Gunhild Alvik Nyborg, MD, PhD, BSc @GANyborg Twitter profile

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Gunhild Alvik Nyborg, MD, PhD, BSc

2 months

«Ikke «gå på limpinnen» hvis en manipulator snakker negativt om en tredje person, vil ha en til å holde noe hemmelig eller gjøre tjenester som en ikke kan stå inne for. … Å lære narsissismens ABC gir en større robusthet i møte med manipulasjon.»

Narsissismens ABC

Nevropsykolog Mia Tuft skriver om hvordan man kan kjenne igjen og håndtere manipulasjonsteknikker.

psykologisk.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

For all those who still believe herd immunity as a concept applies to SARS-CoV-2: It doesn't. We'll be infected again and again, and the data now tell us that the risk of serious long-term effects increases with each infection. Govts need to re-think & find a new & better plan 1/

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Norway is seeing the world’s first omicron superspreader event after a party downtown Oslo last Friday. Of 120 healthy non-symptomatic fully vaccinated individuals with a negative test, two had recently returned from South Africa and turned out to be positive, omicron. 1/

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Now some 80-90 of the 120 are PCR pos, 13 of these confirmed omicron, the rest waiting for sequencing results. Some of those infected w omicron were not at the party but present at the same restaurant that evening. Not looking good re transmissibility.

Omicron outbreak at Norway Christmas party is biggest outside S. Africa -authorities

At least 13 people in Oslo have been infected with the Omicron variant of the coronavirus following a corporate Christmas party described as a "super spreader event", and their numbers could rise to...

www.reuters.com

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

New pre-print that found a very limited immune response after infection with omicron. The desired herd immunity effect may according to this be a far dream still: from this, seems you can be re-infected more or less directly after your last infection

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

So it's clear: SARS-CoV-2 infects T lymphocytes, preferably activated CD4+ cells in vitro, independently of the ACE2 receptor and induces pronounced programmed cell death potentially contributing to the lymphopenia seen in ~80% of hospitalized C19 patients

ACE2-independent infection of T lymphocytes by SARS-CoV-2

Signal Transduction and Targeted Therapy - ACE2-independent infection of T lymphocytes by SARS-CoV-2

www.nature.com

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

8 months

Promising results in treatment of #COVID19 : Oslo team have designed a long-acting viral-entry blocking ACE2 molecule that can be administered needle-free and can block SARS-CoV-2 from getting into cells. Congrats to the team @AndersenJT and first author Sopisa Benjakul

The Lab of Adaptive Immunity and Homeostasis

@AndersenJT

9 months

Story out! An albumin fused ACE2 design that blocks all SARS-CoV-2 variants. The design has a long plasma half-life and can be delivered in a needle-free manner across mucosal surfaces. @CoE_PRIMA @UniOslo_MED @forskningsradet @NTNUnorway @JamesLab9

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Study finds differences in biomarkers in #longCovid Using conventional statistics + state-of-the-art machine learning, two vascular transformation biomarkers were identified distinguishing LC patients from acutely ill C19 inpatients +healthy controls (classification accuracy 96%)

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

"the risks were evident in those who were unvaccinated, had 1 shot, or 2 or more shots prior to the second infection" This figure shows clearly that we cannot rely on vaccines to protect us from serious sequelae from COVID. 2/

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@TheClutterer No. We’re heading for a fall here. Better mask up and order some extra oxygen in case. This can get really, really, really bad. 😞😞😞

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Thanks & congrats to @zalaly et al for another important contribution to the field. They state: "Reducing overall burden of death and disease due to SARS-CoV-2 will require strategies for reinfection prevention." Time to change our ways. #letsdoit

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

This is a massive study with a cohort of people with first infection (n = 257,427), reinfection (2 or more infections, n = 38,926), and a non-infected control group (n = 5,396,855) to estimate risks and 6-month burdens of all-cause mortality, hospitalization, and organ sequelae3/

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Almost 120 people are now infected after the party downtown Oslo Nov 26. Around 70 were with the party of 120, 45-50 other guests at the same venue. Omicron suspected in all, still only verified in 13, sequencing slow, screening underway @Folkehelseinst

- Kan ikke stoppe julebord-utbruddet

Bare realistisk å bremse det, sier smittevernlege. «Veldig inngripende» tiltak innført for alle gjester og ansatte.

www.dagbladet.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

1 year

Small study from omicron era: Researchers consistently detected salivary + airborne SARSCoV2 in air samples + samples from school students over 7 wks. Concentrations of airborne SARSCoV2 were av. 70% lower with mask mandates and 40% lower with air cleaners

Masks and portable air cleaners reduced the spread of COVID-19 in schools, study shows

A new study shows that masking and portable air cleaners reduced the spread of the virus that causes COVID-19 in two Swiss schools.

www.news-medical.net

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Update. Min. 60 at the party infected. Now nearing 100 cases in total that night, some not with the party but present at the same venue. Screening (likely S gene dropout PCR): about 50 suspected Omicron, the rest not yet screened. 13 confirmed Ο. (paywall)

FHI: 19 tilfeller av omikron bekreftet i Norge

Ifølge bydeloverlege Tine Ravnlo har rundt halvparten av de smittede i Oslo sannsynligvis omikron etter screening av prøvene.

www.nrk.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

8 months

New findings on PEM in #LongCovid in Yale study Invasive cardiopulmonary exercise test (iCPET) measured pressure through right heart catheterizaton on 55 patients w/post-Covid exercise intolerance. Result: Oxygen extraction in tissues was compromised 1/

Study helps explain post-COVID exercise intolerance

Exercise intolerance is one symptom associated with long COVID. A new study helps explain its cause.

news.yale.edu

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Important study out in Nature: From this, the mRNA vaccines seem far superior to infection in subsequent protection. IMO, this explains what has been seen on the ground. See the striking difference. You want to be at zero here. 1/ @Folkehelseinst @jonasgahrstore @ingvildkjerkol

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

@Forbes Authorities should be aware of this. We still don't know the long term impact of this virus for human health. Evidence so far & experience from those affected by SARS1 point to serious long term effects. It would be wise to prevent transmission until new vaccines/more knowledge.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

9 months

Preprint from USCF team: Whole-body PET tracing activated T cells showed significantly higher uptake in post-acute COVID (w & w/o LC symptoms) vs controls: in brain stem, spinal cord, bone marrow, gut wall, lymphoid and cardiopulmonary tissues up to 2.5 years post infection 1/

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@DavidSteadson @Gab_H_R Definitely change in testing protocols recently: only adults with 0-1-2 shots of vaccine and with symptoms are required/allowed to test. No testing of kids or those boosted, no testing of asymptomatic. All NPIs stopped. No longer need to isolate or wear mask if pos!!! 1/

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Norway, 2 weeks after schools opened with zero measures to contain the virus. A. Positivity rate (10.2), B. No. of new infections per age group, C. Daily news cases. They say they do it for the kids 😡

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@DavidSteadson @Gab_H_R They’re also saying “everyone shall be infected in the next couple of months”. Clearly! It’s an ethically insane experiment on our population based on flawed scientific premises. Russian roulette. We need luck! w regards to severity, long term disease, neurological affection +++

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Question: What are the long term implications for human health? Here is @Forbes take on the paper in OP⬆️: "As research continues to develop, it will be interesting to discover exactly how this virus attacks and dismantles one of our key defense systems"

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@DavidSteadson Yes, but so far only 13 confirmed as Omicron. The two travelers returning from SA were the only known source of infection though. So all likely omicron. The event was last Friday, six days ago. In a large restaurant downtown Oslo. W after party at a downtown pub. We’re in deep

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@DavidSteadson @Gab_H_R Of course Norway is no longer a deliverer of any form of useful data to the world. We, one of the richest nations in the world, are letting the virus rip through our people, free to mutate, knowing that we’ve been vaxxed &boosted. No solidarity w poorer nations. @WHO should know.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

🧵recap: Several studies have found that the virus causing COVID can infect different cell types in our immune system & many of these cells then die. This may theoretically lead to immune dysfunction/imbalance. It's too early to know the clinical effects from this now& in future.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Could explain observations like this ⬇️ We'll see in the coming weeks what comes out of this.

Dr. S😷😷💪🏽

@DrSalandyinGA

3 years

My latest news is that kids are now getting reinfected within 30 days of their COVID infection...and yes they tested negative in between. If you are a pediatric provider testing at every illness will give you this data. With this virus we can't pretend to know anything . 😐

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@rdmorris Yep. They report a 75% case hospitalization rate among 0-2-year olds; among all the registered cases in this age group, about 75% are now hospitalized in SA. However, non-registered cases are likely very high now. Still goes well with the numbers you refer to here. Very worrisome

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

A total of 19 cases of Omicron verified in Norway by now, around Oslo & elsewhere. Green: No suspected cases. Yellow: Suspected cases. Red: Verified cases (see the tiny red dot on the west coast)

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

"Delta breakthrough infections (n=39) had 57-fold and 3.1-fold titers whereas Omicron breakthrough infections (n=14) had 5.8-fold and 0.32-fold titers compared to uninfected non-boosted and boosted individuals, respectively"

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

UBELIEVEABLE. NIPH today published a report predicting 90.000-300.000 new cases + 50-200 new hospitalizations daily in Norway in only 3 weeks bc of Omicron. Now they advise against school closure as THEY THINK CLOSING SCHOOLS MAY INCREASE SPREAD!! INSANITY

FHI: Tror skolestenging kan øke smitte

FHI tror stenging av skoler har liten smitteeffekt. I tillegg vil de verne barn mot inngripende tiltak.

www.vg.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Several recent studies have found SARS-CoV-2 infects several immune cell populations: neutrophils, macrophages, monocytes, plasma B cells, T cells, and NK cells. Here, monocytes were infected independently of ACE2, leading to massive cell death:

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

Nature - Antibody-mediated SARS-CoV-2 uptake by monocytes and macrophages triggers inflammatory cell death that aborts the production of infectious virus but causes systemic inflammation that...

www.nature.com

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 months

"Every time you get an covid infection, your immune system seems to suffer. .. Every single time there is an increased chance that something bad is going to happen to the immune system, and I think that this influx of illness we are seeing is related to that.” - Dr. David Putrino

Christopher C. Cuomo

@ChrisCuomo

2 months

What’s behind the post covid sickness surge? The vaccine? Immunity suppression? Long Covid? The answer is there is not one answer. It’s complicated and we have to keep the conversation going. Dr. David Putrino, Dir. of Rehabilitation Innovation of Mt Sinai Health System joins me

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@kyhwana @GrrrrAngryShark No data at all on omicron yet, naturally. For Delta, vaccines have been reported to only give about 50% protection against long Covid symptoms, or less - one study found zero protection.

Do vaccines protect against long COVID? What the data say

Nature - Vaccines reduce the risk of developing COVID-19 — but studies disagree on their protective effect against long COVID.

www.nature.com

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Jeg har en kronikk ute på NRK. Pandemien vil vare lenge. Flokkimmunitet er ikke mulig å oppnå med koronaviruset. Norge bør skifte strategi til «Skadebegrensning». Her er oppskriften.

Oppskrift for å hindre katastrofe

Med dagens strategi styrer vi mot en ny nedstengning.

www.nrk.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Reminder: It's been in Putin's interest to weaken Western countries by waging a disinformation war with aim that we let own populations be infected by SARS-CoV-2, ill, not protected by vaccines. Investigations should be made into Russian role in pandemic disinformation campaigns.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Breaking: Norway: 4 - four - days isolation for SARS-CoV-2 positive!! 😳😲😵‍💫

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

"Based on our knowledge of HIV pathophysiology, we hypothesized that SARS-CoV-2 infection-mediated lymphopenia could also be related to T cell apoptosis" If T cells can be infected by SARS-CoV-2 in vivo, leading to apoptosis, this can explain the findings

T cell apoptosis characterizes severe Covid-19 disease

Cell Death & Differentiation - T cell apoptosis characterizes severe Covid-19 disease

www.nature.com

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

What happens over time, and what does this mean? Here, "Five of 35 cases (14%) had Lymphopenia in the later follow-up range of 80–102 days... subgroup analyses showed that patients with lymphopenia experienced more frequently persistent symptoms"

Persistent symptoms and lab abnormalities in patients who recovered from COVID-19

Scientific Reports - Persistent symptoms and lab abnormalities in patients who recovered from COVID-19

www.nature.com

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Proof that representatives from the Norwegian Institute of Public Health (FHI) tried to pressure researchers to change the wording of an accepted scientific article because they didn’t like the conclusions: that children are infected as much as adults

FHI-leger kontaktet forsker om barnesmitte-rapport – ba henne endre i konklusjonen

Infeksjonsmedisiner og forsker Nina Langeland fikk en e-post fra flere ansatte i FHI, der de oppfordrer til å endre deler av konklusjonen hennes om barnesmitte.

www.vg.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Early in the pandemic, an article reporting infection of Jurkat T cells was retracted due to methodological issues. In the OP, this finding is replicated. Still much is unknown, but in sum, it is clear that SARSCoV2 can lead to substantial disturbances in immune cell populations.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

7 months

@Yash25571056 This paper does not hold. The only author, Alberto Boretti, has written loads of pandemic-related papers on many controversial topics with controversial results (see PubMed). Seems he also has published climate denier papers under the name Albert Parker 1/

Making Up Stuff

One of the most effective techniques by which deniers persuade people, especially policymakers, that it’s OK to do nothing about man-made climate change, is also one of the most reprehensible…

tamino.wordpress.com

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Among those tested in this study, after SARS-CoV-2 infection "CD4+ and CD8+ T lymphocytes almost declined to zero in some patients", while B and NK cells were unaffected. Technically: Both Jurkat and M4 cell lines were infected in vitro.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

@HFentonMudd @LeftCoastVegan Several studies have found that the virus causing COVID can infect different cell types in our immune system, & that many of these cells then die. This may theoretically lead to immune dysfunction/imbalance. It is too early to know the clinical effects from this now & in future.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Covid is a systemic disease

Cleavon MD 💉 💉 💉

@Cleavon_MD

3 years

COVID19 is a systemic disease @DrAbdiMahamud

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Through the pandemic I’ve tried to counter the rampant disinformation in my country. For this, I’ve been harassed and ridiculed over >2 years. Some trolls to start with, but they went quiet. So who’s running the show? These days,those related to @Folkehelseinst & their friends.1/

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

"Our study has identified 14 significantly elevated vascular transformation biomarkers", among them two diagnostic biomarkers (ANG-1 and P-SEL). The study also finds angiogenesis as a potential therapeutic target

Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key...

Background Long-COVID is characterized by prolonged, diffuse symptoms months after acute COVID-19. Accurate diagnosis and targeted therapies for Long-COVID are lacking. We investigated vascular...

molmed.biomedcentral.com

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Tokyo of 14 mill. inhabitants reported 13 new SARS-CoV-2 in one day. On Friday, Norway of 5 mill inhabitants reported 5413 cases, two months after the government decided to "learn to live with the virus". Controlling the virus pays off.

Yaneer Bar-Yam

@yaneerbaryam

3 years

The Tokyo Metropolitan Government reported 13 new positive COVID-19 cases Sunday, down by seven from a week before. The daily tally was below 30 for 31 consecutive days.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Here, they found lung-resident macrophages (another immune cell population) were infected by SARS-CoV-2, leading to massive death of these macrophages through pyroptosis. The cells dying prevented further replication of the virus in those cells

Inflammasome activation in infected macrophages drives COVID-19 pathology

Nature - A new humanized mouse model for COVID-19 demonstrates SARS-CoV-2 infection and subsequent activation of inflammasomes in human macrophages as a critical driver of disease.

www.nature.com

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Meta-analysis and systematic review of 21 studies including a total of 80,071 children & adolescents found a prevalence of long COVID of 25.2%. Of these kids, 16.5% experienced mood symptoms, 10% fatigue, and 8% sleep disorders. Not fun for a child

Long-COVID in children and adolescents: a systematic review and meta-analyses

Scientific Reports - Long-COVID in children and adolescents: a systematic review and meta-analyses

www.nature.com

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@cuntext No. Norway has been "learning to live with the virus since September and are in a bad shape already before this.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Norway, as it is happening:

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

1 year

The Director-General of the @WHO , @DrTedros , spoke on #LongCovid at a media briefing this week: “An estimated one in 10 infections results in post-COVID-19 condition, suggesting that hundreds of millions of people will need longer-term care.”

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

6 months

@Prebens Interessekonflikt: Skribenten, som ikke er utdannet helsepersonell, har over mange år tjent mange millioner som instruktør i kurs som fremmer de hypotesene hun fremmer i artikkelen. Ikke helt irrelevant.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Here too CD4+ lymphopenia persisted over some time: A decrease in CD4+ T cells "was observed in 60% (9/15), 60% (9/15), and 46.7% (7/15) of total patients at 0, 8, and 16 weeks after discharge, respectively"

A longitudinal follow-up of COVID-19 patients in the convalescent phase showed recovery in radiol...

A longitudinal follow-up of COVID-19 patients in the convalescent phase showed recovery in radiological results, the dynamics of lymphocytes, and a decrease in the level of IgG antibody: a single-c...

jtd.amegroups.org

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

8 months

Parliamentarians in all countries should hear from experts on #LongCovid We need to spread this knowledge to those in charge. Hear @zalaly ‘s outstanding talk before the U. S. Senate today in the next comment ⬇️

Ziyad Al-Aly, MD

@zalaly

8 months

Today I testified before the U.S. Senate Committee on Health, Education, Labor & Pensions I called for the establishment of a new multidisciplinary research institute to address Infection Associated Chronic Conditions Solving these requires a long-term coordinated approach

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

In Norway, two sides have been fighting to win the narrative during the pandemic. One representing science. The other,the GBD stance. For 1.5 years the first won. This summer the second took over. Results are devastating and drawing international attention

Mai così tanti contagi in Norvegia: cosa sta succedendo nel Paese risparmiato dalle altre ondate

Era uno dei luoghi virtuosi in cui il Covid sembrava sotto controllo, ma in pochi giorni è cambiato tutto: un party aziendale pre natalizio è div…

www.repubblica.it

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Thank God, the @Folkehelseinst /NIPH have now finally acknowledged that aerosols are the main way of transmission for the SARS-CoV-2 virus. This opens for more appropriate measures to be taken to prevent transmission #COVIDisAirborne

Koronapandemien har vist: De små dråpene i luften smitter flest

Omikron ser ut til å smitte på samme måte som de andre virusvariantene, selv om viruset er mer smittsomt. Små, svevende dråper overføres når det er tett kontakt mellom folk.

www.aftenposten.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Intervju i Dagsavisen: Navn i nyhetene

Gunhild Nyborg ble sablet ned etter «Debatten»: – Det var en massiv lynsjestemning

I fjor ble hun idioterklært etter å ha deltatt på «Debatten». Men nå sier koronageneral Espen Nakstad at Gunhild Nyborg hadde rett i mye av det hun hevdet den gangen.

www.dagsavisen.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Now also a superspreader event in Denmark - 53 Omicron cases (15 found by sequencing, 38 by s gene dropout) after a party with 150 participants

Michael Bang Petersen

@M_B_Petersen

3 years

An omicron superspreading event has just been recorded in Denmark: - 150 high school students at a party - 55 infected with covid - 53 of those are omicron positive (38 confirmed via S-gene dropout & 15 via whole genom sequencing) Link to news story:

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Listen to the @WHO and @DrTedros . "Nothing could be further from the truth" than what is being told the citizens of Norway, Denmark, Finland, and Sweden: @jonasgahrstore @ingvildkjerkol @Helsedir @Folkehelseinst

World Health Organization (WHO)

@WHO

3 years

@DrTedros "We’re concerned that a narrative has taken hold in some countries that because of 💉, and because of Omicron’s high transmissibility and lower severity, preventing transmission is no longer possible, and no longer necessary. Nothing could be further from the truth"- @DrTedros

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

This is a disgrace. In Norway, 200,000 people have diligently given info on their post Covid health status over time for the large Korona study. But the researchers have to give up their work on analyzing the data due to lack of funding

Norsk corona-studie: – Har ikke penger til å drive den videre

De fôret myndighetene med informasjon under hele corona-epidemien. Nå sier forskerne at de ikke har penger til å drive studien videre.

www.vg.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

8 months

Jeg støtter prof Arne Søraas, prof Rebekka Cox og forsker Richard A. White ved @FHI 100% i det de sier her. Det er uakseptabelt at ledelsen ved FHI ikke oppdaterer seg på den mengden kunnskap om #LongCovid som vi kjenner til, og informerer befolkningen.

Rekordmange til lege med utmattelse. FHI-forsker slår alarm om senfølger av covid-19.

Tallet på pasienter som oppsøker lege med utmattelse, har eksplodert under pandemien. Nå slår en FHI-forsker alarm.

www.nrk.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

This is a very important 🧵 depicting how organized disinformation from the Swedish Inst of Public Health @Folkhalsomynd has affected policies in Sweden. This has unfortunately applied to Norway, Denmark, and Finland, too, negatively affecting their handling of the pandemic.

Virpi Flyg

@VirpiFlyg

2 years

In spring 2020, when other countries closed all schools, Sweden kept primary schools open, with mandatory in-person attendance and without protective measures such as testing or quarantines. Sweden then told the world COVID didn't spread in schools. It wasn't true. 🧵

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@DavidSteadson Yes. This is really looking very bleak. For Oslo. And for the world.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

They’re sending out those we _know_ are infected - while we know they’re most likely still contagious 🤯 Unbelievable

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Happy to say our theoretical calculations on mass testing as means to control transmission of a(ny) virus, and corresponding comment, have been published in @LancetRH_Europe We must develop more efficient and less restrictive alternatives to protect public health going forward

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

1 year

Som lege har jeg fått problemer i karrieren etter å ha insistert på å skaffe hjelp til pasienter som har blitt behandlet slik. Dette er ikke en enkeltstående hendelse, men en ukultur. Det ødelegger folks liv. Vi er milevis unna likestilling i medisinen.

Mari brukte nesten en million kroner for å få helsehjelp: – Jeg ble ikke trodd

.

www.fvn.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

1 month

Jaja. Nå fikk endelig FHI studert dette selv. De fant det samme resultatet som alle andre seriøse studier har funnet før. Heldigvis for oss alle, for nå kommer det trolig til å komme mer hensiktsmessige råd derfra. #MasksWork

Ny FHI-studie: Munnbind reduserer risikoen for luftveisinfeksjoner

I en ny studie har forskere fra FHI sett tydelige resultater som bekrefter at munnbind har en beskyttende effekt mot smitte.

www.bt.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

1 year

On pandemic #disinformation : «Even before the first wave peaked, doctors suggested the worst was over and that measures to control the virus were more dangerous than the virus itself. This message was repeated regularly throughout the pandemic.»

‘We Want Them Infected’: An Excerpt from Jonathan Howard’s New Book on the COVID-19 Pandemic - Bill...

Even before the first wave peaked, doctors suggested the worst was over and that measures to control the virus were more dangerous than the virus itself.

blog.petrieflom.law.harvard.edu

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@barbvee This also is not looking too good for the "open up and let it rip" crowd. Norway, two months after we did just that - before Omicron arrived.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

This is not good news. They report of a person infected with both delta and gamma at the same time. Then the two variants have recombined in that person, meaning they “swapped” some parts of the genes, put bluntly. This smells like trouble.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@DavidSteadson This is from yesterday, when 60 of the 120 were PCR positive. Of note: of the 13 confirmed omicron cases, some are reported as being other guests not at the party but present at the restaurant the same evening.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

And more: In Denmark, altogether 183 cases are now confirmed, 32 by sequencing, the rest by variant PCR (this method now found to be sufficiently precise by Statens serum Institut SSI). Denmark now reports ongoing transmission among people not traveling

Status på omikron-varianten (B.1.1.529) pr. 05.12.21

Statens Serum Institut finder et stadigt stigende antal omikron tilfælde i Danmark. Samlet er der nu fundet 183 tilfælde af smittede med virus-varianten omikron.

www.ssi.dk

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Important 🧵⬇️ Those who think the scientific community are fighting over COVID/long COVID: A huge part of it is not scientific discourse but intended, organized, repeated dis-/misinformation from a couple of handfuls of players supported by big money from far right capitalists.

Prof Gavin Yamey @gavinyamey.bsky.social

@GYamey

4 years

I want to share my thoughts, as someone who has been so alarmed by the so-called "dissident" scientists like Gupta, Heneghan, Kuldorff, Bhattacharya, & Ioannidis who consider themselves brave Galileos unfairly treated by "establishment scientists." I will try not to swear. 1/n

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@zweinebelkerzen @F_Lund_Johansen Covid actually has few similarities to flu aside from transmission via air. Covid is a systemic disease that damages blood vessels and organs around the body, including lungs and brain, and often leads to the creation of autoantibodies; immunological changes may be long lasting1/

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Kids may not even get T cell responses after mild infection but may brush it off & get little if any protection vs severe disease. Preprint "rapid clearance of SARS-CoV-2 in children may compromise their cellular immunity and ability to resist reinfection"

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

BA.4 and BA.5 are upgraded to variants of concern:

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@music_fan2020 @equibotanica Yesterday they were 60. Let’s count them again in a few days then ask those remaining…

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Major Norw. hospital stops all elective surgery due to increase in C19 admissions/staff sick leave. A wanted situation: Norway has let the virus loose to «live normally". Too bad the virus won’t listen & science finds herd immunity by infection an illusion

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Er det ingen som ser hva som foregår? En stor andel av befolkningen har nylig gjennomgått minst en COVID-infeksjon. Dette gir kognitive problemer hos mange og økt risiko for slag, arytmier og svimmelhet ⬇️ @tryggtrafikk

Har norske bilister blitt mer sløve?

Antall døde i trafikken har doblet seg siden i fjor. Mange bruker mobil, spiser og sminker seg samtidig som de kjører bil. Hva har skjedd med norske sjåfører?

www.nrk.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Her har jeg bare hakeslepp. Er det mulig? Kan slikt passere, for de som sitter øverst? Er ikke spillereglene like for alle? «Alle dyr er like, men noen dyr er likere enn andre.» - George Orwell, Animal Farm. Dette var stygt, @SFlottorp 🙁 @Folkehelseinst

avsloringen2

@avsloringen2

2 years

AVSLØRING: @SFlottorp sikret Landmark godkjenning ved å kontakte nye NEM medlemmer personlig. Dette er "kampfiksing". @forskningsetikk @akbefring @KiellandAnne @HeleneIngierd @FystroGro @LvikG @anineki @CamillaBIvers1 @AnneHafstad @TMisje @anineha @tv2nyheter @Klassekampen /1

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Another side of the coin;"despite Omicron’s extensive mutations and reduced susceptibility to neutralizing antibodies,... Well-preserved T cell immunity to Omicron is likely to contribute to protection from severe COVID-19"

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

The Norway example: what you get when you, after having controlled the pandemic well through TTI, NPIs, and vaccines, at 50% fully vaxx, 70% 1 dose choose to open schools with Delta in circulation, with no measures to control spread. School started week 33.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

Pinlig og graverende. FHI sier at de fortsatt ikke vet om munnbind virker, fordi de selv ikke har fått studert det skikkelig og ikke har fått nye gode data på et år. De sier rett ut at de ikke tar til seg noe av forskningen som foregår i verden -?

Usikkerhet rundt munnbind-effekt: - Vi sliter

Etter to år med pandemi og nylig oppheving av munnbind-plikten, vet vi fortsatt ikke om det egentlig har hatt noe for seg.

www.dagbladet.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

4 months

Jeg svarer @Prebens i dagens @dagogtid . Vi trenger åpen, fri, søkende faglig dialog. Personangrep skader mennesker, karrierer, faget og folkehelsa. Ukultur må ryddes opp i. Hold dere til faglige argumenter, og la meg snakke for meg selv! @Folkehelseinst

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@TheClutterer Yes, I wasn’t really serious about that, stick to high quality masks! But seems there will be logistical challenges as this will likely spread worldwide in a fairly short period of time. Sorry for using such a terrible phrase. Very disillusioned.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

“Where is the sense of urgency?” he asks. “If this is not enough to create urgency, what is?”

One Neurologist’s Quest to Solve Long COVID

Inside Igor Koralnik’s efforts to solve the mystery of COVID’s most puzzling complication.

www.chicagomag.com

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

6 months

@Prebens Det er vist at å pushe folk med post-exertional malaise over grensen, øker skaden på musklatur og mitokontriedysfunksjon. Kanskje det er derfor vi har så mange dårlige ME-pasienter i Norge? Her får leger høre at pasienter ikke trenger å ta hensyn til PEM

Long COVID can destroy your ability to exercise. Now we know why.

As a new study shows, the answer lies in some long COVID sufferers’ muscle damage and their bodies’ ability to make energy.

www.nationalgeographic.com

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

9 months

- In participants with #LongCovid symptoms, cellular SARS-CoV-2 RNA was found in all samples from colorectal tissues 158-676 days after infection Findings suggest that viral persistence in tissue can be associated w long-term immunological perturbations

Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for...

The etiologic mechanisms of post-acute medical morbidities and unexplained symptoms (Long COVID) following SARS-CoV-2 infection are incompletely understood. There is growing evidence that viral...

www.medrxiv.org

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 months

SARS-CoV-2 is able to invade and damage several different human cell types, including cells in the male reproductive system. Here, small study finds the virus in sperm from 8 of 11 moderate to severe COVID-19 patients (72.7%) within 90 days of discharge

Virus that causes COVID-19 can remain in sperm for 110 days after infection

Researchers at the University of São Paulo (USP) in Brazil have shown for the first time that SARS-CoV-2, the virus that causes COVID-19, can remain in the sperm of patients for up to 90 days after...

medicalxpress.com

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@HughSykes Yes. Hospitalizations doubled from Wednesday to Thursday in South Africa though. In spite of early days. So seems we’re in for a hit. Just unknown how bad

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

7 months

Nå føler jeg meg som Semmelweis. De latterliggjorde han for å anbefale legene å vaske hendene. De latterliggjorde meg for å anbefale å begynne å bruke luftrensere.

Slik skal FHI få ned smitte og sykdom i norske klasserom.

Folkehelseinstituttet skal prøve å lufte smittsomme sykdommer ut av klasserommene.

www.aftenposten.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

6 months

@Prebens Til og med WHO advarer mot å pushe folk med PEM over grensen, som norsk helsevesen legger opp til i behandlingen. Kanskje det er derfor antallet pasienter med ME øker så sterkt? Fordi vi trosser internasjonale råd om at pasienter med PEM bør følge pacing, ikke ordinær GET?

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

2 years

Nytt virus fra Wuhan: "FHI er lite bekymret" Viruset sprer seg til Europa: "FHI er lite bekymret" Delta i India: "FHI er lite bekymret" Smitteeksplosjon i skolene: "FHI er lite bekymret" Omikron: "FHI er lite bekymret" Noe nytt fra vestfronten?

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

What do you do if you’re a scientist with knowledge of the epidemic and a strong wish to be well liked these days? You tell them what they want to hear.

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

6 months

Preliminary data shows excess mortality among people 0-59 yrs in Norway 2022-23. Largest percentage increase among 0-19 and 20-39 year olds. Very important work @JEWilthil esp. as our inst. of public health has gone to lengths to cover up over four years

Reagerer på høye dødstall blant unge

For første gang på minst 20 år er det registrert overd��delighet blant unge i Norge. Det viser beregninger forskere har utført. – Jeg har aldri sett noe lignende, sier FHI-statistiker Richard Aubrey...

www.nrk.no

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

3 years

@F_Lund_Johansen Yes,the principle is well known. What’s of interest here is the magnitude of the responses in delta vs omicron & that it seems you build very little immunity from a non-severe omicron infection. Seems from this if you don’t get really sick you don’t gain much in terms of immunity

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Gunhild Alvik Nyborg, MD, PhD, BSc

@GANyborg

6 months

@Prebens Her er en av studiene referert til i artikkelen over. Alle som uttaler seg om ME bør ha lest denne, også @Prebens og @Livelandmark Studien finner økende skader i musklatur etter gjentatt trigging av PEM

Muscle abnormalities worsen after post-exertional malaise in long COVID

Nature Communications - In this longitudinal, case-controlled, cohort design study, authors show that post-exertional malaise is associated with severe exercise-induced myopathy, local and systemic...

www.nature.com

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