Rio Sugimura @rio_sugimura Twitter profile

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Rio Sugimura

2 months

Our new preprint by undergrad Billy and star PhD candidate @chao_yiming . Cool Yiming is corresponding! They data mined and defined senescent and lipidic TAM. aPD-L1 reprograms them to FOLR2+ TAM is responder hallmark @biorxivpreprint

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Rio Sugimura

@rio_sugimura

6 months

Proudest PI moment. Date back my first month as a PI, interviewed a great PhD applicant from under represented country. Though I tried to get him hard, barriered by GPA and QS nonsense. He continued his job in his country, I offered online tutoring in hematology, stem cells, 1/

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Rio Sugimura

@rio_sugimura

6 months

We repeated this for two year cycles. Finally he got a PhD program offer at his dream school🇺🇲 Today heard him working with a great mentor 😃 End/

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Rio Sugimura

@rio_sugimura

2 years

Our review on how to vascularize and immunize organoids is out @KargerPublisher

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Rio Sugimura

@rio_sugimura

6 months

and single-cell technologies. He always chose his 3AM because he had to work daytime 😢. We continued this online teaching for a year. He wanted to apply grad schools. I kept writing letters. Wrote, wrote, wrote. Sent. Sent. Sent. Whoever wanted phane call, I received calls. 2/

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Rio Sugimura

@rio_sugimura

2 years

Woke up with an international grant funded🎉 Call for a new position in my lab will follow soon. #LiverDisease

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Rio Sugimura

@rio_sugimura

5 months

Ready for long haul ✈️

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Rio Sugimura

@rio_sugimura

3 years

Today's read 228 #Organoids @CellCellPress #Organs -on-a-chip models for biological research

Organs-on-a-chip models for biological research

Organ-on-a-chip technologies promise to bridge a long-standing gap between animal models and in vivo human studies, but several challenges remain for making this technology broadly utilizable.

www.cell.com

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Rio Sugimura

@rio_sugimura

9 months

Our lab turns 3 yrs old🎂 3rd Lab Retreat. Productive year with 5 papers, 8 reviews, 1 preprint, 2 grants, 2 awards, 5 trainees poster awards👏 Congrats Theo Aurich for winning the bold idea chalk talk. It is a really great year to host you from Heidelberg

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Rio Sugimura

@rio_sugimura

1 year

Packing for my incoming long haul✈️ multiple destinations. Sharing our recent human Yolk sac organoid @sigtrans_sttt , newest works on mitochondria variant barcoding in human embryonic hematopoiesis, CAR macrophages from hPSC 1/2

Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development...

Signal Transduction and Targeted Therapy - Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis

www.nature.com

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Rio Sugimura

@rio_sugimura

2 years

Granted! Our lab is opening a fully funded postdoc position for modeling and perturb-seqing tumor-associated macrophages soon. More detail will follow.

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Rio Sugimura

@rio_sugimura

2 years

Our second @biorxivpreprint by @cao_handi @DavidXIANG2021 & Shihui is out Started from unexpected observations PD-L1 regulates the development of inflammatory macrophages Here is 🧵 /1

PD-L1 regulates inflammatory macrophage development from human pluripotent stem cells by maintain...

PD-L1 (programmed death-ligand 1) serves as a pivotal immune checkpoint in both the innate and adaptive immune systems. PD-L1 is expressed in macrophages in response to interferon-gamma (IFNγ). We...

www.biorxiv.org

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Rio Sugimura

@rio_sugimura

3 years

500 followers 🥳🎉🎊 Let me reintroduce myself I am a #NewPI @hkumed Hong Kong 🇭🇰 Our lab #THEBEL exploits stem cell technology, cell engineering, #scRNAseq to invent ⬇️⬇️⬇️ 🔥Cancer #immunotherapy in #organoids 🔥 for #precision medicine of #liver cancer

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Rio Sugimura

@rio_sugimura

2 years

Welcoming Haruto Sugimura, our newest member🎊🎉🎂

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Rio Sugimura

@rio_sugimura

1 year

Finally found the famous Cell coloring book for my kids 😂 #KSCancerImmuno23

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Rio Sugimura

@rio_sugimura

11 months

Moved to a better office view

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Rio Sugimura

@rio_sugimura

3 years

1000 followers🥳🎉 I am #NewPI @HKUMed 🇭🇰 Our team is expert of #stem cell engineering & #organoids We pursue 1⃣Remodeling tumor microenvironment with #CAR -T 2⃣Lineage trajectory of #innate immune cells & something #COVID19 THE BEL est 2020

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Rio Sugimura

@rio_sugimura

2 years

Vascular organoid kudos to Alex Chau in our lab. It will be my Zoom BG while😁

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Rio Sugimura

@rio_sugimura

2 years

✅Grant submitted ✅Ready to welcome a new baby tomorrow 👶 #Academicdad #38weeks #planned

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Rio Sugimura

@rio_sugimura

3 years

📢We are recruiting 🔥❗ The Centre for Translational Stem Cell Biology #CTSCB in University Hong Kong🇭🇰 patner with 🤝 Cambridge University 🇬🇧 My group in the Centre studies human immune cell development in single-cell level for advancement of #CAR -T technology

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Rio Sugimura

@rio_sugimura

2 years

Elated to be selected as a recipient of @GileadSciences Liver Disease Scholar 2022 #LiverDisease #Senolytic

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Rio Sugimura

@rio_sugimura

3 years

@OdedRechavi I survived third postdoc🤣🤣🤣 Will never recommend to anyone 😤

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Rio Sugimura

@rio_sugimura

3 years

Thrilled to announce that our lab is funded more! 🎉💰🎊 The money will help us a lot to understand how #immune cells behave in #tumor #microenvironment

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Rio Sugimura

@rio_sugimura

3 years

346 #CancerImmunology #scRNAseq Temporal single-cell tracing reveals clonal revival and expansion of precursor #exhausted T cells during anti- #PD -1 therapy in lung cancer @NatureCancer

Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells...

Nature Cancer - Zhang and colleagues analyzed patients with lung cancer treated with anti-PD-1 with single-cell methods, finding the presence of precursor exhausted T cells in responders that...

www.nature.com

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Rio Sugimura

@rio_sugimura

2 years

2nd lab annual retreat 🎂 Celebrating everyone's progress Intense science and good food

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Rio Sugimura

@rio_sugimura

11 months

The morning starts with cool news. New funding awarded to our lab 💰

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Rio Sugimura

@rio_sugimura

3 years

Academic pedigree I am from a family of no one with PhD or MD, single mom, family bank balance never exceeded 50k JPY (500 USD) till I flew to🇺🇸 for PhD study where I can get over 1500 USD salary. I could not economically afford PhD programs in🇯🇵

@aaronclauset.bsky.social

@aaronclauset

3 years

Slides from my seminar "Faculty hiring and changing representation in academia," today at Berkeley CTEG, connecting work with @alliecmorgan @samfway @laberge_nick @arbesman Mirta Galesic & @DanLarremore to questions of equity in academia

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Rio Sugimura

@rio_sugimura

3 years

Last year of today, I opened my lab #THEBEL @hkusbms @hkumed From scratch, the lab expanded, gained external funding, published a paper, and established collaborations internationally

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Rio Sugimura

@rio_sugimura

1 year

Two grant results a week. Got one. Glass half full🍷 #PILife

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Rio Sugimura

@rio_sugimura

3 years

Delighted to introduce our 2mm-long newest lab member 🤣🤣🤣 #Organoids

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Rio Sugimura

@rio_sugimura

3 years

900 followers🎉🥳 Late for #FluorescentFriday 😅 #Organoids #HappyMonday

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Rio Sugimura

@rio_sugimura

5 months

Novel epigenetic modification😂

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Rio Sugimura

@rio_sugimura

2 years

Thanks @unipv Department of Molecular Medicine hosting my seminar. It has been 3 years since I did a seminar here. Finally came back.

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Rio Sugimura

@rio_sugimura

11 months

New preprint with Sharon and @chao_yiming with @joshuawkho @YuanhuaHuang Used mitochondria variants as innate barcodes to track human embryonic hematopoiesis @biorxivpreprint

Single-cell mitochondrial variant enrichment resolved clonal tracking and spatial architecture in...

The ability to perform lineage tracing at the single-cell level is critical to reconstructing dynamic transitions during cell differentiation. However, prospective tracing approaches inevitably...

www.biorxiv.org

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Rio Sugimura

@rio_sugimura

1 year

How I do meetings today😂 #AcademicChatter #PILife

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Rio Sugimura

@rio_sugimura

3 years

Reached 550 followers 🎉🥳 Our 5-months old lab got 6 summer students 😅 #Organoids generating our FAVE cells😎 #NewPI

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Rio Sugimura

@rio_sugimura

3 years

Wow, another grant just got funded too🥳 Quite symbolic one like R01 in Hk 👉Will post a job opening in our lab soon

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Rio Sugimura

@rio_sugimura

3 years

In the last lab meeting, I introduced our lab policy. In our lab, we believe in the value of - Preprint💻 - Protocol sharing🧪 - To have fun outside of lab🍻 #NewPI

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Rio Sugimura

@rio_sugimura

2 years

2000 followers🥳🎉 We are a lab🧪 📍 @HKUMed @hkusbms @CTSCB_HK 🔬studying #CancerImmunology #Organoids ⚙️with #scRNAseq #SpatialTranscriptomics 🎯for #CellTherapy #ImmunoTherapy

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Rio Sugimura

@rio_sugimura

9 months

If you are interested in immunotherapy and stem cell engineering, watch the video me demonstrating how to make NK cells from human expanded potential stem cells @JoVEJournal

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Rio Sugimura

@rio_sugimura

1 year

Excellent recap of @chao_yiming @hkusbms @CTSCB_HK study @sigtrans_sttt on single-cell & spatial gene landscape of human embryonic organoids Here is 🧵

Organoids meet single-cell and spatial omics

communities.springernature.com

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Rio Sugimura

@rio_sugimura

3 years

Our lab #THEBEL expands Now moving to a bigger space 1 bay ➡️ 2 bays Dedicated TC hood & incubator More storages The lab will turn 1 year old 🎂 Thanks supports from @hkusbms @hkumed

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Rio Sugimura

@rio_sugimura

5 months

Rising-star seminar series. We are hosting e-seminar of John Hickey @johnhickey22 Immune-mediated Tissue Restructuring: A spatial-omics perspective March 28, 9am Singapore/Beijing/Hong Kong time Zoom:

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Rio Sugimura

@rio_sugimura

2 years

Always my greatest pleasure to see #Organoids growing👶. Kudos to @DavidXIANG2021 #LovelyOrganoids

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Rio Sugimura

@rio_sugimura

2 years

📍Rising-Star Journal Club Discuss the coolest paper with the 1st author Feb 1, 9pm EST / Feb 2, 10am HKT Zoom @JuliaJoung @WhiteheadInst will present the hot of the press paper #TFome @CellCellPress

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Rio Sugimura

@rio_sugimura

3 years

335 #Organoids #Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived #cerebral organoids

Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms...

Molecular Psychiatry - Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids

www.nature.com

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Rio Sugimura

@rio_sugimura

2 years

One of the top joy of being a PI is that I can listen the exciting discovery from my lab first in the world #NewPI #Organoids

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Rio Sugimura

@rio_sugimura

4 months

Feeling humbled to join @eLife Reviewing Editor. Thanks to nomination. I will serve stem cells & immunology branches

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Rio Sugimura

@rio_sugimura

8 months

Farewell to Theo. Wonderful year to host him from Heidelberg. He strengthened both science and the spinoff from our lab Best of luck in Berlin!

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Rio Sugimura

@rio_sugimura

3 years

Reached 450 followers🥳🎉 We are recruiting PhD students and Postdoctoral fellows. #THEBEL @hkumed #Organoids #scRNAseq #Cancer #immunotherapy

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Rio Sugimura

@rio_sugimura

3 years

Fully vaccinated 💪💉 #HKTwitterGetsVaxxed

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Rio Sugimura

@rio_sugimura

6 months

Next New PI Cell & Developmental Biology eSeminar is Lucia Borriello @luciaborriell @FoxChaseCancer @TempleUniv "Do the inflammation-induced treatments affect dormant disseminated tumor cells?" 11am EST, March 1st Zoom

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Rio Sugimura

@rio_sugimura

3 years

📢I am giving a seminar @NEWPICELLDEV @hkumed #NewPI #Cell #Developmental #Biology Blood from petri dish - Development of Human Immune Cells and the Road to Cancer Immunotherapy Friday 23rd April, 3pm BST (10pm HK time) Link:

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Rio Sugimura

@rio_sugimura

1 year

Half of my lab is attending. Looking forward to exciting science and 10 F temperatures 🥶 at Banff🇨🇦 #KSCancerImmuno23

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Rio Sugimura

@rio_sugimura

3 years

Our first contribution to #cancer #immunology is accepted 🥳🎉 More will come 💪💪💪 #Liver #Cancer

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Rio Sugimura

@rio_sugimura

1 year

Our postdoc Yuan Wang's review on "ex vivo expansion of hematopoietic stem cells" came out Experimental Cell Research @CTSCB_HK @HKUMed We discussed polymers, small molecules and other factors applied in HSC expansion Quick 🧵 /1

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Rio Sugimura

@rio_sugimura

3 years

Happy Holiday from my daughter 🎄🎂

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Rio Sugimura

@rio_sugimura

3 years

Enjoyed Christmas BBQ @hkusbms . Meanwhile, Undergrads prepping exams... 😂 Will bring them next week lab treat 😉

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Rio Sugimura

@rio_sugimura

3 years

Our first lab retreat #THEBEL The day of science and great food🥳 More than elated that our 1-year old🎂 lab is so productive #ProudPI #NewPI

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Rio Sugimura

@rio_sugimura

3 years

Can't move for next a few hours 😅 #Academicdad #Academicparenting

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Rio Sugimura

@rio_sugimura

3 years

Finishing #NYE2021 Preparing The State of the Lab Talk for the lab retreat in next week. Our 1-year old lab @hkusbms @HKUMed @CTSCB_HK progressed in publication, funding, staffing, and collaborations. This is most striking progress to me #ProudPI

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Rio Sugimura

@rio_sugimura

4 months

Arrived 🇺🇲 Found my postdoc memory cake😂 It was my morning ritual

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Rio Sugimura

@rio_sugimura

3 years

Today's read 124 #Organoids #Gastruloids #SyntheticEmbryos #EmbryoidBodies #Trunk #embryonic #organoid Am I missing any more names?😅 @ScienceMagazine Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites

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Rio Sugimura

@rio_sugimura

1 year

Ready for the long haul ✈️🚂 My reading list

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Rio Sugimura

@rio_sugimura

2 years

First @biorxivpreprint from our lab. @chao_yiming is an excellent informatics scientist. Last year today she joined us. She made a strong team, paired near single-cell level #SpatialTranscriptomics + #scRNAseq 🧵

Yiming Chao 巢怡茗

@chao_yiming

2 years

Excited to share the first work during my PhD on spatiotemporal gene expression of human embryonic development and hematopoiesis in an organoid platform. We used #scRNAseq and 10x Visium #SpatialTranscriptomics to define the development process. 1/

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Rio Sugimura

@rio_sugimura

3 years

Honored to serve as an editorial board of @Diff_Journal 👉

Richard Behringer

@rrbehringer

3 years

Here is the new Editorial Board for Differentiation recruited by Drs. Loydie Jerome-Majewska, Crystal Rogers, & Rosa Uribe. Great diversity! @RogersLabUCD @uribelabrice @lamsciworld @___SDB___

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Rio Sugimura

@rio_sugimura

9 months

If you are looking for a postdoc position at Hong Kong with CAR-macropjage and synthetic immunology, our lab is looking for a postdoc! Application 👉

HKU Careers

The University of Hong Kong (HKU) offers an intellectually-stimulating and culturally-rich academic environment, with attractive remuneration packages.

jobs.hku.hk

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Rio Sugimura

@rio_sugimura

4 months

Our Alex & Alex's SARS-CoV-2 modeling with vascular immune organoids published in @SciReports . Congrats Alexes

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

Scientific Reports - SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

link.springer.com

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Rio Sugimura

@rio_sugimura

3 years

Our first lab gathering! I gave a state of the lab talk on - scientific goals, - strategy, - grants/finances, - manuscripts in pipeline Our lab has hit the road strongly💪 #NewPI during #Covid19

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Rio Sugimura

@rio_sugimura

2 years

Happy new year 2023. Our lab turns 2 years old. A lot of setup and staffing of the two labs was done. We are in production mode.

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Rio Sugimura

@rio_sugimura

5 months

Updated our lab website - Research. Cell fate Immuno-engineering Synthetic immunology

Research — The Blood Engineering Lab

Our vision is to work on the intersection of bioengineering and stem cell biology to invent new tools for understanding and treating immune disorders and cancers. We apply cutting-edge approaches of...

www.riosugimura.com

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Rio Sugimura

@rio_sugimura

3 years

Today's read 126 #Organoids Measuring mechano-sensing in #organoid #tumoroids #mechanobiology @NatureProtocols Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force…

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Rio Sugimura

@rio_sugimura

1 year

Really cool👏 Two students from our lab, Twitter-less Sophronia and Yiming @chao_yiming got appointed as grad student rep in our School @hkusbms #SummerAchivement

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Rio Sugimura

@rio_sugimura

1 year

We appreciate reviewers' comments

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Rio Sugimura

@rio_sugimura

2 years

10 year ago, I got bad fortune cookies twice on a day, two paper/grant rejected on same day. Traumatized and avoided cookies 10 years Today I overcome it💪💪💪 #ChineseNewYear

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Rio Sugimura

@rio_sugimura

7 months

Great piece with our former Laidlaw scholar Echo Luo @Echo_YongqiLuo in Journal of Neuroinflammation @BioMedCentral Taming microglia: the promise of engineered microglia in treating neurological diseases

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Rio Sugimura

@rio_sugimura

3 years

341 #Organoids #Blastoids @Nature Embryo-like models shed fresh light on early #human development

Embryo-like models shed fresh light on early human development

Nature - A wave of stem-cell systems are enabling researchers to unpick what happens after an embryo implants in the uterus.

www.nature.com

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Rio Sugimura

@rio_sugimura

1 year

Under such a wonderful sky, I should write multiple grants😂 #PILife #AcademicChatter

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Rio Sugimura

@rio_sugimura

7 months

Our first journal club paper of 2024. Excited to see scFv-based synthetic receptors enhanced CAR-T infiltration into various types solid tumors including pancreatic cancer

Denis Wirtz

@deniswirtz

8 months

CART therapy has seen little success in patients with solid tumors thanks to poor infiltration. Here, we engineered self-propelled CART cells that readily penetrate solid tumors by expressing synthetic velocity receptors (VELOCIREPTORS!) V2 posted here:

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Rio Sugimura

@rio_sugimura

2 years

It is really nice afternoon to watch ultrasound of a full month baby and get acceptance email of a manuscript. Next few months will be crazy busy #Academicdad 👶👶 #FatherofTwo

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Rio Sugimura

@rio_sugimura

3 years

Reached 400 followers 🎉 Today my daughter called me daddy for the 1st time 🎂🏡 #AcademicTwitter #Academicdad Our lab is growing @hkumed 🔬🧫🧪 "The Blood Engineering Lab" #THEBEL

The Blood Engineering Lab

The Blood Engineering Lab is directed by Dr. Rio Sugimura at the University of Hong Kong. With the goal of inventing new tools for understanding and treating cancers. we apply cutting-edge approaches...

www.riosugimura.com

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Rio Sugimura

@rio_sugimura

4 months

Really cool work!

Ali Shariati علی شریعتی

@Ali__Shariati__

5 months

In our new preprint, we show that CRISPR activation of of just two endogenous regulatory elements is sufficient to self-organize embryonic stem cells into spatially-ordered embryonic patterns. #crispr

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Rio Sugimura

@rio_sugimura

3 years

850 followers🥳🎉 #Organoids join #FluorescenceFriday 🔬 ("nearly" Friday here🇭🇰😅)

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Rio Sugimura

@rio_sugimura

2 years

Another manuscript accepted 🎊 Great work @chao_yiming

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Rio Sugimura

@rio_sugimura

2 years

Unlocked #NewPI moment Crashing with 5 grant deadlines while WFH with my toddler😂 Home is mess. Proposal is mess😂

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Rio Sugimura

@rio_sugimura

2 years

Our review on CAR-T/NK/M is out @Diff_Journal #immunotherapy #CARTcell #CARNK #CARMacrophage

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Rio Sugimura

@rio_sugimura

3 years

#Relocation , relocation, relocation. Is Relocating Necessary in #Academia ? Here is my career move since 2008. 1 ➡️Kansas🇺🇸 2008 2 ➡️Boston🇺🇸 2014 3 ➡️Kyoto🇯🇵 2018 4 ➡️Pavia🇮🇹 2020 5 ➡️HK🇭🇰 2020

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Rio Sugimura

@rio_sugimura

3 years

The venue for our lab retreat #SciencePark 😎 Cannot wait for January 🎉 Exciting day of full of science 💪 #LabRetreat #THEBEL

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Rio Sugimura

@rio_sugimura

2 years

Lunar new year🎉

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Rio Sugimura

@rio_sugimura

3 years

349 #Organoids #Brain #organoid #barcoding Lineage recording in human cerebral organoids @naturemethods

Lineage recording in human cerebral organoids

Nature Methods - A dual-channel recording system for high-resolution lineage tracing.

www.nature.com

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Rio Sugimura

@rio_sugimura

4 years

Reached 150 followers🥳🥁 My lab @hkumed recruits. PhD-trained staffs with hPSC, CAR-T, organoid culture, or innate immune cell expert are super-welcomed💪 #THEBEL #NewPI #Organoid #immunotherapy

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Rio Sugimura

@rio_sugimura

3 years

950 followers🥳🎉 Join our team in Hong Kong to study #organoids #cancer #immunotherapy @hkumed We are actively recruiting a #postdoc fellow. More detail to follow soon 👇The lab page

The Blood Engineering Lab

The Blood Engineering Lab is directed by Dr. Rio Sugimura at the University of Hong Kong. With the goal of inventing new tools for understanding and treating cancers. we apply cutting-edge approaches...

www.riosugimura.com

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Rio Sugimura

@rio_sugimura

2 years

#Organoids Coolest image I saw for years😆 Kudos to twitter-less Alex

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Rio Sugimura

@rio_sugimura

2 years

Tenure track

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Rio Sugimura

@rio_sugimura

3 years

1300 followers🥳🎉 At each 100 followers, I spotlight on our member Handi Cao @cao_handi our postdoc @hkusbms @hkumed @CTSCB_HK Dynamo💪💪 of #THEBEL 1/

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Rio Sugimura

@rio_sugimura

3 years

274 #Organoids #minigut #enteroids #Organchip @Nature Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

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Rio Sugimura

@rio_sugimura

10 months

Woke up with an accepted MS email at 12:20am🌃😂 #PILife

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Rio Sugimura

@rio_sugimura

3 years

Organoid, Spheroid, Organ-on-a-chip, Embryoid body

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Rio Sugimura

@rio_sugimura

3 years

Thanks @the_Node for interviewing me👍 #NewPIinPandemic

the Node

@the_Node

3 years

New on the Node: #NewPI in a global pandemic: a view from Hong Kong @rio_sugimura ( @HKUniversity ) shares his experiences of starting a lab during the pandemic & his search to find a home to do science, and makes an appeal to⬆️ exposure of HK scientists