John Schoggins @jschoggins Twitter profile | Pikagi

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John Schoggins

@jschoggins

3,424

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814

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Professor curious about how mammals 🧘‍♂️🦇 🐭 fight viruses🦠Devote inordinate amounts of time to yoga, breadmaking, coffee. Views my own.

Dallas, TX

https://t.co/h8aLHb0ftc

Joined August 2014

Don't wanna be here? Send us removal request.

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@jschoggins

John Schoggins

1 year

In 1986 Staeheli et al seminal MX1 paper noted re: IFN/ISGs “it is not known...how many of these proteins are required for protection against a particular virus”. 37 yrs later, Phd student @mattbmcdoug 's new paper shines a light. 1/3

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Interferon inhibits a model RNA virus via a limited set of inducible effector genes | EMBO reports

image image ZAP, IFIT3, and IFIT1 are dominant effectors that restrict Venezuelan equine encephalitis virus, while comprising < 0.5% of the total interferon‐induced genes. Viruses may thus be...

www.embopress.org

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@jschoggins

John Schoggins

1 year

‘Niche publication’?! Oh nytimes…

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@jschoggins

John Schoggins

4 years

I am so excited my postdoctoral mentor Charlie Rice has received the Nobel Prize. A truly talented scientist and visionary in virology. What an honor and privilege to have spent 5 years in his lab.

@NobelPrize

The Nobel Prize

4 years

BREAKING NEWS: The 2020 #NobelPrize in Physiology or Medicine has been awarded jointly to Harvey J. Alter, Michael Houghton and Charles M. Rice “for the discovery of Hepatitis C virus.”

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John Schoggins

7 years

If you’re a scientist and feel strongly about this, make sure you ask yourself “what am I doing to effect change?” Check out @swingleft if you haven’t already. Promote science by flipping The House in 2018.

@swingleft

Swing Left

7 years

"The Republican effort to financially punish graduate students is striking...If a nation is to produce quality scholars then we need to make sure higher level education is affordable to everyone." #TrumpTaxScam

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John Schoggins

4 years

5 lingering COVID-19 questions: 1. Why do people respond so differently? 2. What’s the nature of immunity and how long does it last? 3. Has the virus developed any worrying mutations? 4. How well will a vaccine work? 5. What is the origin of the virus?

Five coronavirus mysteries scientists are still racing to solve

Nature - Six months into the outbreak, Nature looks at the pressing questions that researchers are tackling.

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@jschoggins

John Schoggins

5 years

It finally out! LY6E inhibits coronavirus, including SARS-CoV-2 (COVID-19) in vitro and mouse coronavirus in vivo. Our massive collab effort with @ProfVolkerThiel and RiceLab @RockefellerUniv . Co-first authors @katrinabmar @StephaniePfaen1 @UTSWNews

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LY6E impairs coronavirus fusion and confers immune control of viral disease

Zoonotic coronaviruses (CoVs) are significant threats to global health, as exemplified by the recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)[1][1]. Host immune...

www.biorxiv.org

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John Schoggins

4 years

SCIENCE wins!!

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John Schoggins

3 years

Well that was awful. Had a case of #breakthrough #COVID19 . Tested neg upon learning of exposure, but eventually symptomatic. Clinically “mild to moderate”, but experientially pretty miserable…posting more on that later. Just super grateful for vaccine! Happy to field questions.

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John Schoggins

4 years

@TheMenacheryLab I hope people realize how generous posting this data is. Thank you.

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John Schoggins

6 years

Looks like I’m a keeper!! #tenure

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John Schoggins

6 years

Wow. Mitochondria make double stranded RNA that activate innate immune responses.

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John Schoggins

3 years

Cloaked in mystery for decades, the RNA capping mechanism of coronavirus (SARS-CoV-2) is unveiled. Congrats to @UTSWNews colleague V.Tagliabracci & lead authors @ginajpark & A.Osinski for this amazing discovery. @HHMINEWS

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The mechanism of RNA capping by SARS-CoV-2

The SARS-CoV-2 RNA genome contains a 5’-cap that facilitates translation of viral proteins, protection from exonucleases and evasion of the host immune response1-4. How this cap is made is not...

www.biorxiv.org

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John Schoggins

4 years

I’m all for SciComm, but the explosion of discussion on Twitter about virus evolution and viral variants has devolved into a complete shit show, largely because of non-experts with blue checkmarks & large followings tweeting/publishing hyperbolic speculations. Needs to stop!

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John Schoggins

4 years

It should be abundantly clear by now that we need a better arsenal of antiviral therapies to treat active viral disease. Billions of dollars should go into basic research and development of new ways to treat human viral disease.

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John Schoggins

2 years

I’ve dabbled in very amateur photography for years. This might be one of the best photos I’ve ever taken. Cave of Wonders, Dominican Republic. Taken 7/14/22

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John Schoggins

5 years

It's finally out! An updated review article -- "Interferon-Stimulated Genes: What Do They All Do?" A veritable tome on all things ISGs+virus. Topics covered: What is an ISG? How many ISGs are there? How are antiviral ISGs identified? What do ISGs do?

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John Schoggins

4 years

I’m keen to meet TX Gov. Greg Abbott today & present our work on viruses/immunity/SARS-CoV-2. Key points: - Basic science is essential - model/unpopular viruses teach us about the nastier ones - COVID-19 is dangerous, hence the funny suits -masks good, hydroxychloroquine... meh

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John Schoggins

6 years

Regardless of content, the title of my next manuscript submission is going to be: “Single cell analysis of metabolome enriched microbiome after PD1 blockade of CRISPR modified cancer lacking Cryo-EM verified m6a methylation” Gonna leave out “in mice”. #sneaky

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John Schoggins

4 years

Now that more than 4700 high priority and other critical healthcare workers have received the vaccine at our institution, COVID laboratory researchers are eligible. 1st dose down, 2nd one in three weeks. Grateful and hopeful. @UTSWNews

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John Schoggins

4 years

Wasn’t quite sure how I felt about virtual conferences. But it’s Sunday, I’m hunkered down in my office all day at #cytokines2020 and used the coffee break earlier for some yoga. Win win! (This is padma mayurasana, or ‘lotus peacock pose’ for the yoga nerds).

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John Schoggins

4 years

So basically, humans are increasingly at risk for zoonotic disease because we are obsessed with invading ecosystems where we don’t belong. And then we blame the bats, etc. Ugh, we’re such an invasive, destructive species good at playing the victim card.

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John Schoggins

4 years

Lots of new folks to plus-strand RNA virology. Important to know that expressing viral proteins in isolation (esp. immune modulators) can reveal cool biology, but must be validated w/ real virus, which gives proper spatiotemporal viral gene expression and genome replication.

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John Schoggins

6 years

Our new study in @NatureMicrobiol -- A #CRISPR screen found this crazy potent antiviral protein called IFI6--it halts flavivirus replication at the ER. Congrats 1st author grad student @scientistblake , CRISPR guru Maikke Ohlson & others in lab.

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A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus...

Nature Microbiology - Flavivirus replication at the endoplasmic reticulum (ER) is targeted by the interferon response through blocking of the formation of virus-induced ER membrane invaginations by...

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John Schoggins

3 years

Taking a detour from all things interferon to present work on a non-interferon based restriction factor. Postdoc @Wenchun_Fan discovered TRIM7 as a potent inhibitor of multiple human enteroviruses. Now out in @CellPressNews @UTSWNews 1/7

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John Schoggins

4 years

Grant review comment: “The PI is a young investigator w/ outstanding track record...” Thank you so much, but if I may.... “The PI appears young, likely due to years of yoga and judicious use of moisturizer and sunscreen, but I digress, he is tenured and mid-career w/....”

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John Schoggins

3 years

Recently defended or about to finish your PhD? We have postdoc positions available to study host antiviral immunity. From molecular mechanisms to in vivo pathogenesis to comparative evolutionary approaches, there’s something for everyone.

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John Schoggins

5 years

Today marks 50 years since the Stonewall riots. So thankful my husband @ChrisFerguson33 and I were able to visit the Stonewall Inn recently and reflect on the trailblazers who fought for our rights. We owe them a debt of gratitude. #Stonewall50

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John Schoggins

3 years

Excited to share our lab’s latest paper, led by @HannersNatasha , showing that antiviral protein Shiftless inhibits flaviviruses in vitro (as shown by others) & using in vivo knockout model, it protects CNS from Zika infection and pathogenesis.

Shiftless inhibits flavivirus replication in vitro and is neuroprotective in a mouse model of Zika...

Flaviviruses such as Zika virus and West Nile virus have the potential to cause severe neuropathology if they invade the central nervous system. Th...

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John Schoggins

5 years

We made full length N gene RNAs for SARS-CoV-2 and MERS to help a clinical lab troubleshoot RT-PCR. Validated in homemade, non-optimized (and non-approved!) assay. Point is—RNAs available if needed, they’re NOT FDA-approved positive controls, just for troubleshooting or research.

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John Schoggins

4 years

Never thought we’d contribute to clinical trial for COVID-19, but here we are. With @HeshamS70605263 team, we found FDA-approved drugs that curb SARS-CoV-2 in cells. Clinical trial pending approval. Study in Chemrxiv. Details in thread. 1/10 via @figshare

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John Schoggins

6 years

Super cool antiviral mechanism of viperin revealed! Perspective: viperin discovered in 1997, antiviral activity in 2001, mechanism in 2018. The lesson: if your hot molecule is ‘scooped’, there may literally be decades of work left to do. Don’t fret!

A naturally occurring antiviral ribonucleotide encoded by the human genome

Nature - Viperin inhibits the replication of various viruses by catalysing the conversion of CTP to ddhCTP, which is a unique nucleotide that functions as replication-chain terminator of...

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John Schoggins

5 years

My husband’s so excited. His first official invitation to the university community!

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John Schoggins

5 years

Excellent article. Reads like the Significance section of my grants. Hopefully more answers coming soon. How Do Bats Live With So Many Viruses? - The New York Times

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How Do Bats Live With So Many Viruses? (Published 2020)

They are considered the probable source of the coronavirus outbreak spreading from China. It turns out that they may have an immune system that lets them coexist with many disease-causing viruses.

www.nytimes.com

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John Schoggins

8 years

@ChrisFerguson33 and I were excited to meet new friends at our @swingleft house party. Lots of inspiration and hope! #swingleft #TX32

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John Schoggins

5 years

Whoa! A sitting US Senator @SenatorLeahy tweeted what is basically the entire premise of my recent grant proposal to @NIH_CommonFund . Thank you Senator for bringing light to what is indeed an ‘urgent priority’.

@SenatorLeahy

Sen. Patrick Leahy

5 years

Hundreds of thousands of viruses lying dormant in animals have potential to infect humans. Proactive efforts to ID these pathogens & reduce pandemic risk must be an urgent priority for the US and other governments. My #CongressionalRecord statement:

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John Schoggins

6 years

This unusual antiviral response gene, LY6E, actually helps certain RNA viruses enter cells, a conserved function from mouse to human...our new study. Congrats to first author grad student @katrinabmar ! @NatureComms @UTSWNews

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John Schoggins

5 years

So glad another group has confirmed on Biorxiv (2020.04.02.021469) our original data showing LY6E inhibits SARS-CoV-2 + other coronaviruses--remarkably similar assays. Hopefully it was just a simple oversight not to include our study in their references.

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LY6E impairs coronavirus fusion and confers immune control of viral disease

Zoonotic coronaviruses (CoVs) are significant threats to global health, as exemplified by the recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)[1][1]. Host immune...

www.biorxiv.org

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John Schoggins

4 years

Pfizer: 90% Moderna: 94.5% Pfizer: actually, 95% Moderna: 95.1%??? Who’s efficacy is bigger? Will Pfizer stay in the lead? Can Moderna make up ground...perhaps in Maricopa County? Tune in tonight as Steve Kornacki brings us the latest.

@NPR

NPR

4 years

NEW: Pfizer's COVID-19 vaccine was found 95% effective in an updated study analysis. The company says it plans to file for FDA emergency use "within days."

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John Schoggins

5 years

Moms are great—concerned about my grants AND whether we’re going to work on new coronavirus. Oh, and I think mouse coronavirus is an amazing model...just clarifying.

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John Schoggins

5 years

As an editor, I find it concerning when corresponding authors suggest their grad school or postdoc mentors as potential reviewers. It feels like 1) complete cluelessness to the process, or 2) trying to game the system. Either way, leaves a not-so-great impression.

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John Schoggins

5 years

Amazing talk on the fungal world by @ACasadevall1 at our Molecular Microbiology retreat. My favorite intro comment: “Darwin had a huge data set and no mechanism—where would he publish today? This is a problem!”

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John Schoggins

4 years

You can take the scientist out of the lab but you can’t take the lab out of....oh whatever. My kitchen is my lab. Instead of viruses, it’s yeast and bacteria in sourdough starter...was obsessed long before the covid bread craze.

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John Schoggins

4 years

This paper deserves props. Here's why. RNA viruses like corona, flavi, and alpha must encode 3 capping enzymes-TPase, GTase, and MTase. For coronavirus, the GTase has (surprisingly) been a mystery for years. Authors show nsp12 is the missing GTase...wow!

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Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an...

Yan et al. present a cryo-EM structure of the SARS-CoV-2 replication and transcription complex that includes the single RNA-binding protein nsp9. The structural snapshot provides insight into how the...

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John Schoggins

5 years

Off to @GordonConf ‘Molecular Membrane Biology’. Super excited for my poster. Also pretty jazzed about this new coffee travel gear: Aeropress, burr manual grinder, CeramiSteel mug, and get this...a silicone collapsible electric kettle! This coffee thing is getting ridiculous.

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John Schoggins

4 years

“SARS-CoV-2-entry virus” has got to be one of the most misleading terms I’ve seen yet. It’s called: Vesicular 👏 stomatitis 👏 virus 👏 (thathappenstobepseudotypedwiththespikeproteinfromsarscov2)

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John Schoggins

4 years

Excellent review and a reminder from T. Pierson and M. Diamond that flaviviruses are also important emerging viral threats.

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The continued threat of emerging flaviviruses

Nature Microbiology - Flaviviruses, a group of vector-borne RNA viruses that includes dengue virus, West Nile virus, Zika virus and several lesser-known species, often emerge in human populations...

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John Schoggins

4 years

The images and movies in this paper of HIV capsids entering the nucleus are quite stunning.

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John Schoggins

1 year

New NIH grant review criteria starting Jan ‘25. 5 criteria reduced to 3, with study section no longer assessing several admin docs. Seems to be a positive change.

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John Schoggins

3 years

Here' my "n=1 / anecdote / was clearly bored" symptom diary of my #breakthrough #COVID19 case. And a short thread on things I found interesting about the disease process. (1/n)

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@jschoggins

John Schoggins

3 years

Well that was awful. Had a case of #breakthrough #COVID19 . Tested neg upon learning of exposure, but eventually symptomatic. Clinically “mild to moderate”, but experientially pretty miserable…posting more on that later. Just super grateful for vaccine! Happy to field questions.

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John Schoggins

4 years

Pro tip: don’t email your Texas colleagues today and expect a reply. They’re, um....kinda frozen.

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John Schoggins

1 year

👀Check it out! Our new study by @katrinabmar & co., using a panel of KO mice to show antiviral protein LY6E restricts coronavirus in multiple cell types (murine coronavirus) and in lung secretory/ciliated cells (SARS-CoV-2), limiting disease severity. 1/3

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John Schoggins

6 years

Yoga and science in the same write-up! Thanks @UTSWNews !! A new twist on CRISPR technology: In Pursuit - UT Southwestern, Dallas, Texas

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John Schoggins

5 years

A fantastic retrospective on 4 decades of coronavirus research by @weisssr . We stumbled into coronavirus work just 2 years ago, and many others are also new to the field with COVID-19. Nice to have the historical highlights laid out for us.

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John Schoggins

5 years

I love seeing trainees share their very 1st pubs. Mine was 20 years ago this week, which makes me feel like a relic. But I still remember the sheer excitement and disbelief that a low income 1st-gen college kid got published. Keep sharing your stories!

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Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition

Abstract. UV light is a complete carcinogen, inducing both basal and squamous cell skin cancers. The work described uses the selective COX-2 inhibitor cele

academic.oup.com

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John Schoggins

6 years

It’s a good day when your post-doc mentor is in town and gives a seminar that is not only scientifically engaging and thought provoking, but also inspiring. Thanks Charlie Rice!

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John Schoggins

4 years

We have an opening for PhD-level Scientist to lead independent and collaborative BSL2 & BSL3 studies on virus-host interactions in vivo (viruses: flavi, alpha, corona, & flu). Also open to discuss traditional academic postdoc opportunities. Job Details

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John Schoggins

6 years

Thanks @ImmunityCP for including all things interferon in the 25th Anniversary compendium.

@ImmunityCP

Immunity

6 years

. @LazearLab , @jschoggins , & Michael Diamond review the "Shared and Distinct Functions of Type I and Type III #Interferons " #Immunity25th

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John Schoggins

5 years

Amazing talk by my colleague and good friend @jkpfeiff at the @UTSWNews University Lecture Series. Pretty much a master class in how to give a prestigious seminar to trainees, colleagues, chairs, deans, academy members, and Nobel laureates...all of whom were in attendance.

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John Schoggins

5 years

I have to say, I love seeing all the coronavirus experts chiming in with their understanding about this new virus in China. Watching this unfold in real time is kinda riveting.

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John Schoggins

2 years

The people who design manuscript submission systems have clearly never submitted a manuscript.

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John Schoggins

3 years

Well this is unexpected. Rather than a protein substrate, bacterial modification by ubiquitin occurs on LPS, triggering antibacterial pathways. The responsible E3 ligase is RNF213, which, though not mentioned much in paper, is highly interferon inducible.

Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection

Nature - Upon Salmonella invasion of the mammalian cytosol, ubiquitylation of a non-proteinaceous substrate—the lipid A moiety of bacterial lipopolysaccharide—by the E3 ubiquitin ligase...

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John Schoggins

4 years

I wanna see the melt curve and Ct value...daily.

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John Schoggins

3 years

Congrats to @_iboys , the recipient of the 2021 Nominata Award, the highest honor for academic and research accomplishment given by the @UTSWNews graduate school to an advanced graduate student. Great job Ian!

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John Schoggins

1 year

Huge congrats to @Duplicate_Wells in our lab for being named a Hanna Gray Fellow by @HHMI !!

@HHMINEWS

HHMI

1 year

🎉 Today we're thrilled to announce our 2023 #HannaGrayFellows ! Please join us in welcoming and celebrating these outstanding early career scientists! Learn more:

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John Schoggins

4 years

Notes on viruses and bacteria, high school biology, Jan 1992. This is what happens when you take a ‘vacation’ and have nowhere to go.

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John Schoggins

4 years

A tour de force analysis of RNA virus dynamics at single virus resolution. Emerging theme: similar to flaviviruses, interferon suppresion of enterovirus is dominated by ISGs that target viral RNA replication, but not so much earlier stages of viral cycle.

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John Schoggins

4 years

Y’all...it’s out! 👀👇 @katrinabmar & @StephaniePfaen1 study on human LY6E inhibiting many coronaviruses, incl. SARS-CoV-2, and mouse Ly6e modulating immunity to mouse coronavirus. Congrats to all authors, what a great collab with @ProfVolkerThiel and Charlie Rice labs.

@katrinabmar

Katrina Mar

4 years

From preprint to... paper! I'm very excited to share the final product from a fun and fruitful collaboration with @StephaniePfaen1 and @michailidis_hbv @ProfVolkerThiel @jschoggins +Charlie Rice, available today @NatureMicrobiol !

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John Schoggins

4 years

Well, this is just outstanding - antiviral viperins in bacteria!

@AudeBer

Aude Bernheim

4 years

Stoked to report in @nature the discovery of prokaryotic viperins, which naturally produce diverse anti-viral molecules ! After providing us with antibiotics, bacteria might become sources of novel anti-viral drugs. (1/9)

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John Schoggins

6 years

Congratulations to @mattmcdouggie , 1st year PhD student in our lab, for receiving a NSF GRFP award!! Well done Matt! #NSFGRFP

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John Schoggins

6 years

Congrats to grad student, now Dr!!!, @katrinabmar for successfully defending her PhD dissertation today. Celebrating with skull cake and rosé...The future of viral immunology is bright!

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John Schoggins

6 years

Congratulations to @scientistblake for successfully defending his PhD dissertation!

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John Schoggins

3 years

Postdoc position(s) available in the area of antiviral innate immunity and virus-host interactions--funded by NIH and The Clayton Foundation. Details in @jobRxiv listing below.

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John Schoggins

4 years

I wonder if Susan Collins is “deeply concerned” yet.

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John Schoggins

6 years

From eLife's peer review expt: "The most concerning result in the trial so far is that late-career last researchers appear to be more successful than their early- and mid-career colleagues in passing the initial evaluation into peer review." It's called BIAS!

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John Schoggins

5 years

I don't understand people who can't simply send a "decline" when asked to peer review rather than ignore the request. In fact, I'd even prefer a "NO, f&*k off, I hate you, stop emailing me." At least that way I'd know it's a legit decline.

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John Schoggins

5 years

It’s official....Congratulations Dr. Mar!! @katrinabmar

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John Schoggins

5 years

Thanks for your great work @cziscience . Don’t forget the viruses. Nearly 200 different viruses can cause disease in humans. There are no effective ways to treat more than 90-95% of them. Would be amazing to have an RFA on that.

@cziscience

CZI Science

5 years

There are no effective ways to cure, prevent or treat most neurodegenerative diseases like #Alzheimers , #Parkinsons and #ALS . Our new RFA aims to help change that

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John Schoggins

4 years

It’s official! @mattbmcdoug , NSF grad fellow in our lab, is a PhD candidate—successfully defended his Qualifying Exam today. Congrats Matt!

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John Schoggins

5 years

Driving to airport: “I will not buy junky airport food...egg whites and almonds only!” 10 minutes past security: “Hi, can I have a blueberry muffin? Actually no, make it chocolate chip.”

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John Schoggins

7 years

Bat cells have some interesting/unique antiviral features—our lab’s new study by grad student Pam De La Cruz Rivera, collab with @BioinfoMcDermot . From @biorxivpreprint to @J_Immunol

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John Schoggins

3 years

Similar story. When I got to grad school, a pretty famous Prof told us students that we were ‘junior colleagues’ learning from and training with ‘senior colleagues’. I’ll never forget that…it was welcoming and really dialed down the intimidation I felt being around PIs.

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@jschoggins

John Schoggins

6 years

@HarmitMalik Words I dread hearing most in very short talks: “now I’m gonna switch gears”. NO! It’s a 12 minute talk. There’s only one gear.

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@jschoggins

John Schoggins

3 years

Congratulations Dr. Boys for a rigorous and scholarly private defense yesterday, followed by an fun and informative public presentation of your work today. Onward and upward! @_iboys

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@jschoggins

John Schoggins

8 years

Congrats to my trailblazing colleague and friend @jkpfeiff for her recent promotion to Full Professor at #UTSW !!

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@jschoggins

John Schoggins

3 years

If you haven’t checked out the fantastic story on OAS1 as an inhibitor of SARS-CoV-2 and a determinant of severe COVID-19, please do. Tour de force by @virologist_atu @SamJWilsonPhD and co. now out in @ScienceMagazine and my Perspective linked below. 👇

@WilsonLabCITIID

Wilson Lab

@WilsonLabCITIID

3 years

A big thanks to @jschoggins for writing the perspective:

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John Schoggins

4 years

I am deeply saddened by the loss of colleague Beth Levine, who inspired me from the first time we met at my recruitment to UTSW. She was deeply supportive of me and my trainees, a generosity on par with her world class science. I am humbled and grateful to have known her.

@michael_shiloh

Michael Shiloh, MD, PhD

@michael_shiloh

4 years

Beth was an inspiration, not only as one of the preeminent scientists in the world, but also for her humanity. She cared deeply for the success of her friends, colleagues & mentees. I cherish every memory of her & the lessons she imparted. May her memory be a blessing. @UTSWNews

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John Schoggins

5 years

Congratulations to the 2019 Rita Allen Foundation Scholars!! Looking forward to meeting in August. @chromism @mike_doc_B @JosieClowney @Meaghan_Creed @DrPeterGrace @KochMeghan @jordacular @alaurenoconnell @TawfikLab @lizzyzhao

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Announcing the 2019 Rita Allen Foundation Scholars - Rita Allen Foundation

Investing in transformative ideas in their earliest stages to promote breakthrough solutions to significant problems

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@jschoggins

John Schoggins

2 years

Our lab's @mbiojournal study using a new twist on a classic CRISPR screen to identify key ribosome biogenesis factors (SBDS and SPATA5) required for replication of diverse RNA and DNA viruses. Congrats to @MaikkeO et al!!

Genome-Scale CRISPR Screening Reveals Host Factors Required for Ribosome Formation and Viral...

Viruses are well known for their ability to co-opt host ribosomes to synthesize viral proteins. The specific factors involved in translation of viral RNAs are not fully described.

journals.asm.org

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John Schoggins

4 years

426 new human genomes from Africa, comprising 50 ethnolinguistic groups, reveal “62 previously unreported loci that are under strong selection, which were predominantly found in genes that are involved in viral immunity, DNA repair and metabolism”.

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High-depth African genomes inform human migration and health

Nature - Whole-genome sequencing analyses of African populations provide insights into continental migration, gene flow and the response to human disease, highlighting the importance of including...

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@jschoggins

John Schoggins

4 years

Some impressive virological data on SARS-CoV-2 infection in human intestinal cells. bioRxiv viewer

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@jschoggins

John Schoggins

2 years

I miss the 5 years as a postdoc when I got to hear these nuggets of wisdom on a regular basis.

@NobelPrize

The Nobel Prize

2 years

"I think the successful scientists are really doing it because they’re curious and they’re doing this because there’s nothing else we’d rather be doing." - 2020 medicine laureate Charles Rice. Read our interview with him:

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John Schoggins

6 years

Was excited to learn there are algorithms to find proline induced kinks in an alpha helix. Turns out google searching “kink finder” was a bit naive. Yikes...

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@jschoggins

John Schoggins

5 years

Clarification for non-scientists: LY6E is a naturally occurring protein in humans (& all mammals in fact). We all have it and it may be one of the ways our bodies naturally fight the virus. Currently unclear if we can harness LY6E’s effects for treatment. More studies needed.

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@jschoggins

John Schoggins

4 years

Still surprised by some of the PPE for SARS-CoV-2 I see. Trainees doing the work might want to ask their employers, PIs, and biosafety committees to provide HEPA/PAPR and head-to-toe Tyvek. N95+face shield+gown affords some protection, but there are safer setups.

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John Schoggins

7 years

My new mini-review on "Recent advances in antiviral interferon-stimulated gene biology" published by @F1000Research ,

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John Schoggins

5 years

Thank you @LaVendrickS for the accurate and sober report in @Dallasnews on our recent coronavirus study. "Researchers at UT Southwestern have helped identify a human protein they say inhibits the coronavirus."

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UT Southwestern researchers help identify human protein that inhibits coronavirus

Researchers at UT Southwestern have helped identify a human protein they say inhibits the coronavirus. The protein LY6E is produced naturally by the human...

www.dallasnews.com

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@jschoggins

John Schoggins

2 years

TRIM7 Act 2: Last year, postdoc @Wenchun_Fan published that TRIM7 is an antiviral protein that inhibits human enterviruses (PMID: 34062120). In an interesting twist, he now shows that that 3C protease from certain enteroviruses can cleave TRIM7. (1/4)

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Enterovirus 3C Protease Cleaves TRIM7 To Dampen Its Antiviral Activity | Journal of Virology

Enteroviruses are significant human pathogens that cause viral myocarditis, pancreatitis, and meningitis. Knowing how the host controls these viruses and how the viruses may evade host restriction is...

journals.asm.org

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@jschoggins

John Schoggins

5 years

The nitty-gritty of how Zika virus enters cells--our new study led by recent graduate Nick Rinkenberger. @MicrobeTweets

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John Schoggins

6 years

I think there's lots of people who still manually edit/update their clunky biosketches. Why? SciENcv is amazing....generates your bio and autopopulates references from NCBI. Check it out!

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