Degradation of defective or superfluous mitochondria via mitophagy, a specialized form of selective autophagy, is important for maintaining mitochondrial quality and quantity. In yeast, the pro-mit...

Do you hold a BSc degree in life science and are eager to explore the field of ageing research? The Cologne Graduate School of Ageing Research offers a new Master Fellowship programme. Apply now!

The Max Planck Society (MPG) and the Weizmann Institute of Science (WIS) jointly offer outstanding postdoctoral researchers in the fields of physics, chemistry, mathematics, computer science and...

Nature Communications - Nuclear DNA damage downstream of mitochondrial ROS is often cited to contribute to cancer initiation and aging. However, here the authors show that although H2O2 induces DNA...

Nature Cell Biology - Choi et al. show that autophagy is activated in disease-associated microglia in Alzheimer’s disease mouse models, which prevents microglial senescence entry. Blocking...

Kallergi et al. provide a comprehensive map of the brain autophagic degradome. They reveal that protein aggregates, mitochondria, and endoplasmic reticulum, as well as synaptic proteins, are actively...

Nature - A study presents evidence to support a model in which liquid–liquid phase separation of components of the transport machinery mediates formation of transient protein transport...

Nature Cell Biology - Liu, Zhen, Xie, Luo, Zeng, Zhao et al. show that the major nucleoid protein TFAM interacts with cytoplasmic LC3B during oxidative or inflammatory stress to attenuate...

The history of mitochondria begins with their recognition as distinct cellular organelles in 1888 by Walther Flemming and the introduction of the term mitochondrion from the Greek roots meaning ‘thre…

新しい「多摩市立中央図書館」が2023年7月1日(土)にオープンしました。アクセスは小田急・京王・多摩モノレール「多摩センター駅」から徒歩約7分の多摩中央公園内の一角になります。収蔵可能冊数は約17万冊、座席数は140席あります。2階には「カフェれすとモモ」さんが出店。お弁当やお菓子、ドリンクを販売するそうです。

Nature Chemistry - Ribozyme-mediated post-transcriptional RNA modification is a powerful method for site-specific RNA labelling and analysis of RNA functions. Now, an alkyltransferase...

Mitophagy removes defective or superfluous mitochondria via selective autophagy. In yeast, the pro-mitophagic protein Atg32 localizes to the mitochondrial surface and interacts with the scaffold...

image image Metabolic fuel preference is associated with mitochondrial architecture, yet the mechanisms that connect shape and function remain unknown. This study demonstrates selective coupling...

参加人数把握のために以下の参加フォームにお答えください。 博士の学生やポスドクを中心とした勉強会です。 次回は以下の日程と発表者の方で開催いたします。 日程 アメリカ東海岸 5月11日（土）9:00 ドイツ 5月11日（土）15:00 日本 5月11日（土）22:00 発表者 山室禎さん（博士） ハーバードメディカルスクール梶村研究室ポスドク https://researchmap.jp/T...

Nature Chemical Biology - The development of a transgenic mouse line that expresses mitochondrial matrix-targeted APEX2 combined with proteome analysis identified RTN4IP1, which serves as an...

Ferroptosis is an iron-dependent form of regulated cell death characterized by accumulation of peroxidized lipids and plasma membrane disruption, whose molecular mechanism of execution remains poorly...

円安、やばいですね！弊社でもサーバー代が爆上がりしておりますし、アカデミアの皆様は海外の試薬や機器、さらには論文の出版料などの高騰にかなり研究計画を狂わされているのではないでしょうか。しかし、海外学振など、日本のお金で海外留学しているポスドクは特にやばいです。本イベントでは、大阪大学大学院生命機能研

Nature Communications - Autophagic activity declines with age in several tissues and is linked to aging-associated functional decline and pathologies. Here the authors show that Rubicon, a negative...

Nature - During senescence, minority mitochondrial outer membrane permeabilization leads to the release of mtDNA into the cytosol through BAX and BAK macropores, in turn activating the...

Nature Chemical Biology - Screening of a chemical library identifies a novel ferroptosis inhibitor that directly interferes with the formation of intracellular membrane contacts between the...

Nature Chemical Biology - Guo et al. report a small molecule agonist of mitochondrial fusion that activates MFN1, an outer mitochondrial membrane protein, and protects cells from mitochondrial...

Nature Cell Biology - Fu, Sun, Xue, Zhou et al. show that the mitoprotease LONP1 selectively degrades a complex II component to control intracellular succinate levels, which is needed for...

Fukuda et al. identify yeast Atg44 as a membrane fission protein that resides in the mitochondrial intermembrane space and named it mitofissin. Mitofissin drives Dnm1/DNM1L-independent mitochondrial...

参加人数把握のために以下の参加フォームにお答えください。 博士の学生やポスドクを中心とした勉強会です。 次回は以下の日程と発表者の方で開催いたします。 日程 日本 6月15日（土）20:00 ドイツ 6月15日（土）13:00 アメリカ西海岸 6月15日（土）7:00 発表者 須田 晃治郎さん 沖縄科学技術先端大学院大学・膜生物学ユニット https://researchmap.jp/koj...

2021年10月からドイツにあるマックスプランク老化生物学研究所（Max Planck Institute for Biology of Ageing: MPI-AGE）で働き始めました。所属研究室はThomas Langer研究室です。働き始めてから3ヶ月が経過しました。これまでのラボでの研究活動を書きます。 自己紹介：https://www.mashun-onishi.com/cv 1....

ご好評をいただいた本セミナーについて、講演部分のオンデマンド配信が決定いたしました。以下、ご確認ください。 ■オンデマンド配信 言語 日本語※This seminar will be conducte

Mitochondria-ER membrane contact sites (MERCS) represent a fundamental ultrastructural feature underlying unique biochemistry and physiology in all cells. The ER protein PDZD8 is required for the...

Nature Communications - Dysregulated autophagy and mitochondrial function are two well-described hallmarks of aging. Here, the authors describe an unexpected age-associated upregulation of...

image image Mitochondrial DNA (mtDNA) secreted by pyroptotic cells is encapsulated within exosomes and induces excessive inflammation resembling symptoms seen in patients with Behçet's syndrome. In...

株式会社リバネスが設立の支援・助言を行ったN高「研究部」が、いよいよ2021年4月にスタートします。   N高「研究部」とは… さまざまな学術領域で専門的な学修や研究活動を行っている中高生がN高の内外から集い、…

Nature Communications - Autophagic activity declines with age in several tissues and is linked to aging-associated functional decline and pathologies. Here the authors show that Rubicon, a negative...