Tuberculosis is usually treated with a 6-month rifampin-based regimen. Whether a strategy involving shorter initial treatment may lead to similar outcomes is unclear. In this adaptive, open-label, ...

Nature Reviews Urology - New research indicates that the microbiota at many sites in the body, including the urinary tract, might influence urological health. Whiteside et al. review our current...

Eighteen million doses of the first malaria vaccine to become available will be allocated over 2 years across 12 African countries, including Benin, Democratic Republic of the Congo, and Uganda, the...

(1) Background: In the emergency department (ED), ordering urine tests in patients without symptoms of a urinary tract infection can lead to inappropriate antimicrobial treatment. We aimed to...

This Personal View discusses the challenges faced, especially by low-income and middle-income countries (LMICs), in responding to the growing burden of bacterial antimicrobial resistance. Many...

A global-scale metagenomic exploration of Blastocystis was performed from 56,989 individuals across 32 countries. Blastocystis was seen to be widely present in healthy adults, with prevalence and...

Nature - A clinical study shows that immunotherapy with anti-HIV-1 antibodies maintains prolonged viral suppression after anti-retroviral treatment is discontinued and affects the size and...

SUMMARYSince the emergence of COVID-19 in 2020, an unprecedented range of therapeutic options has been studied and deployed. Healthcare providers have multiple treatment approaches to choose from,...

The continued evolution of the SARS-CoV-2 Omicron variant has led to the emergence of numerous sublineages with different patterns of evasion from neutralizing antibodies. We investigated neutraliz...

This secondary analysis of a randomized clinical trial assesses the 3-year clinical outcomes of oral moxifloxacin vs combined intravenous ertapenem plus oral levofloxacin and metronidazole in...

Nature Medicine - HIV remission was achieved for 32 months after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells.

This Viewpoint discusses the current mpox outbreak in Africa and why countries worldwide must urgently act to address it after the World Health Organization declared the event a Public Health...

Nature Reviews Microbiology - A better understanding of the transmission of SARS-CoV-2 is essential to inform public health measures. In this Review, Puhach, Meyer and Eckerle explore insights into...

This JAMA Insights in the Climate Change and Health series discusses the importance of clinicians having awareness of changes in the geographic range, seasonality, and intensity of transmission of...

Earlier in 2024, the World Health Organization (WHO) issued a request for information after several countries reported an increase in isolates identified as carbapenem-resistant hypervirulent...

A 59-year-old treatment-naive patient with advanced HIV infection presented with a severe and protracted course of mpox (formerly known as monkeypox) that did not respond to the current mpox treatm...

This cohort study assesses the association of COVID-19 with new-onset type 1 diabetes among pediatric patients.

This cohort study characterizes inappropriate diagnosis of community-acquired pneumonia among hospitalized patients in 48 Michigan hospitals.

Background Long COVID is a common condition lacking consensus definition; determinants remain incompletely understood. Characterizing immune profiles associated with long COVID could support the...

SARS-CoV-2 breakthrough infections in vaccinated individuals and in those who had a prior infection have been observed globally, but the transmission potential of these infections is unknown. The...

CAP is an acute lung infection that causes 1.5 million hospitalizations in the United States each year. Most outpatients with mild CAP can be treated empirically without diagnostic testing for bact...

Among patients aged >75 years presenting at the emergency department with respiratory or infectious symptoms, respiratory syncytial virus shares a compa

This systematic review and meta-analysis of randomized clinical trials assesses the association of toothbrushing with hospital-acquired pneumonia, mortality, length of stay, duration of mechanical...

Nature - Klunk and colleagues identify signatures of natural selection imposed by Yersinia pestis and demonstrate their effect on genetic diversity and susceptibility to certain diseases in the...

This French cohort study evaluates in-hospital mortality and adverse effects among older adults (≥75 years) who waited overnight in the emergency department for a bed in a hospital ward.

El uso justificado y prudente de los antibióticos es una medida clave para frenar el avance de las resistencias de las bacterias, recuerda el especialista José Miguel Cisneros.

Oral stepdown with fluoroquinolones or trimethoprim-sulfamethoxazole had similar effectiveness for uncomplicated GN-BSI from a urinary source. High-bioavai

Low CD4:CD8 ratios are independently of CD4 cell counts associated with increased risk of AIDS-defining and infection-related malignancies in antiretrovira

This study evaluates the effectiveness of the respiratory syncytial virus vaccine against hospitalization for acute respiratory illness among US adults aged 60 years and older.

La tasa de incidencia de Covid-19 en Atención Primaria en España es de 130,2 casos por 100.000 habitantes, según datos de la semana pasada (del 21 al 27 de agosto), lo que...

A bloodstream infection is a life-threatening condition. Rapid reporting of actionable microbiological results is critical for patient management. Delays i

Abstract. In a multihospital cohort study of 3392 patients, positive urinalysis parameters had poor positive predictive value for diagnosing urinary tract

This review and meta-analysis compared nonneurological syphilis treatments. Results indicate alternative therapies like doxycycline, ceftriaxone, and azith

Signal Transduction and Targeted Therapy - SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells

Autoantibodies against interleukin-12 (anti–interleukin-12) are often identified in patients with thymoma, but opportunistic infections develop in only some of these patients. Interleukin-12 (with ...

Background The proportion of people who are diagnosed late is a key metric to measure the public health response to HIV. But this percentage remains stubbornly high in nearly every country. Delays...