Hello
#PathTwitter
,
@NASA
is planning to set a permanent human base on moon this decade in the
@NASAArtemis
program which will then act as relay point to send Astronauts further to
#Mars
. Just curious what is the future of
#pathology
in low gravity environments ? (1/3)
I recently had a family emergency and I really wanted to go home and be with my family. But I was on surgical pathology rotation and was really worried if I’ll get a leave in such a busy rotation from my department. (1/4)
Why is p53 called p53? 🤔
A 🧵 about the history and discovery of the most studied gene in human history, also known as the guardian of the genome. 🧬
#pathtwitter
#pathX
#molecular
#history
and the program director was in constant contact with me through all this all the time. I received the care same as my family and I can confidently say that I have found a second home miles away from home. Really proud to be a part of Temple Pathology family! (4/4)
My last post about p53 received an overwhelming response so I want to give credit to this amazing book by
@armstrong_sue
that inspired me to write that thread. I personally think this book should be on the bookshelf of anyone related to medicine and science. ✨
Why is p53 called p53? 🤔
A 🧵 about the history and discovery of the most studied gene in human history, also known as the guardian of the genome. 🧬
#pathtwitter
#pathX
#molecular
#history
I talked to the chief resident about this and in an instance the whole department was mobilized to help me. The way my PD, APD, faculty members and the residents came forward to help me out in this situation, I will remember this gesture for the rest of my life. (2/4)
Within minutes I had coverage, the GME office and program coordinator had prepared my documents for traveling so I don’t have any issue on re-entry, the residents were constantly trying to find me low cost tickets as I was booking at the last minute of flights (3/4)
If I had known that all those set backs and failures are actually pointing me towards achieving this I wouldn't have been disappointed on any one of them. Believe in yourself, work hard and carry on until you achieve your dreams.
#pathtwitter
#pathmatch22
The more microscopy I do at work, the more curious I get about how everything around me looks like under the microscope. So treated myself with a brand new microscope to explore the micro-universe around me 🔬🤩✨
#PathTwitter
#pathx
🧵end/
"It's impossible or very difficult to get a malignant tumor without the activity of p53 being disrupted." ~Bert Vogelstein, a legendary figure in p53 story who was the first to termed it as a tumor suppressor gene. 🧬
Signing off with my last interview of the season.Remembring the time when last year on this day I wasn't even done with Usmle Step 1. I couldn't have believed at that time if someone had told me that I would be interviewing for my dream speciality in less than a year
#PathMatch22
🧵12/
Today, more than 70,000 research papers are published on p53, making it the most studied human gene in history. Mutations in p53 are found in >50% of human cancers 🧬
🧵6/
Wait a minute—did I say oncogene? p53 is actually a tumor suppressor gene! This is my favorite plot-twist of the p53 story: its mischaracterization as an oncogene. 🧬
To be honest, before joining pathology, autopsy was the rotation I was really worried about, sometimes fearing that it will affect my love for pathology, but it has done the opposite. (1/5)
Just had my final mock interview session with my bestie before my first interview tomorrow. Wish me luck 🤞
P.S: Yeah I took the mock session seriously and was dress up for like a real interview 😅
#pathology
#PathMatch2022
#path2path
🧵1/
In the 1970s, David Lane & Arnie Levine started studying a virus called SV40. Their interest was in a viral gene responsible for transformation, the SV40 oncogene called large T antigen. 🦠
When you start training your brain as a pathologist, the patterns in everything around you will fascinate you.
These are the beautiful pattern of desert dunes when we were flying over Saudi Arabia ✨
#pathology
#PathTwitter
Just ended my cytology rotation and it became my favorite sub-speciality so far. From observing CT/US/EBUS FNA’s and performing on site evaluation of the sample to spending hours scanning the slides to hunt those cells of concern, I just loved every part of this field. (1/4)
Today is the first death anniversary of my beloved Dad, the kindest person I have ever known. This picture is my last but my favourite memory with him as we were so happy because I had just matched into my residency. Not a day goes by that something hasn’t reminded me of him. 1/
Have you ever seen something like a ‘beautiful death’? This funny-looking organism is Lacrymaria olor, a freshwater ciliate. I was following it for a while through my microscope and noticed something strange in its behavior. I was actually recording its final moments!
🧵3/
Whenever he ran electrophoresis to purify the large T antigen, he always found an unknown protein with a molecular weight of 53 kilodaltons. Initially, others in Lane's lab thought it was a contaminant or a breakdown product of the large T antigen. ⁉️
Just done with my first residency interview of the season. Posting this to create memories for the future me to look back on the efforts I had for my dream speciality.
#Pathology
#PathMatch22
#PathTwitter
#path2path
🧵5/
In 1979, immunological studies identified the p53 protein due to its immunoreactivity with tumor antisera, suggesting its role as a tumor-associated antigen.
Everyone was convinced they had found a new oncogene. The excitement was high! 🚀
#Oncogene
Helping hands award of the year ✨ Thanks to my
@templepathology
family for this. This is for my Dad, who always taught me how to be always available to others. His lessons live on in everything I do ❤️
🧵11/
This conclusion was confirmed by subsequent findings that patients with inherited mutations of p53 were predisposed to diverse tumor types.
Mice with engineered "knock-outs" of the p53 gene were also tumor-prone. 🧬
🧵7/
The initial misclassification was due to the research climate of the time (1980s). Oncogenes were thought to be the key to understanding cancer, and the idea of a tumor suppressor gene was in its infancy.
#genome
#cancer
🧬
Called in to the hospital for the second time in a day for blasts in peripheral blood smear. I guess Hemepath fellowship is already calling me 🩸✨
#hemepath
#molpath
#pathtwitter
🧵8/
As mentioned above, p53 was initially found bound to the major oncogenic protein of SV40, so it was understandable at the time to think it must be an oncogene as well.
However, some experimental observations did not fit well with the idea that p53 was an oncogene. 🧬
#p53
🧵2/
Lane's task was to extract the large T antigen protein from cells infected with SV40. He used electrophoresis to separate the protein molecules based on size and charge. ⚡️
One day iA✨ Cold Spring Harbor Lab also know as The Mecca of Molecular Genetics. It has been home to eight scientists who have been awarded the Noble Prize in Medicine 🧬🔬
Ended my molecular rotation and came to the conclusion that only detecting the genetic mutations and gene fusions is not enough and cancer classification/diagnosis based on Transcriptomic and Proteomic analysis is the next big revolution awaiting to happen in Pathology. (1/3)
The first picture is a screenshot of my 2017 Instagram post. At that time, I didn’t have any plans that I will go down the
#USMLE
route, but still following my passion and love for
#astronomy
I dreamt of visiting
#Griffith
Observatory someday… (1/2)
🧵10/
In 1989, this two-hit model was applied to p53, specifically in colorectal tumors. It fit this model, as in virtually all cases, both copies of p53 were mutated. 🧬
Ever since reading The Alchemist by Paulo Coelho I always wondered what my personal legend would be.I'm now kind of getting the feeling that I've finally found it & I want to see the world behind a lens,whether it's the lens of a camera,lens of telescope or of a microscope📷🔭🔬
Microscope by day, telescope by night!🔬🔭
This universe is more mysterious behind the lens whether u are looking at cellular micro-worlds or gazing into the macro-universe. Remove the H&E stain from the microscopic ones & u can sense the similarity between the two extremes✨
Future Pathologist in space era✨🌌
Using ChatGPT I generated an image prompt for a ‘pathologist in spaceship near a distant planet’ and then used that prompt to generate AI images using the Bing AI Image Creator.
This is what I got! 👇(1/2)
#PathTwitter
#pathmatch2024
#AI
The cycle of life and death. There is one positive thing about death, the death of any living is an opportunity for its atoms to be released and be a part of another organism’s journey. (1/3)
Happy Valentine's. This is Heart Nebula or IC 1805, located 7500 light years away from Earth in Cassiopeia constellation. The constellation is named after the ancient Greek mythology queen Cassiopeia who famously boasted about her unrivaled beauty.
Congratulations
@whosainastro
, our second winner of the
@AMPath
#AMPtutorials
social media challenge the fascinating history of p53 🧬. He's won free registration to the
#AMP24
meeting in Vancouver 🇨🇦
Last night, for the first time I became a part of something beautiful, a Gift of Life.
Getting a call for it late night and then getting up at 3 am and commuting to the hospital seems like tough but when you think of it that you are becoming a part of something beautiful..(1/3)
In the last two months, I did two things that I’m really happy about, completing my first surgical pathology rotation and reading the book “Neanderthal Man” by Svante Pääbo. (1/5)
When you are all set to answer 'Why
#pathology
' & the interviewer ask you 'Why Ancient History' instead. I love it when people get excited by your hobbies & want to know more about it. We talked about Sumarians, the Persian invasions of Greeks & the Romans architectural marvels.
Drumroll please 🎉.... Our
@templepathology
family is expanding and we are happy to announce our incoming PGY1s! Congratulations and we can't wait to see you.
#pathmatch22
Never Look Back.
That's what my shirt says. Looking forward to wear it on
#MatchDay
to keep my mind sane if the match goes either way. 😬
#PathTwitter
#pathmatch22
The best part of my first interview was the moment PD appreciated my educational struggles and started the interview with "So Hussain it must be a struggling long journey for you from Malakand, Swat (the region noble laureate
@Malala
belongs to) to United States".
#PathMatch2022