بحمد الله ثم بفضل دعم وطني - مملكة العز - اللامتناهي 🇸🇦 ،
تم اختياري كأول مُحكّم - دولي - في نهائي مسابقات أطباء زمالة القلب في النسخة الخامسة والسبعين من مؤتمر الجمعية الأمريكية لأمراض وجراحة القلب
#ACC24
Lipids and CCD:
Guidelines highlighted the importance of looking at non-HDL C (cut off > 100 mg/dL or > 2.6 mmol/L) as another indicator to initiate lipid-lowering agents.
Statin is still on the throne for as 1st line lipid lower agent, followed by ezetimibe, and then PCSK9 i.
Continuing on my top learning points/highlights from the recently published
@ACCinTouch
@Cardiology
Guidelines on treatment of Chronic Coronary Disease (CCD):
معاناة "فيكتور فرانكل" في سجون النازيين أثناء الحرب العالمية الثانية ومشاهداته لطريقة تفكير المساجين وتأثيرها على مستقبلهم أعطى لنا ثمرة أفكار "الإنسان يبحث عن المعنى".
المتشائمون كان قدرهم أسوأ من المتفائلين. القوه التحفيزيه الأساسية للفرد هي العثور على معنى في هذه الحياة.
Anti-coagulation on top of anti-platelet (big deal x2):
AFib pt who needs PCI > AC + DAPT (for 1-4 Weeks) then clopidogrel + AC afterwards (class Ia)
Stable CCD and after one-year PCI, AC alone is reasonable.
Anti-platelet and CCD (big deal):
Lower the time for DAPT following PCI to 6 months (class Ia) OR DAPT for 3-6 months then P2Y12 i (SAPT) afterwards (Class IIa).
Longer DAPT beyond one-year - even low risk bleeders - is class IIb (meh!)
Beta-Blockers and CCD:
Guidelines this time become more aggressive on long term treatment with BB in CCD.
In the absence of HFrEF, prior MI, BB is not recommended (no benefit).
Angina and CCD:
Similar recommednaiton from prior, choose one or multiple from: BB, CCB or long-acting nitrite. If still symptomatic, consider ranolazine.
Ivabridine is potentially harmful in the absence of HFrEF (refer to SHIFT Trial).
Revasculization in CCD:
When to revasculrize: Life-style limiting angina despite GDMT + Revasculriable target(s).
HFrEF + LM/ Multi-V disease > CABG
Multi-vessels > Heart Team approach for re-vascularization strategy (PCI vs. CABG)
Highlight on Optimal Medical Therapy
"Medical knowledge is critical for saving lives yet almost useless without competent bedside manner"
~
@MKIttlesonMD
in her great book "Mastering
the Art of Patient Care"
Highlights on HFmrEF and identify them as a different entity than HFrEF and HFpEF. Think of HFmrEF as a transition period to either improved or worsen before they settle in a different category either <40% or > 50%.
By
@AndrewJSauer
#ACC23
#CardioTwitter
@ACCinTouch
بما أننا مقبلين على التقديمات الأمريكية وغيرها لبرامج الزمالة، هذه المقالة (رغم أنها قديمة نوعا ما) إلا أنها ثرية بالكثير من النصائح والدرر للمتقدمين. أسأل الله لي ولكم التوفيق.
#فضفضة_طبيب #الزمالة
DM with Chronic Coronary Disease (DM-CCD):
Add SGLT-2 i ($$) or GLP-1 RA ($$$) to reduce MACE.
My approach:
DM-CCD with CKD > SGLT-2 i
DM-CCD who are obese and can afford $ > GLP-1 RA
Using sacubitril/valsartan among patients with congenital heart disease is extremely underinvestigated - due to multiple reasons -.
My dear friend
@T_GuptaMD
, et al. investigated the safety and efficacy of Sac-Val among ACHD pts.
اللهم إني اسألك خيرها وخير ما فيها وخير ما أرسلت به وأعوذ بك من شرها وشر ما فيها وشر ما أرسلت به.
Barry
إعصار من الدرجة العالية بالقرب من مدينة نيو أورلينز، لويزيانا.
@naif_khalaf
@AlghnamS
- Innovate a track in medical school (MBBS-MS) degrees.
- Creating "Physician–Scientist" Track during residency. One-year dedicated for research.
- Abandon communicating with fake journal and "Tooth Fairy science".
- Good incentives and promotion for high-quality projects.
Colchicine as 2nry prevention in CCD:
Still weak recommendations. This mainly based on LoDoCo trial (Low Dose Colchicine for Secondary Prevention of Cardiovascular Disease)
An attention to the fasting TG level, and to introduce Icosapent Ethyl–Intervention (IPE) if TG > 150 mg/dL (1.7 mmol/L). This after the landmark trial in IPE: REDUCE-IT trial.
كل الشكر موصول للمؤلف فهد الطبيب
@tabibfi
لإرساله نسخة موقعة من آخر إصداراته "أرثر وبلاك".
متشوقٌ لمعرفة الأحداث بين "أرثر أندرسون" و "ستيفاني كلارك" و"بلاك".
Segway to REDUCE-IT Trial: it showed significant reduction in CV death or MI (9.6% vs.12.4%, p < 0.001) but not in All-cause mortality (6.7% vs. 7.6%, p = 0.09). IPE group has higher rate of Atrial fibrillation/flutter: 5.3% vs. 3.9%.
Another brilliant work by Sam Mendes, the movie
#1917
showed excellent representation of Trench Warefare system during WW-I (The first fire trench, zigzag line across communication trenches, reserve trench and the barriers.
تشرفتُ بزيارة جناح ضيف الشرف، جناح المملكة العربية السعودية في #معرض_سيئول_الدولي_للكتاب
أكرمونا بحفاوة الاستقبال والبخور والقهوة السعودية 🇸🇦💚🤍
@KSAembassyKorea
@MOCLiterature
@KSAMOFA
Pregnancy and CCD:
Screening and cardiovascular risk assessment, and potentially cardio-obstetric care team for high risk pts is recommended
Statin has a (meh!) recommendation during pregnancy (Class IIb)
ACEi/ARB/ARNI/MRA are big NO NO during pregnancy
Atorvastatin expressing muscles in its cardioprotective effects among cancer patients who received anthracyclin (STOP-CA Trial).
#ACC23
#CardioOncology
Hypertension and CCD:
Pts without hypertension, the goal for nonpharmacologic strategies when BP > 120/<80 mmgHg.
Pts with hypertension, the goal of their BP is < 130/80 mmHg
Exercise and CCD:
(Combination) of Aerobic and Strength-triaining exercise:
Aerobic: either ~ 150 minutes/wk moderate-intensity or ~ 75 minutes/wk high-intensity
Strength: hit the gym > 2 days/wk for weight lift
Vorapaxar add-on on ASA in prior CVA-CCD is (class IIb), Vorapaxar add-on to DAPT (class III harm)
DAPT post-CABG to decrease saphenous graft failure is class IIb
CCD without ACS or PCI, only ASA is indicated (not DAPT)
Unchanged from prior: avoid prasugrel in CVA and NSAIDs.
Nonatherosclerotic causes of CCD in young:
Kawasaki disease - look for coronary anerysm
Coronary artery anomalies - Refer to ACC Guidelines for Congential Heart Disease 2018
Myocardial bridging - BB is a good option / restriction intense physical activity
CABG vs. PCI in CCD (not going to open a bag of worms):
CABG preferred over PCI in:
- LM with high complex CAD
- CAD with SYNTAX score >33
- DM with LAD (conditional use of LIMA-LAD)
The rest of lesions, use: Heart Team approach
Chronic management of SCAD (spontaneous coronary artery dissection):
It is imperative to rule out other organs' vasculopathies which can co-exist with SCAD.
Think of aneurysm or pseudoaneurysm in brain and other organs.
Among women who underwent Bio AVR/MVR vs. Mech AVR/MVR and subsequently got pregnant:
MechVs carried a higher risk of Pregnancy loss | Maternal morbidity | and Hemorrhage in delivery.
Both groups: accelerate time to reoperation.
Batra J, et al. Am J Card. 2018.
#Cardiotwitter
Teaching points from the leading author in the consensus document, Dr. Angiolillo from Jacksonville, FL:
- Drop Aspirin when feasible (days post PCI in high bleeders or one month in low-risk bleeders).
- NOAC preferred over VKA
- Use standard dose for NOAC as for stroke PPx