Melike Lakadamyali @Melike_Lak Twitter profile | Pikagi

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Melike Lakadamyali

@Melike_Lak

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Professor, Perelman School of Medicine, University of Pennsylvania,

Philadelphia, PA

Joined June 2017

Don't wanna be here? Send us removal request.

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@Melike_Lak

Melike Lakadamyali

3 years

The lab website is finally up to date after 2 years of not having the time. Took a while to add all the accomplishments of lab members and publications. And we have open Postdoc positions in many topics. Check our work out and get in touch if interested:

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Lakadamyali Lab

The official website of the Lakadamyali Lab at the University of Pennsylvania.

www.lakadamyali-lab.com

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@Melike_Lak

Melike Lakadamyali

8 months

I’ve been promoted to Full Prof. Grateful to past/present lab members, past/present mentors, colleagues, collaborators (too many to name but you know who you are) and my family. Best part of this coinciding with #BPS , many awesome friends and mentors are here to celebrate with.

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@Melike_Lak

Melike Lakadamyali

5 years

Just got the Notice of Award from NIGMS for my RO1! It's been a journey and I am so grateful for amazing colleagues who have been so generous with their time and provided so much help and support along the way! I am very lucky to be in such an amazing environment here at Penn!

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@Melike_Lak

Melike Lakadamyali

3 years

Proud mama of a 5 year old who is loving his birthday gift. Like mother like son 😊

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@Melike_Lak

Melike Lakadamyali

3 years

Bad news, I broke my ankle, good news, RO1 scored above payline. Everyone needs some balance in their lives I guess 🤷‍♀️

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@Melike_Lak

Melike Lakadamyali

5 years

Happy to see our Perspective article on how live-cell and super-res imaging is transforming our understanding of 4D genome organization out in @naturemethods . Thanks to @rita_strack and great reviewer suggestions, I really enjoyed writing this and love the end product.

@EricTopol

Eric Topol

5 years

Our classic view of the human genome needs to be revamped and updated in the era #4D high resolution and live-cell imaging @NatureMethods by @Melike_Lak @PennMed and Maria Pia Cosma @CRGenomica

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@Melike_Lak

Melike Lakadamyali

3 years

Happy to see our work on super-res imaging of tau aggregation in press. Spearheaded by my talented and brave PhD student @melina_gyparaki and a great collaboration with @jiexiao_lab developing new methods (look out for a methods paper on DDC coming soon)

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Tau forms oligomeric complexes on microtubules that are distinct from tau aggregates | PNAS

Tau is a microtubule-associated protein, which promotes neuronal microtubule assembly and stability. Accumulation of tau into insoluble aggregates ...

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@Melike_Lak

Melike Lakadamyali

3 years

Please RT. My lab has an open position for a Research Specialist to work on computational tool development for image analysis of single molecule and super-resolution data. Here is a detailed job description and send me your CV if you are interested:

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@Melike_Lak

Melike Lakadamyali

5 years

Our paper on quantitative super-res imaging out in Biophysical Journal.

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Quantifying Protein Copy Number in Super Resolution Using an Imaging-Invariant Calibration

The use of super-resolution microscopy in recent years has revealed that proteins often form small assemblies inside cells and are organized in nanoclusters. However, determining the copy number of...

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@Melike_Lak

Melike Lakadamyali

2 years

My department has an open search for tenure track Assistant Professors. This is a fantastic department with great science and collaborative, supportive colleagues. Please apply and RT.

@UPennPhysiology

UPenn Physiology

@UPennPhysiology

2 years

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@Melike_Lak

Melike Lakadamyali

3 years

Check out our latest review on super-resolution microscopy in press @MolecularCell This was a lot of work and kudos to Charlie @Bondtanamo_bay , Adriana and Qing for doing all the hard work and putting out what I hope will be a great resource.

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@Melike_Lak

Melike Lakadamyali

4 years

My journey: J1-F1-OPT-J1-O1, BS in Physics, UT-Austin, PhD in Physics, Harvard, postdoc, Harvard, Asst Prof UPenn, Associate Prof. UPenn. My husband: J1-H1B, PhD in Comp. Biology MIT, senior director of BD, GTP-UPenn. Each EO adds so much anxiety to our lives.

@jeremysliew

Jeremy Liew

4 years

I came to the US on an h1b visa. I’d like to think I’ve been a net positive for the country. RT if you or a family member are also an immigrant who has been net positive for the US

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@Melike_Lak

Melike Lakadamyali

2 years

Goodbye Barcelona! We had a great time. My son finally got to explore his birth place and was in awe. But we are all happy to be back home in Philly!

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@Melike_Lak

Melike Lakadamyali

6 years

Congratulations to my former mentor and an inspirational scientist Xiaowei Zhuang for her well deserved Breakthrough Prize:

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Harvard’s Xiaowei Zhuang awarded 2019 Breakthrough Prize

Harvard Professor Xiaowei Zhuang has been named the recipient of the 2019 Breakthrough Prize in Life Sciences in recognition of her pioneering work in the development of super-resolution microscopy...

news.harvard.edu

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@Melike_Lak

Melike Lakadamyali

6 months

Our collaborative work with @piacosma lab is now online at Cell Reports. We dissect chromatin remodeling and gene activation kinetics at the onset of reprograming using super-resolution. Kudos to Jose-Angel for getting this to the finish line!

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Dissecting gene activation and chromatin remodeling dynamics in single human cells undergoing...

Martinez-Sarmiento et al. demonstrate that, during heterokaryon reprogramming, global chromatin decondensation and loss of repressive histone modifications occur at late stages after cell fusion....

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@Melike_Lak

Melike Lakadamyali

6 years

So happy to see our latest work online in PNAS. We have developed a new multi-color single-molecule/super-resolution imaging method based on frequency multiplexing. Great collaboration with my colleague Maria Garcia Parajo's lab.

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@Melike_Lak

Melike Lakadamyali

2 years

This is a very sad day. Friends in PA, upcoming governor elections are crucial for defending women’s and human rights in this state. Please vote and donate to the cause.

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@Melike_Lak

Melike Lakadamyali

11 months

Thrilled to see our work on microtubule detyrosination in press. This is the amazing work of postdoc extraordinaire Qing Tang, who is currently on the faculty job market and will be a catch for any department lucky enough to recruit her.

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@Melike_Lak

Melike Lakadamyali

6 months

I’m excited to share our new pre-print from fearless Adriana Santiago-Ruiz, with co-authors @shugelier , @Charlie_R_Bond , and our amazing collaborator @TNRLab examining Tau hyperphosphorylation in human postmortem brain tissue using DNA-PAINT imaging:

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Super-Resolution Imaging Uncovers Nanoscale Tau Aggregate Hyperphosphorylation Patterns in Human...

Tau aggregation plays a critical role in Alzheimer’s Disease (AD), where tau neurofibrillary tangles (NFTs) are a key pathological hallmark. While much attention has been given to NFTs, emerging...

www.biorxiv.org

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@Melike_Lak

Melike Lakadamyali

4 years

Physiology Department @Penn is recruiting new faculty. Come be my colleague in a fantastic scientific environment that is also very supportive.

@PaulTitchenell

Paul Titchenell

@PaulTitchenell

4 years

Please Retweet: My home department (Physiology) @Penn is recruting for TT faculty positions. Apply!

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@Melike_Lak

Melike Lakadamyali

3 years

Thank you @NIGMS for the nice article on my science and career. It's a true honor to be interviewed and featured in the Biomedical Beat Blog. I am ever grateful to @NIGMS for the funding that supports my lab and our science.

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@Melike_Lak

Melike Lakadamyali

3 years

Happy to see this fantastic collaboration with @HeoLab , @RobertMauck11 come together so nicely. Fruit of many years of hard work and fun. Chemo-Mechanical Cues Modulate Nano-Scale Chromatin Organization in Healthy and Diseased Connective Tissue Cells

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Chemo-Mechanical Cues Modulate Nano-Scale Chromatin Organization in Healthy and Diseased Connective...

Microscale changes in tissue environment are translated to changes in cell behavior and phenotype, yet the mechanisms behind how these phenotypic changes occur are poorly understood. Here, we...

www.biorxiv.org

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@Melike_Lak

Melike Lakadamyali

4 years

We would be in Barcelona with family eating amazing food right now. I would complain to no end about traveling with a toddler, the jet lag... 2020 thought me to appreciate what life has to offer. Missing family and loved ones this holiday season.

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@Melike_Lak

Melike Lakadamyali

5 years

Some positive news to get my mind off the current situation. Just received the NoA for @NIGMS RM1 grant with Ostap lab, @ErikaHolzbaur , Dominguez lab, @DVavylonis . Can't wait to get back in lab to work with these amazing scientists. Meanwhile, we go on remotely. #SocialDistancing

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@Melike_Lak

Melike Lakadamyali

2 years

First stop Woods Hole #AQLM2022 and then off to CSHL for an exciting meeting on Genome organization and nuclear function!

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@Melike_Lak

Melike Lakadamyali

2 years

Thank you @NIGMS for funding and highlighting our work.

@NIGMS

NIGMS

2 years

. @Melike_Lak ’s lab at @PennMedicine develops cutting-edge microscopy tools and uses them to study cells’ intricate organization. Her story was one of our most popular #BiomedialBeat blog posts in 2022! Find out what other stories stood out this year.

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@Melike_Lak

Melike Lakadamyali

7 years

I am still hiring postdocs for an exciting project on super-resolution imaging of chromatin. Please spread the word.

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@Melike_Lak

Melike Lakadamyali

5 years

Lakadamyali lab is hiring a postdoc funded by the Linda Pechenik Montague Investigator award. We are excited by the bold projects this flexible funding scheme will enable and thank the Penn PSOM for the recognition. Thanks for helping spread the word.

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@Melike_Lak

Melike Lakadamyali

3 years

First lab gathering since the😷 and new group photo. Missing a few people but was fun to see most of the lab. Celebrated many things, most of all, the amazing trio, Adriana Santiago-Ruiz, Patty Colosi and Charlie Bond @Bondtanamo_bay for unanimously passing their prelims

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@Melike_Lak

Melike Lakadamyali

4 years

Excited to be part of this stellar team of scientists. We have collaborative open postdoc positions in the lab to work on imaging chromatin in disease funded by @4DNucleome ! Please apply.

@pennbioeng

Penn Bioengineering

4 years

Two teams of @PennEngineers & @PennMedicine researchers - led by #PennBioengineering Associate Professor @CreminsLab - have been awarded major NIH grants to understand 3D genomic interactions: #genomefolding #bioengineering #research #medicine #health

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@Melike_Lak

Melike Lakadamyali

3 years

Thinking about getting into single molecule localization microscopy? Check out our primer for beginners tips and catching up with the latest developments. Great team effort lead by Christophe Zimmer, with contributions from Ralf Jungmann, @SulianaManley @LabSauer and us.

@MethodsPrimers

Nature Reviews Methods Primers

@MethodsPrimers

3 years

Go beyond the diffraction limit with our single molecule localization microscopy Primer by Zimmer et al.! @Melike_Lak @PennEpiInst @PennMuscle @PennCDB @institutpasteur @ImodLab @GriffieJuliette @EPFL_en @EPFL_Imaging @SulianaManley @LabSauer @FSchueder

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@Melike_Lak

Melike Lakadamyali

3 years

Please RT! JOIN US: My department () is hiring! Assistant/Associate level. Reasons to apply: Amazing and supportive environment, great colleagues and great resources! DM me if you have any questions. I maybe biased but I highly recommend this department!

www.med.upenn.edu

@UPennPhysiology

UPenn Physiology

@UPennPhysiology

3 years

Physiology Department at Penn is hiring Assistant/Associate Professor to work in interdisciplinary environment. Outstanding conditions. Underrepresented individuals encouraged to apply ( and )

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@Melike_Lak

Melike Lakadamyali

7 months

Very excited to see this work from PhD student @Charlie_R_Bond and co-authors ( @SHugelier , Victor Xing and Elena Sorokina) out in the world. We used multiplexed DNA-PAINT and developed a quantitative pipeline to uncover substantial heterogeneity in the protein makeup of lysosomes

@Charlie_R_Bond

Charlie Bond

@Charlie_R_Bond

7 months

Interested in organelle biology? Lysosomes? We know these organelles play MANY crucial roles in cells, but is every lysosome the same? Check out our preprint on a new framework to study organelle heterogeneity with a focus on lysosomes! Highlights below👇 @Melike_Lak @SHugelier

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@Melike_Lak

Melike Lakadamyali

1 year

Check out our preprint ECLIPSE, a machine learning approach for classifying structures in super-resolution data. ECLIPSE is broadly applicable and we would love for you to try it on your favorite structures:

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ECLiPSE: A Versatile Classification Technique for Structural and Morphological Analysis of Super-...

We introduce a new automated machine learning analysis pipeline to precisely classify cellular structures captured through single molecule localization microscopy, which we call ECLiPSE (Enhanced...

www.biorxiv.org

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@Melike_Lak

Melike Lakadamyali

4 years

Good things happen in Philadelphia!

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@Melike_Lak

Melike Lakadamyali

2 years

I am so glad to finally see this work out in @natBME This has been a true team effort with great collaborators ( @HeoLab @MauckLab @ShenoyLab @BurdickLab ) spanning so many disciplines brought together under one umbrella by @CEMB_STC and a tour de force by Su Chin @HeoLab

@HeoLab

The Heo Lab

2 years

Check out our recent collaborative paper in @natBME ! Via experimental observation and theoretical modeling, we show that diseased connective tissue cells change the physical structure of their genomes @Melike_Lak @MauckLab @ShenoyLab @CEMB_STC @BurdickLab

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@Melike_Lak

Melike Lakadamyali

6 years

@FOMconferences @SuperResoluSian @gailmcconnell @SusanSuperRes Is this tweet meant to suggest that there are no great female scientists doing microscopy? It's not that hard to create gender balance and keep the science at the highest level at the same time.

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@Melike_Lak

Melike Lakadamyali

3 years

Learning how to do in person lab meetings again! Some small technical glitches with the acting up of the projector but mostly just wonderful to be back in the same room with these amazing people and so much more enjoyable than Zoom!

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@Melike_Lak

Melike Lakadamyali

3 years

Interested in working at the cutting edge of light microscopy and analyzing multi-modal, big imaging data? Come work with @MustafaMir16 and I!

@MustafaMir16

Mustafa Mir

3 years

My & @Melike_Lak s lab are looking to jointly hire a computational specialist. The role will include developing analysis pipelines & implementing new algorithms for dealing with TB scale microscopy datasets. Please help spread the word!

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@Melike_Lak

Melike Lakadamyali

1 year

#celldyn2023 comes to an end for me. Leaving inspired. It’s been one of the best meetings. Kudos to organizers @ErikaHolzbaur @JLS_Lab Michael Way and Rob Parton for hitting it out of the ballpark with organizing an amazing meeting with awesome science and venue

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@Melike_Lak

Melike Lakadamyali

5 years

Moving your lab to another country? Check out some useful advice from Science magazine’s recent article, with quotes from the great Antoine van Oijen @van__Oijen and few lines of wisdom from my own experience:

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@Melike_Lak

Melike Lakadamyali

3 years

I am so sad to miss Qing and Melina crushing it at #bps2022 @BiophysicalSoc . Proud PI. All the pictures and posts are giving me conference envy!

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@Melike_Lak

Melike Lakadamyali

6 years

Very proud of my former postdoc Nitin Mohan, now a PI at the IIT, Kanpur, for his great work, online as of today in JCB. Detyrosinated microtubules spatially constrain lysosomes facilitating lysosome–autophagosome fusion

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@Melike_Lak

Melike Lakadamyali

8 months

#BPS2024 is on! Check out presentations from the lab. 🧵 I am giving a talk at the Biological Fluorescence subgroup today in Room 201A/B about new work on Alzheimer’s disease

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@Melike_Lak

Melike Lakadamyali

1 year

Preprint alert for two preprints, one from our lab and one from the @NHatzakis lab on machine learning frameworks for classification and analysis of super-resolution data.

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@Melike_Lak

Melike Lakadamyali

11 months

If you are headed to #cellbio2023 check out our lab's work: Qing Tang presents her work on Microtubules on Sunday Dec 3rd, 1:45-3:15pm, Board 120 and Charlie Bond @Charlie_R_Bond presents his work on Lysosomes on Tuesday December 5th, 12:15-1:45, Board 345!

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@Melike_Lak

Melike Lakadamyali

5 years

Congratulations to my former mentor Xiaowei on this award. So well deserved!

@RockefellerUniv

Rockefeller University

@RockefellerUniv

5 years

Xiaowei Zhuang, inventor of super-resolution and genome-scale imaging techniques, is this year's recipient of the Pearl Meister Greengard Prize! Join us on Rockefeller's campus on Nov 19 for the award ceremony. #PMGPrize #WomenInScience #WomeninSTEM

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@Melike_Lak

Melike Lakadamyali

8 months

That’s a wrap for #BPS with an amazing session on genome organization. Amazing talks and so much fun to hang out with the stars of chromosome biology

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@Melike_Lak

Melike Lakadamyali

3 years

Thanks Penn Epigenetics for an amazing retreat! My first in person event since the pandemic. Great location, organization and amazing science. I feel rejuvenated! @PennEpiInst

@Marisa_S_B

Dr. Marisa Bartolomei

3 years

Penn Epigenetics Retreat. A great day of trainee science in person at Citizens Bank Park and also with the Phillie Phanatic. @PennEpiInst @berger_lab

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@Melike_Lak

Melike Lakadamyali

7 years

Posdoc position in my lab to work on chromatin nano-structure in reprogramming with super-res and ChIP-Seq. Get in touch if interested.

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@Melike_Lak

Melike Lakadamyali

2 years

We managed to get outside on a nice, sunny Philly day for a lab picnic at Penn park with this wonderful group of people. Thanks to @SHugelier and Adriana for organizing and all members of the Lakadamyali lab for the fun.

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@Melike_Lak

Melike Lakadamyali

1 year

Great opportunity alert. @BB_UPenn is a stellar department and @PennEpiInst is a stellar institute. Please apply and come work in an intellectually stimulating and supportive environment with top notch colleagues.

@BB_UPenn

UPenn Dept of Biochem & Biophys

1 year

We are hiring for an assistant/associate professor along with the Penn Institute for Epigenetics! @PennEpiInst View the position listings at and

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@Melike_Lak

Melike Lakadamyali

2 years

It’s a good morning. Fetterman wins PA! And we got this much anticipated book in the mail after pre-ordering and patiently waiting for it for months! Can’t wait to read it @doctheagrif

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@Melike_Lak

Melike Lakadamyali

2 years

Had a great time celebrating the year with my awesome team, old colleagues/friends @HeoLab and new colleagues/friends @NChanaday . The lab and my office door are looking very festive post holiday party too. Happy holidays everyone!

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@Melike_Lak

Melike Lakadamyali

1 year

Also huge thanks to @Co_Biologists and @J_Cell_Sci for the amazing organization. Did you know that @J_Cell_Sci plants a native tree in a UK forest for every research and review paper they publish? They are also preserving ancient woodlands and dedicating the trees to reviewers!

@Melike_Lak

Melike Lakadamyali

1 year

#celldyn2023 comes to an end for me. Leaving inspired. It’s been one of the best meetings. Kudos to organizers @ErikaHolzbaur @JLS_Lab Michael Way and Rob Parton for hitting it out of the ballpark with organizing an amazing meeting with awesome science and venue

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@Melike_Lak

Melike Lakadamyali

6 years

Our collaborative work with Josep Dalmau on the cover of @CellReports . Congratulations Laurent Ladepeche @LauLadep and co-authors. Check out the cover and paper:

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@Melike_Lak

Melike Lakadamyali

3 years

Check out the pretty cover artwork from our latest paper in Molecular Cell drawn by Laura Martin in @piacosma lab:

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@Melike_Lak

Melike Lakadamyali

5 years

Physical Cell Biology subgroup happening now at the BPS2020. Come to Ballroom 20A, which is packed. Great job @JulieBiteenLab and Keng-hui for putting together a great program. @johan_elf_ and me have big shoes to fill next year at BPS2021

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@Melike_Lak

Melike Lakadamyali

4 years

So excited to be charging the Physical Cell Biology subgroup symposium @BiophysicalSoc with @johan_elf_ 10am-2pm EST today. Check out our awesome line up of speakers and join us @JulieBiteenLab @jiexiao_lab @RuedaLab

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@Melike_Lak

Melike Lakadamyali

2 years

I have FOMO for not being able to go to #bps2023 this year but if you are curious what the lab has been up to, check out these poster and platform presentations by my amazing lab members

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@Melike_Lak

Melike Lakadamyali

5 years

So excited to be co-organizing this meeting at CRG, Barcelona. Amazing lineup of speakers. Come join us at Seeing and decoding nuclear function & structure @CellViewer_EU @CRGenomica

@meshorer1

Eran Meshorer

5 years

@CellViewer_EU Symposium Alert! Seeing & decoding nuclear function & structure. Amazing lineup! CRG, Barcelona, Jan 27-28, 2020. Don't miss it!

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@Melike_Lak

Melike Lakadamyali

4 years

It sure is a beautiful day!

@ShorterLab

ShorterLab

4 years

It's a beautiful day in Philadelphia!

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@Melike_Lak

Melike Lakadamyali

3 years

An amazing video showing a new paradigm for the folding of the genome. Thanks @giacomo_cavalli for including some of our work from super-resolution imaging in this incredible animation. I will be incorporating this into my teaching lectures! Beautifully done!

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@Melike_Lak

Melike Lakadamyali

5 years

I am so excited about Decoding Nuclear Function and Structure meeting I am co-organizing! Submit your abstract and join us in Barcelona at the end of January to hear about amazing science from an incredible lineup of speakers!

@meshorer1

Eran Meshorer

5 years

Seeing and Decoding Nuclear Function and Structure: Barcelona, Jan 27-28. Incredible lineup! Join us, and submit your abstract by Dec-20

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@Melike_Lak

Melike Lakadamyali

4 years

This will be an awesome seminar, Penn colleagues don’t miss👇

@PennMuscle

PennMuscle

4 years

Save the Date for an upcoming Pennsylvania Muscle Institute Virtual Seminar on April 5th at 2pm EST! "Emerging Imaging Technologies to study cell architecture, dynamic, and function" Presented by Jennifer Lippincott-Schwartz, PhD @HHMIJanelia Join the event via Zoom ⬇️

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@Melike_Lak

Melike Lakadamyali

2 years

Lakadamyali lab’s entry for the Halloween door decoration contest featuring Reviewer #2 . Thank you @NChanaday for organizing!

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@Melike_Lak

Melike Lakadamyali

3 years

Happy to have contributed to this nice tool development from @jiexiao_lab . Great collaboration. See the use of DDC in our recent PNAS paper on imaging ray aggregates!

@naturemethods

Nature Methods

3 years

dSTORM blinking artifacts got you down? Distance distribution correction (DDC) eliminates repeat localizations caused by fluorophore blinking without the need for calibrations. @jiexiao_lab @Melike_Lak

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@Melike_Lak

Melike Lakadamyali

9 months

Our 4 years of luck ran out and 7yo has Covid. A very mild case thankfully and husband and I are ok so far 🤞It’s day 2 and kid is totally bored so he asked to make this video and share it with the world. That occupied 5 minutes, now what 😂

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@Melike_Lak

Melike Lakadamyali

3 years

Thanks @ElphegeNoraLab for this nice preview on our collaborative work just out in @MolecularCell with @piacosma

@ElphegeNoraLab

Elphege Nora Lab at UCSF

@ElphegeNoraLab

3 years

Is transcription and torsional stress of DNA good or bad for cohesin loop extrusion? In this preview @_RiniShah from our group highlights new stunning microscopy data from work led by Victoria Neguembor with super-resolutive duo @piacosma and @Melike_Lak

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@Melike_Lak

Melike Lakadamyali

3 years

Looking forward to presenting our work at this webinar 👇

@GENbio

Genetic Engineering & Biotechnology News

3 years

Mark your calendars for June 1st for our free webinar sponsored by @oniHQ . Our speaker, @Melike_Lak will present her work on using #superresolution #microscopy to visualize and quantify chromatin nanostructure in single cells. Register today:

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@Melike_Lak

Melike Lakadamyali

4 years

Congratulations Erika @ErikaHolzbaur ! So well deserved!

@SDFlies

Steve DiNardo

4 years

Deserved, deserved, deserved! The 2020 WICB Sandra K. Masur Senior Leadership Awardee, our own *Erika Holzbaur* #cellbio2020 @pennbgs @CAMBUpenn

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@Melike_Lak

Melike Lakadamyali

2 years

Made it to #FOM2023 after a lot of uncertainty and grateful to be here in beautiful Porto. Looking forward to exciting science and nice scenery.

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@Melike_Lak

Melike Lakadamyali

3 years

And here is a lay person write up from Pennmedicine news:

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@Melike_Lak

Melike Lakadamyali

1 year

#ICBP2023 #seoul #friends

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@Melike_Lak

Melike Lakadamyali

5 years

Excited to have a new student joining the lab to work on further developing and applying our recent multi-color super-resolution imaging approach fm-DNA-Paint:

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Excitation-multiplexed multicolor superresolution imaging with fm-STORM and fm-DNA-PAINT | PNAS

Recent advancements in single-molecule-based superresolution microscopy have made it possible to visualize biological structures with unprecedented...

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@Melike_Lak

Melike Lakadamyali

5 years

I had a great visit to UW-Madison. Thanks to Jill Wildonger for the invitation and the opportunity to share our work with the great community at UW-Madison.

@UWBiochem

UW–Madison Biochem

5 years

This afternoon! @Melike_Lak is here to share her work using super-resolution microscopy in cell biology:

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@Melike_Lak

Melike Lakadamyali

6 months

It was a great symposium and I had an amazing time meeting everyone and hearing about all the exciting science. Thanks for inviting me @BackmanLab and for the stimulating discussions @MarceloBonini8 and others.

@MarceloBonini8

Marcelo Bonini, Ph.D.

@MarceloBonini8

6 months

Thanks ⁦ @BackmanLab ⁩ & ⁦ @NorthwesternEng ⁩ for this stimulating symposium on Physical sciences applied to chromatin biology research and cancer - in this picture surrounded by geniuses ⁦ @MadhuraPandkar ⁩, Flavio Palma, Melike Lakadamyali of UPenn and Igal Szleifer

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@Melike_Lak

Melike Lakadamyali

7 years

Our collaborative paper with the Stromblad lab on active and inactive integrin organization in focal adhesions is now out in JCB:

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@Melike_Lak

Melike Lakadamyali

2 years

This is so heartbreaking, the pain is just unimaginable. This is literally my backyard in Philly. When will America stop killing its children? These deaths are the responsibility of every politician who does not support sensible gun laws.

@EllieRushing

Ellie Rushing

2 years

This is still an evolving case, and we hope to have more information in the coming days. For now, here's what we know:

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@Melike_Lak

Melike Lakadamyali

3 years

Thank you for a wonderful visit. I had an amazing time talking exciting science all day with amazing scientists @nyugrossman . My first in person seminar since the pandemic. How I missed the intelectual stimulation of in person visits. Feeling rejuvenated!

@castel_pau

Pau Castel

3 years

Wonderful talk today by @Melike_Lak from @PennMedicine as part of the seminar series of the Biochemistry Department at @nyugrossman !! Melike discussed their recent discoveries in chromatin organization using super-resolution microscopy. More here:

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@Melike_Lak

Melike Lakadamyali

4 years

Thanks @rita_strack - amplify 10 women scientists and keep it going! @moiseenkovabell @ErikaHolzbaur @channyskye @meera_sundaram @SunnyShinLab @golnaz_v @CreminsLab @BurkhardtLab @aleestout @VRodriguezBravo and many more...

@rita_strack

Rita Strack

4 years

Thanks @zha_lab - amplify 10 women scientists and keep it going! @LabRadenovic @ctmurphy1 @madhuramukho @AllisonDoerr14 @rushingmania @SulianaManley @Caroline_Bartma @Melike_Lak @KrishnanYamuna @KRogers1001 @i_jayas

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@Melike_Lak

Melike Lakadamyali

6 years

@ReynaudEmmanuel @FOMconferences That's just ridiculous. Plenty of females developing innovative microscopy and applying it to exciting biology.

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@Melike_Lak

Melike Lakadamyali

6 years

happy to see our latest JCB paper featured in the Special Issue on autophagy highlighting "most exciting articles recently published in JCB that advance our understanding of the mechanisms and disease relevance of autophagy." See all the exciting papers:

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@Melike_Lak

Melike Lakadamyali

4 years

Looking forward to presenting at this exciting meeting!

@djost_physbiol

Daniel Jost

@djost_physbiol

4 years

The Interdisciplinary School 3DGenomics2020 goes ONLINE from Nov 23rd to Nov 26th 2020 at 3-6 pm CET. Very exciting program with leaders in the field. Registration is free but mandatory at .

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@Melike_Lak

Melike Lakadamyali

7 years

Attending ASCB? Stop by the Saturday session I am co-organizing. Amazing line up of speakers:

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@Melike_Lak

Melike Lakadamyali

4 years

RIP RBG! Such a sad day. This year just keeps getting worse.

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@Melike_Lak

Melike Lakadamyali

4 years

So happy to see this work out in molecular cell. Great collaboration with @lernerjona and Zaret lab.

@MolecularCell

Molecular Cell

4 years

Online Now: Two-Parameter Mobility Assessments Discriminate Diverse Regulatory Factor Behaviors in Chromatin

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@Melike_Lak

Melike Lakadamyali

3 years

I am sad to miss #bps2022 @BiophysicalSoc this year but if you are going, don't miss these exciting talks from the lab:

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@Melike_Lak

Melike Lakadamyali

2 years

I am so excited to start this project with a stellar team!

@HeoLab

The Heo Lab

2 years

Penn Achilles Tendinopathy Center of Research Translation (PAT-CORT). Congratulations 🎉

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@Melike_Lak

Melike Lakadamyali

3 years

So happy to be part of this amazing team and looking forward to 5 more years of exciting science with the best collaborators!

@HeoLab

The Heo Lab

3 years

OMG! Our First R01 is slowly coming to the lab! Huge thanks to @Melike_Lak @RobertMauck11 @MauckLab @BurdickLab @LingQin6 Dr. James Carey @McKayLaboratory !

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@Melike_Lak

Melike Lakadamyali

4 years

Looking forward to learn about how nuclear pores regulate genome stability and function in cancer. To all my Penn colleagues: don’t miss Veronica’s talk tomorrow!

@VRodriguezBravo

Veronica Rodriguez-Bravo

@VRodriguezBravo

4 years

Very excited about my visit to @Penn tomorrow. Looking forward to talk about my lab latest work 🧫 🔬 and to stimulating scientific interactions.

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@Melike_Lak

Melike Lakadamyali

4 years

Congratulations Xiaowei! So well deserved!

@Vilcek

The Vilcek Foundation

4 years

Congratulations Xiaowei Zhuang! The @Harvard University professor and biophysicist is the recipient of @FNIH_Org 's 2021 Lurie Prize in Biomedical Science. In 2020, Xiaowei received the #VilcekPrize for her work on super-resolution imaging. #WomeninSTEM

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@Melike_Lak

Melike Lakadamyali

3 years

Congratulations to James Wilson and the whole team who pulled this off including my husband @ramonsalsas . Looking forward to following G2's accomplishments.

@PhilaEnergyGal

Laurie Actman

@PhilaEnergyGal

3 years

Amazing news day @Penn , @Pennmedicine , @pennpci --Passage Bio co-founders launch new company with $200M to fund gene therapies coming out of Penn via @PHLBizJournal

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@Melike_Lak

Melike Lakadamyali

3 years

Guilty! So relieved!

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@Melike_Lak

Melike Lakadamyali

4 years

Happy to be part of this incredible network @4DNucleome and amazing group of scientists.

@4DNucleome

4DNucleome

4 years

Thank you and warm congratulations to all the @NIHFunding 4D Nucleome Phase II members for a successful 3 days virtual kick-off meeting. We heard a lot of exciting science and collaboration ideas from leaders in the #4dnucleome field. 🧬🔬

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@Melike_Lak

Melike Lakadamyali

1 year

Excited to see these preprints out in the world.

@NHatzakis

Nikos Hatzakis lab

1 year

Super excited to present two machine learning frameworks for the classification and analysis of super resolution data : SEMORE from my lab at @CHEMUCPH and ECLiPSE from @Melike_Lak lab, that are submitted in parallel (1/n)

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@Melike_Lak

Melike Lakadamyali

4 years

@HenriquesLab The worst for me is when my name is pronounced Me-Like by English speakers. Who would name their child with that?! I am Mel for Starbucks.

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@Melike_Lak

Melike Lakadamyali

3 years

@jmuiuc I have been asked this too many times to count. Are you a biologist or a physicist? How can you supervise biology students on a biologically driven proposal? (one that I conceived of and wrote, unimaginable!). Being multidisciplinary is a strength not a weakness!

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@Melike_Lak

Melike Lakadamyali

4 years

This is awesome news. We need school teachers vaccinated and keep schools open and safe.

@lab_hill

David A. Hill, MD, PhD (Hill Lab)

4 years

We vaccinated 509 school teachers today! Way to go @ChildrensPhila and @PHLschools ! #covid #vaccine #schoolsreopening

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@Melike_Lak

Melike Lakadamyali

4 years

@naturemethods Thanks for the shout out!

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