Nature - An extensive global transcriptomics analysis of in vivo responses to 86 cytokines across more than 17 immune cell types reveals enormous complexity of cellular responses to cytokines,...

Nature - Glucocorticoids reprogram the mitochondrial metabolism of macrophages, resulting in increased and sustained production of the anti-inflammatory metabolite itaconate and, as a consequence,...

Nature Immunology - Epithelial cells can use an immune-like mechanism to extrude neighboring precancerous cells; however, the recognition and control mechanisms of this process are unclear....

The microbiota influence systemic immunity in ways that are not fully understood. Erttmann et al. show that the release of the membrane vesicles from the gut microbiota leads to the systemic delivery...

Nature - Learning results in persistent double-stranded DNA breaks, nuclear rupture and release of DNA fragments and histones within hippocampal CA1 neurons that, following TLR9-mediated DNA damage...

Nature Immunology - Blind mole rats are small rodents characterized by an exceptionally long lifespan and resistance to both spontaneous and induced tumorigenesis. Gorbunova and colleagues show...

Nature Immunology - Oxidized host-derived phospholipids such as oxPAPC can play important roles in atherosclerosis. Zanoni and colleagues demonstrate that oxPAPC generates a distinctive metabolic...

Tissues pose distinct challenges that macrophages must overcome, including limited nutrient availability (glucose, oxygen), to perform essential functions such as apoptotic cell clearance (efferocy...

Nature - Oocytes prevent the production of reactive oxygen species by remodelling the mitochondrial electron transport chain through elimination of complex I, a strategy that enables their...

Nature Immunology - Rinkevich and colleagues show that preexisting matrix is transferred by neutrophils across organs into injured sites in a manner dependent on integrin activation.

Interferons (IFNs) are among the first vertebrate immune pathways activated upon viral infection and are crucial for control of viral replication and dissemination, especially at mucosal surfaces as...

Caloric restriction (CR) reduces inflammation and enhances longevity, but the identity of CR-mimetics that improve health span is unclear. Ryu et al. reveal that sustained CR in humans reduces...

Nature - PD-L1 expression by senescent cells renders them resistant to clearance by CD8 T cells, suggesting PD-L1 as a target for mitigating the effects of ageing.

Nature Immunology - How the mitochondrial electron transport chain (ETC) interacts with the NLRP3 inflammasome is somewhat unclear. Here the authors use individual complex inhibitors and new...

Nature - Work in experimental autoimmune models shows that the lung microbiome is linked to immune reactivity in the brain through a mechanism in which the balance of pulmonary microorganisms...

Nature - Live-seq, a single-cell transcriptome profiling approach that preserves cell viability during RNA extraction using fluidic force microscopy, can address a range of biological questions by...

Macrophages detect invading microorganisms via pattern recognition receptors that recognize pathogen-associated molecular patterns, or via sensing the activity of virulence factors that initiates...

Immunology Explained is a resource from The American Association of Immunologists to help you understand the science behind our immune system.

Wang et al. report the mechanistic regulation of homeostatic type I IFN production by caspase-8 through the RIPK1-TBK1 axis. Hyper-activation of this pathway due to loss of caspase-8 has profound...

Sugar in mouse diets promotes metabolic disease by upsetting the gut microbial balance and driving loss of the Th17 cells that regulate lipid absorption by the intestinal epithelium.

A system of macrophages in the heart supports cardiomyocyte health by phagocytosing exopher particles ejected from cardiomyocytes that contain defective mitochondria, among other cellular contents.

Nature - Pathologically activated neutrophils, termed myeloid-derived suppressor cells, in the tumour microenvironment spontaneously undergo ferroptosis, which negatively regulates anti-tumour...

Lymphatic vessels are immunological highways that connect lymph nodes to peripheral tissues. Ataide et al. found that tissue-derived UTCs also continuously migrate via this route. This migration...

Nature - Pregnancy-induced post-translational antibody modification enables protection against the prototypical intracellular pathogen Listeria monocytogenes.

Improved understanding of how the lung stroma contributes to the development of an immunosuppressive pre-metastatic niche could potentiate new anti-cancer treatments. Here, Gong et al. identify...

Welcome to Zanoni Laboratory! We unravel inflammatory networks to understand homeostasis and fight inflammatory disorders

Takahashi et al. demonstrate that engineered epigenetic modifications and associated phenotypes can be transmitted across multiple generations in mammals.

Nature Immunology - The mechanism by which ingested material accesses the cytosol for cross-presentation is unclear. Caetano Reis e Sousa and colleagues demonstrate that signaling via the lectin...

A central paradigm of immunology is that the innate immune system first detects infectious agents in peripheral tissues, shortly after a pathogen has breached an epithelial barrier. This detection...

Olfactory receptor 2 and its ligand, octanal, play roles in atherosclerosis through their effects on vascular macrophages.

The mechanism by which IFNβ, a pro-inflammatory cytokine, mediates its paradoxical immunosuppressive effects in autoimmunity and chronic viral infections remains elusive. Fueyo-González et al. use a...

Nature - In a mouse model of breast cancer, a low-protein diet induces engulfment activities and mTORC1 signalling in tumour-associated macrophages to suppress engulfment-dependent mTORC1...

Molecular biology; Immunology; Cell biology; Functional aspects of cell biology

Neuronal ensembles in the mouse insular cortex activated during distinct inflammatory conditions are capable of retrieving or suppressing the associated peripheral immunological responses.

Nature - Manipulation of TIM-1-expressing B cells enables engagement of the second arm of adaptive immunity to promote anti-tumour immunity and inhibit tumour growth.

Nature - The COVID Human Genetic Effort examines the molecular, cellular and immunological determinants of the various SARS-CoV-2-related disease manifestations by searching for causal errors of...

Interferons can both enhance and abate the severity of respiratory viral infections.

Cytosolic LPS triggers non-canonical NLRP3 inflammasome activation, but how the NLRP3 inflammasome is ignited is still vague. In this issue of Immunity, Zhu et al. show that Nur77 detects both the...

Nature Immunology, ranked first out of more than 100 primary immunology research journals, brings together the most significant immunology research from every ...

Nature Communications - MAVS is an adapter protein involved in RIG-I-like receptor (RLR) signaling. Here, the authors show how MAVS link RLR-mediated signaling and glucose metabolism, employing...

Nature Cell Biology - Lanna and colleagues discover extracellular vesicle-mediated transfer of telomeres from antigen-presenting cells to T cells, which enables elongation of chromosomes,...

Most immune cells express little, if any, of the canonical SARS-CoV-2 receptor, ACE2. Lu et al. report that C-type lectins and TTYH2 act as SARS-CoV-2 myeloid cell-interacting partners that trigger...

Nature Communications - T-cell activation primarily occurs in the lymph nodes, highly organized and specialized secondary lymphoid organs. Here the authors show that the acidic extracellular pH in...

Nature - Immune tolerance to food is mediated by CD4+ T cells forming subsets of T helper cells lacking the capacity to trigger gut pathology but able to produce regulatory T cells that may...

Nature - Single-cell transcriptomics studies on human and mouse non-small cell lung cancer and conditional knockout mouse models show that IL-4 from bone marrow basophils drives the development of...

Lower respiratory tract infections are a leading cause of mortality driven by infectious agents. RNA viruses such as influenza virus, respiratory syncytial virus and the new pandemic coronavirus...

Nature - Serum MMP8 is increased in stress-susceptible mice following chronic stress and leads to brain structure and behavioural changes in mice.

To understand the function of the DNA sensing protein STING in intestinal inflammation, Shmeul-Galia et al. utilize a constitutively active STING mouse model that exhibits dysbiosis, severe colitis,...

Disease-associated mutations in the kinase Lrrk2 promote association of gasdermin D with mitochondrial membranes, which induces release of reactive oxygen species, a switch toward necroptotic cell...

Nature Immunology - Abramson and colleagues show that Aire+MHCII+ ILC3s sense, internalize and present Candida albicans and modulate the induction of C. albicans-specific TH17 cells.

Nature - LRRC15-positive cancer-associated fibroblasts constitute a pivotal axis in tumorigenesis and are potential therapeutic targets to improve responses to immune checkpoint blockade.

Dietary-antigen-dependent cleavage of Gasdermin D maintains food tolerance irrespective of pyroptosis.