Luis Pedro Coelho (in Shanghai 14-24 Oct) Profile Banner
Luis Pedro Coelho (in Shanghai 14-24 Oct) Profile
Luis Pedro Coelho (in Shanghai 14-24 Oct)

@luispedrocoelho

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3,697
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803
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group leader at @CMR_QUT science. microbiome. content creator for Elsevier, NPG and others! traveling salesman of second hand ideas

Brisbane
Joined January 2010
Don't wanna be here? Send us removal request.
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
5 months
AMPSphere published in @CellCellPress . A thread on the main results We obtain nearly 1 million novel antimicrobial peptides from the global microbiome! In vitro testing showed that at least 79/100 are true positives
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 year
So far, when it comes to LK-99, everyone is behaving like the cliché: China: a bunch of university labs worked to replicate as fast as possible US: a private company sponsored a replication as a marketing gimmick Russia: cat girl, but whole thing is unclear Europe: on holiday
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
@S_Insley_H Men plot to rule the galaxy instead of going to therapy
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
6 years
Imagine unscheduled phone calls didn't exist and someone came up with the idea: "it's an alarm to schedule a meeting RIGHT NOW." "And who can ring the alarm?" "That's the beautiful part: anyone in the world can ring a loud alarm in your house or office!" "I'll pass, thanks."
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 year
@ftuuky Thanks, I didn't know that! Blessed be the Eastern Europeans!
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Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 months
@stylewarning They used 1-based indexing
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 months
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
3 years
"Towards the biogeography of prokaryotic genes" is finally out at @Nature We wanted to know what genes are out there and how they are distributed around the world A 🧵 on the main findings 1/18
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
26 days
@inerati How much are you valuing your own time spent preparing and cooking? Even a simple meal can easily take >30 minutes
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 year
@Simon__Grimm Found it!
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
@smolrobots Answering "almost" to the question of "you had fun, right?" is objectively hilarious
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Luis Pedro Coelho (in Shanghai 14-24 Oct)
3 years
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
18 days
It's Nobel week, so—after a break last year when this account became a Karikó stan account—I am reposting my annual plea to give Lipman and Myers a Nobel Prize for creating BLAST
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 month
@btharris93 If anything, there is a stronger signaling/deterrence argument for throwing her in jail Sending a message that "spying for a foreign power is not okay" is still relevant in a way that "leading an SS Einsatzgruppe is not okay" is not
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
3 years
@timminglab Emeritus Professor: I was supposed to start this talk 7 minutes ago, but I forgot about it until someone came to get me in my office. Let's do this!
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
Remember when people would pretend that monkeypox spread had nothing to do with sexual contact? That we were just on the verge of seeing the disease spread outside MSM networks?
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 month
Why are bioinformatics results so full of false positives? I've been thinking about this for a few years: the incentives in the field are to produce false positives (link in next tweet)
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
17 days
@apenwarr It's good UX to check if a file exists as soon as you are aware that it will be needed A pipeline that runs for 2 hours before erroring out because the user mistyped an input file that is only needed at step 5 is bad (Agree on check-before-opening being wrong, though)
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
7 months
@Hieraaetus European states will send someone with a gun to arrest you if you shoot a wolf. If you resist arrest, they will send more people with more guns They have a stronger hold on the monopoly of violence so they often don't need to use as much violence, but the threat is there
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 years
In computational biology, we don't say "I love you", we say "I will kill my jobs on the cluster so you can run yours" and I think that's beautiful
@sanjanacurtis
s🎃njana curtis! 🦦
4 years
In physics we don't say "I love you" we say "I think your solution makes sense” and I think that’s beautiful
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Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 months
@Finnothyjest Europeans do this all the time: get very upset that conservatives in the US are doing something to make the US more like Europe Chevron is a bit too niche, but certainly Dobbs and immigration fall into that category
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
3 years
It's deliciously ironic how much the anti-Facebook case is built on fake news and misinformation
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
3 years
World seems to be coming to its senses about climate change and nuclear
@AlecStapp
Alec Stapp
3 years
Good news from Japan
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 month
@JosephPolitano This is, at minimum, misleading Direct election of Head of State is common, but direct election of head of the executive (most often, prime minister) is not
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 years
Both "we don't want to pay full tuition for Zoom classes" and "we are working extra to provide this service" are 100% correct and not contradictory The simple fact is that covid has made the world poorer This is what it means to be poorer: we work harder and get less
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
7 months
@nikicaga France has more wind and is sunnier. It's the only possible explanation
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
10 months
@DRMacIver That sounds like a good rule, but only if everyone follows it, but because of the prisoner's dilemma, some people will defect
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 months
@vanillaopinions Things would change (which people don't like) and people's houses would go down in value (which people also don't like)
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Luis Pedro Coelho (in Shanghai 14-24 Oct)
11 months
@ruth_hook_ H. pylori causing ulcers
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
5 years
Riffing on @tylercowen 's earlier Bloomberg column: The covid situation is a great example of the ADVANTAGES of globalization [thread]
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
5 years
Perception: Using an institutional email in a paper affiliation: Professional Using a gmail/personal email: Unprofessional Fact: My personal email has been the same for 15 years, during which time I had 7 institutional emails, so all my old papers have unusable addresses
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 years
As a reviewer, I think that bioinformatics/compbio papers can make three different types of contribution: 1. A new method/algorithm/insight (bioinformatics advance) 2. Novel biological insight (computational biology) 3. A tool for others to use (public goods contribution)
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
5 months
A full thread on the science later, but I'm very happy that, after 5 years of work, the AMPSphere manuscript is out at @CellCellPress Congrats to @celiodiasjunior @mdt_torres @delafuenteupenn @cocodyq @TSBSchm @alvarordr @jhcepas @BorkLab ...
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 months
@AlexGodofsky In Europe, micro filtration is allowed as an alternative to pasteurization as it achieves similar levels of bacterial load reduction If this is what they are selling, it's a good product and what I used to consume in Luxembourg
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 year
Woohooo!! My @arc_gov_au Future Fellowship application got funded! We'll be working on the small proteins of the global microbiome! I'm very excited about this science and I'm very happy that @arc_gov_au agreed with me on the promise of small proteins
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 months
@tlakomy June 16
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
10 days
@AlexGodofsky "This is the standard in the field"
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Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 months
@GarrettPetersen @Aella_Girl Bacteria already evolved to digest plastic on their own, but it is not a great energy source, so there is actually little risk that they will start digesting the water bottle on your cupboard shelf
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
@LouisatheLast Dior deodorant is 29 dollars! That's four hours of min wage labour for a single stick of deodorant!!
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
After speedrunning the epidemic in 3 weeks, Shanghai is back
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
7 months
@Noahpinion It's a general cliché that it's the diaspora that takes irredentist positions, while the locals want a peace treaty so they can get on with their lives The Palestinians have an extended diaspora, fighting for their cause, but not for them
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 months
Twitter is serious people pretending to be insane LinkedIn is insane people pretending to be serious
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
3 years
Internet punditry, circa 2011: you try to blog your way into a journalism job that actually pays the bills Internet punditry, circa 2021: you try to journalism your way into a blog that actually pays the bills (we call them newsletters now)
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 years
1920's-level logistics could get it done, no question about about it The question is how to do it with 2020 institutions
@AriSchulman
Ari Schulman
4 years
- Tents in church, mall, school parking lots 7 days/week - Staff to the gills, workers get hazard pay - Allot a certain number of doses daily - 6 am - 6 pm: HCWs and 60+ only - 6-10 pm: remaining doses open to all Seems doable with 1920s-level US logistical competence.
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
How many in the "we will never pay for bluechecks!" crowd have bemoaned the ad-revenue-driven business model for giving us clickbait?
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
8 months
Preliminary results from a side project on the most solved problem in bioinformatics: How do you map short reads to a database?
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 years
I used to come home from conferences with a long list of research ideas. Both completely new projects as well as minor tweaks to ongoing projects Many of these were bad, mind you, but the interactions were very stimulating intellectually. Zoom conferences don't do this
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
9 months
New experiment: I will work on a project (starting question: what antibiotic resistance genes co-occur in genomes/metagenomes and does it matter?) completely in the open
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
5 years
Why are bathrooms generally cleaner in countries where labour costs are higher?
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
The loss of trust in institutions is real and a real problem, but institutions also need to stop lying to people all the time
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
5 years
Dear submitter of papers in biology with neural network results, please include a baseline using logistic regression to show some value to all that computing Signed, reviewer #2
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
@EmmaRAndersson Review-to-submit: if you don't review, nobody should review your papers either
@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
The solution is "review to submit" - papers from authors who don't review other papers are simply administratively rejected
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
5 years
The theory that that, if China hadn't delayed in admitting how bad things were, we would have prepared makes perfect sense, except for the existence of February In February, it was clear it was bad and little was done — it even lasted 29 days this year
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 months
@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 months
Twitter is serious people pretending to be insane LinkedIn is insane people pretending to be serious
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Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 year
@upzone_CA On the list, position #3 is literally "China" lol
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
5 years
This is both funny and an unambiguously good idea.
@meghara
Megha Rajagopalan
5 years
Americans in Austria can now seek consular assistance at McDonalds. This is actually a real thing.
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Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 year
@tingstormen @ftuuky It's short for "Europeans who were on the wrong side of the Iron Curtain"
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
5 years
I see too many people discussing Facebook's Libra in reference to bitcoin and not enough discussing it in reference to WeChat.
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
6 years
Good news : Germany is lowering its CO2 emissions in 2018 after years of stagnation or increasing emissions Bad news: mostly because global warming makes people use less heating
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 year
Recently, I read "Lying for Money", which introduced me to the concept of "criminogenic environment" I think many PIs create "fraudogenic environments" in their labs while keeping plausible deniability
@cshperspectives
Richard Sever
1 year
A culture that "reward[s] 'winners' (postdocs who generate favorable results) and marginalizes 'losers' (postdocs who struggle to generate such data)” leads to 20 years of "fudging of results [in] labs at three separate institutions".
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
7 months
@maiab In this case, one has to ask whether the airlines paid for Google to do so
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
@acidshill The world if anti-nuclear Greens hadn't won the intellectual battles of the 1970s
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 year
I officially start on Monday, but since I'm visiting campus today...
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
3 months
@SwannMarcus89 If Republicans stand for something, they stand for their unwavering respect for the sanctity of electoral results
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 months
@AdamDullinger The grocery store should be so close that you think of it as an extension of your pantry
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
5 years
Flight attendant: Is there a doctor on board? Dad: That could have been you... Go see if they need a bioinformatician! FA: Bioinformatician? Perfect, the passenger in 12B needs help with bioconda and incompatibility errors! Me, sighing: I cannot help him... Nobody can
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
5 years
Latest Stanford study shows again that serology surveys are NOT useful when the prevalence is known to be lower than the test's false positive rate Here, the authors tried to argue that their test was specific enough, but they need more evidence for that
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
7 months
@Jess_Osterhout Selling and networking are a part of the job, as much as anything else. You can and should get better at it Written rules are often guidelines Distinguish tasks that need your best (typically, your science) and those that don't (typically, internal tasks)
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 year
Has the EU threatened to ban superconductivity yet?
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
"I'm moving to mastodon because I cannot be associated with a company that treats staff as disposable," said an academic
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
3 years
@GermanAmbUSA It's been 6 weeks, though The nuclear power stations that were turned off could be producing again already
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
I'm a computational biologist by day and a computational biologist by night I just have bad work/life boundaries, really
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
10 years
Many scientists say "I cannot stand more than two back-to-back conference presentations", then happily put their kids in traditional school
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
6 years
You know that reviewer that writes "this is a good paper, but belongs in a lower tier journal"? I'm writing a review and am tempted to write "this is so good, it belongs in a higher tier journal."
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
@john_voorheis This was an explicit strategy to get parents to buy their children iPhones
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
3 years
How many times do I need to explain that I didn't sell my soul to the devil, I sold a token which is associated with the hash of my soul on the blockchain to the devil?
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 years
It's that time of year, when I repost my plea that BLAST get Its Nobel Prize. Not that I have any pull with the Academy, but I still think it should get one
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
@roramdin I don't understand X I don't understand Y Therefore, X=Y
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
4 years
If only more people studied the humanities, we would have fewer people who think that studying the humanities is a solution for extremisms
@lastpositivist
Liam Bright
4 years
If only Heidegger had had training in the humanities 😢
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
Building MAGs (metagenome-assembled genomes) from multiple metagenomes using SemiBin Using multiple samples improves results at the cost of more computation
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
6 years
@CutTheKnotMath Here's the intuition: once Alice gets a first heads, she will keep tossing only while she gets only heads: the first tails and she is done. While Bob, if he sees a heads followed by a tails, he's back at the beginning.
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
5 years
What the rest of Europe should learn from Italy is not "we're all going to die". We're not The lesson is "once you get past 100 new cases per day, shutdowns are inevitable. Waiting only means that they will last longer and more people will be dead at the end of it"
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
10 years
Newspapers are doomed bc my mental reaction to a paywall is often positive "yeah, I didn't really want to read that, tx for saving me time"
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
5 years
I was reviewing a paper today and explicitly tried to summon my inner @MicrobiomDigest to spot any duplications I didn't see any, but before following her on Twitter, it would not even have crossed my mind to actively search for duplication
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 year
@StefanFSchubert This plus the stagnation of Europe and Brexit means that, contrary to the narrative of the early 2000s, the US is becoming even more dominant
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 year
All #ISMBECCB2023 sessions Easy to filter/search
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
China is such a "high trust society" In the last few weeks, I have sold off a few things by (1) posting a few pictures online, (2) having complete strangers text me money and their address, and (3) shipping them their things Not even a reputation mechanism
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 year
@0x00B1 This looks so trivial that I had to read it a few times to figure out what I missed. In the end, I think it really is just trivial
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
5 years
The three levels of research code: 1) one-off script 2) generates plot/table for paper 3) library for reuse by others There is a 5-10x effort difference between each level, so library code should be 25-100x more effort than a one-off
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
1 year
@AdamSinger There is a collective action element here If a parent helps a child, that helps the child. But if all parents helped their children, the effect would be different We fundamentally need more housing
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
11 years
"Oh, the intellectual freedom of academia" he thought while filling out a time sheet which checks that he does not work on non-grant science
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 months
@irockgnomes They do. They get local governments to make rules like zoning to stop each other from building enough housing to make prices go down
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
3 years
They: "When the facts change, I change my mind. What do you do, Sir?" Me: "I question the processes that led me to be wrong in the first place. To simply change one's mind about the object level is not enough."
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
7 months
@revhowardarson This seems exactly like the kind of thought that SBF would have, so I support it for him specifically
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@luispedrocoelho
Luis Pedro Coelho (in Shanghai 14-24 Oct)
2 years
In August 2023, I will join @CMR_QUT in Brisbane (Australia) and I'm very excited to join the great team they have there! My scientific interests remain the global microbiome (including small proteins), with a mix of method development and applications projects
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