with external matched controls; b) therapy based on the concept of provoking a broader, anti-tumor immune response than is available from conventional therapies of checkpoint blockade

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Steven Brem

@StevenBremMD

8 months

Kudos to @StephenBagleyMD , Zev Binder, Donald M. O'Rourke and our team of collaborators for the publication today @NatureCancer on the Phase 1 study of CAR T cell therapy with #pembrolizumab , showing biological activity in the #TME , but limited clinical efficacy, pointing to

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Steven Brem

@StevenBremMD

1 year

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Steven Brem

@StevenBremMD

2 years

Key points of the Lepski et al. study: i) GDC - Genomic Data Commons as an external control population; ii) OS 75% greater in vaccinated GBM group (82% RRR-relative reduction in risk- of death at any timepoint); iii) 200% greater OS in the vaccinated astrocytoma 4 group (47% RRR)

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Steven Brem

@StevenBremMD

11 months

Dr. Kati Kariko @kkariko pays tribute to the resilience of immigrants, like herself, and women in research.

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Steven Brem

@StevenBremMD

11 months

Historic day today with a unique blend of inspiration, and celebration marking the 2023 Nobel Prize Awards to Dr. Katalin (Kati) Kariko @kkariko and Dr. Drew Weissman.

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Steven Brem

@StevenBremMD

1 year

Wonderful celebration today led by @DanielYoshor to celebrate our @PennNSG 7 medical students who had exceptional success in #MatchDay , #Match 2023. Special cameo appearance and congratulations from Suzanne Rose, MD, MSEd, Senior Vice

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Steven Brem

@StevenBremMD

3 years

Excited that PENN just opened a new trial (PURSUE) for brain metastases after Radiation Therapy requiring neurosurgical resection. PET scanning with F18-Fluciclovine can distinguish between necrosis (Treatment effect) vs. Progression. We previously published using F18-PET for GBM

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Steven Brem

@StevenBremMD

2 years

@PennNSG . Kudos to @stephenpmiranda who received the award today at the Pan Philadelphia Neurosurgical meeting for best presentation, for his work on TBI. He is celebrating with his mentor, Dr. Sean Grady, at the historic @TheUnionLeague . @PennMedicine #braininjury #Neurosurgery

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Steven Brem

@StevenBremMD

10 months

Fantastic site visit @theABTA to @PennNSG led by @NdukaAmankulor . Celebrating 50th Anniversary of @theABTA with Team Gingras: Jonathan Gingras, @ChristianGingra , @OniskeyRIck , and Team ABTA: @RalphDeVitto , @KellyDSitkin , @nwillmarth , Great overview of the Penn Brain Tumor Center

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Steven Brem

@StevenBremMD

8 months

So grateful for our partners at NBTS @NBTStweets , @dfarons and Kirk Tanner, PhD, @NBTSCSO , for their generous educational grant in support of tomorrow's 11th Neuro-Oncology Brain Tumor Symposium. Register today to learn about the five technological

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Steven Brem

@StevenBremMD

11 months

Kudos to the all-star team, @QOstrom , @NCIJBSloan , @KristinWaite , Carol Kruchko, Mackenzie Price, Corey Neff, Gino Cioffi, who today published the 2023 CBTRUS Statistical Report- the most widely cited article in our field of neuro-oncology. #SNO2023 @NeuroOnc

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Steven Brem

@StevenBremMD

10 months

@NCITomMisteli @NCIResearchCtr @NIHDirector @NIH @NCI The appointment of Dr. Monica Bertagnolli is great news for the NIH, the scientific and cancer communities. With her experience/ expertise in clinical trials, as well as her research focus on inflammation and how it underscores cancer development, as well as many other human

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Steven Brem

@StevenBremMD

1 year

Kudos to Penn's luminaries, @NdukaAmankulor and Hongjun Song who represented Penn Brain Tumor Center at the 2023 @GordonConf on #braintumors . @PennNSG @PennMedicine #Neurosurgery

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Steven Brem

@StevenBremMD

2 years

Tremendous, historic event last night to honor Dr. Sean Grady and Dr. Bert O’Malley for their incredible leadership and growth of the departments, respectively, Neurosurgery/ ENT-Head & Neck Surgery. Many classic photos, speeches to be “unveiled”. A moment that will live forever.

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Steven Brem

@StevenBremMD

2 years

Aneek Patel, sub-I from @NYUneurosurgery , presented his work with @DastagorzadaY , Donato Pacione, and Johnn G. Golfinos @nyulagone on the value of iMRI in endoscopic, endonasal resection of pituitary adenoma, with comments from @PennNSG : Sean Grady @DanielYoshor & @DrLeeBrainSurg

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Steven Brem

@StevenBremMD

1 year

This week we honor the brave patients who are fighting valiantly against #glioblastoma . Dr. Donald O'Rourke and I want you to hear the story of Rachel Rabinowitz, robbed of a promising life by the beast, and whose mother Kathy Savitz has been an amazing advocate for research.

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Steven Brem

@StevenBremMD

1 year

At Journal Club today, @DanielYoshor congratulated @DrLeeBrainSurg , our three residents who each discussed a major topic in the emerging fields of #neuromodulation , #brainspineinterface , and @iahncajigas who leads the RESToRe Lab (Research Engineering Strategies to Recovery).

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Steven Brem

@StevenBremMD

2 years

Welcome Hasan Ahmad @hsacahmad ! He graduated summa cum laude @berkeleybioe , @berkeleyhaas , translational neuromodulation research @NeurosurgUCSF with Dr. Edward Chang, @PennNSG now published 9 papers on #AI , data driven phenotyping of lumbar fusion, smartphone #DataAnalytics

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Steven Brem

@StevenBremMD

1 year

A 'real-time' #biomarker is the 'Holy Grail' in #neurooncology . Excited that our work to "Tame #glioblastoma in 'Real Time', was published @CCR_AACRonline today. @PennNSG @PennRadiology @PennCancer

Taming Glioblastoma in "Real Time": Integrating Multimodal Advanced Neuroimaging/AI Tools Towards...

The highly aggressive nature of glioblastoma carries a dismal prognosis despite aggressive multimodal therapy. Alternative treatment regimens, such as immunotherapies, are known to intensify the...

pubmed.ncbi.nlm.nih.gov

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Steven Brem

@StevenBremMD

1 year

Looking forward to tomorrow's historic symposium honoring the contributions of M. Sean Grady, MD, a neurosurgical giant who has shaped American Neurosurgery and the work of countless neurosurgeons. The symposium starts at 1:30, ends at 4:30, but the Grady legacy lives forever.

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Steven Brem

@StevenBremMD

2 years

Proud to serve on the @theABTA Discovery Grant Review Committee chaired brilliantly by @CraigHorbinski , working with colleagues @ManishKAghi , @KeithLigon5 , E. Antonio ("Nino") Chiocca, Minesh Mehta, and other superstars. Exciting new targets, technologies & translational science!

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Steven Brem

@StevenBremMD

3 years

6.19.21 - Dr. Daniel Yoshor and Dr. Sean Grady gave a spirited tribute to our chief residents, Patti Zadnik Sullivan (Spine Fellowship, Brown), Tracy Ma Flanders (Pediatric NS Fellowship, CHOP), Ryan Salinas (U. Washington-Seattle), receiving their personalized Penn chairs.

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Steven Brem

@StevenBremMD

1 year

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Steven Brem

@StevenBremMD

6 months

NEUROSURGERY MATCH DAY - The Ides of March- The Ideas of March- The Yes of March (Previously posted as an X Article) Today, #MatchDay2024 , and fingers crossed for all the aspiring neurosurgeons. We will soon discover the fortunate few who matched to @PennNSG and other wonderful

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Steven Brem

@StevenBremMD

1 year

@nickeworth Remember what our Philly sports hero (Eagles QB) Jalen Hurts says, “I found my purpose before others formed their opinion.” Neurosurgery is an exceptional profession. Maximize it. Maximize yourself. Ignore other’s biases, opinions, zingers. There will always be naysayers, and

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Steven Brem

@StevenBremMD

2 years

Excited to be P.I. of Glioma Connectome Project, @StacheStrong , as we entered our first patient- of @NdukaAmankulor , Dr. Stephen Bagley. Kudos to @PennRadiology , Dr. Michael Hoch, co-PI, and NCRD. Recurrent, temporal #glioblastoma , using rs-fMRI . @o8tNeuro

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Steven Brem

@StevenBremMD

2 years

1.15.23 @PennNSG celebrated a fantastic Holiday Party today at the Rittenhouse Hotel. Great "esprit de corps" led by @DanielYoshor @PennMedicine @SpadolaMD @SoniaAjmera Inspiring message from the Chair (see thread) in advance of #MLKDay tomorrow.

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Steven Brem

@StevenBremMD

1 year

Dr. Isaac Chen, Residency Program Director @PennNSG points to the graduates. Following 3 powerful, from-the-heart talks, from each of the graduating residents, Svetlana Kvint, Ashwin Ramayya, Saurabh Sinha, receive their precious, hard-earned, magnificent certificates.

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Steven Brem

@StevenBremMD

6 months

@DrBonillaOnc @DavidFajgenbaum @EveryCure @DefeatDIPG Wow! This is an amazing story of the power of personalized genomic medicine coupled with targeted therapy and using a repurposed drug to cure an incurable disease. The young man should be the poster child for Every Cure and proof-of-concept for the recently awarded ARPA_H grant

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Steven Brem

@StevenBremMD

2 years

Congratulations to Dr. Yi Fan, @JDWinkler1956 , Stephen Bagley, MD, MSCE and Penn Team for exciting discovery of a small molecule, toosendanin, which suppresses IL-6, reverses macrophage-mediated immunosuppression to overcome #GBM resistance to

Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma...

T cell-based immunotherapy holds promise for treating solid tumors, but its therapeutic efficacy is limited by intratumoral immune suppression. This immune suppressive tumor microenvironment is...

pubmed.ncbi.nlm.nih.gov

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Steven Brem

@StevenBremMD

2 years

While the city of #Philly celebrates #SuperBowlLVII tonight, there are #Eagles and @PennNSG that serve the community 24/7/365. This week, we celebrate the historic ribbon-cutting and official, new home for the Penn Presbyterian (Presby) Medical Center- Neurosurgery Service

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Steven Brem

@StevenBremMD

7 months

Dr. Katalin Kariko, @PennNsgy ’s first #NobelPrize winner with our chair of #Neurosurgery , @DanielYoshor on 2.15.24 to hear an inspiring lecture from Dr. David Langer, a @PennNsg alumnus, and Grand Rounds speaker on “Invisible Forces that Shape the Medical Career”. (This grand

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Steven Brem

@StevenBremMD

3 years

Weekend highlight was the 7.24.21 meeting of CBTRUS, its Board of Directors and the @theABTA leadership. Kudos to Carol Kruchko, President, and PIs @NCIJBSloan and @QOstrom who annually produce the widely cited CBTRUS report published in Neuro-Oncology. @BrainTumorStats

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Steven Brem

@StevenBremMD

2 years

@sentimentstock @Ali_Nabavizadeh @PennCancer @PennNSG @PennRadiology Yes, already FDA-approved fir recurrent Prostate cancer.

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Steven Brem

@StevenBremMD

2 years

Inspiration everywhere, beautiful spring day, notable sign en route to #AANS2022 . "ON COURSE TO CHANGE THE WORLD" Same site previously featuring the Brain Cancer Immunorevolution. Stay tuned: The best is yet to be! @PennNSG , @PennMedicine #Neurosurgery #braintumor #AANS

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Steven Brem

@StevenBremMD

1 year

Nothing is ‘hard,’ — it’s only your resistance to it that makes it so. by @Alexmathers84 One of the better essays I have ever read. For your daily dose of inspiration. Happy Easter!

Nothing is “hard,” — it’s only your resistance to it that makes it so.

Last week, I gave myself hell anticipating a social event I didn’t want to go to.

link.medium.com

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Steven Brem

@StevenBremMD

1 year

Exceptional, memorable evening last night to celebrate our three graduating neurosurgical residents at the Rittenhouse Hotel, honoring Svetlana Kvint, MD, Ashwin Ramayya, MD, PhD, and Saurabh Sinha, MD. @PennNSG @PennMedicine #neurosurgery

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Steven Brem

@StevenBremMD

2 years

Looking forward to @PennNSG next Grand Rounds speaker, 7/28/22, @TedSchwartz13 , David & Ursel Barnes Professor of Minimally Invasive Neurosurgery, greeted by our formidable skull base team, @DanielYoshor , @DrLeeBrainSurg , @Dr_CJackson , M. Sean Grady, MD.

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Steven Brem

@StevenBremMD

3 years

Stellar lecture today @PennNSG Grand Rounds by Dr. Amy Pruitt: the unexpected neurological consequences of the I/O Revolution. A comprehensive review, timely, as the NRG-Brain-010 trial (Atezo + Toci + SRS) now open nationwide; next-gen of PENN CAR-T therapy set to open in 2022.

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Steven Brem

@StevenBremMD

2 years

The first Kim Family Lectureship, brilliantly given by William J. Mack, MD, a sweeping lecture covering surgical nuances, translational studies of inflammation, blood-brain barrier, cognitive function, and the neurosurgical career. @PennNSG @PennMedicine #carotid #inflammation

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Steven Brem

@StevenBremMD

2 years

6/25/22, 3 Chief Residents each give a poignant, memorable, emotional tribute to their family, friends, fellow residents, O.R. staff, and the faculty mentors. @PennNSG @DanielYoshor

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Steven Brem

@StevenBremMD

5 months

@sixers @PennMedicine Kudos to Dr. Amankulor for his surgical skills and to Georgina Weber for her bravery and trust in Penn Medicine. Where surgery is performed has a huge impact on the ultimate outcome and we are seeing more and more long- term survivors. For Georgina Weber, her expectant baby, and

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Steven Brem

@StevenBremMD

2 years

Great celebration, 4.28.22, at the historic Union League to celebrate major birthday of H. Richard Winn, MD, organized by Sean Grady, Matthew Howard, and raise funds for the Winn Prize. Joined by David Kung and James Schuster. @SNS_Neurosurg , @PennNSG , #AANS2022 , #Neurosurgery

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Steven Brem

@StevenBremMD

9 months

Kudos to the 3 chairs, @rhrosenwasser , @DanielYoshor , Michael Weaver, MD, for a truly spectacular 35th annual Pan-Philly conference covering 4 key subspecialties of #neurosurgery : #functional neurosurgery, #cerebrovascular , #spine , and #tumor . @PennNSG @JeffersonUniv @TempleUniv

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Steven Brem

@StevenBremMD

3 years

@StevenBremMD Registration now open for the first SNO symposium @NeuroOncon CONNECTOMICS and TUMOR VISUALIZATION (Fluorescence) 12.6 /12.7.21-featuring a stellar group of innovators. @hadjiMDPhD @michelle_monje @Ragini__Verma @SughrueMichael @HerveyJumper

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Steven Brem

@StevenBremMD

1 year

On a historic day (5.11.1751 Pennsylvania Hospital charter granted), @PennNSG makes history anew the KIM FAMILY Lectureship by Dr. Michael Lawton, @mtlawon (winner of 2023 AANS CUSHING AWARD). First, presentation by Dr. Susanna Howard, #ECICBypassGraft by Dr. Jan-Karl Burkhardt

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Steven Brem

@StevenBremMD

9 months

@SameerShethMD @BCMNeurosurgery - great keynote talk: Psychiatric Neuromodulation. Note the expert panel & summaries. Take-home message: "Circuit- Based dissection provides a new world of opportunities in human neuroscience... Network disorders demand network-based therapies".

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Steven Brem

@StevenBremMD

2 years

@PennNSG welcomes @ayanmandal_ on the neurosurgical service @pennsurgery . Dr. Mandal received his doctorate degree at the University of Cambridge, a @Gates_Cambridge Scholar, and is a pioneer in the field of #connectomics . He authored "A Stethoscope to the Brain".

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Steven Brem

@StevenBremMD

2 years

@StevenBremMD Sweeping Grand Rounds lecture by @chriskellnerMD on minimally invasive (SCUBA) treatment of ICH, multicenter trials, importance of timing, prognostic factors, and neural preservation. #ICH #PennNSG . Dr. Chris Kellner introduced by @DanielYoshor and @BrianJankowitz

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Steven Brem

@StevenBremMD

1 year

Kudos to the "Penn Pioneers" leading the way at #AANS2023 , starting with @DanielYoshor , FAANS, Charles Harrison Frazier Professor and Chair, updating progress, Monday, 4.24.23, " Visual Cortex Prostheses"

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Steven Brem

@StevenBremMD

6 months

Kudos to Grace Kimbaris, MD, Lovisa Ljungberg, MD who organized a successful Brain-Behavior course for Penn MS1 students featuring with hands-on demonstrations, including #thrombectomy taught by @visishs . We are all "On-Call" for the Cerebrovascular Division @PennNSG .

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Steven Brem

@StevenBremMD

2 years

Superb @PennNSG Grand Rounds lecture by @TedSchwartz13 , Minimally Invasive Anterior Skull Base Surgery- Lessons Learned Over 25 Years. #braintumor #skullbase #neurotwitter @PennMedicine

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Steven Brem

@StevenBremMD

3 years

Kudos to GKS team @PennNSG for publication by @MariaPunchak89 , Dmitriy Petrov @cheesesndwch , John Lee @DrLeeBrainSurg , on outcomes in patients with multiple metastases. Survival effects of surgery on "dominant" lesion, chemotherapy, immunotherapy, and radiation therapy analyzed.

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Steven Brem

@StevenBremMD

2 years

@PennNSG proud to host @MichaelLimMD , 1.18.23, at the dinner in Dr. Lim's honor in Rittenhouse Square with many of the spirited, brain tumor/vascular neurosurgeons in attendance. Collegiality, mentorship, learning never gets old. In advance of the 27th Sandra Altman Lectureship.

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Steven Brem

@StevenBremMD

8 months

@PennNSG @DanielYoshor hosted a fantastic dinner @surayaphilly in honor of our 28th Annual Sandra Altman Lecture, @HerveyJumper Dr. Shawn Hervey-Jumper who will speak today at #Neurosurgery Grand Rounds on the Surgical Management of Diffuse #Gliomas in the Molecular Era.

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Steven Brem

@StevenBremMD

2 years

Delighted to learn that our great colleague, Mark Gilbert, MD, @MRGneuroonc , Chief/Senior Investigator, @NIHBrainTumor , CCR (Deputy Director), NCI is the 2022 recipient of the Joel A. Gingras Award, the highest honor of @theABTA , for leadership of impactful clinical trials.

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Steven Brem

@StevenBremMD

1 year

The YouTube link:

White House Cancer Moonshot Forum on Brain Cancers

On Thursday, May 25, 2023, the White House Cancer Moonshot convened patients, caregivers, oncologists, researchers, and administration officials to advance p...

www.youtube.com

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Steven Brem

@StevenBremMD

9 months

@PennNSG proud of our two residents, Sabrina Heman-Ackhah, MD, DPhil, @sm_hemanackah and John Arena, MD who were the two winners of the Resident Research Competition at the 35th Annual Pan Philadelphia Neurosurgery Conference! #neurosurgery @PennMedEVDCSO #education #research

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Steven Brem

@StevenBremMD

3 years

@DanielYoshor spoke tonight at the Philadelphia Neurological Society, on developing next-gen visual cortical prosthetic devices (VCPs), e.g. the Orion VCP. Dynamic current steering showing promise to deliver visual information. restoring vision, and hope!

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Steven Brem

@StevenBremMD

1 year

@PennNSG welcomes Shreya Parchure, MSE, a second-year PSOM student who starts her neurosurgery rotation today at H.U.P. Her research interest is in engineering personalized #neuromodulation approaches for cognitive and psychiatric disorders. @PennMedicine @pennsurgery

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Steven Brem

@StevenBremMD

2 years

@PennNSG welcomes Muskaan Aggarwal, a Penn MD-PhD student. She attended @MIT , worked at Harvard, studied the immune response to flu, and co-authored work linking chromosomal aneuploidy, Myc oncogene to tumorigenesis & response to tamoxifen.

Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis -...

Chromosome gains and losses are a frequent feature of human cancers. However, how these aberrations can outweigh the detrimental effects of aneuploidy remains unclear. An initial comparison of...

pubmed.ncbi.nlm.nih.gov

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Steven Brem

@StevenBremMD

2 years

@Ali_Nabavizadeh @JournalofNucMed @PennCancer @PennRadiology @stevebagley @Ali_Nabavizadeh Kudos to your team @PennRadiology @PennCancer @PennNSG for this exciting innovation fulfilling a huge unmet need: to distinguish between glioma progression vs. pseudoprogression. #GBM #glioma #PET #neuroimaging @PennMedicine @BlueEarthDx

Distinguishing Progression from Pseudoprogression in Glioblastoma Using 18F-Fluciclovine PET -...

Accurate differentiation between tumor progression (TP) and pseudoprogression remains a critical unmet need in neurooncology. 18F-fluciclovine is a widely available synthetic amino acid PET radiotr...

pubmed.ncbi.nlm.nih.gov

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Steven Brem

@StevenBremMD

3 years

At 7.24.21 @theABTA and CBTRUS meeting, Matt Tifft made a cameo appearance - incredibly inspiring story of personal courage and survivorship- told by a young @NASCAR racing star turning car No.78 into a fund-raising vehicle (!) for ABTA, truly heroic race for a cure. @matt_tifft

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Steven Brem

@StevenBremMD

2 years

Exciting article in @nytimes with @elonmusk and our own @DanielYoshor . Imagine if the vast resources of @elonmusk would synergize with the great wisdom of @DanielYoshor to create a device to gift vision to the blind. Science = "the art of the soluble."

Elon Musk Hopes to Test a Brain Implant in Humans Next Year (Published 2022)

The tech multibillionaire said his company, Neuralink, was seeking government approval to test his device in people, and predicted it could happen in six months. Others have been conducting similar...

www.nytimes.com

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Steven Brem

@StevenBremMD

2 years

Her clinical interest is in Surgery. Welcome Muskaan Aggarwal to Neurosurgery, where she looks to meld her interest in immunology and oncology.

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Steven Brem

@StevenBremMD

11 months

25 (or more) years of work and today an "overnight success". Two of the most deserving colleagues whose work has led to the COVID mRNA vaccines-- saving millions of lives, the power of translational science, grit, and perseverance. Incredibly inspiring. Bravo!! Never Give Up!

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Steven Brem

@StevenBremMD

3 years

Thrilled to learn today (7/2/21) that our NRG-BN010 clinical trial, targeting IL-6, is set for accrual as of 7.6.21. Kudos to Yi Fan and Steve Bagley who took a genomic-based hypothesis to the lab (YF) and then translated it to the clinic (SB). There is a new weapon to fight GBM.

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Steven Brem

@StevenBremMD

1 year

Time to shine for our current group of 4 @PennNSG sub-Is. Great talks today were started by Alice Hsu @EmoryNeurosurg speaking of her work at the @hiti_lab , on #datascience , deep learning, #AI , predictive modeling for #vasospasm , and much more.

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