Hiten Madhani MD PhD @hitenmadhani Twitter profile

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Hiten Madhani MD PhD

@hitenmadhani

3 years

New billboard in San Francisco.

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Hiten Madhani MD PhD

@hitenmadhani

4 years

No, not a software problem. More like a biochemistry, genetic, cell and developmental biological, and whole animal complex physiology problem only adressable by decades of federally supported experimental research that makes rocket science seem easy...

Elon Musk

@elonmusk

4 years

@SamTalksTesla @tlowdon @daniellevitt22 In principle, I think synthetic RNA (and DNA) has amazing potential. This basically makes the solution to many diseases a software problem.

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Hiten Madhani MD PhD

@hitenmadhani

2 years

Our latest work is out today in @Nature ! Forward yeast genetics meets innate immunity to reveal a secreted effector produced by a human fungal pathogen that promotes pathogenic macrophage polarization via TLR4 and STAT3. 1/5

Secreted fungal virulence effector triggers allergic inflammation via TLR4

Nature - Cryptococcus neoformans secretes CPL1 protein, which induces alternative activation of macrophages via Toll-like receptor 4 in mice and is essential for fungal virulence.

www.nature.com

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Hiten Madhani MD PhD

@hitenmadhani

6 years

Dear Journal Editors: Character limits should not include methods and references -- it's bad for science.

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Hiten Madhani MD PhD

@hitenmadhani

5 years

RT if you dare! Out in @CellCellPress today. A revolutionary paper from Sandra Catania in the lab along with important contributions by Phillip Dumesic in the lab and …

Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo...

The pathogenic fungus Cryptococcus neoformans encodes a functional maintenance methyltransferase for 5mC but no de novo enzyme; 5mC has been maintained for millions of years by a combintation of...

www.cell.com

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Hiten Madhani MD PhD

@hitenmadhani

2 years

Deeply saddened by the passing of Prof. Christine Guthrie, a brilliant and brave scientist who had an enormous influence on the lives of many including my own. 1/6

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Hiten Madhani MD PhD

@hitenmadhani

3 years

That was fast.

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Hiten Madhani MD PhD

@hitenmadhani

1 year

I ran into a former UCSF student who now has 10 yrs of experience in biotech (oncology). She said that the top companies hire people who are well-trained in how to think/ask questions rather than a specific technique or topic (which changes fast). #basicscience

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Hiten Madhani MD PhD

@hitenmadhani

4 years

This whole “Let’s make WFH a permanent thing” movement underestimates the many benefits of random /ad hoc /hallway interactions and the barrier zoom scheduling is to just having a chat. I for one have had enough WFH for a lifetime.

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Hiten Madhani MD PhD

@hitenmadhani

2 years

🥳🎉I am delighted to announce that the Madhani lab @UCSF is recruiting at all levels. 2-3 staff and 2-3 fellows. Staff: 1 PhD-level scientist to oversee a cell biology resource development project with 1-2 technicians. Job ads are being spun up now. And... 1/2

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Hiten Madhani MD PhD

@hitenmadhani

4 years

I am pleased to announce that we have completed our Cryptococcus neoformans knockout collection. Strains are available without restriction via the Fungal Genetic Stock Center (). New QC information is also included.

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Hiten Madhani MD PhD

@hitenmadhani

6 years

Batch effects are the bane of genomics experiments. Sometimes I get strange looks when I say that controls and experimentals need to be prepared on the same day with the same batches of culture media. This paper from 2010 explains why as well as any.

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Hiten Madhani MD PhD

@hitenmadhani

5 years

20th anniversary of our lab @UCSF this month!! Advice: 1) decide on your scientific and personal values and 2) never stop fighting for them, 3) minimize effort on tasks/people that don’t support your values, 4) be (very) patient and 5) take advice with a grain of 🧂

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Hiten Madhani MD PhD

@hitenmadhani

1 year

“even yeast cell biologist”

Katharina Schmack

@KathaSchmack

1 year

I want my children to follow their passions, not my expectations. They can pick any profession they want: neuroscientist, immunologist, even yeast cell biologist, all sound wonderful to me.

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Hiten Madhani MD PhD

@hitenmadhani

5 years

Lab closed & everyone is 'sheltering in place.' I told the lab that we're not have any Zoom meetings until next week -- let's take some mental health time to adjust and re-orient.

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Anybody else being asked to decide who is allowed back in lab? Talk about amplifying inequities. I'm not even sure I have any legal authority to decide. And we're supposed to negotiate with adjacent labs. Imagine an assistant professor negotiating with a full professor...

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Point I make repeatedly to trainees: the probability that your paper is accepted is proportional to the clarity and persuasiveness of the writing and figure presentation. It’s at least as important as the results themselves.

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Hiten Madhani MD PhD

@hitenmadhani

6 years

Observation: peoples' reaction to papers on phase separation in cells separates into two groups that do not seem to want to mix. #irony

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Great to be recognized by @AAAS ! Grateful to past and present lab members who drove basic science projects that pushed the envelope to reach new heights. Looking forward to the next unexpected discoveries!

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Hiten Madhani MD PhD

@hitenmadhani

3 years

*ALERT* NIH may be trying to make your favorite model organism database disappear. It is imperative that you respond to the survey link described on this page Tell them why they shouldn't kill SGD, flybase, wormbase, ZFIN, etc. Please RT!

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Self care sometimes means purchasing a Father’s Day gift for yourself. Don’t judge me.

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Hiten Madhani MD PhD

@hitenmadhani

5 years

@vidaahyong We have at least a couple in our lab at Genentech Hall. Still need them?

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Hiten Madhani MD PhD

@hitenmadhani

5 years

Best seminar title ever? Looking forward to hosting ⁦ @ZandersLab ⁩ next Tuesday!

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Is it too much to ask for free parking for lab members so they don’t have to use mass transit?

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Just explained to my brother (who has a PhD from @MIT ) exactly what a virus is and how they replicate and are transmitted. He didn’t seem to know. And why should he - he studied robotics. Now I might understand why @elonmusk is upset about lockdowns-he doesn’t know either.

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Please retweet : Fully funded postdoctoral position available for any PhD student who publishes “Four Seasons Landscaping” as a gene name.

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Hiten Madhani MD PhD

@hitenmadhani

3 years

Congratulations to my friend, collaborator, and colleague Geeta Narlikar on election to the US National Academy of Sciences!

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Hiten Madhani MD PhD

@hitenmadhani

5 years

Emails going around the @UCSF campus asking PIs if they have a particular Roche qPCR instrument. The question I have is why the Federal Government isn't buying Roche qPCR machines, RNA extraction, and RT-PCR kits for every hospital lab in the country now. @SpeakerPelosi

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Hiten Madhani MD PhD

@hitenmadhani

3 years

Paper accepted. Nice way to start a week.

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Hiten Madhani MD PhD

@hitenmadhani

7 years

Basic science research is not merely an investment. It is the embodiment of human curiosity and a foundation of a progressive society.

UC San Francisco

@UCSF

7 years

Basic science research is an investment in the future. #UCSFStandsUp

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Hiten Madhani MD PhD

@hitenmadhani

6 years

Thoughtful advice from Ron Vale. Focus on the joy of discovery (yours and others). Keep Your Eyes on the Prize

Keep Your Eyes on the Prize

It is a great honor for me to receive the prestigious Gairdner Award for Biomedical Research. The title of this essay might imply that it will contain advice on how to win such a major scientific...

www.cell.com

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Hiten Madhani MD PhD

@hitenmadhani

3 years

🎉🥳Paper accepted @MolecularCell ! Congrats to Sandra Catania in the lab on her 3rd paper on Dnmt5! Three very positive reviews with minimal additional data required. A good mid-week boost. Almost identical to this preprint:

Structural basis of ATP-dependent high-fidelity epigenome maintenance

Epigenetic evolution occurs over million-year timescales in Cryptococcus neoformans and is mediated by DNMT5, the first maintenance-type cytosine methyltransferase identified in the fungal or protist...

www.biorxiv.org

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Hiten Madhani MD PhD

@hitenmadhani

7 years

Is "Helicopter PI" a term? Been suggesting to jr. PIs that giving people more responsibility for their research is good for all involved. Students shouldn't confuse good mentoring with being given constant direction. RT if you agree -- maybe it will help.

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Hiten Madhani MD PhD

@hitenmadhani

3 years

**POSTED TODAY!** We are HIRING. At least 2 tenure-track faculty positions, one in my Dept (Biochemistry and Biophysics) and one in the Cellular and Molecular Pharmacology Dept. , both at the Mission Bay Campus (ignore the photo below!) 1/

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Friends: excited to receive an NOA from NIH in support of our SARS-CoV-2 work with Raul Andino (in addition to funding from FastGrants and LGR already in hand). Pls RT as we seek 1-2 postdoctoral fellows (with mol. bio. training) to move this work forward rapidly. Thanks.

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Faculty meeting quotes: "I'm on a task force but we don't know what the task is and what force we have." "What's the difference between a task force and a committee?"

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Recently a collaborator told me that I write so well that I should write the entire grant. So I did. At least this way I didn’t have to deal with mediocre writing. But now I feel used. But paradoxically also satisfied as the grant does read really well. Sigh.

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Hiten Madhani MD PhD

@hitenmadhani

4 years

When I was an assistant professor, a senior faculty member implied that I was dressed too casually (I was wearing a t-shirt and shorts). In my defense, I didn't care.

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Hiten Madhani MD PhD

@hitenmadhani

6 years

Apparently there is a giant budding yeast cell beyond our solar system.

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Hiten Madhani MD PhD

@hitenmadhani

3 years

Just signed up my 12 yr old for dose 1 tomorrow at the local Walgreens. First time ever that she is excited about a vaccination.

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Hiten Madhani MD PhD

@hitenmadhani

4 years

I can’t count the number of times I’ve been asked this. Then when I say I was born in London but grew up in Seattle people say ‘but you have no accent’. Then I say we moved to Kenya when I was a few months old and the US when I was 5 and they get really confused.

Nuwan Dissanayaka

@nuwandiss

4 years

For anyone who’s ever said “But where are you really from?”

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Hiten Madhani MD PhD

@hitenmadhani

4 years

A devastating loss. Everybody loved her. For her brilliance, honesty, bluntness, loyalty and zest for life. And she was funny. So very funny. Rest In Peace dear dear friend. Deepest condolences to her family and the @MIT community.

IMP

@IMPvienna

4 years

We are very sad that @AngelikaAmon , first generation PhD student at the IMP, former IMP board member, and lifelong friend of the house, has lost her battle against cancer. Her contributions to science form a lasting legacy we are grateful for. Our thoughts are with her family.

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Better days with @AngelikaAmon . I’ve been fortunate to have two of her trainees in my lab. Of course I could not live up to their expectations of a PI. She was always supportive of me from the time of my job search to hosting me for a seminar any time I was in town.

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Hiten Madhani MD PhD

@hitenmadhani

5 years

“Shields up!” Congrats to our 3rd floor Genentech Hall neighbor ⁦ @joeBondyDenomy ⁩ and lab on their latest. A bacteriophage nucleus-like compartment shields DNA from CRISPR nucleases | Natuure

A bacteriophage nucleus-like compartment shields DNA from CRISPR nucleases

Nature - The jumbo phage ΦKZ constructs a proteinaceous nucleus-like compartment around its genome that protects phage DNA from degradation by DNA-targeting immune effectors of the host,...

www.nature.com

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Hiten Madhani MD PhD

@hitenmadhani

9 months

The truth from Ruth! @REMLehmann cc: @NIHDirector

Basic science is not just a foundation

Nature Cell Biology - Intellectual freedom for scientists, unconstrained by commercial interests and direct application, fuels unexpected discoveries. Curiosity-driven, basic science has yielded a...

www.nature.com

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Hiten Madhani MD PhD

@hitenmadhani

2 years

🔥Preprint alert 🔥 Phenomenal work from postdoctoral fellow Irene Beusch @pauletteoctopus brings a yeast genetics mindset to an essential process in human cells, obtaining new insight into the function of a new player in human cancer. 🧵1/n

Targeted high throughput mutagenesis of the human spliceosome reveals its in vivo operating...

The spliceosome is a staggeringly complex machine comprising, in humans, 5 snRNAs and >150 proteins. We scaled haploid CRISPR-Cas9 base editing to target the entire human spliceosome and interrogated...

www.biorxiv.org

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Hiten Madhani MD PhD

@hitenmadhani

5 years

Big loss for @UCSF . Great gain for @WhiteheadInst .

Whitehead Institute

@WhiteheadInst

5 years

Whitehead Institute announced today that the globally respected cell biologist Jonathan Weissman has become the Institute’s newest Member and will be the inaugural Landon T. Clay Professor of Biology at Whitehead Institute:

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Dranonican cuts by NIH to model organism databases, particularly a 50% cut in funding for the Saccharomyces genome database. Please contact your representative and ask that funding be restored. Please RT. @NIH @NIHDirector @SpeakerPelosi MODs in need

MODs in need

Lab Animal - MODs in need

www.nature.com

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Hiten Madhani MD PhD

@hitenmadhani

6 years

Keep talking. This will make it only easier for us to recruit the best to @UCSF and raise money from donors.

Jeffrey Flier

@jflier

6 years

As a dean of a major academic institution, I could not have said this. But I will now. Requiring such statements in applications for appointments and promotions is an affront to academic freedom, and diminishes the true value of diversity, equity of inclusion by trivializing it.

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Hiten Madhani MD PhD

@hitenmadhani

4 years

I have a joke about Cell, but I can’t legally access it @UCSF .

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Eventually we’ll have an alliance of all of the states. Call it the ‘United States’ or something catchy like that.

Emily Hoeven

@emily_hoeven

4 years

BREAKING: Nevada and Colorado join California, Oregon and Washington's "Western States Pact," a regional vision for fighting COVID-19 & modifying stay-at-home orders

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Hiten Madhani MD PhD

@hitenmadhani

3 years

12 yr old got Pfizer shot 1 today. Still won’t do her homework that’s due tomorrow, so...we’re all good.

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Rotation student from hell..

James McInerney

@jomcinerney

4 years

For years afterwards Boris cursed that they didn’t just read his CV, with its mesmerising Latin quotes, but unfortunately they asked him to demonstrate his skill set.

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Hiten Madhani MD PhD

@hitenmadhani

3 years

Taking the long way home today.

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Hiten Madhani MD PhD

@hitenmadhani

5 years

A well-written abstract can bolster your chances of publication by stating the major points up-front in a clear and concise manner. Here is an example.

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Phase separation field continues to be phase-separated.

Tjian + Darzacq Group

@TjianDarzacq

4 years

In case you missed Tij’s quote on the recent @BoijaAnn @IsaacAKlein @youngricka condensate paper:

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Hiten Madhani MD PhD

@hitenmadhani

5 years

@UCSF has announced a hiring freeze for all staff and academic positions through June of 2021. Difficult to understand as PIs are paying for their people through grants and fellowships. And if people are doing SARS-CoV-2-related work they may need to hire. Doesn't add up.

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Hiten Madhani MD PhD

@hitenmadhani

3 years

HAPPY FRIDAY! Ending the week with a preprint post and a 🧵 ! New work on how a deadly fungal pathogen reprograms innate immunity to its advantage. Hold on to your hat-- there's a lot here to explain: (1/n)

bioRxiv Immunology

@biorxiv_immuno

3 years

Mechanism of innate immune reprogramming by a fungal meningitis pathogen #biorxiv_immuno

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Hiten Madhani MD PhD

@hitenmadhani

8 months

Thanks to ⁦ @doudna_lab ⁩ for visiting and giving a terrific seminar on the latest in Cas9 basic science and its application. An enzyme for the ages!

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Hiten Madhani MD PhD

@hitenmadhani

1 year

🔥🥳🎉The work we reported at the @RNASociety meeting in Boulder last June is out *TODAY* in @MolecularCell ! Congratulations to Irene Beusch ( @pauletteoctopus ) and coauthors. Tweetorial on preprint:

Molecular Cell

@MolecularCell

1 year

Online Now: Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles

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Hiten Madhani MD PhD

@hitenmadhani

3 years

Pls RT🙏🙏 Two weeks before we start looking at applications for at least two faculty tenure-track hires. Find out more by ....1/

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Solidarity with my female colleagues today (from someone who had a female thesis advisor). What nonsense.

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Hiten Madhani MD PhD

@hitenmadhani

5 years

Does nobody remember the boiling lysis miniprep?

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Hiten Madhani MD PhD

@hitenmadhani

2 years

Oh great -- my flooded car made the @nytimes . Dude standing to the door is the driver of a different submerged car that I am chatting with from the cab. Tow truck driver came back for him.

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Hiten Madhani MD PhD

@hitenmadhani

6 years

If I could name a new Drosophila gene it would be called Childish Gambino.

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Hiten Madhani MD PhD

@hitenmadhani

6 years

Our paper on Spliceosome Profiling it out! Back to back with similar work from @mooreorless62 . I remember first meeting Melissa at a CSHL RNA processing meeting when she was a postdoc and I was a student. We've come full circle!

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Just did an (unpaid) 1 hr outreach session for a corporation explaining to 500 employees how vaccines work, how the mRNA vaccines work and why I consider them extremely safe. Reach out to your non-science local networks -- there is a LOT of demand out there. Do some good!

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Hiten Madhani MD PhD

@hitenmadhani

6 years

⁦ @stephenfloor ⁩ is teaching Linux command line to our incoming Tetrad program students @UCSF . Computational skills are increasingly necessary to be an experimental biologist.

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Hiten Madhani MD PhD

@hitenmadhani

3 years

A decade late to the Cas9 party but we finally made it. And for a good cause: we can now engineer the genome of Cryptococcus neoformans using just 50 bases of targeting homology and an electroporator. 1/3

Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables...

Cryptococcus neoformans , the most common cause of fungal meningitis, is a basidiomycete haploid budding yeast with a complete sexual cycle. Genome modification by homologous recombination is...

www.biorxiv.org

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Hiten Madhani MD PhD

@hitenmadhani

5 years

piRNAs against a germline-transmitted retrovirus in Koala Bears are derived from unspliced RNA suggesting that stalled spliceosomes are a trigger! Delighted to see that this mechanism seems to be conserved from yeast (Cryptococcus) to mammals! Cell

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Hiten Madhani MD PhD

@hitenmadhani

4 years

If you don't get a response to an email that you sent to me today, please resend after January 20th.

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Good morning Genentech Hall!

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Hiten Madhani MD PhD

@hitenmadhani

5 years

Never gets old: the look on the face of a lab member when they learn that their paper is accepted in principle. One of the best aspects of being a PI. #epigeneticsrules

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Like RNA? If so, check out our latest: Coupling of spliceosome complexity to intron diversity

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Hiten Madhani MD PhD

@hitenmadhani

3 years

Intronic sequences (but not splicing) protect genes from HUSH-mediated silencing. Another example of the Frustrated Gene concept. Intriguing work from Paul Lehner's Group. Genome surveillance by HUSH-mediated silencing of intronless mobile elements

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Hiten Madhani MD PhD

@hitenmadhani

2 years

Is a PNAS communication really a peer-reviewed paper? It would seem more like a preprint with comments from a couple of friends. If they are indexed in PubMed then shouldn't preprints also be?

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Mini-Professor—>Midi-Professor—>Maxi-Professor

Keith Schnakenberg

@keithschnak

4 years

Assistant Professor —> Associate Professor —> Professor is extremely lame and makes my friends think I’m an apprentice to a professor. Professor should be the bottom rank and it should be Professor —> Advanced Professor —> Master Professor

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Hiten Madhani MD PhD

@hitenmadhani

4 years

Appreciation is nice. Robust funding would actually help. Academic research has been underresourced. Yet how do we know anything about coronaviruses? You guessed it: academic research. But we could have been much further along and for pennies on the bailout dollars.

Andy Slavitt 🇺🇦

@ASlavitt

4 years

I hope when this is all done, we will have a new appreciation for scientists.

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Hiten Madhani MD PhD

@hitenmadhani

2 years

New office deco. Thanks to Rob at Frames on 3rd for his excellent service.

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Hiten Madhani MD PhD

@hitenmadhani

1 year

Intrinsic mesoscale properties of a Polycomb protein underpin heterochromatin fidelity | Nature Structural & Molecular Biology

Intrinsic mesoscale properties of a Polycomb protein underpin heterochromatin fidelity

Nature Structural & Molecular Biology - Here, the authors show that anchoring of the PRC2 complex to its own sites requires nuclear condensation of Ccc1, a H3K27me3 reader in the yeast...

www.nature.com

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Hiten Madhani MD PhD

@hitenmadhani

6 years

This view on the bike ride to work ⁦ @UCSF ⁩ is the reward for going over the hill instead of around it. True for science as well.

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Hiten Madhani MD PhD

@hitenmadhani

6 years

Chromosome number evolvability is evolvable! Thrilled to be part of work Suzanne Noble showing evolution of a H2A variant and regulated CENPA deposition enables programmed aneuploidy. Chromatin rewiring mediates programmed evolvability via aneuploidy

Chromatin rewiring mediates programmed evolvability via aneuploidy

Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis[1][1], and yet specific aneuploidies can be adaptive during environme...

www.biorxiv.org

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Hiten Madhani MD PhD

@hitenmadhani

4 years

My question: why hasn’t @USCF solved the bureaucratic problem that prevents PIs from reimbursing lab members, especially trainees, for parking costs during a pandemic? Or why haven’t fees been waived altogether?

Campus Life Services

@UCSF_cls

4 years

Do you have questions about parking at UCSF? Whether you work on campus or just visiting, we can help you understand the various parking rates.

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Hiten Madhani MD PhD

@hitenmadhani

5 years

Never thought we would be running MonoQ columns in the lab, but here we are. Genetics can’t solve all problems — just most of them!

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Hiten Madhani MD PhD

@hitenmadhani

9 months

Congratulations to my colleague and friend Geeta Narlikar on being appointed as our next department chair (our Dept rotates its chairs). Thanks to Geeta for taking on this thankless job!

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Hiten Madhani MD PhD

@hitenmadhani

1 year

Nice day for a hike with some epigenetic friends!

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Hiten Madhani MD PhD

@hitenmadhani

2 years

Three weeks before the app deadline for our faculty search! If you're looking for a collegial and collaborative environment in which to do cool science (in any area) consider applying. Great colleagues, facilities and city!

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Hiten Madhani MD PhD

@hitenmadhani

6 years

Sometimes when I get an @NIH grant funded I get a nice letter from my rep @NancyPelosi congratulating me on it. Nice to have a rep that appreciates the value of scientific research @UCSF .

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Hiten Madhani MD PhD

@hitenmadhani

5 years

San Francisco is gearing up to test and trace every COVID case. @UCSF medical students are going to help. @czbiohub is ramping testing up even more. San Francisco is should one of the safer places to be in the next couple of years. #publichealth

How San Francisco plans to trace every coronavirus case and contact

Assembling a team to identity and isolate infections could be a crucial step in getting the city back to work.

www.technologyreview.com

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Hiten Madhani MD PhD

@hitenmadhani

5 years

A love letter to the phase separation field this is not.

Genes & Development

@GenesDev

5 years

This Perspective finds that the evidence for in vivo LLPS is often inadequate and urges the application of more stringent criteria to understand the functional role of LLPS condensates in cells. @MustafaMir16 @XDarzacq @TjianDarzacq @dmcswiggen1

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Hiten Madhani MD PhD

@hitenmadhani

6 years

Asked by an undergraduate summer student: what's going to be hot in 5 years? I'm told that's what I should be aiming for! Me: asking good questions using genetics and biochemistry. Love influencing young ambitious minds!

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Hiten Madhani MD PhD

@hitenmadhani

6 years

Heading to Bethesda for study section. Nearing the end of my second stint. It’s not a fun form of service but an important one. And you cant complain about peer review if you are not willing to serve.

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Hiten Madhani MD PhD

@hitenmadhani

3 years

**Stanford peeps** I am super-excited to be giving my first in-person seminar since March 2020! I'll be giving the Frontiers Seminar this Wednesday. Looking forward to seeing some old friends, making some new ones, and meeting the students! It should be a blast!!

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Hiten Madhani MD PhD

@hitenmadhani

3 years

Do you truly *LOVE* RNA? If so, do check out our latest paper entitled "Coupling of spliceosome complexity to intron diversity" now out @CurrentBiology . 3/3 glowing reviews (it happens!). 1/ Share link :

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Hiten Madhani MD PhD

@hitenmadhani

5 years

Hard to believe that @SpeakerPelosi ‘s office has the time to send PIs @UCSF congratulatory notes. Seems like they would be busy with more important tasks.

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Hiten Madhani MD PhD

@hitenmadhani

6 years

I like yeast.

Kristen

@Kica333

6 years

Ruin a first date in four words or less.

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Hiten Madhani MD PhD

@hitenmadhani

5 years

Oh no! Epigenetic resistance to caffeine - no wonder I have to drink three cups to wake up! But seriously, this paper is important as it demonstrates chromatin-based epimutation as an adaptation an environmental change in S. pombe Great work from @Allshire_Lab !

bioRxiv

@biorxivpreprint

5 years

Epigenetic gene silencing by heterochromatin primes fungal resistance #bioRxiv

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Hiten Madhani MD PhD

@hitenmadhani

6 years

Here's the first attempt at Sci Twitter recruiting: A 3.0 percentile score on an R01 means our lab is recruiting. Details here: . How was that?

Join the Lab — Madhani Lab

Positions Available

madhanilab.ucsf.edu

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Hiten Madhani MD PhD

@hitenmadhani

4 years

It’s so great to have a @VP who knows and appreciates and values that we scientists travel to Bethesda to review grants. How does she know? Her Indian-American mom served on study section when she was a kid! I had no idea until today. What a breath of fresh air and hope.

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Hiten Madhani MD PhD

@hitenmadhani

3 years

Wow!! Congratulations to my Genentech Hall colleague Dave Julius! A win for curiosity driven basic science reseach. @DJuliusSF @hollyingrahamSF

The Nobel Prize

@NobelPrize

3 years

Cheers and congratulations to our newest medicine laureate David Julius! Here Julius and his wife Holly Ingraham are celebrating his #NobelPrize with a cup of early morning coffee. Photo: Holly Ingraham.

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