PGC Consortium @PGCgenetics Twitter profile

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PGC Consortium

@PGCgenetics

7 years

@lilycollins thanks for helping end the #stigma .

PGC Consortium

@PGCgenetics

7 years

@cbulik @psychgenomics #Anorexia has high mortality, poor tx options & counter-intuitive, unusual psych and physio. #PGC3 aim to change this

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@PGCgenetics

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Latest #GWAS from the @PGCgenetics #bipolar disorder working group identifies 64 loci, 33 of them novel, using over 40k European BD cases – now published in @NatureGenet . Results could eventually aid #precision #medicine . 1/7

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@PGCgenetics

7 years

A profoundly sad day for science as we mark the passing of our brilliant colleague and friend Dr. Pamela Sklar. A scientific visionary and pioneer taken far to early from this life.

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@PGCgenetics

3 years

Out today in @NatureNeuro , the largest genomic study of #depression to date (>1.2 Million individuals) led by @dflevey1 of @Yalepsych / @YaleMed . Provides new insight into the genetic etiology of depression and related traits. Great work @dflevey1 and team!

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@PGCgenetics

4 months

New pre-print from the @PGCgenetics #Depression Group: Multi-ancestry GWAS of depression with 685,000 cases identifies 697 independent associations, implicating known & novel drug targets. 🔗 1/n

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@PGCgenetics

2 years

I’m incredibly lucky to be part of PGC Africa as the Autism research network lead! If you’re interested or working on Autism research in Africa, I’d be happy to hear from you & add you to the PGC Africa neurodevelopmental network! @patkipkemoi

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@PGCgenetics

6 years

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD. The largest ever genetic study of #ADHD has been published @NatureGenetics

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity...

Nature Genetics - A genome-wide association study for attention deficit/hyperactivity disorder (ADHD) identifies 12 loci and implicates neurodevelopmental pathways and conserved regions of the...

www.nature.com

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@PGCgenetics

2 years

Congrats to Dr Alicia Martin @genetisaur , who is instrumental in developing statistical methods and resources for multi-ethnic studies and underrepresented populations! She is the recipient of the 2022 Sklar Innovation Award. #WCPG2022 1/2

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PGC Consortium

@PGCgenetics

9 months

@PGCgenetics are dismayed that @OrchidInc ’s embryo testing includes common chronic disorders such as schizophrenia Their information on the genetics of schizophrenia refers to @PGCgenetics research

Is there a genetic test for schizophrenia?

Understand what’s possible to predict through genetic testing for schizophrenia and how recent advances allow genetic risk to be better quantified.

guides.orchidhealth.com

Orchid

@OrchidInc

9 months

We’re excited to announce the first whole genome screening for embryos is available! Parents can get 100x more data about their embryos’ genomes, empowering them to make an informed decision and give their baby the best chance at a healthy start.

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@PGCgenetics

6 years

ADHD shows significant genetic overlap with 43 other traits, including depression, anorexia, insomnia, smoking, neuroticism, obesity and educational outcomes

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@PGCgenetics

2 years

How combining rare and common genetic variants using WGS solved most of the 'missing heritability' issue for height!

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@PGCgenetics

2 years

Check out this exciting study by Andrew Grotzinger ( @Andrew_Grotz ) and colleagues in @NatureGenet , where they examined shared genetic architecture across 11 major psychiatric disorders!

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@PGCgenetics

4 years

New preprint from @PGCgenetics - PGC3 bipolar disorder (BD) GWAS identifies 64 GW sig loci 2020.09.17.20187054v1

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@PGCgenetics

3 years

Is #depression one disease, or the common outcome of distinct pathways? Are our ways to study depression #heterogeneity adequate to truly uncover its nature? A recent review by @caina89 , @karmelchoi and @EikoFried in @hmg_journal explores this:

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@PGCgenetics

1 year

Just on line: Multi-omics cannot replace sample size in genome-wide association studies. @David_Baranger @AlexanderHatoum @RenatoPolimanti @HEdenberg2 @GWAS_lit .

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@PGCgenetics

3 years

Dr. Cathryn Lewis is Professor of Statistical Genetics & Head of @SGDPCentreKCL . She is a world-class researcher, mentor, and co-chair of the @PGCgenetics MDD Workgroup. #IWD2022 @cathrynlewis

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PGC Consortium

@PGCgenetics

5 years

The latest @PGCgenetics study of #anorexianervosa has just been released in @NatureGenet ! Here's a brief tweetorial telling you everything you need to know about our paper. 1/9

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@PGCgenetics

5 years

Just out: @PGCgenetics Genome-wide association study identifies 30 loci associated with bipolar disorder: Bipolar I strongly correlated with schizophrenia, Bipolar II with major depression.

Genome-wide association study identifies 30 loci associated with bipolar disorder

Nature Genetics - Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including...

www.nature.com

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PGC Consortium

@PGCgenetics

3 years

Need guidance analyzing cross-population genetic data? See our primer in Cell! Genome-wide Association Studies in Ancestrally Diverse Populations @PetersonRoseann @KKuchenbaecker @HEdenberg2 @AlicePopejoy @RJStrawbridge @hailianghuang @laramieduncan

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@PGCgenetics

3 years

Dr. Karmel Choi is a clinical psychologist, assistant professor @HarvardMed , & director of the Precision Prevention Program @MGHPrecisionPsy . Her research focuses on big data, resilience, and prevention in stress & mental health. #IWD2022 @karmelchoi

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@PGCgenetics

5 years

The incredible & inspiring #PGC Major Depressive Disorder Working Group #WCPG2019

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@PGCgenetics

6 years

#DepressionReading The horrifying statistics of UK male #suicide . More lethal than cancer, transport accidents or other diseases in 15-34 year olds. #depression #SuicidePrevention

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@PGCgenetics

3 years

Congrats to the #NeuroGAPPsychosis team for leadership in tackling the diversity problem in psychiatric genetic studies! They are the recipients of the 2021 Sklar Innovation Award. #WCPG2021 1/4

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PGC Consortium

@PGCgenetics

6 years

Results from the new method Genomic SEM show evidence for a general "P" dimension underlying schizophrenia, bipolar, major depressive disorder, PTSD, and anxiety. Schizophrenia and bipolar disorder loaded the strongest onto the genetic P-factor:

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@PGCgenetics

7 years

ADHD shows genetic correlations with: depression, neuroticism, obesity, smoking, lower IQ/educational attainment & many other phenotypes

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PGC Consortium

@PGCgenetics

11 months

The incredible & indefatigable PGC Major Depressive Disorder Working Group. Safe travels home everyone, from @cathrynlewis & @mcintosh2001 (photo: @mja & Marissa at PMG)

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@PGCgenetics

3 years

And that brings us to this graph, which sums up where we are in terms of our knowledge of the genetic basis of #schizophrenia .

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@PGCgenetics

3 years

Dr Kimberley Kendall is a general adult psychiatrist at Cardiff University. Dr Kendall's work focuses on the role of rare variants such as CNVs in psychiatric disorders, and their translation to the clinic. @DrKKendall #IWD2022

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@PGCgenetics

7 years

Psychiatric genetics and the structure of psychopathology

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@PGCgenetics

7 years

No evidence that schizophrenia candidate genes are more associated with schizophrenia than non-candidate genes

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@PGCgenetics

3 months

A fantastic study by @xiangruimeng158 @Kkuchenbaecker and colleagues was recently published in Nature Genetics. The paper studied genetic risk for major depression across 1.8 million individuals with 54% from non-European ancestry. link: 🧵below

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@PGCgenetics

4 months

🧬🧠📚Want to learn more about the genetic and phenotypic similarity across major psychiatric disorders? Check out this recent systematic review by the @JacquemontSeb team:

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@PGCgenetics

6 years

The genetic overlap between psychiatric disorders is in line with shared gene-expression profiles:

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@PGCgenetics

6 years

#WhoStudiesMDD ? Meet Dr. @cathrynlewis , co-chair of @PGCgenetics MDD Working Group and leader of the Statistical Genetics Unit @KingsCollegeLon . She is a pioneer in the #genomics of #depression , its treatment & comorbidities, and a highly regarded mentor @SGDPCentreKCL . 1/4

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@PGCgenetics

5 years

#WCPG2019 Pamela Sklar Innovation Award presented to Lea Davis by @cathrynlewis

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@PGCgenetics

3 years

Want to know how polygenic risk scores (PRS) work? @deanna_brockman @jsdron @amitvkhera at the @broadinstitute made this interactive explainer:

Polygenic Scores Explained

polygenicscores.org

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PGC Consortium

@PGCgenetics

3 years

Dr Sophie Legge is a post-doctoral researcher in psychiatric genetics & epidemiology @MRCCardiff . Her work is focused on understanding the role of genetic & environmental factors in dissecting heterogeneity in psychosis & schizophrenia. #IWD2022 @sophlegge

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@PGCgenetics

7 years

Study of 55k subjects identifies the first genetic variants influencing ADHD:

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@PGCgenetics

6 years

New Mendelian Randomization study in JAMA Psychiatry by Karmel Choi PhD working in Jordan Smoller lab and with Karestan Koenen and others suggests a causal benefit of physical activity in reducing depression. #mdd #exercise

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PGC Consortium

@PGCgenetics

10 months

Want to know more about #ADHD and its overlap with other psychiatric disorders and cognition-related phenotypes? Check out this review 📖summarizing the genetic architecture of these comorbidities #genetics 🧬 Work led by Marta Ribasés @bcormand & others!

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@PGCgenetics

3 years

Dr. Gita Pathak is a geneticist focusing on integrating multi-omics data to understand neuropsychiatric disorders. She was recognized as an Early Career Investigator by the @ISPGnet 2021, and MVP Science Program 2020. #IWD2022 @GitaPathakPhD

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@PGCgenetics

6 years

Polygenic risk for #depression increases vulnerability to depression through independent pathways of #neuroticism & low psychological #resilience . Suggests that risk ≠ resilience. @mcintosh2001 @PGCgenetics

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@PGCgenetics

2 years

I couldn’t be more excited to be part of the young and energetic PGC Africa team and to be leading on the Schizophrenia Working Group. @lcmajara

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@PGCgenetics

3 years

Dr. Naomi Wray is Professor @QldBrainInst and a leader in the field of statistical and psychiatric genetics. #IWD2022 @WrayNaomi

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@PGCgenetics

1 year

Only 11% of #depression loci previously identified in individuals of European descent were found in a recent #GWAS study among 194,548 individuals of East Asian ancestry 🧬 @KKuchenbaecker @cathrynlewis @PGCgenetics

Genetic Architecture of Depression in Individuals of East Asian Ancestry

This genetic association study investigates the genetics of depression across multiple data sets of individuals of East Asian and European descent living in different countries and within different...

jamanetwork.com

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PGC Consortium

@PGCgenetics

5 years

Does depression have a genetic component? Yes! We can identify genetic variants associated with depression Two @PGCGenetics papers and where we pooled studies from @PGCgenetics , @23andMe , @uk_biobank , #iPSYCH and more

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@PGCgenetics

2 years

Study using @iPSYCHdk data shows that childhood, persistent and late-onset ADHD have distinct profiles in terms of 🧬genetic variants 🧬polygenic risk load 🧬shared genetic risk with psychiatric traits Exiting work by @doctorveera and team!

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@PGCgenetics

11 months

Very excited to share this preprint from the PGC SUI Working Group and the MVP, “Genome-wide association study meta-analysis of suicide attempt in 43,871 cases identifies twelve genome-wide significant loci" Check the 🧵 below @uofu_hmhi @bunsenmercury

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@PGCgenetics

3 years

Professor Anita Thapar is a child psychiatrist at @cardiffuni & key member of the ADHD group. She is a force in ADHD & neurodevelopmental disorder genetic research, making sure to translate discoveries to the clinic & public policy. #IWD2022 @anita_thapar1

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@PGCgenetics

7 years

Genetic denialism is unhelpful - genes play a role in who we are. Fantastic article by @MarcusMunafo from March

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@PGCgenetics

2 years

A recent study in @BiologicalPsyc1 by @NiamhAMullins and many PGC folks examined genetic influences on suicide in ~30k cases and ~520k controls. They found significant genetic overlap btwn suicide attempt and numerous psychiatric disorders. Read more here:

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@PGCgenetics

3 years

HI EVERYONE. I'm Andrew Grotzinger ( @Andrew_Grotz ) and I'll be tweeting on behalf of PGC Cross Disorder working group (CDG) from the @PGCgenetics account for the next two weeks.

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PGC Consortium

@PGCgenetics

2 years

Curious about the mechanisms that might underlie shared genetic influences on psychopathology? Wondering what biological pathways might be involved? Check out this stellar review in @BiologicalPsyc1 by Phil Lee @AnnejaneF and @jorsmo !

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@PGCgenetics

1 year

Pain et al. performed a GWAS of antidepressant response and looked at SNP-based heritability, genetic correlations, and PRS prediction. Check out the full article here:

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@PGCgenetics

5 years

#WCPG2019 Twitter Hero = @Joni_Coleman Astonishing ability to integrate and curate. Thanks from @PGCgenetics who was left in the dust and just retweeted your amazing tweets.

Joni Coleman

@Joni_Coleman

5 years

@ISPGnet Personal twitter summary for #WCPG2019 : 650* tweets, ~183K** impressions. *Estimated - includes non-WCPG tweets and a weirdly low number of tweets on Tuesday that I don't believe. **Approximate - @twitter analytics is bugged for Sat-Tues

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@PGCgenetics

4 months

Shared genetic effects contribute significantly to the co-occurence of autism (and ADHD) phenotypes with co-occurring physical health conditions, including epilepsy and gastrointestinal disorders.

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@PGCgenetics

4 months

The most recent genome-wide association study of autism identified 5 genome-wide significant loci 🧬🧬. You can find the study here: This study was performed in 2019, but new findings are on the way!

Identification of common genetic risk variants for autism spectrum disorder

Nature Genetics - A genome-wide-association meta-analysis of 18,381 austim spectrum disorder (ASD) cases and 27,969 controls identifies five risk loci. The authors find quantitative and qualitative...

www.nature.com

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PGC Consortium

@PGCgenetics

7 years

A tribute to Pamela Sklar, our visionary colleague

Pamela Sklar 1959–2017

Nature Neuroscience - Pamela Sklar, Chair of the Department of Genetics and Genomic Sciences and endowed Professor of Psychiatric Genetics at the Icahn School of Medicine at Mount Sinai in New York...

www.nature.com

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@PGCgenetics

5 years

This stacking rings activity is used at public events to open up conversations around #mentalhealth , #risk and #resilience . (Inspired by @J9_Austin 's jar analogy) #PublicEngagement #ScienceCommunication #MHDSScot

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@PGCgenetics

7 years

Wonderful summary of some fundamental concepts in statistical genetics by Robert Maier from @WrayNaomi 's group

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@PGCgenetics

3 years

Susan Kanjira is a PhD student with university of Edinburgh based at @MEIRU_MALAWI in #psychiatricgenetics , focusing on #depression in the African population @KanjiraSusan #IWD2022

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@PGCgenetics

2 years

A recent study by @cato_romero and colleagues (incl. the original LAVA team) examined local genetic correlations and more among 12 psychiatric disorders. Check out their pre-print:

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@PGCgenetics

2 years

Today we are featuring the landmark #NeuroGAPPsychosis study. NeuroGAP-Psychosis is the largest psychiatric 🧬 study in Africa. Goal -> recruit 43k participants in Ethiopia, Kenya, South Africa, and Uganda

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@PGCgenetics

3 years

Our most recent update on the genetic picture of #bipolar found 33 new common genetic variants associated with BD, with a strong role for calcium signalling and some possible druggable candidate genes worth following up 🧬 Read more here:

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@PGCgenetics

5 years

Genetic overlap between cognitive ability and major depressive disorder in the @uk_biobank . This study suggests substantial pleiotropy between cognitive ability and #depression . @SaskiaHagenaars

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@PGCgenetics

4 months

For those that want to learn more about research techniques in psychiatric genetics, we got you covered! The Video Textbook contains information on GWAS, polygenic scores, and more and even provides software tutorials. Check it out ⬇️

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@PGCgenetics

6 years

The post-doc stage and fellowship writing process is notoriously hard. This blog by @Tom_A_McAdams , Henry Dale fellow @SGDPCentreKCL @KingsIoPPN includes lots of useful tips:

Tips for Fellowships

blogs.kcl.ac.uk

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@PGCgenetics

3 years

Excluding admixed individuals from GWAS? Tractor enables inclusion of admixed individuals by incorporating local ancestry. The Atkinson lab is hiring! @egatkinson

Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost...

Nature Genetics - Tractor is a statistical framework that facilitates the inclusion of admixed individuals in association studies by leveraging local ancestry. Tractor generates accurate...

www.nature.com

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@PGCgenetics

7 years

Are psychiatric disorders the extreme end of population traits? A new twin study by @SthlmMark suggests so #BGA2017

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@PGCgenetics

3 months

A recent paper in @NatureGenet by @caina89 and @andywdahl et al showcases methods to integrate 200+ phenotypes in the @uk_biobank to impute the 80% missing values in a deeply-phenotyped definition of #depression :

Phenotype integration improves power and preserves specificity in biobank-based genetic studies of...

Nature Genetics - Phenotype imputation increases the effective sample size of major depressive disorder cases in UK Biobank, enhancing study power and polygenic risk score (PRS) accuracy. A new...

www.nature.com

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@PGCgenetics

5 years

The number of genetic loci known to be associated with depression has grown substantially in the the last few years as studies have included more participants.

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@PGCgenetics

3 years

Professor Lea Davis at @VanderbiltU is a major reason why we can share PGC data efficiently and responsibly! She is an expert in the genomics of complex phenotypes and has made important contributions to many PGC groups including OCD #IWD2022

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@PGCgenetics

1 year

What impact does MDD have on brain gene expression? How does that relate to genetics of MDD? A review by @EmilyKozik3 @LauraHuckins @MattGirgenti integrates transcriptome, genetics & environment to explore predispotion, illness onset & disease trajectory.

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@PGCgenetics

6 years

#WhoStudiesMDD ? Meet Dr. @NiamhAMullins , a postdoctoral fellow @IcahnInstitute at Mount Sinai who works in psychiatric #genetics . 1/4

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@PGCgenetics

6 years

Profs Wray & Visscher in excellent talks challenge us to think big when it comes to complex trait genetics @karolinskainst @WrayNaomi

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@PGCgenetics

2 years

Earlier this year, @josefinwerme and colleagues published LAVA 🌋, a novel framework for evaluating local heritability and genetic correlation 🧬 @NatureGenet :

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@PGCgenetics

3 years

Terrific meeting of the PGC Major Depressive Disorder Working Group. Lots of new analyses, novel findings, exciting initiatives & future plans #WCPG2021 #mentalhealth

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@PGCgenetics

2 years

Estonian Biobank pheWAS study using #ADHD PRS from @PGCgenetics 🧬ADHD genetic liability is associated with ⬆️ risk of medical conditions: Important work by: Elis Haan, @kristi_krebs , Urmo Võsa, @IsabellBrikell , @LarssonPsychEpi , @lehto_kelli

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@PGCgenetics

1 year

❓How do GWAS variants functionally contribute to #anorexianervosa disease risk, symptomatology, and clinical presentation? New paper by @jsj8duke et al investigated this by exploring the associations between AN genetics and clinical phenotypes 🧵1/6

Mapping anorexia nervosa genes to clinical phenotypes - PubMed

Our BMI-stratified results provide potential avenues of functional mechanism for AN-genes to investigate further.

pubmed.ncbi.nlm.nih.gov

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@PGCgenetics

3 years

Structural MRI data from @enigmabrains show that case vs. control brain differences are correlated between SCZ and BD, OCD, MDD, and ASD, and correlations in MRI traits were correlated with the #genetic correlations derived from #GWAS . . @PGCgenetics

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@PGCgenetics

3 years

Starting tomorrow (3/15), the @PGCgenetics Major Depressive Disorder ( #PGCMDD ) group is kicking off their two-week Twitter takeover. Stay tuned for posts from our members about everything #depression and #genetics !

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@PGCgenetics

7 years

Pleiotropy seems to be a (near) universal property of genetic variants contributing to human phenotypic variation:

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@PGCgenetics

2 years

Meta-analyses for suicide death (SD) and suicidal behavior (SB) were performed in individuals of European ancestry. One locus was identified for SD and two were replicated for SB that remained significant after conditioning on MDD.

Genome-wide association study meta-analysis of suicide death and suicidal behavior

Molecular Psychiatry - Genome-wide association study meta-analysis of suicide death and suicidal behavior

www.nature.com

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PGC Consortium

@PGCgenetics

3 years

Our @cathrynlewis speaking about the polygenicity of mental health disorders

Journal of Child Psychology and Psychiatry

@TheJCPP

3 years

Editorial by @Gelironald gets a mention in the podcast with @cathrynlewis , head of @SGDPCentreKCL . As well, Catherine talks investigating the interplay of genetics and environment on #development . Full podcast & transcript on the @acamh website #genetics

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@PGCgenetics

3 years

As the PGC MDD two-week twitter takeover draws to a close, we'd like to thank our amazing co-chairs @cathrynlewis & @mcintosh2001 for helping progress #depression genetics further and of course the one & only @karmelchoi for organising this years takeover. See you all soon 👍🧬

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@PGCgenetics

6 years

Article on largest GWAS to date on alcohol dependence. Cover is clever, by Rebecca Gelernter. @PGCgenetics

Nature Neuroscience

@NatureNeuro

6 years

Our December issue is now live!

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@PGCgenetics

9 months

The @PGCgenetics hosts genetic summary results for use by researchers. Any use for commercial testing or for testing of unborn individuals violates the terms by which PGC & our collaborators’ data are made available

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PGC Consortium

@PGCgenetics

3 years

During our @PGCgenetics PTSD Working Group & @ISTSSnews Twitter takeover, we are featuring Anne Stevenson today. @annehstevenson is the student rep of the ISTSS Genomics and Trauma special interest group. Twitterverse, please reach out to her and say hello! 1/4

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@PGCgenetics

3 years

Dr Kaarina Kowalec is assistant professor at the University of Manitoba. Dr Kowalec's work aims to identify precision medicine approaches to neurological diseases & psychiatric disorders, specifically schizophrenia. @KaarinaKowalec #IWD2022

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@PGCgenetics

1 year

Each day this week will cover a unique theme, ranging from the longitudinal course of #depression to understanding its heterogeneity. Stay tuned here at @PGCgenetics and share any related questions.

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@PGCgenetics

5 years

Earlier this year we identified the first genome-wide significant variants for #ADHD (Ditte Demontis et al., 2019; ). We are busy genotyping new samples to run the biggest GWAS of #ADHD yet. Stay tuned!

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@PGCgenetics

3 years

Dr. Brenda Penninx is Professor of Psychiatric Epidemiology @PsychRes who leads the multi-site Netherlands Study of Depression and Anxiety (NESDA). #IWD2022

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@PGCgenetics

2 years

Hello World...for the next fortnight, psychiatric genetics goes afrofuturist...we profile prospects, people, projects and publications centred on continental Africa and the diaspora. Asante sana!

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PGC Consortium

@PGCgenetics

3 years

There are many different types of genetic variations. A lot of research in the area talks about common variants (usually SNPs), but as you can see from this illustration, there are lots of different types of variants! To find out more about them read:

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@PGCgenetics

7 years

#GWAS meet TWAS: Use of gene expression to estimate cross disorder #genetic correlation.

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@PGCgenetics

6 years

First Sklar award so deserved to @J9_Austin . An inspired and perfect choice to capture the spirit and brilliance of Pamela. #WCPG2018

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PGC Consortium

@PGCgenetics

3 years

Dr Tyne Miller is a Postdoctoral Research Fellow at at Vanderbilt University Medical Center. She works on genomewide association studies for Tourette Syndrome and tic disorders. #IWD2022 @science_tyne

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@PGCgenetics

3 years

Prof Barbara Franke is chair of @DondersInst , co-lead of PGC ADHD and co-founder of @enigmabrains . She is a leader in ADHD research by integrating many approaches to help shape our understanding of the biology of ADHD. #IWD2022 @BFranke_lab

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PGC Consortium

@PGCgenetics

3 years

Did you hear about Grady Trauma Project (GTP)? The large-scale study investigates impact of #stress and #trauma related risk factors for #PTSD and related behavioral&physical health comorbidities in a high risk, highly trauma exposed urban population of Black Americans in Atlanta

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PGC Consortium

@PGCgenetics

6 months

(1/7) Happy #InternationalWomensDay2024 ! PGC outreach members @DrNiamhRyan @AbiterKuile will highlight women’s role in #mentalhealth research & celebrate @PGCgenetics women leaders in psychiatric genomics. More on their work here 👉 #IWD2024 #WomenInSTEM

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