Nature Neuroscience - Dräger et al. establish a rapid, scalable platform for iPSC-derived microglia. CRISPRi/a screens uncover roles of disease-associated genes in phagocytosis, and regulators...

Dozens of scientists funded by the Chan Zuckerberg Initiative urged Mark Zuckerberg to enforce stricter policies around the spread of misinformation and incitements to violence.

Nature Neuroscience - Leng et al. establish CRISPRi screens in astrocytes to dissect pathways controlling inflammatory reactivity. They uncover two distinct inflammatory reactive signatures that...

Funded by Alzheimer’s Association Zenith Society members, The Zenith Fellows Awards are among the most prestigious in Alzheimer's research worldwide.

Gene expression changes in brain microglia from mouse models of Alzheimer’s disease (AD) are highly characterized and reflect specific myeloid cell activation states that could modulate AD risk or...

In response to central nervous system injury or disease, astrocytes become reactive, adopting context-dependent states with altered functions. Certain inflammatory insults induce reactive astrocyte...

Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically...

Inflammatory reactive astrocytes lose homeostatic functions and can be neurotoxic, potentially contributing to neurodegenerative diseases. However, the underlying cell biological mechanisms are not...

Astrocytes respond and contribute to neuroinflammation by adopting inflammatory reactive states. Although recent efforts have characterized the gene expression signatures associated with these...

High-throughput functional analysis reveals cell-type-specific regulatory networks that mediate genetic risk for dementia.

Understanding the complex interplay between gene expression and neuronal activity is crucial for unraveling the molecular mechanisms underlying cognitive function and neurological disorders. In this...

Alzheimer’s disease (AD) is characterized by the selective vulnerability of specific neuronal populations, the molecular signatures of which are largely unknown. To identify and characterize select...

The sheer complexity of the brain has complicated our ability to understand its cellular mechanisms in health and disease. Genome-wide association studies have uncovered genetic variants associated...

CRISPRoff programs heritable epigenetic memory and is able to heritably silence most genes, including genes without CpG islands. This heritable silencing is highly specific and persists through...

Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo remains largely uncharacterized, in part due...

Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo remains largely uncharacterized, in part due...

A team of researchers has identified for the first time the neurons that are among the first victims of Alzheimer’s disease.

Single-cell transcriptomics provide a systematic map of gene expression in different human cell types. The next challenge is to systematically understand cell-type specific gene function. The...

Autism Spectrum Disorders (ASD) are a set of neurodevelopmental disorders with complex biology. The identification of ASD risk genes from exome-wide association studies and de novo variation analyses...

CRISPR-based genetic screening directly in mammalian tissues in vivo is challenging due to the need for scalable, cell-type selective delivery and recovery of guide RNA libraries. We developed an in...

The discovery of how to shift damaged brain cells from a diseased state into a healthy one poses a potential new path to treating Alzheimer’s and other forms of dementia, according to a new study...

September 25, 2024 (Washington, DC)—The Kissick Family Foundation Frontotemporal Dementia (FTD) Grant Program, in partnership with the Milken Institute Scienc

A hallmark of age-associated neurodegenerative diseases is the aggregation of proteins. Aggregation of the protein tau defines tauopathies, which include Alzheimer’s disease and frontotemporal...

Nature Biotechnology - Gene expression is precisely modulated with CRISPR interference and mismatched guide RNAs.

Nature - Low-density lipoprotein receptor-related protein 1 (LRP1) is shown to be a critical determinant of tau propagation in the brain.

The prion-like spread of protein aggregates is a leading hypothesis for the propagation of neurofibrillary lesions in the brain, including the spread of tau inclusions associated with Alzheimer’s...

In mammalian cells, mitochondrial dysfunction triggers the integrated stress response (ISR), in which eIF2α phosphorylation upregulates the transcription factor ATF4. However, how mitochondrial...

Researchers used CRISPR tools to identify genes controlling cells in the brain called microglia, which are involved in Alzheimer’s disease and other brain disorders.

The inter-cellular prion-like propagation of α-synuclein aggregation is emerging as an important mechanism driving the progression of neurodegenerative diseases including Parkinson’s disease and...

Robust and scalable iPSC-derived human neurons are generated to model 4R tauopathy phenotypes. CRISPRi-based functional genomic screening in this model identifies genetic modifiers of seeding-induced...

Nature - CRISPR–Cas9 screens in cultures of young and old neural stem cells (NSCs) and in vivo in old mice identify gene knockouts that can boost old NSC activation and neurogenesis, with...

Endolysosome leakiness allows tau to build up in cells.

Compartmentalization is a defining characteristic of eukaryotic cells, partitioning cellular processes into discrete subcellular locations. High throughput microscopy[1][1] and biochemical fraction...

Nature Communications - Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show...