Mike Inouye @minouye271 Twitter profile

Last Seen Profiles

@meowspaw

@boii41

@2xbutter

@EVargasTV

@widener

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@sgp_soccer

@AR__Wrestling

@StFrancis_IMres

@myBurbankNEWS

@TavaresSSB

@kswavyy

@AquelaLara

Mike Inouye

@minouye271

5 years

This zombie snail. A parasitic worm Leucochloridium has taken over its motor functions and eye stalks, making them into caterpillar mimics so birds will eat them. The worm can then reproduce in the bird's GI tract, eventually transmitting via its faeces 🤯

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Mike Inouye

@minouye271

5 years

This insanely cool dynamic history of infectious diseases before/after vaccines. Makes you want to stand up and cheer every time a disease bar goes green and slams down 👨🏻‍🔬👩🏽‍🔬 Another big h/t to u/rarohde

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Mike Inouye

@minouye271

4 years

After hours and hours of editing... this

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Mike Inouye

@minouye271

6 years

Some of the best mimicry I've ever seen (from )

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Mike Inouye

@minouye271

2 years

Ok who did this

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Mike Inouye

@minouye271

6 years

Holy moly, this crow is snowboarding! ....we are not alone

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Mike Inouye

@minouye271

1 year

Dear Parents in Science, @daniela_witten has our all of our backs

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Mike Inouye

@minouye271

6 years

Yet another incredible case of (aggressive) mimicry! An orchid mantis

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Mike Inouye

@minouye271

6 years

This is an awesome catalogue of postdoc funding opportunities: >230 grant schemes worldwide w/ links, duration, eligibility (h/t @DieterLukas @Jquintanalcala @khanaziz84 )

Funding Schemes and Opportunities for Postdoc Fellowships

A detailed list of funding schemes and opportunities for postdoctoral fellowships.

asntech.github.io

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Mike Inouye

@minouye271

7 years

Looking at lots of manuscripts and CVs at the moment & thought of this fantastic guide to better tables. Simplicity + elegance!

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Mike Inouye

@minouye271

1 year

📣📣 Latest paper from the lab just out @Nature ! An atlas of genetic scores to predict multi-omic traits A new community resource to genetically impute multi-omics data at population-scale. Check out OmicsPred portal

An atlas of genetic scores to predict multi-omic traits

Nature - A machine learning approach is used to analyse multi-omics (proteomics, metabolomics and transcriptomics) data, producing genetic scores for more than 17,000 biomolecular traits in human...

www.nature.com

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Mike Inouye

@minouye271

5 years

Yes!!! r/gifs

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Mike Inouye

@minouye271

4 years

The 9 types of PIs

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Mike Inouye

@minouye271

5 years

Pretty cool. Mapping the evolution of our alphabet

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Mike Inouye

@minouye271

7 years

We have reached peak GWAS.

bioRxiv

@biorxivpreprint

7 years

Genome-Wide Association Studies Identify 15 Genetic Markers Associated with Marmite Taste Preference #bioRxiv

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Mike Inouye

@minouye271

1 year

Cat's a bit out of the bag so just a brief 📣 I've recently been elected to the Professorship in Systems Genomics & Population Health @Cambridge_Uni 😊 More news to come but for now just want to highlight the lab's amazing current/past research+people! 👏

Inouye Lab

We are a dynamic, transnational research lab with nodes in both the UK and Australia. In the UK, we are part of the BHF Cardiovascular Epidemiology Unit in the Department of Public Health and Primary...

www.inouyelab.org

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Mike Inouye

@minouye271

2 years

🎉🎉🎉🎉 Our paper out today @NatureGenet on the combined effects of host genetics and diet on human gut microbiota and incident disease So many goodies in here re LCT/Bifido, ABO/F.lactaris, Morganella->depression Co-led w/ the fab @QinYouwen @phylogeo !

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Mike Inouye

@minouye271

2 years

Postdocs: We deserve higher salaries! Students: We deserve higher stipends! PIs: There's not enough money in the system! Journals raking millions in APC revenue: 🤫🤫🤫

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Mike Inouye

@minouye271

7 years

If u want to learn statistics in bite-sized chunks, check out the excellent fiveMinuteStats from @mstephens999 & co

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Mike Inouye

@minouye271

7 years

Respiratory systems are incredible things! Here's an elegant comparison across species

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Mike Inouye

@minouye271

2 years

Anyone asks you "what ever has GWAS done for biology?" hand them A brief history of human disease genetics High profile examples: -complement pathway in acute macular degeneration -synaptic pruning in schizophrenia -autophagy in inflammatory bowel disease

A brief history of human disease genetics

Nature - This Review describes progress in the study of human genetics, in which rapid advances in technology, foundational genomic resources and analytical tools have contributed to the...

www.nature.com

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Mike Inouye

@minouye271

4 years

So this. h\t @phylogeo

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Mike Inouye

@minouye271

7 years

Months 3 - 17 of being a new parent #DataIsBeautiful

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Mike Inouye

@minouye271

1 year

Academic cheat code: Ignore all manuscript formatting requirements prior to in-principle acceptance. Nearly every journal worth a damn does not enforce them until that point.

Madhu Pai, MD, PhD

@paimadhu

1 year

Remember all the reformatting we do for different journals? It comes at a massive cost! " 2.5 billion USD could be lost between 2022 and 2030—solely due to reformatting articles after a first editorial desk rejection"

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Mike Inouye

@minouye271

5 years

Any baby or child in England admitted to intensive care with an unexplained condition will now be eligible, together with their parents, for whole genome sequencing. Amazing job by the Next Generation Children Project

Genome sequencing 'revolution' in diagnosis of sick children

From next year, all seriously ill children in England can have their DNA analysed to help get a diagnosis.

www.bbc.co.uk

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Mike Inouye

@minouye271

7 years

Merry single-cell christmas!

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Mike Inouye

@minouye271

3 years

When this is all over I'm flying to Switzerland

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Mike Inouye

@minouye271

2 years

Human genetics evidence supports two-thirds of the 2021 FDA-approved drugs

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Mike Inouye

@minouye271

4 years

Like clockwork @redpenblackpen

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Mike Inouye

@minouye271

3 years

Operational Genomic Units (OGUs) enable effective, phylogeny-aware analysis of even shallow metagenome community structures

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Mike Inouye

@minouye271

3 years

What a wonderful primer! This captures nearly 15 years worth of methods research on GWAS. Looking back on it now, presented like this... just wow, what a fantastic community 🕺🏽😁

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Mike Inouye

@minouye271

4 years

PI to student: "Hey, I just saw this new preprint for [Tool X], why don't you run it on these data and see if it works"

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Mike Inouye

@minouye271

7 years

In case there was any doubt about how cool Japan is, here's some robotic fish

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Mike Inouye

@minouye271

2 years

Nearly 10k healthy population-based individuals with blood shotgun metagenomics. Does human blood have a microbiome? No. Does human blood sometimes have transient microbes from other body sites? Yes.

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Mike Inouye

@minouye271

3 years

Super excited for dual publication of the: - @PGSCatalog resource paper @NatureGenet - PRS Reporting Standards (PRS-RS) @nature Fantastic collabs w/ @genandgenes @hannah_wand @iamslambert @JALMacArthur @DrP_stuff & many more!

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Mike Inouye

@minouye271

11 months

DNA methylation networks underlying mammalian traits -Methylation in ~15,000 samples across 348 mammalian species -Divergence of DNA methylation mirrors genetic evolution -Methylation signatures in long lived species (eg HOXL, OCT4, SOX2, and NANOG)

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Mike Inouye

@minouye271

2 years

📣📣📣 Massive new paper from the lab!! An atlas of genetic scores to predict multi-omic traits. OmicsPred portal (revamped) w/scores, summaries, viz etc👉 Led by the excellent @IamYuXu w/huge contributions from many collaborators

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Mike Inouye

@minouye271

2 months

Required reading for anyone working in (gen)omics

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Mike Inouye

@minouye271

6 years

In case you freakin’ missed it, here’s the first photo of an electron’s orbital around a hydrogen atom.

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Mike Inouye

@minouye271

5 years

More cellular drama! A red killer T cell latches onto a cancer cell and rolls it around, all while injecting it with cytotoxins. Great work by Gillian Griffiths and co @TheCIMR @Cambridge_Uni <- so many more cool vids in this paper

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Mike Inouye

@minouye271

4 years

IT BEGINS: 90 year-old Margaret Keenan from Enniskillen in N Ireland has become the first person in the world to receive the Pfizer/BNT vaccine against Covid, outside trial conditions. She received the injection from Matron May Parsons at Uni Hospital in Coventry at 06:30 GMT.

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Mike Inouye

@minouye271

4 years

I've posted my #ESHG2020 talk on opportunities and challenges for polygenic risk scores in the clinic here for everyone to access (with audio!) Fantastic talks all round!

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Mike Inouye

@minouye271

5 years

Just up on biorxiv: We've used meta-scoring and the amazing @uk_biobank to construct the most powerful stroke GRS to date. GRS is now a stronger predictor than family history and comparable to other conventional risk factors (smoking, BMI, blood pressure)

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Mike Inouye

@minouye271

4 years

Wonderful to see our latest @NatureComms dissecting the genetics of neonatal gene expression & its links with immune diseases! Loads of goodies: (response) eQTLs in T cells & monocytes/macrophages, colocalisation, mediation & MR. Well done @qinqin_huang !

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Mike Inouye

@minouye271

4 years

Preprinting = single most effective thing a new PI can do. Since 2013 our lab policy is to preprint *every* paper. It's been hugely positive in every way including raising funds. Only once did it affect journal consideration & we successfully argued against that journal's policy.

A/Prof Jodie Ingles

@jodieingles27

4 years

What’s your strategy for submitting work to preprint servers? Do you submit every paper? Does it ever impact journal review? Are there some papers you strategically choose not submit? Thanks! #AcademicChatter

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Mike Inouye

@minouye271

4 years

👉Estimate age for >45M human SNPs 👉SNP age & frequency across geography 👉Value of age for interpreting SNP function & selection 👉Approach for inferring shared genomic ancestry & quantify genealogy thru time Atlas of Variant Age

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Mike Inouye

@minouye271

3 years

Super excited to go live with OmicsPred!! OmicsPred is a resource for predicting multi-omics data directly from genotypes. It's based on a single cohort (INTERVAL) with extensive multi-omics data which we use to train genetic scores (using Bayesian Ridge)

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Mike Inouye

@minouye271

4 years

The first big UKB exomes paper out in @nature : "Exome sequencing and characterization of 49,960 individuals in the UK Biobank". Just a taste during the build up to the full 500K exomes being released.

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Mike Inouye

@minouye271

6 years

The Great Wave, Candida medium @DrKatHolt 😄

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Mike Inouye

@minouye271

8 years

Every young scientist should be listening to George Church ( @geochurch )

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Mike Inouye

@minouye271

5 years

One of the many positive impacts of @biorxivpreprint on genomics is our refocusing on the actual content of papers. People just aren't noticing as much in which journals papers end up being published. As a field, our research has sped up & we're all more widely read. 👌👌👌

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Mike Inouye

@minouye271

6 years

WGS of 4,810 Singaporeans (2,780 Chinese, 903 Malays, 1,127 Indians) at 13X depth: >40M new SNPs/indels (not in dbSNP) 126 new common deleterious mutations Fine scale genetic structure that empowers genetics-based discovery in diverse ethnicities

bioRxiv

@biorxivpreprint

6 years

Large-scale whole-genome sequencing of three diverse Asian populations in Singapore #bioRxiv

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Mike Inouye

@minouye271

5 years

Many noting the shifting x-axis (to keep up with the frequent crashing of ID cases). Be sure to watch to the end for a striking zoom out of all the changes.

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Mike Inouye

@minouye271

3 years

Immensely proud of this one! A deep dive into race/ethnicity/ancestry and the problematic language of human genetics... examples, PCA pitfalls, social environment and more. With the incomparable @ewanbirney @JenniferRaff @AdamRutherford @aylwyn_scally 👉

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Mike Inouye

@minouye271

6 years

Shoe shopping will never be the same

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Mike Inouye

@minouye271

5 years

Right so that's 3.2M impressions and not slowing down It doesn't matter anymore if my PRS research transforms healthcare, there's no way I'm living this tweet down

Mike Inouye

@minouye271

5 years

This zombie snail. A parasitic worm Leucochloridium has taken over its motor functions and eye stalks, making them into caterpillar mimics so birds will eat them. The worm can then reproduce in the bird's GI tract, eventually transmitting via its faeces 🤯

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Mike Inouye

@minouye271

3 years

WOOT!📣 Our integrative analysis linking the plasma proteome with polygenic risk of CAD, T2D, stroke, CKD is out @NatMetabolism . Led by the exceptional @sritchie73 Our take: Polygenic scores can be used to uncover (potentially druggable) disease biology☺️

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Mike Inouye

@minouye271

6 years

I am thankful for @PreetBharara 's podcast

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Mike Inouye

@minouye271

1 year

Polygenic scores confer unmodifiable risk of disease right? Maybe not There are (druggable) proteins that are downstream mediators of polygenic risk And OmicsPred analysis in UKB identified 8 of 11 protein mediators of the CAD PRS

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Mike Inouye

@minouye271

11 months

Brief 🧵: The exodus of early career researchers from academia is linked to PI behaviour. There are very serious and high-profile examples of course, some of which may even break the law, but PIs also need to appreciate their day-to-day behaviour also profoundly affects ECRs.

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Mike Inouye

@minouye271

11 months

Very cool tech 👉 A genome-wide atlas of human cell morphology Multiple genome-scale genotype-phenotype maps using >20,000 single-gene CRISPR-Cas9-based knockout experiments in >30 million cells

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Mike Inouye

@minouye271

1 year

This study is a bit of a thunder bolt. ~80% of genes DE b/n living & postmortem human brain No eQTL analysis. Surely that's to come. Incredibly important to see extent of (post mortem) effect modification... maybe a lot of GWAS loci to reinterpret 😕

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Mike Inouye

@minouye271

2 years

Very insightful Q&A with polygenic score experts just published in @NatureRevGenet . Including the incomparable @genetisaur @cathrynlewis @nilanjan10c @samrip @iftikhar_kullo +1 👉 Read only 👉

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Mike Inouye

@minouye271

2 years

Spoiler alert ‼️ Y'all a computational biologist (Syabira Yusoff, PhD) just won the Great British Bake Off LinkedIn 👉

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Mike Inouye

@minouye271

7 years

Mind blowing 👉 the protein folding problem is essentially solved. This was the original grand challenge in computational biology. If ur a grad student, consider going back to the future cuz synthetic protein design could change _everything_

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Mike Inouye

@minouye271

1 year

Nice succinct research briefing of OmicsPred from @IamYuXu @sritchie73 -> Source paper ''An atlas of genetic scores to predict multi-omic traits"

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Mike Inouye

@minouye271

3 years

The @GenomicsEngland 100K pilot study just came out at NEJM Bottom line: Embedding WGS in national healthcare can increase diagnostic yields for rare diseases and save a lot of taxpayer money.

100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care — Preliminary Report | NEJM

The U.K. 100,000 Genomes Project is in the process of investigating the role of genome sequencing in patients with undiagnosed rare diseases after usual care and the alignment of this research with...

www.nejm.org

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Mike Inouye

@minouye271

4 years

I wish someone had warned me how much of my research career would happen over the phone. After 15 years of morning, day and evening telecons, here are my top 5 tips for good telecon science.

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Mike Inouye

@minouye271

6 years

Excited to announce I've taken up a joint position @BakerResearchAu & @CAMBRIDGE_CEU @DPHPC to head up the new Cambridge Baker Systems Genomics Initiative! We're tackling big questions in multi-omics, genomic AI/IA and disease prediction.

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Mike Inouye

@minouye271

1 year

PSA: If you're analysing the UK Biobank Nightingale metabolomics data, be sure to check out @sritchie73 's work on technical effects, quality control and normalisation Code (ukbnmr):

Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK...

Scientific Data - Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants

www.nature.com

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Mike Inouye

@minouye271

7 years

Latest @NatureGenet : Classification of common human diseases derived from shared genetic and environmental determinants. Very cool.

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Mike Inouye

@minouye271

4 years

Born under lockdown and destined to be a bookworm 🥰

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Mike Inouye

@minouye271

1 year

Cool preprint. Using DNA variation to predict gene expression in single cells is challenging but possible Via transfer learning with a pre-trained epigenomic model to create gene embeddings that capture sequence logic of transcriptional regulation

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Mike Inouye

@minouye271

1 year

Now published @NatureHumBehav : African genomes hold the key to accurate genetic risk prediction From @SFatumo and me

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Mike Inouye

@minouye271

3 years

The carbon footprint of bioinformatics Fantastic work by @Jason_Grealey @Loic_Lnlg and co to quantify the CO2 emissions of common bioinformatic tools and practices! Our emissions tool:

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Mike Inouye

@minouye271

6 years

Our latest now published in JACC @JACCJournals Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention. A fantastic collaboration of the @uk_biobank CardioMetabolic Working Group!

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Mike Inouye

@minouye271

2 years

Finally!! @bvilhjal @privefl & co have given us a paper showing how powerful multi-PGS is for a wide range of traits! 👏😁

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Mike Inouye

@minouye271

2 years

WOOT!! 🎉🎉 A wonderful paper led by PhD student Yang Liu just published in @Cell_Metabolism : "Early prediction of incident liver disease using conventional risk factors & gut-microbiome-augmented gradient boosting"

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Mike Inouye

@minouye271

4 years

Keep seeing this over and over. The machine learning researcher with the best and most robust results is not necessarily the one using the most sophisticated algorithms. Instead they are meticulous with their data wrangling, quality control, normalisation, and model fitting.

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Mike Inouye

@minouye271

4 years

WOOT! An in-depth analysis of machine and deep learning approaches for polygenic scores of blood cell traits Fantastic work led by @IamYuXu with many fab contributors @Jason_Grealey @iamslambert @nicolesoranzo @d__vuckovic @sritchie73 et al!

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Mike Inouye

@minouye271

4 years

GenZ: Scientific writing is difficult if you don't have the recipe. Well, here's the recipe.... and to get your attention here's a baby platypus.

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Mike Inouye

@minouye271

3 years

📣 The @ICDAbio PRS Task Force just published this fantastic piece @NatureMedicine on the potential benefits, risks & remaining gaps for the responsible use of PRSs in the clinic Such an exceptional and multidisciplinary group of experts! 👏👏👏🎉

Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps

Nature Medicine - As polygenic risk scores move closer to widespread clinical use, this Perspective summarizes the benefits, risks and challenges to be overcome.

www.nature.com

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Mike Inouye

@minouye271

4 years

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Mike Inouye

@minouye271

4 years

Masterchef but for bioinformatics

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Mike Inouye

@minouye271

7 years

When making figures remember that 6% of men (0.5% of women) have this color spectrum.

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Mike Inouye

@minouye271

4 years

😂🤔🤔

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Mike Inouye

@minouye271

5 months

Just out at @GenomeMedicine : our review on recent advances in polygenic scores: translation, equitability, methods and FAIR tools Well done to the team @RXiang5 @iamslambert Martin Kelemen @IamYuXu @DrP_stuff @HarrisWiseman !

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Mike Inouye

@minouye271

9 months

Latest from @xilin_jiang , Alkes Price, Gil McVean and co 👉 Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk

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Mike Inouye

@minouye271

5 years

Students and postdocs in genomics: If you read one book this year, please make it John Sulston's seminal The Common Thread. If you're wondering how the genomics field came to be, why we collaborate, share, and ultimately preprint everything - this is it

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Mike Inouye

@minouye271

2 years

Prohibit. Confiscate. Scrap. Shred. Australia did it and you can too.

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Mike Inouye

@minouye271

5 years

It's that time of year - Xmas wreathes for computational biology!

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Mike Inouye

@minouye271

2 years

WFH done right

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Mike Inouye

@minouye271

5 years

This classic of Th2 immunity. Eosinophils have important roles in promoting allergy, asthma and autoimmunity. But if you give them a parasite, like this nematode (roundworm), they get the job done. (and interestingly eicosanoid lipids are mediators)

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Mike Inouye

@minouye271

6 years

The life cycle of the nectar of the gods 🙇🏻‍♂️

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Mike Inouye

@minouye271

3 months

🎉📣 Latest preprint from the lab: Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction Led by the exceptional @RXiang5 (now head of comp bio at AgriBio @VicGovAg )!

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Mike Inouye

@minouye271

2 years

Can I just say that the recent focus of statistical genetics on transferability/fairness/equity of polygenic scores across ancestries and other demographies is the single greatest cultural shift I've seen since the HGP. Simply phenomenal.

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