The Metastasis Research Society (MRS) is dedicated to supporting progressive metastatic cancer research with the goal of improving treatments and patient lives.
The road less travelled -
@NatureRevCancer
's 1st Roadmap, by MRS board members Erik Sahai (
@eriksahailab
), Thomas R. Cox (
@thomasrcox
) & colleagues, asks the question ‘why do patients with cancer die?’.
| Read the Roadmap → ← |
We are delighted to award the MRS Paget-Ewing award (the society’s highest honour) to
@AshaniTW
for her pioneering work and substantial contributions to metastasis research.
Congratulations Ashani!
We mourn the loss of Dr. Isaiah Fidler, an icon and internationally respected scientist in metastasis research, and a founding member of MRS. He has been a pioneer in understanding the biology of metastasis. We extend our deepest sympathies to his wife, Dr. Margaret Kripke.
We mourn the loss of Dr. Zena Werb, an icon and internationally respected scientist in the
#TME
and
#metastasis
research. Dr. Werb has been a pioneer in understanding the role of
#ECM
proteolysis in tumor progression. We extend our deepest sympathies to her family and friends.
Congratulations to Dr. Johanna Joyce for being selected as the
#MRS
I.J. "Josh" Fidler Innovation in Metastasis Research Award! Dr. Joyce will be presenting at
#MRS2022
, be sure not to miss it!
#metastasisresearch
#metastasis
Interesting review article
@NatureRevCancer
describes the hallmarks of cancer cell dormancy and how the dormant cancer cell life cycle offers opportunities to target not only the cancer but also its environment. Please read the full article:
What do cancer patients actually die from? The precise causes of mortality and patient deterioration before death in patients with cancer remains poorly understood | → ← | 🧵(1/5)
A new article
@NatureRevCancer
discusses how
#CTC
analysis at single-cell resolution provides insights into
the biology and heterogeneity of cancer metastasis which cannot be revealed by analysis of circulating
tumor DNA derived from
#LiquidBiopsy
.
Meet the presidents! Dr. Alana Welm
@AlanaWelm
is Senior Director of Basic Science
@huntsmancancer
and the Metastasis Research Society’s incoming president (2024-2026). We interviewed Dr. Welm about her research and involvement with the society. 🧵(1/10)
That's a wrap for the MRS 20th Biennial Congress! Thank you to everyone who attended, to all of our speakers and to our awardees for making this a great congress! See you at the next one and stay tuned for info about upcoming Early Career panel webinar; safe travels everyone!
Dates confirmed for the MRS 20th Biennial Congress → June 23-26, 2024 ← | The Francis Crick Institute, London | The MRS Board is busy finalising the program which will be available soon | A list of confirmed speakers can be found here:
A new review article
@NatRevImmunol
describes how dysregulated immune cell crosstalk enhances cancer progression and metastatic spread. Please Read the full article:
A review article
@NatureRevCancer
from Dr. Ashani Weeraratna Lab
@AshaniTW
provides an overview of the interactions that occur between tumor cells and aged tumor microenvironment, and how they influence tumor progression, metastasis & therapeutic response.
Congratulations to Mikala Egeblad for being selected as the Metastasis Research Society Fidler Innovation awardee for 2024! Mikala will be presenting at
#MRS2024
(), be sure not to miss it!
@megeblad
The MRS is pleased to announce that registration for the 20th Biennial Meeting in London (23-25 June 2024) is now open here | → ← | Early Bird Registration is available until 31st March 2024 | MRS Members - keep an eye on your inboxes for more info.
Congratulations to Karuna Ganesh for being selected as the Metastasis Research Society Sue Eccles Early Career Investigator awardee for 2024! Karuna will be presenting at
#MRS2024
(), be sure not to miss it!
@KarunaMDPhD
Congratulations to Clare Isacke from
@ICR_London
on being awarded the MRS Women in Science Award for exceptional contributions to scientific discovery in the field of metastasis research
#MRS2024
#metastasis
Congratulations to Clare Isacke for being selected as the Metastasis Research Society Women in Science awardee for 2024! Clare will be presenting at
#MRS2024
(), be sure not to miss it!
@ClareIsacke
Congratulations to David C. Lyden for being selected as the Metastasis Research Society Paget-Ewing awardee for 2024! David will be presenting at
#MRS2024
(), be sure not to miss it!
We are delighted to welcome Dr. Julio Aguirre-Ghiso
@JAguirreGhiso
as the new MRS President and Dr. Erik Sahai
@eriksahailab
as the new MRS President-Elect. We are looking forward to working together under your leadership.
SAVE THE DATE! The Early Career Leadership Council (ECLC) of the MRS will host a webinar entitled “Stem cell Plasticity Drives Tumor Growth and Metastasis,” presented by Dr. Jacco van Rheenen
@vanRheenen_Lab
on Friday, June 5, 2020, at 10AM (EST).
Meet the presidents! We asked the current president of the Metastasis Research Society
@MetastasisRS
Dr. Erik Sahai
@eriksahailab
@TheCrick
about his research and story with the society. 🧵 1/8
Congratulations to 29 leaders in the field for describing a framework for advancing our understanding of cancer-associated fibroblasts. Please read this interesting Consensus Statement
@NatureRevCancer
:
Don't forget to register for this months upcoming MRS ECLC Webinar on how Stromal and immune plasticity shape the metastatic microenvironment by Neta Erez (
@ErezNeta
) on 23rd August. More details and register here:
Congratulations to MRS Board Member, Dr. Thomas Cox,
@TCox_Lab
and ECLC member Dr. Amelia Parker for their recent review article
@FrontOncology
describing the role of the ECM in lung cancer dormancy and outgrowth. Please read the full article here:
Kicking off the 3rd day of the MRS Congress is
@megeblad
who is this years recipient of the MRS Fidler Innovation Award for innovative contributions to metastasis research
#MRS2024
#metastasis
Congratulations to ECLC Chiar, Dr. Lucia Borriello
@luciaborriell
and colleagues on their review article describing the role of the tumor
#tumor
microenvironment in
#breast
cancer intravasation and dissemination. Please read the full article here:
📢 Register for our first FREE webinar of 2022 by
@AlanaWelm
and hear about how
#PDXmodels
developed in her lab at
@huntsmancancer
are leveraging
#metastasis
research globally.
📆 February 9 2022; 7PM EST, 5PM MT, 4PM PST
✍️ Register here:
Are you interested in learning more about “Metastasis”? Register for the Webinar organized by the ECLC of the MRS and learn more about “organ-specific approaches to understand metastasis” with Dr. Manuel Valiente
@valientelab
on , October 9 2020.
We are pleased to announce the opening of registration for the MRS 2020 Meeting in Buenos Aires, Argentina. We have a fantastic lineup of speakers. Conference Chairs are: Drs. Julio Aguirro-Ghiso and Dihua Yu.
@JAguirreGhiso
. Please visit our website. .
Congratulations to MRS President-elect, Dr. J Aguirre-Ghiso
@JAguirreGhiso
for receiving an Endowed Chair as Mount Sinai Professor in Cancer Biology in recognition of his outstanding record of accomplishment. This is one of the highest honors in academic medicine
@IcahnMountSinai
The mission of the MRS Early Career Leadership Council (ECLC) is to support ECRs to establish successful careers in
#metastasis
research. Here are our wonderful ECRs at the dedicated ECR workshop as part of the MRS 20th biennial congress in London
#MRS2024
Next up is David Lyden from
@WeillCornell
, the winner of this years MRS Paget-Ewing Award for scientific excellence and substantial contributions to metastasis research
#MRS2024
#metastasis
Congratulations David!
Dr. Lyden's lab focuses on the 'premetastatic niche'. His work revealed that factors secreted by primary tumors prime distant organs, facilitating metastasis. Lyden's team discovered the role of exosomes in this process and their impact on organ-specific metastatic tropism. 3/5
SAVE THE DATE! The Early Career Leadership Council (ECLC) of the MRS will host a webinar entitled “Organ-specific approaches to understand metastasis” presented by Dr. Manuel Valiente
@valientelab
on Friday, October 9 2020, at 9 AM (CET). Sign up now!
Kicking off the final session of the MRS meeting on Metastasis biology-specific clinical trials is
@JAguirreGhiso
talking about his outstanding work on Pre-clinical & clinical strategies derived from understanding cancer cell dormancy
#MRS2022
Dr. Egeblad is the recipient of the 2024 Metastasis Research Society (MRS) Fidler Innovation Award! This prestigious award recognizes her innovative contributions to metastasis research and influence on the direction of the field. 2/5
Abstract submissions are now open for the 20th Biennial Meeting of the
@MetastasisRS
, 23-26th June
@TheCrick
. All abstracts will be accepted for poster presentations or short talks. Early Bird Registration ends March 31st - don't miss out! 🧬 🔬 💊 🧫 4/4
A new article
@FrontImmunol
from
@DanielaQuail
Lab discusses the interactions between immune cells, endothelial cells, and tumor cells, and how they influence the metastatic progression.
#metastasis
.
#Immunology
. Read the full article:
Congratulations to MRS Board Member, Thomas Cox
@thomasrcox
and colleagues
@Timpson_Lab
on their review article in
@trendscancer
describing the different aspects of CAF heterogeneity and therapeutic approaches to target protumorigenic CAF . Read article
Congratulations to new MRS Board Member, Dr. Neta Erez
@ErezNeta
and colleagues on their article establishing a new model of spontaneous breast cancer metastasis to bone.
Please read the full article here:
A new review article from
@GoetzJacky
&
@Timpson_Lab
Labs summarizes how body fluids, vessel size and shear stress influence the survival of circulating tumor cells and steps of
#metastasis
. Read the full article
@NatResCancer
Tumor cells' soft spot! A new perspective on
@Dev_Cell
reviews the importance of the regulation of tumor cell mechanical properties during metastatic dissemination, highlighting the relevance of this overlooked field of research.
🗣️ Excellent line-up of speakers in the upcoming Early Career Research Virtual Meeting!
🧐 Discover ongoing research on
#metastasis
:
#dormancy
,
#vasculature
& draining
#lymphnodes
,
#therapy
, & more!
📅 Nov 28-29
Registration extended to Nov 24!
SAVE THE DATE! The ASMB Society
@amsocmatbio
will host a special e-Symposium dedicated to Dr. Zena Werb to celebrate her exceptional contributions to our community! Speakers are: Dr. Mikala Egeblad
@megeblad
, Dr. Sarah Knox, and Dr. Mina Bissell. Link:
Three dimensional in vitro cultures are more relevant than ever as a new study has identified full-length collagen VI as a novel driver of TNBC cell invasion and was enhanced with obesity in patients.
@ScienceAdvances
#TNBC
#collagen
#obesity
Register now for our next FREE ECLC-organized webinar by Dr. Leah M. Cook from the University of Nebraska on bone
#metastasis
and how curiosity shaped her career
Register here:
Are you interested in learning more how “Stem cell Plasticity Drives Tumor Growth and Metastasis”?
Register for the Webinar organized by the ECLC of the MRS and learn about
#stemcells
and
#metastasis
with Dr. Jacco van Rheenen
@vanRheenen_Lab
.
Are you interested in learning more about “Metastasis”? Register for the Webinar organized by the ECLC of the MRS and learn more about “organ-specific approaches to understand metastasis” with Dr. Manuel Valiente
@valientelab
on , October 9 2020.
A new article
@NatResCancer
by Erik Thompson & colleagues
@OzEDW
describes the evidence for Epithelial–Mesenchymal Plasticity (EMP) in cancer metastasis, and highlights strategies to target the EMP process. Read the full article:
Do not miss our next *FREE* ECLC-organized webinar by
@DLawsonlab
from
@UCIrvine
on tumor heterogeneity and
#metastasis
at
#single
-cell resolution!
Register here:
📅 Tuesday, April 4, 2023
🕑 USA (PDT): 2:00PM, USA (EDT): 5:00 PM, EU (CET): 22:00
We would like to congratulate our MRS President
@JAguirreGhiso
who has just been appointed to the Scientific Review Council of the Pershing Square Sohn Cancer Research Alliance, which works to support Young Investigators in Cancer Research
@psscra
Cancer cell dormancy and reawakening: an interesting and fascinating area of cancer metastasis. Read the perspective by Dr. Aguirre-Ghiso,
@JAguirreGhiso
, one of the foremost experts on tumor dormancy, here
@sciencemagazine
: .
Congratulations to MRS President-elect, Dr. Julio Aguirre-Ghiso
@JAguirreGhiso
and his lab members on their perspective on
#dormancy
and disseminated tumor cells
@NatureCancer
. Please read this interesting article:
Hot off the press this week. The great debate on whether the lymphatics are a route for metastasis! A new functional network of intratumoral lymphatics that facilitates metastatic seeding and targeted therapy.
@CancerDiscovery
#lymphatics
Congratulations to Dr. Zena Werb
@UCSFCancer
for receiving the 2020 Paget-Ewing Award in recognition of her outstanding contributions to metastasis research.
A review article from
@BravoCorderoLab
discusses the imaging tools that have helped to study the different cell types of the
#tumourmicroenvironment
and how these cells communicate with each other to orchestrate metastasis. Read the full article:
In a new study treated metastases often harbored private ‘driver’ mutations, whereas untreated metastases did not, suggesting that treatment promotes clonal evolution.
@NatureGenetics
@Stanford
@MRS
#Clonalevolution
A new study on
@NatureMedicine
explains why patients with liver metastasis respond poorly to immunotherapy. By causing apoptosis of CD8+ T cells, macrophages in the metastatic liver act as sponges of systemic anti-tumor immunity.
Congratulations to MRS member, Dr. Edna Cukierman
@ednacukierman
and colleagues on their review article discussing the dynamic and reciprocal interactions between stromal cells and extracellular matrices. Please read this article here:
Join us for our next webinar of 2021!!
When: Sep 21, 2021 08:00 AM Mountain Time (US and Canada)
Featuring Dr. Ana Correia
@alpcorreia
“Revisiting NK cell immunity to prevent breast cancer metastasis”
Register in advance for this webinar:
We are delighted to officially announce that Dr. Julio Aguirre-Ghiso
@JAguirreGhiso
has been elected new President-elect (2020-2024) of the Metastasis Research Society. Congratulation and looking forward to working together to find new strategies to prevent metastasis.
Rounding out the afternoon session is Erica Sloan
@CNI_lab
, from
@MIPS_DDB
. We’re all ‘fired up’ for a ‘stimulating’ talk on the importance of the nervous system in cancer and metastasis 🧠
#MRS2024
#metastasis
VEGF targeting leads to primary tumor shrinkage, but it increases intra-tumor hypoxia, resulting in a higher CTC cluster shedding rate and metastasis formation.
@CellReports
#CTCs
#Avastin
A new article
@NatureCancer
from Rubén Pio Lab
@CIMA_unav
shows intermittent fasting synergizes with PD-1 blockade to inhibit lung cancer progression and metastasis. Please read the full article here article:
🧐 Check out the final program for the upcoming Early Career Research Virtual Meeting (times are in EST)
🕙 For other time zones, check the program on the MRS website:
✍️ Register here: - registration deadline is now Nov 26!
A new study in
@Gut_BMJ
describes a novel crosstalk between macrophages, CAFs and tumor cells in PDAC, ultimately promoting metastasis.
#PancreaticCancer
#PanCancer
Congratulations to Dr. Maria Soledad Sosa for being selected as the
#MRS
Sue Eccles Early Career Investigator Awardee! Dr. Sosa will be presenting at
#MRS2022
, be sure not to miss it!
#metastasisresearch
#metastasis
Prof
@Johanna_A_Joyce
from
@Joycelab
is the 2022 recipient of the MRS Fidler Innovation Award. Looking forward to hearing all about your work on Microenvironmental Regulation of Metastasis
#MRS2022
This International Women in Science Day we recognize the many contributions women have made to metastasis research. This year, we celebrate
@Clarelsacke
with our Women in Science award for her ongoing leadership in the field.
Dr. Lyden is the recipient of the 2024 Metastasis Research Society (MRS) Paget-Ewing Award! This prestigious award recognizes his scientific excellence and substantial contributions to understanding and controlling cancer metastasis. 2/5
We are pleased to announce that we are opening up virtual registration for our 19th Biennial Congress (13th-16th November) - Register here: & join us for a fantastic lineup of world-class talks on all things metastasis
#metastasis
#CancerResearch
@OzMRS1
A new Nature article reveals a previously unknown mechanism that enables circulating tumour cells to successfully colonize new sites via a partnership with neutrophils.
#metastasis
#immunotherapy
Check out this review hot off the press on the immune microenvironment of the pre-metastatic niche published by the Lyden lab on Cancer Cell.
#metastasis
#microenviornment
Brilliant and successful 2018 Biennial Congress of the MRS & YISM. We want to thank all speakers, participants, patients, editors, and sponsors for making this conference a scientifically excellent and vibrant experience. Looking forward to meeting you in Buenos Aires!
The epidemiological link between night-shift work and increased cancer risk has been revealed in mice and displays enhanced metastasis.
@NatureComms
#shiftwork
Congratulations to MRS Past-President, Dr. Danny Welch, and MRS member Dr. Douglas Hurst, on their review article “Defining the Hallmarks of Metastasis”.
#TumorMicroenvironment
#metastasis
.Read the full article
@CR_AACR
This year's Sue Eccles Early Career Investigator awardee, Dr. Karuna Ganesh
@KarunaMDPhD
, will be presenting at
#MRS2024
(), early bird registration now open! (6/6)
A new review article discusses the current technologies that can be used to detect and characterize circulating tumor cells in surveillance of minimal residual disease. Read the full article
@NatRevClinOncol
: