Seurat is an R package developed by Rahul Satija’s lab at
@nygenome
. Read our blog post to discover the steps for using Seurat to analyze CODEX datasets and perform cellular neighborhood analysis.
#spatialbiology
#singlecell
#spatialanalysis
New
@ScienceMagazine
paper uses
#PhenoCycler
to create a
#spatialatlas
of the gut and its rewiring during ulcerative colitis (UC) pathogenesis! The spatial atlas is publicly browsable & has 42 tissue regions from 29 patients w/ UC & 5 healthy individuals.
Using
#PhenoCycler
, researchers at
@StanfordMed
generated high-dimensional spatial maps of
#colorectalcancer
(CRC) tissue & identified distinct cell types & “cellular neighborhoods” to understand how interactions between cells/neighborhoods can influence CRC patient outcomes.
🎉 We are thrilled to be recognized as one of the top five public companies in this year's Top 10
#SpatialBiology
Companies list by
@GENbio
! Being on this list is a great honor & a testament to our dedication to spatial biology.
#cancerresearch
#biotech
Developed by
@Penn
researchers, STvEA is a multi-omics method that maps the CITE-seq transcriptome to spatially resolved CODEX mIHC data while retaining single-cell spatial resolution. Read the paper on
@ScienceAdvances
:
In case you missed last week's big announcement,
#AkoyaBio
&
@UQMedicine
researchers have optimized and applied an ultra-high plex,
#singlecell
spatial protein analysis in
#headandneck
squamous cell carcinomas.
Tissues were analyzed with a panel of 101 antibodies that targeted
Pleased to see this first set of tonsil images that our customer,
@LGMartelotto
@UniofAdelaide
generated using
#PhenoCycler
. Thanks to our Field Application Scientist, Dr. Williams for the exceptional onsite training including how to pair PhenoCycler w/ a
@zeiss_micro
microscope!
In this week's
@Nature
issue, a paper shows how researchers use an imaging technique called
#CODEX
(now rebranded as
#PhenoCycler
) and
#singlecell
technologies to map the human
#intestine
.
Learn how the study results describe the complexity of this organ's cell composition,
Amazing image produced using
@QuPath
software by
@Theo_BrainC_lab
.
The image showcases a blood vessel surrounded by various immune cells, including T-cells, B-cells, macrophages, and collagen.
This image was captured from a
#wholeslide
image of human
#glioblastoma
, generated
Today, we showcase a fascinating hamster bone for
#TissueTuesday
using our
#PhenoImager
solution. This bone is from a Golden Syrian Hamster femur stained w/ various proteins, including
#SARSCoV2
nucleocapsid protein (NP), ACE2, TRAP, CD68, & IL-1β.
#SciArt
Check out this human skin tissue sample that shows the spatial interactions of immune cells and skin epidermal cells in a
#psoriasis
rash. Immune cells (in orange) are seen to cluster beneath the epidermis as part of the local immune response.
#psoriasisawarenessmonth
#sciart
For today's
#TissueTuesday
, we're sharing a 48-tissue microarray of
#lungcancer
run on the
#PhenoCycler
system in collaboration w/ researchers
@UU_University
. This image shows us how intricate and different the immune microenvironment of lung cancer is across different
#tumors
.
For today's
#TissueTuesday
, we're featuring high-plex
#PhenoCyclerFusion
images of the mouse brain.
The first image presents a whole slide view of a mouse brain, showcasing the normal brain tissue and the presence of
#Glioblastoma
. The second image zooms in on the hippocampus
The mouse embryo model is one of the most common animal models for studying
#developmentalbiology
.
Here, we showcase two
#mouseembryos
using FFPE tissue at different stages of development stained with a 36-plex panel on
#PhenoCyclerFusion
.
Kudos to our Apps Group for
Beautiful
#PhenoImager
image, showing a lung cancer FFPE tissue sample w/ little immune infiltration & high numbers of PD-1- & PD-L1-positive immune cells & FoxP3-positive cells in the surrounding microenvironment, indicating an “immuneexcluded” phenotype.
#tissuetuesday
#sciart
We've entered into a license and distribution agreement with
@ThermoFisher
for
#spatialbiology
systems & reagents—providing researchers with a streamlined workflow for rapid and whole-slide imaging of RNA and protein biomarkers.
#ThermoFisher
@GenomeWeb
Using PhenoImager HT, researchers at
@thecrick
and
@ucl
have identified stem cells in the human
#thymus
for the first time. These cells represent a potential new target for understanding
#immunediseases
and cancer and how to boost the
#immunesystem
.
📢 Don't miss
@Aruthak
’s poster presentation (Poster
#114
) at
#AGBT24
today until 3:30 PM!
The presentation titled "From Pixels to Clinical Insights: Ultra-Deep Spatial Proteomic Profiling of the
#HeadandNeck
Cancer
#TumorMicroenvironment
" is an impressive study that uses our
Want to enhance your ability to interpret complex
#spatial
#phenotypes
& extract info such as ‘SpatialScore,’ adapted from Dr.
@GarryPNolan
's lab?
Watch our webinar to learn about a framework for analyzing
#multiplex
IF images generated on
#PhenoImager
.
Check out this
@NatureCancer
cover featuring tertiary lymphoid structures as immunotherapy biomarkers. This image is from a paper that explains how the presence of tertiary lymphoid structures has been associated w/ improved survival in tumor types.
Remarkable Nature paper introduces a cell-matching algorithm, MARIO, which matches and integrates data from different
#singlecell
#proteomic
and multimodal methods, including spatial techniques, and has cross-species capabilities.
@GarryPNolan
@SizunJ
Who knew a tonsil tissue could look so amazing? 😮 Image credit goes to Sarah Nersesian, MSc (
@NersesianSarah
) who captured this image at 20X & re-created it digitally in collaboration w/ David Edgar, a young artist who suddenly passed away in July.
@JeanetteEB
@Dal_micro_immun
The power of
#spatialbiology
can be fully realized when we
#phenotype
every cell across an entire microscopic slide, leaving no detail behind.
Explore our
#spatial
biology platforms that can map every cell, across every tissue, in just a few minutes.
This groundbreaking study, published in
@Nature
using our
#PhenoImagerHT
platform, offers a fresh perspective on the
#pathology
and heterogeneity of
#rheumatoidarthritis
. The findings hold promise for developing innovative targeted treatments for patients with this condition.
🙌
📢 We are thrilled to have our
#PhenoCyclerFusion
platform selected as the core technology to revolutionize how
#cancer
& other debilitating diseases are diagnosed and treated at the newly established
@Qld_SBC
in Brisbane, Australia!
View Press Release:
It’s a beautiful day in the intestinal neighborhood! 🚎🥼
This is a
#PhenoCycler
image of the
#intestines
, courtesy of
@JohnHickey22
.
"Looking at the presence or absence of a
#singlecell
doesn't tell you much; it's how cells are grouped together that defines their
🧬 Mapping the future of personalized medicine, one disease, one organ, and one cell at a time.
This 3D animated video showcases the transformative power of precision medical research. Narrated by the voices of hope—Michel Itel (a patient), Professor John Fraser (a doctor), and
Great
@Nature
paper on
#multiplexed
antibody-based imaging and outlines considerations for planning multiplexed protein detection experiments that can provide the much-needed highly resolved
#spatialcontext
when creating true cell & tissue atlases.
Researchers developed a 7-antibody
#PhenoImager
panel and imaged samples from 8 colorectal/pancreatic adenocarcinomas.
The study demonstrated that the adenosine pathway can modulate multiple aspects of the tumor immune microenvironment and suggests that blockage of this pathway
The cerebellum, or the little brain, is a crucial part of the human brain. Although it makes up only about 10% of its mass, it contains more than half of its neurons. Explore our dataset of a human
#cerebellum
on
#PhenoCyclerFusion
:
#BrainWeek
Excited to kick off Day
#3
at
#AGBT23
w/ our in-suite talk from 10:30 - 11:00 AM titled, "Spatial Multiomics: Insights Into Immunotherapy Response via Mapping Patient Journey" in Suite
#313
!
☕ Food/refreshments will be served.
@aruthak
@Pinkcigarette2
We are breaking new ground in
#ovariancancer
research. 🔬
Join our webinar on May 14 to learn how researchers from
@DalhousieU
turned to
#spatialproteomics
to understand how the immune system interacts with high-grade serous ovarian carcinoma (
#HGSOC
). The insights gained bring
Wishing you a
#ValentinesDay
filled with striking red roses and heart-shaped tissues! 🌹
🌹The roses are made from FFPE breast tissue with a pattern of red and green stains.
💗The heart-shaped tissues are made from FFPE breast cancer using PhenoCycler-Fusion.
@conrad45605
📢 Introducing the first comprehensive atlas of the non-hematopoietic human
#bonemarrow
microenvironment.
Utilizing our 54-plex
#PhenoCycler
(formerly known as
#CODEX
) panel across 18 individuals and
#singlecell
sequencing, researchers brilliantly spatially phenotyped and
🎉 Congrats to
@NersesianSarah
from
@JeanetteEB
's lab at
@Dalhousieu
on leading a great study on high-grade serous carcinoma of the ovary (
#HGSC
) using our
#PhenoImager
solution to analyze tumor immune cell infiltration and localization patterns & their associations w/ clinical
The spatial phenotypic signature continues to demonstrate its predictive value for identifying patients who have a positive response to
#immunotherapy
.
Learn how this innovative biomarker testing approach is moving us closer to
#personalizedmedicine
.
A new
@Biocompare
article highlights research examples of how scientists are mapping tissues today using
#spatialbiology
, including Akoya's, which offers protein-based
#spatial
mapping—detecting proteins using fluorescently labeled antibodies.
👀 Another amazing
#TissueTuesday
image of a lymph node made by
@HuBMAP
researcher
@archie_enninful
from the
@RongFan8
lab at
@Yale
.
📸 Have an image you'd like featured? Tag us and/or submit it to the Akoya Image Contest! Deadline now extended:
So proud of our VP of Innovation, Research & Development, Dr. Julia Kennedy-Darling for receiving the Women Changing Science award!
#AGBT23
#spatialbiology
🫁 Lung cancer is the 3rd most common form of cancer in the US. Our PhenoCode Signature Panels can help by enabling comprehensive analysis of the
#tumormicroenvironment
.
This image is of
#lungcancer
FFPE samples phenotyped using a
#PhenoCode
Signature Immuno-Contexture Panel.
Tertiary lymphoid structures (TLS) are lymph node-like organizations of immune cells within inflamed tissues that can drive immune cell activation.
Learn how our team studies
#tertiarylymphoidstructures
—a promising
#biomarker
for
#immunotherapy
.
This 2-part image of a tissue sample demonstrates not just
#multiplexing
&
#singlecell
resolution, but the overlay of nearest-neighbor information. Learn how
#spatialanalysis
of cellular neighborhoods helps uncover complex interactions in tissue biology:
Today is the last
#TissueTuesday
of 2022! To honor all the great beauty that science brings us we're sharing our top-liked tissue images of the year.
1) Colon, PhenoImager
@AbbVie
2) Liver, PhenoImager
@ICR_London
3) Tonsil, PhenoCycler
@LGMartelotto
More to come in 2023!
Great
@CellPressNews
paper that presents Tissue Schematics, a conceptual framework building upon cellular neighborhoods, assessing how complex functions can be used to further map the intricate interactions between cell types and structures.
@GarryPNolan
Take a deep dive into the
#hallmarksofcancer
and learn how rapid, deep
#spatialphenotyping
can unveil novel insights into tissue architecture, cellular metabolism and more.
Watch this on-demand webinar featuring Dr. Oliver Braubach:
@Pinkcigarette2
Illuminating the unseen landscape of pediatric high-grade
#glioma
(
#pHGG
)! 🧠 New research utilizes cutting-edge tech, a 52-plex
#PhenoCycler
panel, and
#singlecell
profiling to assess the
#spatial
landscape of pHGG, a devastating brain malignancy, throughout standard therapy
Spatial phenotyping enables scientists to visualize and quantify hundreds of
#biomarkers
in a single tissue sample while maintaining cellular and sub-cellular detail. Read this
@GENbio
Spotlight article on shifting the paradigm of modern
#spatialbiology
.
The
@BioTrac
#SpatialBiology
Symposium and Workshop is only one week away! Join us as we sponsor this must-attend event in Germantown, MD, if you are local and work in the
#spatial
biology field.
Key Dates:
Thurs, Sept 14 - Hands-on Workshop
Fri-Sat, Sept
Spatial biology is transforming
#cancerresearch
!
Check out this exclusive
#ONCOLife
interview with Dr. Arutha Kulasinghe (
@Aruthak
) from The University of Queensland's Clinicalomics Lab, where he shares his insights on the power of
#spatialbiology
.
View pages 12-15:
We've been named one of the top-5 A-List public
#spatialbiology
companies by
@GENbio
! 🎉 We're grateful to be on this list and look forward to continuing to provide innovative
#spatialphenotyping
solutions.
Ever wonder what it's like to analyze over 2 million cells in a single tissue across a
#wholeslide
?
Take a look at these incredible human tonsil tissue images from our latest
#100plex
dataset powered by
#PhenoCyclerFusion
.
Explore the dataset:
Come to
#AACR24
poster
#283
until 5 pm today to hear Nicole (
@nicruzreyes
) from
@MayoClinic
present on the fibroblast diversity and immune microenvironment in pseudoangiomatous stromal hyperplasia!
@AACR
Have you registered for these June
#spatial
webinars yet? 💻
On June 13, learn how advances in
#spatialomics
technologies can elucidate human tissue architecture and its impacts on physiology & disease.
On June 21, learn about the use of a 51-plex panel