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Natalie Schaworonkow Profile
Natalie Schaworonkow

@nschawor

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investigating electric waves in the brain, thinking about visualization, interfaces, art & beauty with computers.

Frankfurt am Main, Germany
Joined January 2015
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@nschawor
Natalie Schaworonkow
2 months
made a new website: (containing EEG/MEG/LFP demos & animations)
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@nschawor
Natalie Schaworonkow
2 years
learning how to 3D print! this is a Purkinje neuron from a rat cerebellum.
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@nschawor
Natalie Schaworonkow
2 years
IKEA shopping for neuroscientists – lamp ISKÄRNA
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@nschawor
Natalie Schaworonkow
3 years
I posted a number of electrophysiology and signal processing demos here on twitter over the last year. collected them on this page with tags:
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@nschawor
Natalie Schaworonkow
4 years
invasive recording over the human visual cortex: a beautiful alpha-rhythm. a visual stimulus is shown during the shaded intervals, the stimulus attenuates the rhythm. the rhythm returns when the stimulus is turned off. (neat to see this classic effect so clearly in ECoG ♥️)
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@nschawor
Natalie Schaworonkow
2 years
simulated propagating activity waves over a smooth cortical surface vs. over a brain with pronounced gyri and sulci.
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@nschawor
Natalie Schaworonkow
3 years
"but the correlation is so large, it must be a robust effect" 🤔 for small samples, large values for the computed correlation coefficient are more likely to appear, even in the absence of any relationship. see here for 2 independently generated variables & different sample sizes:
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@nschawor
Natalie Schaworonkow
6 months
simulated a bursting neuron, using an analog circuit. 🙂 (had to buy more cables for this one).
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@nschawor
Natalie Schaworonkow
8 months
in the field of brain rhythms, one of the rock-solid empirical findings is that frequency increases across development, for alpha and mu rhythms. in this new 〰️preprint〰️, we also look at waveform shape across development & neurodevelopmental disorders:
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@nschawor
Natalie Schaworonkow
3 years
the EEG signal is a mixture of many different contributions. for example: midfrontal theta-, sensorimotor mu- and posterior alpha-rhythms, as well as muscle noise & eye blink artifacts. below, these components are added up successively onto electrode signals for illustration.
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@nschawor
Natalie Schaworonkow
2 years
& I have been awarded a Marie Skłodowska-Curie postdoc fellowship for my project to study traveling waves in the brain, here at @ESI_Frankfurt . looking forward to tell you all more about it in the next 2 years! 🌊🙂 #msca #wavescope
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@nschawor
Natalie Schaworonkow
4 years
I like this tool for graphical exploration of scientific literature: you put in some seed papers & it returns a network, with papers that are commonly citing or cited by seed papers. very helpful, often papers already exist, one just needs to find them. 🙂
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@nschawor
Natalie Schaworonkow
8 months
intracranial EEG data from the human brain features extremely rich dynamics. this is a scan through frequency space to find pronounced oscillations in different regions. 〰️🙂〰️ some of these rhythms are quite hard to see with non-invasive recording modalities!
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@nschawor
Natalie Schaworonkow
1 year
I saw lots of beautiful beta-rhythm work lately! there is one specific aspect which I find non-optimal: in the human brain, there are also lots of alpha-rhythms, which may produce harmonics in the beta-band. I wrote about it here in this short article:
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@nschawor
Natalie Schaworonkow
4 months
waveform shape of oscillations can reflect properties of underlying spiking dynamics. if neuronal units fire in synchrony, the local field potential can be more asymmetric (here: sharp troughs). read about this & cool bat rhythms 🦇 in our new paper:
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@nschawor
Natalie Schaworonkow
5 years
A large portion of measured EEG signal is of non-neuronal origin. Signal separation techniques like independent component analysis can help to identify these. Here, noise components are slowly projected out, revealing the interesting bits, the alpha oscillations.
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@nschawor
Natalie Schaworonkow
3 years
new preprint!🌟we show how data-driven referencing can be useful for analyzing oscillations in intracranial electrophysiological recordings and explore waveform shape & spatial spread & variability across participants: (1/n)
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@nschawor
Natalie Schaworonkow
5 years
A classic effect in the sensorimotor cortex: event-related desynchronization. Strong mu-rhythm oscillations attenuate as soon as the participant starts to contract a muscle. Where do they go? 🧐
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@nschawor
Natalie Schaworonkow
3 years
many EEG analyses are done in sensor space. in this preprint with Vadim Nikulin @MPI_CBS , we investigate how different types of alpha rhythms contribute to activity of individual EEG electrodes. 1/8
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@nschawor
Natalie Schaworonkow
2 years
there are different models of how the brain responds to rhythmic input, 1) by adjusting an intrinsic oscillator or 2) by a series of evoked responses. adjusting the input rate, the 2 models have different properties, exhibiting a constant or variable phase shift to the input.
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@nschawor
Natalie Schaworonkow
1 year
1/f-exponent & E/I-balance: while changes in synaptic time constants certainly influence spectral measures, not all changes in the 1/f-exponent can be interpreted as changes in E/I-balance: starting with the most basic things like artifacts, here shown for EEG & eye blinks.
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@nschawor
Natalie Schaworonkow
4 years
two oscillatory sources, producing rhythms of same frequency. both contribute to activity of nearby electrodes with a distance-dependent weighting. changing the phase relationship of the sources changes the traveling wave direction that can be measured on the electrode signals.
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@nschawor
Natalie Schaworonkow
4 years
oscillations recorded with EEG electrodes are a mixture of different sources. therefore, phase of sensor space signals does not necessarily reflect the phase of a singular oscillation; swinging back & forth in phase space, depending on synchronization of underlying rhythms.
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@nschawor
Natalie Schaworonkow
2 years
you want to extract instantaneous phase of a signal, the textbooks say to narrowband filter before computing the analytic signal. but why? using a broadband signal, the resulting phase corresponds to the circular mean of the analytic signals of the constituents (here: 🔴=🟢+🔵).
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@nschawor
Natalie Schaworonkow
3 years
spike-field coupling: when spikes occur at a preferred phase of an ongoing oscillation. in below example, a homogeneous Poisson spike train (spiking is distributed uniformly across time) is morphed into an inhomogeneous one, with more frequent spikes at the trough of the LFP.
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@nschawor
Natalie Schaworonkow
4 years
the two hemispheres have their own neuronal rhythms. sometimes they swing together for a bit, then drift apart again. (EEG, resting state sensorimotor mu-rhythms)
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@nschawor
Natalie Schaworonkow
3 years
ordered some MEG/EEG books for the fledgling lab library! any other recommendations?
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@nschawor
Natalie Schaworonkow
4 years
when recording EEG, the orientation of underlying dipoles will heavily influence what kind of field will be picked up on the sensor level. (single dipole placed in hand knob area of primary motor cortex)
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@nschawor
Natalie Schaworonkow
1 year
the institute storage rooms just keep on giving, found some beautiful old scientific posters there: "electrical stimulation points in the human cortex" (1931)
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@nschawor
Natalie Schaworonkow
11 months
my perspective on beta activity in the human cortex is now one of the first articles in the new @ImagingNeurosci journal! 🌟
@nschawor
Natalie Schaworonkow
1 year
I saw lots of beautiful beta-rhythm work lately! there is one specific aspect which I find non-optimal: in the human brain, there are also lots of alpha-rhythms, which may produce harmonics in the beta-band. I wrote about it here in this short article:
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@nschawor
Natalie Schaworonkow
3 years
during a long experiment, there can be different sources of variability. for example, the participant can get sleepy, which influences measures like reaction times on a slower timescale. these slow drifts can then mask differences between experimental conditions.
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@nschawor
Natalie Schaworonkow
3 years
prominent oscillations in the brain recorded with 3 different recording modalities🌟(different participants, ~10 Hz rhythms)
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@nschawor
Natalie Schaworonkow
3 years
when analyzing LFP & spikes, only few units exhibit spike-field coupling. but there are lots of rhythms in the brain, how do they arise? this toy model here shows that only a small fraction of oscillatory units need to be active in synchrony to result in a discernible rhythm.
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@nschawor
Natalie Schaworonkow
2 years
wow, perfect beer to celebrate a paper about gamma-oscillations. @uranc__ found this for his new article in Neuron 🎉:
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@nschawor
Natalie Schaworonkow
4 years
a glimpse on the electric orchestra that is playing all the time in the brain, with EEG rhythms appearing and disappearing concurrently. for all of them: distinct peak frequencies and waveforms, distinct spatial topography, distinct modulation by behavior. 🌊
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@nschawor
Natalie Schaworonkow
1 year
when recording from the brain using MEG, distance to the sensors is crucial in determining the signal. here is a fun test we ran when presenting auditory stimuli: squeezing the participant close to the sensors results in quite a boost in evoked response amplitude.
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@nschawor
Natalie Schaworonkow
2 years
how could one arrive at a traveling wave signal with EEG? take 1 occipital & 1 sensorimotor alpha rhythm. the resulting EEG signal will have varying peak times along the posterior-anterior direction. apparent wave direction will depend on phase shift between rhythms.
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@nschawor
Natalie Schaworonkow
2 years
does phase of a rhythm matter? had a chance to talk about our closed-loop TMS experiments recently and decided to plot everything in a more single-trial manner. I would say it looks quite nice. 🙂 a macroscale rhythm, detected in a non-invasive way, with effects on excitability.
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@nschawor
Natalie Schaworonkow
4 months
in auditory paradigms using MEG, peak activation is over temporal sensors. with EEG, curiously often peak activation is on vertex channels. 🤔 it feels counterintuitive, given the distance from source, right? but it is expected, as this simulation with 2 active dipoles shows.
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@nschawor
Natalie Schaworonkow
4 years
♥️ anatomical line drawings in old papers, here: distribution of alpha and beta rhythms across the cortex in electrocorticography recordings. Jasper & Penfield (1949)
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@nschawor
Natalie Schaworonkow
1 year
we often use Fourier analysis (=sinusoids) to represent brain signals. does this mean that there are many sine oscillators in the brain (1 per frequency)? we can also use triangular functions to reconstruct the signal. so are there 1000 tiny triangular oscillators in the brain?
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@nschawor
Natalie Schaworonkow
2 years
it was fun to see our paper on the cover of NeuroImage last month🙂 (more trippy oscillation plots in there: )
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@nschawor
Natalie Schaworonkow
1 month
sometimes for electrophysiological signals, mean spectral power in specific frequency bands is computed, often with a kind of normalization. ➡️ demo how to get different ratios of low & high freq power without any oscillatory contribution (by changing 1/f-exp. & spectral knee).
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@nschawor
Natalie Schaworonkow
5 months
Fourier Transform: transform time-domain signals into the spectral domain, easy. but why use only these two domains? ➡️ fractional Fourier Transform, for transform into the space in between. time domain – alpha=0; spectral domain – alpha=1, other alphas: a strange world. 🙃
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@nschawor
Natalie Schaworonkow
2 years
one reason why I think it's always good to see original spectra before running any kind of fancy analysis: it's quite easy to create oscillations magically out of noise. for instance, in the below demo by grouping trials (which contained only 1/f-activity) by frequency content.
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@nschawor
Natalie Schaworonkow
3 years
participant with such high SNR for the visual alpha-rhythm in EEG, making it possible to see the harmonic spectral peaks clearly. ♥️
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@nschawor
Natalie Schaworonkow
3 years
recorded EEG recently for the first time in 3 years! still feels great watching the squiggly lines on the screen. 🙂 & my colleague @pwdonh has some amazing mu-rhythms.
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@nschawor
Natalie Schaworonkow
4 years
besides occipital alpha- & sensorimotor mu-rhythms, there are also other ~10 Hz rhythms in the human brain. for instance, tau-rhythms originating in the temporal lobe, which have been linked to auditory function. have not seen a temporal rhythm so clearly before. ECoG ❤️!
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@nschawor
Natalie Schaworonkow
28 days
influence of muscle noise on spectrum & 1/f-exponent estimation, example from EEG. generally: the more muscle noise, the flatter the spectrum at higher frequencies.
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@nschawor
Natalie Schaworonkow
4 years
for me, the hardest step is always averaging over subjects, since they display large heterogeneity. here an example of how alpha-power is related to visual target detection (the classical result: lower occipital power for hit trials), in the average & for some selected subjects.
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@nschawor
Natalie Schaworonkow
4 years
Sensorimotor oscillations are not passively idling, they modulate cortical excitability with behavioral consequences. Magnetic stimulation given at the trough of the EEG mu-rhythm results in much larger muscle responses compared to peak stimulation.
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@nschawor
Natalie Schaworonkow
3 years
I am moving to Germany/Rhine-Main area in the fall & looking for a new postdoc-type job then! if you know something cool, send it my way. 🙂 love data and all the beautiful patterns in EEG/ECoG/LFP-recordings of brains.
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@nschawor
Natalie Schaworonkow
2 months
MEG/EEG: "we use source reconstruction" – all problems solved? plotted here: crosstalk – possible contribution from other locations to reconstructed activity @ red dot. no strong activity at these locations: 👍 otherwise: 🫠 ➡️crosstalk can be from distant locations
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@nschawor
Natalie Schaworonkow
3 years
first day at @ESI_Frankfurt , with welcome chocolate. ❤️🙂
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@nschawor
Natalie Schaworonkow
4 years
calculating power spectra with Welch's method entails splitting the signal into segments of a certain length and averaging across segments. too short segments: low frequency resolution. low number of segments: noisy estimates. the sweet spot: somewhere in between. 🤔
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@nschawor
Natalie Schaworonkow
4 years
the analytic signal obtained via the hilbert transform for broadband 🌸 and narrowband 🔴 filtered data.
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@nschawor
Natalie Schaworonkow
3 months
now I am in Toronto @ #CNS2024 . if you want to chat about oscillations, come by today in the afternoon poster session, poster E97. 〰️🧠🌊〰️
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@nschawor
Natalie Schaworonkow
4 years
2 different signals, for which the phase is extracted via the hilbert transform. one will get some numerical values for phase in any case, but these values are not always meaningful in a physiological sense, without an oscillation present.
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@nschawor
Natalie Schaworonkow
3 years
sound direction can be inferred from temporal differences of sound arrival at each ear. Jeffress model accomplishes this by mapping time into space with delay lines: spatially arranged units are activated depending on when inputs from both ears arrive simultaneously at the unit.
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@nschawor
Natalie Schaworonkow
4 years
EEG analysis in sensor space may yield distorted measures. 2 rhythms (at red & blue locations) with slightly different peak frequency mix across space. the power spectrum of the signal recorded at the green electrode now has 2 peaks in the alpha band. 🤔
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@nschawor
Natalie Schaworonkow
3 years
apparently, many students at @neuromatch academy have interest in working with EEG/MEG/ECoG (good choice 🙂). the organizers are looking for mentors (postdocs & PIs) who can help guiding data analysis projects! small time commitment in July, easy sign-up:
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@nschawor
Natalie Schaworonkow
1 month
"beta-activity as bursts", I am def 💯 OK with that. but imho the pendulum has swung too far in the direction that all beta activity equals close to 1-2 cycle bursts. so just to illustrate diversity, here is some more sustained beta-activity, resting-state EEG. 〰️🙂〰️
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@nschawor
Natalie Schaworonkow
2 years
if you combine two rhythms, what determines the resulting modulated signal? one aspect is the difference between the two frequencies, resulting in two spectral peaks left and right from the center frequency.
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@nschawor
Natalie Schaworonkow
4 months
investing the last remaining grant money into some fundamentals 💫
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@nschawor
Natalie Schaworonkow
5 years
Inter-trial coherence measures phase-synchronization across trials. It is the circular sum of phases at a certain point in time (length of red arrow). It reaches its maximum value of 1 for perfectly phase-aligned signals and becomes 0 as the phase distribution becomes uniform.
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@nschawor
Natalie Schaworonkow
3 years
tracking phase with a phase-locked loop: phase of a signal is compared to a reference oscillation. depending on the low-pass filtered phase difference, the reference frequency is adjusted. filter properties determine whether phase can be tracked after sudden frequency jumps.
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@nschawor
Natalie Schaworonkow
5 months
intracranial activity from the awake but resting human brain in the delta-frequency band (1–4 Hz), a couple of bursting cycles, not a sustained rhythm.
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@nschawor
Natalie Schaworonkow
3 years
what happens if you apply PCA on traveling wave type activity? this will result in two phase-shifted principal components, which can be combined to reconstruct the original wave. (example for laminar LFP recordings)
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@nschawor
Natalie Schaworonkow
3 years
traveling waves & sources, the empirical edition: for hippocampal theta, 2 different sources can reliably be found, which show specific phase shift. the phase extracted from raw LFP points to a traveling wave direction that is in agreement with that (here: ~top to bottom row).
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@nschawor
Natalie Schaworonkow
4 years
sadly, this interesting representation of EEG power spectra in the form of chernoff faces (ten spectral parameters mapped onto features of faces) from 1987 did not reach mainstream. 😀
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@nschawor
Natalie Schaworonkow
4 years
oscillations and ERPs often feel like separate worlds, but in some ways, they are different sides of 1 coin. according to the baseline shift account, late ERPs arise because of the non-zero mean property of oscillations, which change their power in the presence of stimuli.
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@nschawor
Natalie Schaworonkow
3 years
imagine: you train a classifier to predict something from a bunch of recording electrodes. you obtain weights, 1 value for each electrode. if only 1 weight is unequal 0, does it mean the informative signal is only present on that single electrode? 🧵⬇️
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@nschawor
Natalie Schaworonkow
4 years
the alpha rhythm is the most prominent rhythm in the human brain. some animals also have prominent resting alpha-rhythms, including cats & dogs. while brain size changes a lot when comparing across species, alpha peak frequency curiously seems to be quite consistent.
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@nschawor
Natalie Schaworonkow
4 years
same frequency spectra, but very different time domain signals. simulation: non-sinusoidal mu-rhythm vs. sinusoidal mu-rhythm + beta-bursts. 🤔
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@nschawor
Natalie Schaworonkow
2 years
our article illustrating sensor space spatial mixing of different alpha-rhythms is now out in @NeuroImage_EiC : you can check out the thread describing the preprint here:
@nschawor
Natalie Schaworonkow
3 years
many EEG analyses are done in sensor space. in this preprint with Vadim Nikulin @MPI_CBS , we investigate how different types of alpha rhythms contribute to activity of individual EEG electrodes. 1/8
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@nschawor
Natalie Schaworonkow
4 years
EEG alpha peak frequency varies as a function of alpha power for some subjects, as shown by below spectra computed for segments sorted by power in alpha band. I wonder how this could influence gradients in peak frequency along posterior-anterior axis. 🤔
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@nschawor
Natalie Schaworonkow
4 years
the power spectrum & the autocorrelation function (ACF) of a signal are heavily related. so, spectral & ACF measures will capture similar aspects of the data. shown here: how changes in spectral exponent lead to changes in ACF full width at half-maximum amplitude.
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@nschawor
Natalie Schaworonkow
3 years
now published: may be of interest if you want to look at oscillations in ECoG. 🙂 (python code provided)
@nschawor
Natalie Schaworonkow
3 years
new preprint!🌟we show how data-driven referencing can be useful for analyzing oscillations in intracranial electrophysiological recordings and explore waveform shape & spatial spread & variability across participants: (1/n)
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@nschawor
Natalie Schaworonkow
9 months
getting ready for our #CuttingGardens conference next week: ✅MEG/EEG-themed stickers
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@nschawor
Natalie Schaworonkow
3 months
good looking N100 🙃 (the university hospital where we record MEG had a cyber attack in October and it took until last week to get MEG data access reinstated... but now the data is back! ♥️🧲🙂)
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@nschawor
Natalie Schaworonkow
3 years
a report from Adrian & Yamagiwa (1935) on the EEG alpha-rhythm, recorded with electrodes placed on the midline. it is mostly about rhythm-localization, but one interesting figure shows alpha as a traveling wave, with propagating peaks and troughs. 🌊
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@nschawor
Natalie Schaworonkow
4 years
behavioral and neuronal measures acquired over the course of an experiment display fluctuations on fast as well as slow scales. if one computes a correlation between two _independent_ sets of such measurements, very likely strong spurious correlations will be seen.
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@nschawor
Natalie Schaworonkow
1 year
if you are interested in time series analysis of oscillations, check out this! my most common burst recommendations are implemented: ✅ determine frequency band of interest via spectrum ✅ sensitivity analysis of main output measures to show independence from chosen parameters
@fgarciaro92
Francisco Garcia-Rosales
1 year
Bats have beautiful rhythms! In a new preprint, @nschawor , @Talking_Bat and myself characterize and compare the waveform shape of delta and gamma oscillations in the bat auditory and frontal cortex. We found some cool things! 🧵
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Natalie Schaworonkow
4 years
A single ion channel is stochastic; but looking at many of them at once will reveal regularities, slowly approaching a time course as described by the Hodgkin-Huxley model. (here: delayed rectifier potassium channels in a voltage clamp setup; inspired by rereading Dayan & Abbott)
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Natalie Schaworonkow
3 years
"7 things to consider when analyzing oscillations in the brain" are we really measuring what we intend to measure? for me, getting a definite "yes!" to this question is the foundation of solid science. we try to provide a field guide to methods aiming at that for oscillations.👇
@Tomdonoghue
Tom Donoghue
3 years
New Preprint 🎉 "Methodological considerations for studying neural oscillations" With Natalie Schaworonkow ( @nschawor ) and Bradley Voytek ( @bradleyvoytek ), we review key methodological issues and concerns for analyzing oscillatory neural activity. 🧵:
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@nschawor
Natalie Schaworonkow
3 years
traveling waves, 1973 edition: a video showing the work of Walter Freeman III in the olfactory bulb & cortex, looking at evoked responses and spontaneous waves with an electrode grid in the cat. (thanks to @researchEnginee for this obscure find!♥️)
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@nschawor
Natalie Schaworonkow
4 years
Across participants, there is a large range of measurable EEG oscillation strength. For some participants, oscillations are very pronounced, for others miniscule. One can exclude participants for the sake of good measurement, but then the generalizability suffers. Tough choice!
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@nschawor
Natalie Schaworonkow
5 years
Reproducing really old results (~1930s): EEG visual alpha frequency increases over development. So many subjects in one scatter plot 😮. All of the extensive data wrangling by Voytek lab graduate rotation student Andrew Bender.
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@nschawor
Natalie Schaworonkow
1 year
magically (almost) observing the brain during thinking via tiny magnetic fields. I look forward to a summer with lots of MEG 🙂🧲
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@nschawor
Natalie Schaworonkow
5 years
I really like papers with many beautiful raw traces. These are from Contreras & Steriade (1995, ) and shows simultaneous EEG&intracellular recordings in motor cortex. Cool looking bursts! (sadly, this presentation form seems to have gone a bit out of style)
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Natalie Schaworonkow
4 years
built a spikeling: a model neuron that runs on a small arduino nano chip & can fire action potentials. for instance, by shining light on a photodiode the neuron can be excited (1st half of video) or inhibited (2nd half). love the sound output!
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Natalie Schaworonkow
3 months
made a new account to retweet neuroscience workshops & summer course announcements: 🧠 @BrainCourses 🧠 (co-maintained with @nayanikab20 )
@nschawor
Natalie Schaworonkow
6 months
updated for 2024: list of summer schools & short courses in the realm of (computational) neuroscience or data analysis of EEG / MEG / LFP and the like:
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Natalie Schaworonkow
2 years
the whole lab has pretty diverse backgrounds. so in order to establish some common ground, we decided to read a book in journal club earlier this year. we picked this one, "slim" in the title was also decision factor 🙂 & I liked that it featured a bunch of very recent studies.
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@nschawor
Natalie Schaworonkow
4 years
reading some older papers without any kind of uncertainty estimates reminded me of this nice figure. inspiration of what to show in plots comparing traces between two conditions. (figure from: )
Tweet media one
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@nschawor
Natalie Schaworonkow
3 years
sorry @bradleyvoytek , the lab output will now be exclusively in GIFs, abandoning this antiquated medium "papers" 🌟
@saydnay
Sydney Smith
3 years
I couldn't find an autocorrelation GIF I liked, so made my own! #Autocorrelation function (ACF) measures self-similarity of a signal by correlating it to itself + a time lag. As the lag increases, the correlation gets weaker. ACF can be used to approximate neural timescales.
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