Alexander Bartelt @BarteltLab Twitter profile

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Alexander Bartelt

9 months

Our new 2023 group pic - as my beard is becoming whiter the lab is being continuously rejuvenated. While I’m sad to see my students leave I’m very proud when they spread their wings and move on to new challenges. This is the way.

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Alexander Bartelt

@BarteltLab

10 months

Today I presented our unpublished data on new adipocyte genes and got zero feedback - great success!

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Alexander Bartelt

@BarteltLab

5 months

I am a PI ... get me out of here! First poster in years 😅

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Alexander Bartelt

@BarteltLab

11 months

Today, my first PhD student submitted her thesis and I think that’s beautiful!

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Alexander Bartelt

@BarteltLab

1 year

OTD 10 years ago, I moved to USA for a postdoc. It was an outstanding experience, but also the most difficult challenge of my life. The last 10 years have been rough, I lost my best friend, and the love of my life twice, but science gives me hope every day❤️

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Alexander Bartelt

@BarteltLab

4 years

Me and my brain child #Fettversteher - feels like first first author paper ☺️

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Alexander Bartelt

@BarteltLab

2 years

Manuscript accepted, happy weekend!

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Alexander Bartelt

@BarteltLab

3 months

I present to you the first PhD to graduate from our lab: Dr. Imke Lemmer - heartfelt congratulations 🎈🎉🎊🍾

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Alexander Bartelt

@BarteltLab

3 months

Today, we report that IF1 is a cold-regulated switch of ATP synthase to support thermogenesis in brown fat. 👇

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Alexander Bartelt

@BarteltLab

3 years

Extremely honored to receive the 2021 #Obesity Research Award @DAG_Presse - took me a while to digest this news. #Obesity is one of THE major challenges of our time & @BarteltLab will continue its ongoing mission to understand the nature & power of #metabolism !

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Alexander Bartelt

@BarteltLab

3 months

Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-seq of islets we define a β-cell maturation score, which was linked to T1D in humans. 👇

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Alexander Bartelt

@BarteltLab

28 days

In the first 6 months of 2024 our lab peer-reviewed 40 manuscripts. Underestimating we spent 4 h per MS, this makes 160 h pro bono work. If we charged the publishers, this would amount to a decent salary for a PhD student. Happy weekend!

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Alexander Bartelt

@BarteltLab

1 year

What fuels thermogenesis🔥? Ummmm - let's say, it depends - see our comment on an elegant new study in Nature Metabolism Here a link to the free view-only version:

Brown fat has a sweet tooth

Nature Metabolism - An elegant quantitative analysis of brown fat and skeletal muscle metabolite flux reveals unpredicted fuel usage during thermogenesis, which suggests that brown fat...

www.nature.com

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Alexander Bartelt

@BarteltLab

1 year

Today, we report a novel adaptive mechanism of muscle biology, remodeling of the ubiquitin-proteasome system in obesity, and its global regulation by the transcription factor Nfe2l1 🧵

Nfe2l1-mediated proteasome function controls muscle energy metabolism in obesity

Muscle function is an important denominator of energy balance and metabolic health. Adapting the proteome to energetic challenges, in response to diet or fasting, is facilitated by programs of...

www.biorxiv.org

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Alexander Bartelt

@BarteltLab

6 months

Today, we say farewell to our PhD student @nwillemsen95 who will continue her postdoctoral career @KingsCollegeLon 🇬🇧. There isn’t enough space here to say how proud I am of you and your achievements. I have no doubt you’ll do great, best of luck🖖🍀🧿

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Alexander Bartelt

@BarteltLab

2 years

40 - cheers

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Alexander Bartelt

@BarteltLab

11 months

Being a PI and mentor is sometimes challenging as there isn’t really any training and you don’t get a lot of feedback so I’m very happy about the birthday card the lab wrote me ❤️

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Alexander Bartelt

@BarteltLab

3 years

This week, two papers accepted, one grant won - Good week for @BarteltLab - Happy Friday!

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Alexander Bartelt

@BarteltLab

2 years

To all my tweeps, colleagues, friends, family, my haters & lovers, and reviewer #3s Merry Xmas & Happy Holidays

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Alexander Bartelt

@BarteltLab

1 month

Today, we report a new imaging approach that provides remarkable contrast deep within tissues for contrast agent-free visualization of physiology in whole animals and intraoperative imaging in humans: Shortwave infrared Raman scattering 👇

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Alexander Bartelt

@BarteltLab

4 years

Fascinated by the biology of fat cells I was asked by @Ullstein publishing to write a popular science book about #metabolism , #diet and #obesity - VERY happy that the work is done now and the book is going to be released Jan 12th 2021 👇 - in German

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Alexander Bartelt

@BarteltLab

1 year

Happy 18th Birthday, my son 🎂 I love you and I couldn't be prouder of you today ❤️

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Alexander Bartelt

@BarteltLab

2 years

😱Today I’m having a very important #proudPI milestone moment - first student out for postdoc interview (hope student doesn’t see this tweet but let’s all wish best of luck 😜🍀🧿) it feels like as if I was being interviewed 😅😬 #AcademicTwitter

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Alexander Bartelt

@BarteltLab

3 years

“… manuscript acceptable with minor revisions.” Happy Friday, everyone!

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Alexander Bartelt

@BarteltLab

8 months

These incredible stunts of nature remind me of why I became a scientist

Massimo

@Rainmaker1973

8 months

Chlorophyll and Hemoglobin The major difference is that plant blood carries a Magnesium (Mg) molecule where our blood contains a Iron (Fe) molecule. Magnesium is what is responsible for making plant blood green, and iron is what makes our blood red.

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Alexander Bartelt

@BarteltLab

3 years

JUST published: HAND2 is a novel #obesity -linked adipogenic transcription factor regulated by glucocorticoid signalling BIG THX to lead author Dr. Maude Giroud👩‍🔬, our generous collaborators, @AvHStiftung @ERC_Research and the editorial team @DiabetologiaJnl for a fair review

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Alexander Bartelt

@BarteltLab

2 years

New 2022 @barteltlab group picture

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Alexander Bartelt

@BarteltLab

3 years

Why I love @twitter ? Best way to find out you got scooped!

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Alexander Bartelt

@BarteltLab

1 year

Paper accepted. It’s the little baby steps you have to celebrate.

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Alexander Bartelt

@BarteltLab

4 years

Panorama view from @BarteltLab on beautiful Bavarian 🍁fall - it’s harvest season so let’s collect all the fruits of our hard work at the bench #thanksgivingCanada 🇨🇦

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Alexander Bartelt

@BarteltLab

9 months

“Boss, we told you you mustn’t do experiments in the lab anymore, you’re too old for this shit”

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Alexander Bartelt

@BarteltLab

8 months

During grant writing I consume 2 g/kg/d chocolate in all forms and flavors 🧠

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Alexander Bartelt

@BarteltLab

4 months

I stayed in a academia because 1. I was fortunate enough to be given the choice (luck) 2. I was supported by mentors and advocates who believed in me (network) 3. I’m extremely stubborn (perseverance & hard work) 4. It’s my dream job (Idealism) Happy Friday

Receptor Biology Lab

@StuartMaudsley

4 months

11 reasons why we’ve stayed in academia

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Alexander Bartelt

@BarteltLab

2 years

Just got the news that our @CRC1123_Athero will be funded for another 4 years by @dfg_public 🎉big THX to the reviewers, peers, and all people involved @LMU_Muenchen @LMU_Uniklinikum @TU_Muenchen for their hard work!

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Alexander Bartelt

@BarteltLab

3 years

🎉Paper submitted - 🥳Happy Friday and big congrats to @nwillemsen95 et al. we show that #proteasome function is required for making 🔥hot🔥 and fat adipocytes - new mechanistic insight into the link of #proteasome , #proteostasis , and #inflammation @biorxivpreprint @ReviewCommons

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Alexander Bartelt

@BarteltLab

4 years

🎉 Master's thesis submitted 🥳- incredibly proud of our student Janina Caesar 👩‍🔬- she discovered which #adipocyte transcriptional networks sustain #proteostasis and suppress #inflammation in #obesity - now off to new shores at @Roche - #WomenInSTEM

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Alexander Bartelt

@BarteltLab

1 year

Paper submitted 🍻🔥

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Alexander Bartelt

@BarteltLab

5 months

We have a new PhD in the house - congratulations to Dr. Felicitas Böhm to a successful PhD defense 🎉

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Alexander Bartelt

@BarteltLab

1 month

You win some, you lose some - this week grant rejected, but paper accepted! Embracing failure, learning from it, and turning it into victory is a key asset in academia, as frustrating as it may be. We will prevail - Happy Weekend

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Alexander Bartelt

@BarteltLab

4 years

JUST SUBMITTED🎉 - Our @ERC_Research PhD students @ImkeLemmer and @nwillemsen95 have worked very hard to put together "A guide to understanding ER stress in metabolic disorders" - #ProudPI - see the graphical abstract below👇 #ER_literature

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Alexander Bartelt

@BarteltLab

3 years

Paper accepted, have a nice day 👋 @cddpress @SpringerNature

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Alexander Bartelt

@BarteltLab

10 months

I have been to Oktoberfest six days in a row - follow me for more survival strategies in extreme academic conditions

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Alexander Bartelt

@BarteltLab

4 years

🤩Extremely grateful to @ERC_Research and @SableSysEurope as we have now set-up our new @SableSys PROMETHION for studying #real #live #invivo #energy 🍔 #metabolism 🏃‍♀️ #exercise 💩 #brownfat 🔥 #thermogenesis @ipekresearch @LMU_Uniklinikum @LMU_Muenchen

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Alexander Bartelt

@BarteltLab

1 year

We have to do so much better to support & empower women in #science - enable them to make choices, family and career, and protect them from bullies #WomenInScienceDay #WomenAndGirlsInScience

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Alexander Bartelt

@BarteltLab

5 months

On this #InternationalWomensDay I want to testify that women are still being discriminated in science and the numbers don't lie. Projects, authorships, grants, panels, or whatever we have support #womeninSTEM better so that they may leverage their potential without barriers!

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Alexander Bartelt

@BarteltLab

1 year

🔥Hot off the press - Today, we report on the role of the proteasome activators PA28αβ and PA200 in brown adipocyte differentiation and function

Frontiers | The role of proteasome activators PA28αβ and PA200 in brown adipocyte differentiation...

IntroductionBrown adipocytes produce heat through non shivering thermogenesis (NST). To adapt to temperature cues, they possess a remarkably dynamic metaboli...

www.frontiersin.org

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Alexander Bartelt

@BarteltLab

3 years

Paper accepted - best way to start the new year - big thanks to the reviewers and editors for working on this during the holiday season!

Alexander Bartelt

@BarteltLab

3 years

Excited to share our work led by @s_kotschi on the regulation of #ferroptosis by NFE2L1-mediated proteasome function - extremely grateful to @Conrad_Lab @sanathkr_ for their help understanding the link to GPX4 & @dfg_public @Ferroptosis2306 for funding!

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Alexander Bartelt

@BarteltLab

10 months

This month, our lab turns 5 - and what a ride it has been! I am extremely grateful to all the people who have helped building the lab baby step by baby step and making every day enjoyable! Thank you, AB ❤️

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Alexander Bartelt

@BarteltLab

4 years

Paper accepted. That's the tweet! 😌 @ImkeLemmer @nwillemsen95 @ipekresearch @helmholtz_diabc @LMU_Muenchen @LMU_Uniklinikum @ERC_Research @dzhk_germany @dfg_public

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Alexander Bartelt

@BarteltLab

1 year

Best way to end the week are the two magic words: paper accepted 🥳 @zeynepkocberber @nwillemsen95 Happy Friday, folks!

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Alexander Bartelt

@BarteltLab

6 months

Today, we are celebrating #WomenAndGirlsInScienceDay . There are still so many things to be done to protect #WomenInSTEM from sexism, structural and conscious/unconscious bias. Let’s support them better!

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Alexander Bartelt

@BarteltLab

7 months

Happy Holidays to all my lovers, haters, family, friends, collaborators, colleagues, & reviewers 1-8. Hope your drinks were as good as mine🎄

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Alexander Bartelt

@BarteltLab

9 months

I don’t know who needs to hear this (students?) but your mentors also struggle at times. We will get thru anything and everything together!

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Alexander Bartelt

@BarteltLab

2 years

These days, I spend many mornings with my students working on their manuscripts - sadly, my schedule doesn’t allow much of this but it’s really the best part of my job - sit down in peace and quiet, discuss, and harvest the fruits of their hard work 😃

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Alexander Bartelt

@BarteltLab

3 years

🥳Online now @MolMetab NFE2L1-mediated proteasome function protects from ferroptosis - congrats to @s_kotschi et al. @Ferroptosis2306 @Conrad_Lab @LMU_Muenchen @helmholtz_diabc @HelmholtzMunich

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Alexander Bartelt

@BarteltLab

1 year

Sent from my vacation

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Alexander Bartelt

@BarteltLab

4 years

#OTD 10 years ago we @JoergHeeren published my PhD work @NatureMedicine - became one of the highest cited #brownfat 💩 papers ever - laid the foundation for many new lines of research, PhD theses, and papers - reproducibility is key for sustainable science

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Alexander Bartelt

@BarteltLab

1 year

We have a new master in the house!

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Alexander Bartelt

@BarteltLab

4 years

#OTD 10 years ago I defended my #PhD - what an exciting journey it has been - but that was just the beginning - extremely grateful for everything #science has given me and to my mentors @JoergHeeren and @ghotamis - All I ever wanted was to boldly go where no one has gone before🧑‍🔬

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Alexander Bartelt

@BarteltLab

3 years

Excited to share our work led by @s_kotschi on the regulation of #ferroptosis by NFE2L1-mediated proteasome function - extremely grateful to @Conrad_Lab @sanathkr_ for their help understanding the link to GPX4 & @dfg_public @Ferroptosis2306 for funding!

NFE2L1-mediated proteasome function protects from ferroptosis

Objective Ferroptosis continues to emerge as a novel modality of cell death with important therapeutic implications for a variety of diseases, most notably cancer and degenerative diseases. While...

www.biorxiv.org

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Alexander Bartelt

@BarteltLab

3 years

Off to the 44th @society_eas European Lipoprotein Club with posters and talks in our bags - excited for new science and meeting our dearly missed colleagues in person ☀️

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Alexander Bartelt

@BarteltLab

1 year

The science of fat is beautiful. Please be kind to people struggling with their body weight. Obesity is a disease and not a choice #WorldObesityDay

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Alexander Bartelt

@BarteltLab

3 years

😢Today, we say farewell to the VERY FIRST member of @BarteltLab 🫀 - I am beyond grateful to @sajjad_khani for helping me create our #science playground out of nothing, for being a great mentor to the younglings, and so much more🐑🔥- you will be missed - godspeed at @CECAD_ 🙋‍♂️

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Alexander Bartelt

@BarteltLab

1 year

All I see is differentiating adipocytes

Microscopic Pictures

@MicroscopePicsx

1 year

Zooming into a cup of coffee

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Alexander Bartelt

@BarteltLab

1 year

Just finished the brown fat💩 and thermogenesis🔥 symposium with representation of our lab

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Alexander Bartelt

@BarteltLab

2 months

Conferencing in style with @Anahita_Ofoghi

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Alexander Bartelt

@BarteltLab

2 years

Signing off - take care, everyone ❤️

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Alexander Bartelt

@BarteltLab

1 year

I ❤️ Copenhagen 🇩🇰 even on a rainy day! Off to the Scandinavian Athero Meeting with @_Anna_Jung @CarolinMuley @HenverBrunetta & @s_kotschi ☔️

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Alexander Bartelt

@BarteltLab

3 years

To all tweeps, former, current, future lab members, colleagues, collaborators, reviewers, friends, and family, wherever you are, whatever you are celebrating these days, Happy Holidays, to good health and good fortune! 🙋‍♂️

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Alexander Bartelt

@BarteltLab

3 years

"Adipocyte function and the development of cardiometabolic disease" by @GiroudMaude Henrika Jodeleit & @KaceyPrentice now accepted @JPhysiol - graphical abstract inspired by dancing @GurdeepPandher - big thanks to @Peter_Aldiss & @joedwardlewis @ThePhySoc for the invitation!

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Alexander Bartelt

@BarteltLab

24 days

INTERNS … ASSEMBLE!!! Finally got the students of summer 2024 together in one picture 📸 @shruthiraju @deniizaydiinn @selinaltunkara @zegeates Jana Ebeling @c_consmueller

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Alexander Bartelt

@BarteltLab

1 year

Today marks the end of era for me. For 10 years, I was affiliated with Harvard and it brought me enormous joy and professional success. Many of my fellow postdocs during those years have become my PI peers, and remain friends with so many memories attached ❤️✊

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Alexander Bartelt

@BarteltLab

9 months

Today, we say farewell to our technician Silvia who with her great heart, organization talents, and pipetting skills kept the lab running, had a watchful eye on the juniors, and was always there to help! We will miss you 🙋‍♂️

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Alexander Bartelt

@BarteltLab

1 year

We all know that UCP1 is regulated by cold but what about coupled respiration during thermogenesis🔥? Check out our new study on the roles of IF1 and the reverse mode of ATP synthase for bioenergetics in brown adipocytes💩 👇

IF1 controls UCP1-dependent mitochondrial bioenergetics in brown adipocytes

In thermogenic adipocytes, uncoupling protein-1 (UCP1) is a key mediator of non-shivering thermogenesis (NST) by uncoupling the electron transport chain from FoF1-ATP synthase-mediated ATP producti...

www.biorxiv.org

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Alexander Bartelt

@BarteltLab

3 years

Happy to share our free guide to understanding ER stress @MolMetab - we provide a fresh and updated view beyond just UPR and IRS, now including ERAD, UPS, lipotoxicity, and glycosylation @ImkeLemmer @nwillemsen95 @ERC_Research @dzhk_germany @dfg_public

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Alexander Bartelt

@BarteltLab

2 years

#NewProfilePic

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Alexander Bartelt

@BarteltLab

1 year

Warm welcome to our two new summer students @barkinstanne and @ozgeddeniz 👨‍🔬👩‍🔬🧪🧫💥

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Alexander Bartelt

@BarteltLab

6 months

On #WomenAndGirlsInScienceDay a picture of my daughter isolating DNA. Our universities, academic leadership, and funders need to implement more structural programs for supporting #WomenInSTEM @dfg_public

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Alexander Bartelt

@BarteltLab

3 years

Out now! #Fettversteher

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Alexander Bartelt

@BarteltLab

2 years

Monday morning - paper accepted @nwillemsen95 #EASCongress2022

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Alexander Bartelt

@BarteltLab

2 years

We @BarteltLab have peer-reviewed more than 80 manuscripts this year. I hope this pro bono effort was worth it, as we try to provide constructive criticism of methods and conclusions, simply to help make the science better and reproducible

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Alexander Bartelt

@BarteltLab

2 years

Just realized that our recent paper @nwillemsen95 et al. was my 50th peer-reviewed publication🤩! Infinitesimal step for mankind, important milestone for @BarteltLab

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Alexander Bartelt

@BarteltLab

9 months

Nowadays, one can still find a peaceful place for a moment of silence ☮️

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Alexander Bartelt

@BarteltLab

1 year

🚨Thesis submitted🚨Congrats to @lukas_blaas 🥳🎉

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Alexander Bartelt

@BarteltLab

3 years

Usually I don’t tweet private stuff but today is my son’s @Pablog11524023 #SWEET16 🎂 bday - Happy Birthday 💕

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Alexander Bartelt

@BarteltLab

3 months

🚨Attention you Bavarians! We invite scientists interested in energy metabolism & mitochondria🔥 to participate in our 🇧🇷🇩🇪 workshop this September 2024. Details below & more info to follow! 👇

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Alexander Bartelt

@BarteltLab

2 years

Masters thesis ✅ Congratulations @_Anna_Jung 🎉 Terrific work, we are very proud of you - joint effort of @TU_Muenchen & @LMU_Muenchen and big THX to @NatalieKrahmer @helmholtz_diabc

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Alexander Bartelt

@BarteltLab

4 years

First time I see my #Fettversteher baby displayed in store😱 and promptly TOP3 😊 - @REWE_Supermarkt - hope it gets highly cited @Ullstein

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Alexander Bartelt

@BarteltLab

11 months

Today, we report a new role for the human lncRNA AATBC for adipocyte mitochondrial function and obesity - check it out:

The obesity‐linked human lncRNA AATBC stimulates mitochondrial function in adipocytes | EMBO reports

image image Screening of human adipose tissue and cultured human adipocytes has identified the lncRNA AATBC, which is a obesity‐linked regulator of adipocyte plasticity and mitochondrial function in...

www.embopress.org

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Alexander Bartelt

@BarteltLab

1 year

Being on TV brings me back to feeling like it’s my PhD defense🫣

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Alexander Bartelt

@BarteltLab

3 years

Discovery of a new hormone by @KaceyPrentice New @Nature study from @ghotamis lab @sabriulkerctr @MET_HSPH @HarvardHSPH @Harvard

A hormone complex of FABP4 and nucleoside kinases regulates islet function

Nature - Hormonal FABP4 is discovered to be a pivotal regulator of an adipose–beta-cell endocrine axis that coordinates energy status and metabolic organ function, and targeting this axis...

www.nature.com

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Alexander Bartelt

@BarteltLab

3 years

I'm really sick and tired of reading magic fairy tale research papers 🧵

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Alexander Bartelt

@BarteltLab

1 year

Mitochondria make fatty acids and this has huge impact on metabolism 🤯 excited to see this collaborative effort by @SchleinLab @annawo13 et al. @UKEHamburg out there!

medRxiv

@medrxivpreprint

1 year

Mitochondrial fatty acid synthesis is essential for coordinated energy transformation #medRxiv

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Alexander Bartelt

@BarteltLab

2 years

#NewProfilePic - white beard it is 😅

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Alexander Bartelt

@BarteltLab

1 year

This week, we got exciting new data that gave me goosebumps - these moments make up for all the lows along the long and winding road to scientific discovery - happy weekend!

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Alexander Bartelt

@BarteltLab

4 years

At the end of this somewhat unusual year I would like to thank the @BarteltLab family for making me very #proudPI 😊 - no matter the circumstances you keep up with me and your #research - 🎉 #HappyNewYear2021 🎉 with exciting new #science to come!