Effective July 1, you can call me PROFESSOR Aggarwal!🌟🌟🌟
Thrilled to have been promoted
@Penn
. I could not have done it without the incredible mentorship and collegiality of my colleagues
@PennMedicine
@PennCancer
(and worldwide). Special thanks to all the letter-writers and
My husband like me, is an oncologist. Like our colleagues, we are anxious & grieving. But we’re learning new ways to de-stress.
With one foot in front of another, we will show up, and take care of our pts when they need us most.
A little levity in the time of
#COVID19
@ASCO
Three people pose for a photo during the Spanish Flu in 1918. Almost a century later, so many things are the same, yet so different...
#History
#Lessons
#MaskUp
#COVID19
Promoted to Associate Professor
@PennMedicine
@PennCancer
!
So amazing to hear+see the news in my office with a congratulatory message from
@lynn_schuchter
and colleagues in the division of hem onc! Grateful for my mentors, advisors, family and letter writers.
#Yay
!!!!
Hi, I’m a medical oncologist. You might know me from my greatest hits “Sugar doesn’t feed cancer” “Vitamin C doesn’t cure cancer” And the chart topping “Palliative therapy doesn’t mean giving up...”
Hi, I’m a senior engineer. You might know me from my greatest hits “but *why* is it null?” “There is greater honor in deleting code than in writing more” And the chart-topping “let’s just walk over to them and ask”
Breaking barriers & shattering ceilings is what the Woman Disruptor of the Year is doing 💁♀️
The award, presented with
@WimedicineOrg
, goes to
@CharuAggarwalMD
! 🏆
Dr. Aggarwal is leading & setting the tone for successful careers with meaningful advancements. Congrats! 🎉
New guidelines for vaccinating individuals with
#Cancer
with
#COVID19
vaccines released by
@NCCN
✴️Vaccine is recommended for all pts on active therapy
✴️Delay vaccine ~3 months following transplant/ CAR-T therapy
✴️Immunize household members
Tonight I was appointed the inaugural chair holder of the Leslye Heisler endowed professorship
@Penn
@PennCancer
to support research in
#LungCancer
. I am incredibly honored, humbled & grateful to the Heisler Family for this gift, and for everyone who has supported me.
#CureCancer
Pembrolizumab is now approved by the
@US_FDA
for adjuvant therapy. Note that there is no restriction by stage or PDL1 expression, unlike the approval for atezolizumab. I don’t think this rather broad approval including in PDL negative population is helpful
#LCSM
Prioritizing speaking opportunities as a parent of young kids is super hard, especially in academic medicine.
But, these are the moments that are worth it! We have a Swim Champion in the family! 🙌🏽
Won’t miss this for the world!
#ProudMom
#WorkLifeBalance
@WeAreWLO
@WomeninOnc
We congratulate PC3I Faculty
@CharuAggarwalMD
on her appointment as Director of PC3I’s Program in Precision Oncology Innovation.
🔍Learn more about Dr. Aggarwal:
➕Follow us to hear more about our work in
#precisiononcology
#innovation
.
My husband like me, is an oncologist. Like our colleagues, we are anxious & grieving. But we’re learning new ways to de-stress.
With one foot in front of another, we will show up, and take care of our pts when they need us most.
A little levity in the time of
#COVID19
@ASCO
Beautiful, eloquent and poised discussion of
#LAURA
by
@LeciaSequist
emphasizing the importance of PFS benefit in this population, preventing morbidity from CNS Mets while balancing the issue of cost, QoL and biomarkers 👏🏽🫁
@ASCO
#ASCO24
@OncoAlert
There are many gaps associated with
#Biomarker
Testing in
#NSCLC
. Striking to see that using commercial and medicare claims data, approximately 64% of potentially eligible pts do not get personalized therapy!
@JCOPO_ASCO
SO excited to co-chair
@PennCancer
’s
#COVID19
and Cancer Conference, with Dr. Fauci as our guest speaker!!
I am honored and humbled to lead a Q&A session with Dr. Fauci with Dr. Vonderheide, in what promises to be an amazing evening. Woohoo!
ctDNA clearance is becoming an emerging molecular biomarker of response. Data from
#TATTON
trial presented
@AACR
#AACR20
show that clearance of circulating
#EGFR
ctDNA from plasma can predict for longer PFS, longer PFS seen in patients that cleared ctDNA (9.1 mo vs. 3.9 mo)
#LCSM
Overheard this conversation b/w my girls this morning:
3 yo: I want to be a doctor when I grow up, just like mama.
5 yo: I don’t know, I want to be a mama when I grow up, just like mama.
I like both options! I guess I’m doing something right!
#parenting
#WomenInmedicine
En route to
@myESMO
#ESMO23
! Looking forward to an exciting meeting with an impactful scientific agenda with practice changing implications in
#LungCancer
. Can’t wait to connect with friends! Madrid, see you in 7 short hours! 🇪🇸
Our paper exploring the value of plasma tumor mutation burden (
#TMB
) as a biomarker in
#NSCLC
pts receiving
#pembrolizumab
based therapy, including chemo-immunotherapy came out online
@CCR_AACR
today.
Why this may be important?
(1/6)
@EricaCarpenter1
5 year update of PACIFIC data being presented
@ASCO
#ASCO21
. Using consolidation
#Immunotherapy
, with one year of duevalumab, substantial % of pts are alive at 5 years 42.9% vs. 33.4%
#LCSM
My amazing AA made a folder for
#ASCO22
including an annotated map of the conference hall and the exhibit booths! 😮 So grateful to have a rockstar supportive team who understands the craziness of
@ASCO
AM w/o even being there!
@PC3Innovation
@PennPrecisMed
@HemOncWomenDocs
Let’s take a minute. Have we seen anything like this in NSCLC before? mPFS NR at 5 years? 👏🏽👏🏽👏🏽👏🏽
These curves are very impressive, and should urge us to think about management of AEs and optimize 1L Tx for ALK+ NSCLC
@ASCO
#ASCO24
@ALKPositiveinc
@OncoAlert
@bensolomon1
#ASCO24
News Planning with
@ASCO
Cancer Communications Committee today!
Thanks to this group of volunteers for the incredible effort to create a fantastic press program for the AM. Lucky to have had
@elmayermd
, immediate past chair guide me in this role of CCC Chair and look
.
@HosseinBorghaei
was celebrated today amongst friends and family
@FoxChaseCancer
as he became the inaugural Gloria and Edmund Dunn chair in Thoracic Oncology. I was honored to be invited to celebrate and humbled to call him my friend. Congratulations Hoss!
Sotorasib in KRASMT
#NSCLC
@myESMO
#ESMO20
- 59 pts with NSCLC, 34 treated at 960 mg
- G3/4 in ~18%, diarrhea in about 25%
- ORR 32.2.%, median DOR 10.9 mos
- Activity in STK11MT as well, and across different mutations
- Promising drug, excellent presentation
#LCSM
KRAS inhibitors are finally here!
➡ Not one, but 4 other drugs are in clinical trials, w/ others being developed.
➡ There is an impact of co-MT, including STK11/KEAP
➡ Future lies in combination therapies, in trials now
#WCLC20
@IASLC
@kRasKickers
Plasma based genotyping can increase detection of molecular alterations in patients with
#NSCLC
- and we are building upon this observation ()
Working w/ Drs. Jeff Thompson and
@EricaCarpenter1
, we are continuing to move the front door... (1/6)
Let’s take a minute. Have we seen anything like this in NSCLC before? mPFS NR at 5 years? 👏🏽👏🏽👏🏽👏🏽
These curves are very impressive, and should urge us to think about management of AEs and optimize 1L Tx for ALK+ NSCLC
@ASCO
#ASCO24
@ALKPositiveinc
@OncoAlert
@bensolomon1
Not to steal the thunder from the oral session today, but this is the CROWN PFS curve, more or less flat between 2-5 years and still 60% progression free at 5 years!
#ASCO24
#LCSM
Is it worth the side effects of lorlatinib to turn ALK+ NSCLC into CML?
Thrilled to see "Aumolertinib in EGFR-Mutant Lung Cancer: Will the Promise of Cost Disruption Ease Access?" in print. We discuss implications for clinical trial design, and cost, and access - with the brilliant
@oncology_bg
out in
@JCO_ASCM
#LCSM
Voting for the
@ASCO
Election is now open. I am honored and humbled to be running as one of the candidates for the Nominating Committee, alongside many talented friends and colleagues.
Visit to learn more about the candidates and place your votes!
Molecular Testing in Early Stage NSCLC
@JAMAOnc
@JackWestMD
and I discuss that it is most appropriate to get comprehensive NGS in early stage NSCLC where systemic therapy is indicated.
#LCSM
#BiomarkerTesting
Meta-analysis of AEs post
#Immunotherapy
w aPD-1/PDL-1 ~ 20k pts, 66% w/ at least 1 AE, 14% >= G3 AE. Sobering reminder that even though overall irAE
#pneumonitis
was 2.7%, and >= G3 was only 0.67%, it was the cause of death for 28% of the cases!
#OncoAlert
#LCSM
@JAMAOnc
Comprehensive meta-analysis of 125 trials treating w anti-PD-1 & anti-PD-L1 inhibitors across a broad range of cancers reveals patterns of observed toxicities & significant differences among different checkpoint inhibitors
#immunotherapy
"My advice is that universally people should assume that they could be carrying the virus." Dean J. Larry Jameson, MD, PhD, spoke with
@phillymag
on why
#socialdistancing
is so important. Stay home to keep yourself and others safe.
Getting ready for
@IASLC
#WCLC19
!
Which data are you most excited to see? I’ll start (in no particular order):
- tTMB in KN21, KN189
- Neg predictor MT in plasma for response to IO (MYSTIC)
- plasma TMB in chemoIO
- CASPIAN: durva+EP in SCLC
- FLAURA 3
#OncoAlert
#LCSM
Those who cannot learn from history are doomed to repeat it. Yet those who *do* study history are doomed to standby helplessly while everyone else repeats it.
We must learn from 1918, and from Italy
#InItTogether
#SocialDistancing
#COVID19
Lung Plenary
#LAURA
Osi in Stage III unresectable
#NSCLC
- amazing results and will definitely affirm my practice to deliver targeted tx for pts w/ EGFR Mutation
@EGFRResisters
mPFS 39.1 vs. 5.6 months, HR 0.16
Well done,
@RamalingamMD
and investigators
@ASCO
#ASCO24
FDA Approves New Pembrolizumab Dosing Schedule, this is really impactful in the
#COVID19
era, and will help us minimize exposure for patients with
#NSCLC
#LCSM
@OncoAlert
New report of Exon 16–Skipping HER2 as a mechanism of resistance in
#EGFR
L858R/T790M+
#NSCLC
post-osimertinib; very important to remember to obtain molecular sequencing at the time of PD
@JTOonline
#LCSM
#Biomarker
Testing for
#NSCLC
➡️ Only a third to half of pts getting tested for EGFR/ALK/BRAF/ROS
➡️ Only 50% tested within 30 days of new dx
➡️ Median test to treatment ~ 16 days
While there seems to be a trend towards improvement, we NEED to do better!
#LCSM
@IASLC
#WCLC20
Honored and humbled to be accepted into the
@ASCO
Leadership Development Program ‘19-‘20. Looking forward to a year of learning from the best, and to connect with friends, mentors and colleagues who have been previous
#asco_ldp
participants!
@PennCancer
Before we all continue to pile on
#ADAURA
, can someone tell me % of patients who received Immunotherapy upon progression on IM-010 or KN-91.
See figure.
I will remind you that immunotherapy alone or in combination is THE SOC for 1L Metastatic NSCLC. How come we don't see that
Hey
@JackWestMD
, did you already see p25 of the
#ADAURA
supplementary appendix? Curious of your thoughts given 88% of pts in the placebo arm who developed progression and were fit enough to get more tx got a TKI.
#ASCO23
As many of us leave the
#ASC019
meeting, let’s take an opportunity to thank the
@ASCO
staff, volunteers, and meeting organizers for a job well done. Getting so many people under one roof and keep the “buses running on time” is no child’s play. Congratulations to these
#Heroes
@IASLC
#TTLC22
Meeting Chairs invite you to Save the Date for this dynamic meeting (Feb 23-26). Presenters will summarize data on relevant targets for new therapies & preclinical/early clinical data for ea. of the drugs directed against these targets
#LCSM
Wonderful tribute to Dr. Jamie Von Roenn who has been a force in shaping educational programming for
@ASCO
, who is retiring this year - the Jamie Avon Roenn Excellence in Teaching Award announced tonight at
@ASCOPres
dinner 👏🏽👏🏽👏🏽 Standing Ovation!
She has been an exceptional
I am hopeful for a better future for my fellow Americans, my patients and my family. I voted today to make my voice heard. Have you?
#MakeAmericaKindAgain
#VOTE
#OncoAlert
phase III KN48 data just presented at
#ASCO19
Pembro Improves OS against EXTREME with or w/o chemo, in pts w/ PD-L1 CPS>1. RR higher when added w/ chemo, but so is toxicity. Emerging clear standard to go with P, PC—> I have reservations given high tox
#HNCSM
I was shocked to read the
@TheCancerLetter
piece today. Heard from many colleagues that this behavior was known in the field and went on for years. Years.
Check out this abstract on findings of sexual harassment of oncologists
@ASCO
#ASCO21
.
We need to do better.
.
@theNASEM
“Iceberg” provides the critical framework around which we reconcile our perceptions and understanding of
#sexualharassment
. The egregious cases make the news but we’re here to address that COMPLICIT OCEAN that keeps this ENTIRE ICEBERG afloat.