Kentsis Research Group @KentsisResearch Twitter profile

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Kentsis Research Group

@KentsisResearch

4 years

KRG | Biology and Pharmacology of Childhood and Developmental Cancers

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Kentsis Research Group

@KentsisResearch

2 years

For those of you interested in science history, we present you with first generation micropipette

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Kentsis Research Group

@KentsisResearch

4 years

The ⁦ @sloan_kettering ⁩ facilities staff have outdone themselves again with an extraordinary holiday display, and during pandemic! Wow! #MSKKids thank you!

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Kentsis Research Group

@KentsisResearch

4 years

@RuthGotian Please make sure to take advantage of this opportunity to write a clever response.

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Kentsis Research Group

@KentsisResearch

4 years

#immigrantscience I came to US with my parents as a refugee, naturalized and became US citizen. My lab has always been mostly immigrants on OPT, J1, and H1 visas. Exchange of ideas and people is an inherent part of science, and fundamental part of USA since inception.

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Kentsis Research Group

@KentsisResearch

3 months

New record for the lab (and not a good one). Revision of latest manuscript contains 79 new figure panels to address reviewers’ questions. To quote Hidde Ploegh: End the tyranny of reviewer experiments!

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Kentsis Research Group

@KentsisResearch

3 years

Another marvelous holiday display from ⁦ @sloan_kettering ⁩ facilities staff! #MSKKids thank you!

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Kentsis Research Group

@KentsisResearch

2 years

Another magical display from ⁦ @MSKCancerCenter ⁩ facilities staff. With a surprise appearance by our local yeti.

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Kentsis Research Group

@KentsisResearch

6 months

Human cancer is a disease of somatic mutations. As we age, tissues accumulate errors in DNA, but what causes mutations in young healthy cells? Read our new paper “Childhood cancer mutagenesis caused by transposase-derived PGBD5” 1/n

Childhood cancer mutagenesis caused by transposase-derived PGBD5

Induction of somatic oncogenic mutations by the domesticated transposase-derived gene PGBD5 promotes medulloblastoma development.

www.science.org

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Kentsis Research Group

@KentsisResearch

5 years

Another awesome holiday display being created by awesome support staff ⁦ @sloan_kettering ⁩

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Kentsis Research Group

@KentsisResearch

5 years

@JSheltzer The brilliant @lydfinley and @IntlekoferLab have a great primer for all interested in this question:

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Kentsis Research Group

@KentsisResearch

3 years

Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis

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Kentsis Research Group

@KentsisResearch

4 years

#BlackLivesMattter ⁦ @sloan_kettering ⁩

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Kentsis Research Group

@KentsisResearch

2 years

Marveling at this latest result: Pgbd5 DNA transposase expression in developing mouse

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Kentsis Research Group

@KentsisResearch

6 years

Deeply grateful for recognition and support of our lab’s work @sloan_kettering

St. Baldrick's Foundation

@StBaldricks

6 years

BIG ANNOUNCEMENT! Introducing the North American recipient of the St. Baldrick's 2018 Robert J. Arceci Innovation Award - Dr. Alex Kentsis! See his work & how his research for better treatments for kids with cancer will leap forward – thanks to YOU:

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Kentsis Research Group

@KentsisResearch

5 years

Science brothers ⁦ @KharasLab ⁩ ⁦ @KentsisResearch ⁩

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Kentsis Research Group

@KentsisResearch

3 years

Yes! @KharasLab tenure seminar!

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Kentsis Research Group

@KentsisResearch

4 years

Research Shows How Common Feature of Blood Cancers Can Be Targeted

Research points to the role of a protein called MYB, which has long been known to play a role in cancer.

www.mskcc.org

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Kentsis Research Group

@KentsisResearch

5 years

Alu transposon rearrangements cause re-expression of neomorphic BRCA1 genes that bypass BRCA1 mutations and cause resistance to PARP inhibition:

BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance

Nature Communications - BRCA1 mutations located within the BRCT domain result in proteasomal degradation and sensitivity to PARP inhibitors (PARPi). Here, the authors report genetic rearrangements...

www.nature.com

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Kentsis Research Group

@KentsisResearch

5 years

Need hand sanitizer? 70% ethanol, 10% isopropanol with 1% glycerol in water works great! Add whatever scent you wish.

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Kentsis Research Group

@KentsisResearch

5 years

TWEETORIAL to explain my lab's plan for the next few weeks (sent to my lab via email, and included here for others should it be helpful, modified as needed) 1/n

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Kentsis Research Group

@KentsisResearch

5 years

Comprehensive proteogenomics is here! Nearly complete detection of the majority of proteins and their complete sequences expressed by different human leukemias (using multi-protease digestion and multi-dimensional high-accuracy mass spectrometry)

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Kentsis Research Group

@KentsisResearch

6 years

Happy Chinese New Year ⁦ @sloan_kettering ⁩ #MSKPediatrics

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Kentsis Research Group

@KentsisResearch

8 months

Epigenetic Combination Therapy Could Overcome Treatment Resistance in Epithelioid Sarcomas and Rhabdoid Tumors @MSKCancerCenter @Maggies_Mission @Cycle4Survival @PershingSquare , led by inimitable @YKazansky with many collaborators and Mrinal Gounder:

Epigenetic Combination Therapy Could Overcome Treatment Resistance in

Learn about a possible new treatment approach for soft tissue sarcomas.

www.mskcc.org

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Kentsis Research Group

@KentsisResearch

2 years

@KSadtler Go to the next level with

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Kentsis Research Group

@KentsisResearch

2 years

Read our latest on the causes of oncogenic DNA rearrangements in medulloblastomas, a common childhood brain tumor: Childhood cancer mutagenesis caused by a domesticated DNA transposase

Childhood cancer mutagenesis caused by a domesticated DNA transposase

Genomic rearrangements are a hallmark of most solid tumors, including medulloblastoma, one of the most common brain tumors in children. Childhood cancers involve dysregulated cell development, but...

www.biorxiv.org

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Kentsis Research Group

@KentsisResearch

4 years

Are you interested in chemical biology, biochemistry and chemical proteomics? Well-known #proteomics secret: the majority of all recorded mass spectra currently remain unassigned. Read our latest manuscript by @paolocifani , Danmeng Luo, and Zhi Li on solving this problem. 1/n

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Kentsis Research Group

@KentsisResearch

5 years

Lab knows the key to my heart!

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Kentsis Research Group

@KentsisResearch

5 years

Cannot thank enough for their support of childhood cancer research ⁦ @Sloan_kettering ⁩

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Kentsis Research Group

@KentsisResearch

5 years

Are you interested in oncogenic transposons, chromatin, and DNA nucleases? We are looking for ambitious post-doctoral research fellows: please join us! It's an exciting project!

Alex Kentsis, MD, PhD - 2019 Pershing Square Sohn Prize Mathers...

Alex Kentsis, MD, PhD, Memorial Sloan Kettering Cancer Center - Mathers Foundation Fellow: The laboratory of Dr. Kentsis studies DNA transposase molecules that can…

vimeo.com

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Kentsis Research Group

@KentsisResearch

4 years

Genome-wide screen in triplicate of a few billion leukemia cells? No problem says @u2ma316 as he dispenses 10 liters of media in tissue-culture bags. Bravo! This one is especially for you @TuomasTammela

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Kentsis Research Group

@KentsisResearch

5 years

⁦ @HellerLab ⁩ poses next to a plaque commemorating his grandfather’s synthesis ⁦ @Pfizer ⁩

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Kentsis Research Group

@KentsisResearch

7 years

Read our latest: chemotherapy resistance, leukemia stem cells, proteomics, CRISPR mouse engineering, and regulation of kinase-dependent control of pioneer transcription factors as improved therapy of AML. Many thanks to all the collaborators!

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Kentsis Research Group

@KentsisResearch

4 years

Please read and use our latest work with @CompProteomics on agnostic chemical proteomics: Discovery of Protein Modifications Using Differential Tandem Mass Spectrometry Proteomics

Discovery of Protein Modifications Using Differential Tandem Mass Spectrometry Proteomics

Recent studies have revealed diverse amino acid, post-translational, and noncanonical modifications of proteins in diverse organisms and tissues. However, their unbiased detection and analysis remain...

pubs.acs.org

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Kentsis Research Group

@KentsisResearch

5 years

Together with @KharasLab @HellerLab , we've made contingency plans for our labs @sloan_kettering , should more intensive COVID mitigation measures will need to be implemented, summarized below 1/n

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Kentsis Research Group

@KentsisResearch

4 years

#BlackLivesMatter ⁦ @sloan_kettering ⁩

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Kentsis Research Group

@KentsisResearch

6 years

Transposable elements drive widespread expression of oncogenes in human cancers.

Transposable elements drive widespread expression of oncogenes in human cancers

Nature Genetics - A pan-cancer analysis identifies 129 transposable-element-driven promoter-activation events involving 106 oncogenes. At the AluJb-LIN28B locus, deletion of the transposable...

www.nature.com

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Kentsis Research Group

@KentsisResearch

3 years

Fascinating comparison of single-cell (stable) proteomes and (noisy) transcriptomes from ⁦ @labs_mann ⁩ ⁦ @fabian_theis ⁩ et al. Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation.

Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation...

image image A new ultra‐high sensitivity LC‐MS workflow increases sensitivity by up to two orders of magnitude and enables true single‐cell proteome analysis. In‐depth comparison indicates that the...

www.embopress.org

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Kentsis Research Group

@KentsisResearch

5 years

@iannisaifantis1 It’s a problem that’s only getting worse, with only a few attempting to solve it @eLife , and what Hidde wrote a long time ago is still true:

End the wasteful tyranny of reviewer experiments

Nature - Peer review of scientific papers in top journals is bogged down by unnecessary demands for extra lab work, argues Hidde Ploegh.

www.nature.com

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Kentsis Research Group

@KentsisResearch

5 years

High-throughput proximity labeling proteomics

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Kentsis Research Group

@KentsisResearch

3 months

Reviewed a manuscript for a prominent journal from authors I know but not friendly with: "This is an important study that should be published. The manuscript is well written and conclusions are well supported. My only request is that the data are made publicly available."

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Kentsis Research Group

@KentsisResearch

6 years

Please read our latest! Optimized cross-linking mass spectrometry for in situ interaction proteomics

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Kentsis Research Group

@KentsisResearch

2 years

It’s been almost 10 years of KRG ⁦ @MSKCancerCenter ⁩ #MSKKids . Hear the latest perspective on Monday.

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Kentsis Research Group

@KentsisResearch

4 years

@jkpritch We are planning to have an open search, so please tell them to apply!

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Kentsis Research Group

@KentsisResearch

10 months

Top secret experiment in the lab

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Kentsis Research Group

@KentsisResearch

3 years

An Integrated Strategy for Mass Spectrometry-Based Multiomics Analysis of Single Cells

Single-cell-based genomics and transcriptomics analysis have revealed substantial cellular heterogeneity among seemingly identical cells. Knowledge of the cellular heterogeneity at multiomics levels...

pubs.acs.org

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Kentsis Research Group

@KentsisResearch

10 months

Interested in epigenetic therapies? Read updated @YKazansky ’s manuscript on Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy, which shows that E2F-RB1 axis is a major mechanism of tazemetostat resistance

Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy

Essential epigenetic dependencies have become evident in many cancers. Based on the functional antagonism between BAF/SWI/SNF and PRC2 in SMARCB1 -deficient sarcomas, we and colleagues recently...

www.biorxiv.org

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Kentsis Research Group

@KentsisResearch

3 years

Excited about new logo. Though not completely intentional, the symbol combines DNA helix, ion beam, and caduceus, all of which are prominent in the lab.

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Kentsis Research Group

@KentsisResearch

4 months

@lpachter @NatureRevGenet There is a statistically significant absence of correlation between x and y

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Kentsis Research Group

@KentsisResearch

5 years

Visiting Barbara McClinitock’s first research lab: though her transposon discovery was made @CSHL , the corn came from here @Cornell

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Kentsis Research Group

@KentsisResearch

6 years

Another fall Saturday writing #Science grants

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Kentsis Research Group

@KentsisResearch

4 years

Thanks to the laboratory medicine ⁦ @Sloan_kettering ⁩ for this easy and fast #COVID surveillance test: spit and go!

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Kentsis Research Group

@KentsisResearch

10 months

Another marvelous Facilities ⁦ @MSKCancerCenter ⁩ holiday display!

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Kentsis Research Group

@KentsisResearch

3 years

New faculty recruitment @sloan_kettering : Protein Systems Initiative (PSI) is a newly formed initiative to develop innovative proteomics technologies to propel transformative biological questions. 1/n

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Kentsis Research Group

@KentsisResearch

6 years

Sadly, @ProPublica and @charlesornstein have stooped to tabloid writing, at the expense of a life-saving @sloan_kettering institution that seeks nothing more than bringing knowledge and care to patients and science. Shame. On. You.

Chris Iacobuzio

@ciacobu

6 years

Impressive reporting, you got a transcript of people trying to work through an internal problem in a private setting. Hope you didn’t get a papercut in the process.

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Kentsis Research Group

@KentsisResearch

2 years

Quantitative Cell Proteomic Atlas: Pathway-scale targeted mass spectrometry for high-resolution functional profiling of cell signaling from @paolocifani and openly available at

Quantitative Cell Proteomic Atlas: Pathway-scale targeted mass spectrometry for high-resolution...

In spite of extensive studies of cellular signaling, many fundamental processes such as pathway integration, cross-talk and feedback remain poorly understood. To enable integrated and quantitative...

www.biorxiv.org

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Kentsis Research Group

@KentsisResearch

4 years

Why do young people get cancer? I summarize a general framework of the causes of early‐onset cancer development in children and young adults by relating inherited and constitutional cancer predisposition, oncogenic pathogens, and developmental mutations.

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Kentsis Research Group

@KentsisResearch

4 years

Very nice! Noncanonical open reading frames encode functional proteins essential for cancer cell survival

Noncanonical open reading frames encode functional proteins essential for cancer cell survival

Nature Biotechnology - Noncanonical open reading frames are shown to be essential for cancer cell function.

www.nature.com

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Kentsis Research Group

@KentsisResearch

5 years

Pharmacology Retreat! ⁦ @sloan_kettering ⁩ ⁦ @WeillCornell ⁩

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Kentsis Research Group

@KentsisResearch

6 years

Interested in why young people get cancer and how to develop new therapies to target them? Read @anton_gh and our new JCI Insight - Emerging functions of DNA transposases and oncogenic mutators in childhood cancer development

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Kentsis Research Group

@KentsisResearch

7 years

Researchers @sloan_kettering find fatal flaw in childhood tumors

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Kentsis Research Group

@KentsisResearch

3 years

Awesome work from @NLKProteomics et al: The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells

The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells

Deep top-down proteomics reveals that proteoforms have higher cell-type specificity than unmodified proteins.

www.science.org

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Kentsis Research Group

@KentsisResearch

4 years

Are you interested in cancer biology and pediatric oncology? I will be presenting @AlexsLemonade as part of their Register to receive a link for August 19:

Childhood Cancer Speaker Series

Watch virtual lectures on a variety of topics presented by childhood cancer experts.

www.alexslemonade.org

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Kentsis Research Group

@KentsisResearch

5 years

@chorye @JSheltzer That’s the best answer so far, e.g. tumor cells tolerate aberrrant expression of oncogenes and loss of tumor suppressors, but normal cells cannot. Same for loss of BRG1 or SMARCB1...

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Kentsis Research Group

@KentsisResearch

5 years

@timothykeyes It’s a marathon, not a race. Focus on fundamental problems that will leave a long-lasting impact on people and fields. No amount of money or “accomplishments” beats this.

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Kentsis Research Group

@KentsisResearch

2 years

Glad to see this work from @NovartisScience building on our probes to target MYB! Design and Biochemical Characterization of Peptidic Inhibitors of the Myb/p300 Interaction Clinical-grade inhibitors next!

Design and Biochemical Characterization of Peptidic Inhibitors of the Myb/p300 Interaction

The Myb transcription factor is involved in the proliferation of hematopoietic cells, and deregulation of its expression can lead to cancers such as leukemia. Myb interacts with various proteins,...

pubs.acs.org

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Kentsis Research Group

@KentsisResearch

6 years

Great review from many terrific colleagues and must-read for anyone interested in genetics! Ten things you should know about transposable elements.

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Kentsis Research Group

@KentsisResearch

1 year

Read our latest, led by inimitable @LuzJubierre , defining the physiologic functions of PGBD5: A transposase-derived gene required for human brain development

A transposase-derived gene required for human brain development

DNA transposable elements and transposase-derived genes are present in most living organisms, including vertebrates, but their function is largely unknown. PiggyBac Transposable Element Derived 5...

www.biorxiv.org

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Kentsis Research Group

@KentsisResearch

2 months

We posted an update to "A transposase-derived gene required for human brain development" including additional patient families with PGBD5 deficiency syndrome and mouse model studies for its unanticipated (neuron genome remodeling!) mechanism of action:

A transposase-derived gene required for human brain development

DNA transposable elements and transposase-derived genes are present in most living organisms, including vertebrates, but their function is largely unknown. PiggyBac Transposable Element Derived 5...

www.biorxiv.org

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Kentsis Research Group

@KentsisResearch

6 years

Thank you @feistyfeminist3 and @jorie_graham for this refreshing perspective. The Doctor Healed Us. Now We Rise to His Defense.

Opinion | The Doctor Healed Us. Now We Rise to His Defense. (Published 2018)

The psychologist Carol Gilligan and the poet Jorie Graham offer praise for the cancer doctor José Baselga.

www.nytimes.com

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Kentsis Research Group

@KentsisResearch

3 years

@lstops 1) Manage goals, not tasks. 2) Begin every meeting with questions about person, not project. 3) Recruit people who will complement you, not replicate you.

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Kentsis Research Group

@KentsisResearch

3 months

Delighted to be back on Mayer 6

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@KentsisResearch

7 years

Transposase-driven rearrangements in human tumors

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@KentsisResearch

5 years

COVID-19 projections by US state with confidence intervals

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Kentsis Research Group

@KentsisResearch

6 years

Today: a morning of caring for sick children with inspiring nurses and NPs, mid-day of interviewing stellar MD-PhD applicants, afternoon of discussing new science with passionate lab fellows, evening of writing new grant proposal and manuscript. #nofilterneeded

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Kentsis Research Group

@KentsisResearch

5 years

The importance of labels in science: I’ve finally figured out how to operate window shades correctly. But WHY? @KharasLab @KeshariLab @David_Lab_MSK @DBachovchin @grimmrad @LewisLabMSKCC

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Kentsis Research Group

@KentsisResearch

4 years

A note to the lab for Happy New Year, from an extraordinary 2020.

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Kentsis Research Group

@KentsisResearch

5 years

@DrSidMukherjee Sid, I would include a discussion of the causes of cancer in young people as opposed to those due to aging and environmental exposure. This includes inheritance of cancer-predisposing mutations and aberrant activity of endogenous mutators, such as RAG1/2 in lymphoid cancers.

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Kentsis Research Group

@KentsisResearch

5 years

Look at that energy! @LuzJubierre spreading her new findings of PGBD5 DNA transposase in brain development.

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Kentsis Research Group

@KentsisResearch

6 years

Original corn from Barbara McClintock showing DNA transposition controlling gene expression #cshlTE18

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Kentsis Research Group

@KentsisResearch

3 years

Fantastic work by @sloan_kettering colleagues. Diet-regulated production of PDGFcc by macrophages controls energy storage . Makes one wonder if mutant macrophages in people with clonal hematopoiesis have altered fat regulation and energy balance?

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Kentsis Research Group

@KentsisResearch

4 years

Why Do Young People Get Cancer? PGBD5 and Other Developmental Mutators: 2020 ALSF Virtual Childhood Cancer Lecture ☛

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Kentsis Research Group

@KentsisResearch

1 year

Goodbye FASEB Heme Malignancies, one of the best meetings in the field. Sorry we could not stay the whole time! Science awaits.

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@KentsisResearch

6 years

Deep learning enables de novo peptide sequencing from data-independent-acquisition mass spectrometry.

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@KentsisResearch

3 years

First in-person group meeting since spring 2020. What a breath of fresh air! Great science, great discussion, and such a delight to speak with everyone!

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@KentsisResearch

5 years

The Landscape of L1 Retrotransposons in the Human Genome Is Shaped by Pre-insertion Sequence Biases and Post-insertion Selection

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@KentsisResearch

4 years

Farewell @PhillipDemarest ! Look forward to your discoveries as a neuroscientist!

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@KentsisResearch

2 years

Faculty Recruitment for the @MSKCancerCenter Tow Center for Developmental Oncology. Join us!

Faculty Recruitment for the Tow Center for Developmental Oncology

The Tow Center for Developmental Oncology is recruiting new physicians and scientists to conduct research and develop new therapeutic approaches for their definitive therapy and control.

www.mskcc.org

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Kentsis Research Group

@KentsisResearch

4 years

We are (carefully) beginning to resume our lab research: if you are interested in a Position for a Post-Doctoral Research Fellow in Functional Cancer Genomics - we are looking for new colleagues ☛

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Kentsis Research Group

@KentsisResearch

4 years

Come and join us at @WeillCornellGS @sloan_kettering @RockefellerUniv and see this every day!

Weill Cornell GSMS

@WeillCornellGS

4 years

Beautiful view of the East River, even on a cloudy day.

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@KentsisResearch

5 months

Aww. Thank you for my wonderful group. I owe this to many of them over the many years.

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Kentsis Research Group

@KentsisResearch

6 years

Important and exciting work from Jeff Tyner, Brian Druker et al. Functional genomic landscape of acute myeloid leukaemia.

Functional genomic landscape of acute myeloid leukaemia

Nature - Analyses of samples from patients with acute myeloid leukaemia reveal that drug response is associated with mutational status and gene expression; the generated dataset provides a basis...

www.nature.com

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Kentsis Research Group

@KentsisResearch

6 years

Another beautiful study from Neal Rosen and colleagues on blocking oncogenic BRAF fusions: RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling.

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Kentsis Research Group

@KentsisResearch

8 years

Proud of what we do every day @sloan_kettering to understand and treat cancer:

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Kentsis Research Group

@KentsisResearch

5 years

KRG fall celebration

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Kentsis Research Group

@KentsisResearch

5 years

In these stressful times, I am sending books to students, technicians and fellows in my lab, here they are in no particular order, hoping they will bring spark, resolve, inspiration or just a smile. Enjoy and share your books and tips!

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Kentsis Research Group

@KentsisResearch

4 years

Preparing to submit @ReviewCommons revision of our manuscript on oncogenic gene control in AML and grateful to Sumiko Takao, @u2ma316 , Shuyuan Cheng and many colleagues for the heavy lift during the COVID pandemic to finish this work.

Therapeutic remodeling of CBP transcription factor complex controls oncogenic gene expression in...

Highlights Summary Dysregulated gene expression is one of the most prevalent features in human cancers. Here, we show that most subtypes of acute myeloid leukemia (AML) depend on the aberrant...

www.biorxiv.org

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Kentsis Research Group

@KentsisResearch

4 years

Got my lab these “awesome” gifts because they are “awesome” during these challenging times.

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Kentsis Research Group

@KentsisResearch

5 years

Life of an academic: the joy of a manuscript that goes to review in a day

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@KentsisResearch

5 years

Look at this @TODAYshow of the awesome holiday display by @sloan_kettering plumbers, electricians, painters, mechanics and other outstanding facilities support staff to brighten up #MSKKids

TODAY

@TODAYshow

5 years

For kids undergoing treatment at Memorial Sloan Kettering Cancer Center, the holidays are a whole lot brighter this year thanks to a group of employees with hearts of gold.

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Kentsis Research Group

@KentsisResearch

3 years

Absolute tour de force by Sumiko Takao in the lab! 10L lentiviral culture->functional genetic library transduction of patient AML cells->labeling and dox-induction in transplanted mice->multicolor FACS to isolate and sequence leukemia quiescent stem cells to identify regulators.

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