Hattie Chung @hattaca Twitter profile

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Hattie Chung

1 year

Excited to announce I will start as an Assistant Professor @Yale @YaleMed on Jan 1, 2024! Our lab's mission is to build tools to study cellular states in their native tissue contexts, focusing on drug response, aging, and cardiovascular disease.

Hattie Chung Lab

www.hattiechunglab.bio

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Hattie Chung

@hattaca

2 years

Profiling the molecular heterogeneity in diverse patients is key to precision medicine & therapeutics. But single cell methods need fresh/frozen tissues (hard to scale), while FFPE tissues are routinely collected. We share single nucleus RNA-Seq for FFPE:

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Hattie Chung

@hattaca

4 years

Excited to share our #preprint on inCITE-seq for measuring nuclear protein levels + transcriptome at single cell! Like CITE-seq for cell-surface proteins, we use DNA-conjugated antibodies to measure proteins, but now inside the nucleus + transcriptome.

Simultaneous single cell measurements of intranuclear proteins and gene expression

Identifying gene regulatory targets of nuclear proteins in tissues remains a challenge. Here we describe intranuclear Cellular Indexing of Transcriptomes and Epitopes (inCITE-seq), a scalable method...

www.biorxiv.org

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Hattie Chung

@hattaca

3 years

inCITE-seq is now online at @naturemethods ! We now include joint embedding of RNA profiles from inCITE-seq and snRNA-seq that helps resolve low RNA complexity due to fixation 1/n

Hattie Chung

@hattaca

4 years

Excited to share our #preprint on inCITE-seq for measuring nuclear protein levels + transcriptome at single cell! Like CITE-seq for cell-surface proteins, we use DNA-conjugated antibodies to measure proteins, but now inside the nucleus + transcriptome.

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Hattie Chung

@hattaca

7 months

After 3 months of hard work, excited to unveil the Chung lab’s computational space @YaleCVRC @YaleMed ! Gratifying to see our vision come to life. We are recruiting both computational and wet lab postdocs - join us!

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Hattie Chung

@hattaca

4 years

Meanwhile, many postdocs + grad students like myself would volunteer to vaccinate people 24/7 in a heartbeat! I'm dextrous and work with needles, plus also (unfortunately?) used to working long and odd hours.

Eric Topol

@EricTopol

4 years

That we only vaccinated 292,552 Americans today, having been able to hit 800,000 Thursday (7 Jan), speaks to the lack of any 24/7 plan or ability to execute. Emergencies don't take off weekends.

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Hattie Chung

@hattaca

2 years

#SingleCell twitter: What’s the current state of the art for integrating scRNA and snRNA data from the same tissue? Each dataset is fully annotated, and most cell types are found in both, but a few types are unique to each modality. Tried Harmony and scVI so far.

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Hattie Chung

@hattaca

2 years

On being an interdisciplinary scientist: words of wisdom from my mentor Aviv Regev on her non-traditional path, with minor contributions from me. Reported by the amazing @metricausa

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Hattie Chung

@hattaca

3 years

Honoring today’s Nobel by stimulating my TRPV1 channels with capsaicin

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Hattie Chung

@hattaca

3 years

Patients on ventilators often suffer from bacterial infections. In a prospective study, we show that antibiotic resistance muts expand or contract in vivo within days of therapy during acute infection, highlighting the impt of short-term therapy choice.

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Hattie Chung

@hattaca

6 years

New from Regev Group: multiplex samples of single nuclei for droplet sequencing with barcoded antibodies -> say bye to batch effects and save 5x $: @broadinstitute

Nuclei multiplexing with barcoded antibodies for single-nucleus genomics

Single-nucleus RNA-Seq (snRNA-seq) enables the interrogation of cellular states in complex tissues that are challenging to dissociate, including frozen clinical samples. This opens the way, in...

www.biorxiv.org

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Hattie Chung

@hattaca

2 years

I’ve been waiting to share this groundbreaking work from @AndyRusss @jacksonweir4 and team. This is true single cell spatial multi-omics. No more pixelated spatial data. And harness all the omics built on droplet based platforms. Can’t wait to use and build with it!

Andy Russell

@AndyRusss

2 years

Single-cell or spatial? Our new technology - Slide-tags - allows both in the same experiment, enabling true single-cell multi-modal spatial genomics ➡️

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Hattie Chung

@hattaca

4 years

You’ve had sushi, but have you had Korean kimbap? Filled with warm, cooked things. My simple version with garlic fried shiitake, fragrant sesame leaves, crispy pickled daikon

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Hattie Chung

@hattaca

3 years

It was a pleasure to present inCITE-seq at Single Cell Proteomics towards bridging sc genomics and proteomics. And nothing beats the in-person discussions that followed. Thank you @slavov_n for the invitation and for putting together a fantastic conference!

Single-Cell Proteomics Conference

@SCP_meeting

3 years

Simultaneous single cell measurements of intranuclear proteins and gene expression A presentation by Dr. Hattie Chung ( @hattaca ) at the 4th single-cell proteomics conference #SCP2021 .

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Hattie Chung

@hattaca

4 months

Bookending the week with fantastic talks and visits to Yale from old mentors, my PhD advisor @RoyKishony and Galit Lahav!! @QbioYale @YaleWestCampus @HMS_SysBio

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Hattie Chung

@hattaca

1 year

Grateful to the amazing @GCRLE1 community and pilot grant to study the spatiotemporal dynamics of ovarian aging with an all-star team! @jenngarrison

GCRLE

@GCRLE1

1 year

We’re incredibly proud to announce the 2023 GCRLE Grant recipients! These 28 exceptional researchers from across the globe will advance our understanding of ovarian aging #GCRLEGrants #ReproductiveAging @jenngarrison @buckinstitute

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Hattie Chung

@hattaca

4 years

Cell division never ceases to amaze. It’s like an earthquake — everything about it is destructive and catastrophic, yet it’s a basic part of eukaryotic life that happens over and over again. Maybe that’s why life is a continuous cycle of growing pains?

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Hattie Chung

@hattaca

4 years

fun to share our short work on multi-view representation of molecules @lmrl_bio #neurips2020 ! v. proud of my high school student Jonathan Yin who led this work. written: spoken:

Hattie Chung · A multi-view generative model for molecular representation improves prediction tasks

slideslive.com

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Hattie Chung

@hattaca

4 years

@MichaelSkolnik Tried to hold it together emotionally as I was at work, but Amanda Gorman did me in. She is a prodigy.

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Hattie Chung

@hattaca

2 years

A most wonderful two weeks in Bordeaux teaching inCITE-seq to brilliant students! And a treat in St Émilion after an intense and successful week of experiments. Merci @KharchenkoLab @HjerlingLeffler @Cajal_Training @bdxneuroschool @zinahwassouf @marekbartosovic @AMunozManchado

Jens Hjerling Leffler ⭐️⭐️🇺🇦⬜️🟥⬜️

@HjerlingLeffler

2 years

Great evening with all the instructors of #SCPAN . Thanks for your amazing effort with the students and projects over the last week! And thanks to @anna_beyeler for taking the picture. @KharchenkoLab @hattaca @AMunozManchado @marekbartosovic @zinahwassouf

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Hattie Chung

@hattaca

3 years

It was a delight to talk science with the inimitable @metricausa who is full of insightful questions!

Rahul Satija

@satijalab

3 years

Great to see this piece from @metricausa at @naturemethods on single-cell multi-omics highlight the contributions of junior researchers, including @timoast , @hattaca , and Stephen Clark:

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Hattie Chung

@hattaca

4 years

Looking forward to sharing our work at #singlecellgenomicsday tomorrow! Livestream at

Single Cell Genomics Day

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satijalab.org

Rahul Satija

@satijalab

4 years

Our free Single Cell Genomics Day livestream starts tomorrow at 10AM EST! You can ask questions during talks via twitter (include #singlecellgenomicsday ) and we'll relay them to speakers, see you soon!

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Hattie Chung

@hattaca

3 years

So proud of my former student Jonathan Yin!! I know he’s had a blast at @OctantBio - thanks for creating such an exciting and nurturing place for him @srikosuri

Sri Kosuri

@srikosuri

3 years

So fun to have Jonathan Yin (Yale) join us this summer! After building 100 of thousands of compounds towards our discovery efforts, we've built up a lot of data. He worked on calculating reaction yields for all of our syntheses in more automated ways. [1/2]

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Hattie Chung

@hattaca

3 years

In my enthusiasm, I did not include the link to the paper 🤦‍♀️

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Hattie Chung

@hattaca

4 years

And it goes without saying, a HUGE thanks to my mentor and advisor Aviv Regev, who is a bona fide superhuman, but also an incredibly supportive + kind human being!

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Hattie Chung

@hattaca

3 years

Fascinating study showing that the microbiome is an endocrine organ. Gut microbes of patients with castration-resistant prostate cancer are enriched for species that produce androgens, and antibiotic therapy delays castration resistance in mice.

Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis

The gut microbiota contributes androgens to promote endocrine resistance in prostate cancer.

www.science.org

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Hattie Chung

@hattaca

3 years

Wow. Every cell in our body must be adjusting their state to the thousands of chemical signals in their tissue milieu! "Sensory periphery separates signals from predictable background via a transcriptional rheostat whose ... state reflects the past and constrains the future".

Sandeep Robert Datta

@Datta_Lab

3 years

Olfactory sensory neurons (OSNs) use transcription to make flexible predictions about the environment and dynamically change odor responses, now in our new paper led by the amazing @TatsuyaTsuka0 and @davidhbrann ! Thread about what we found 👉1/n

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Hattie Chung

@hattaca

4 years

“good morning” in 2020 was an empty phrase until today

The Washington Post

@washingtonpost

4 years

Biden has taken the lead in both Georgia and Pennsylvania this morning as votes continue to be counted: Results are here as they come in: Georgia: Pennsylvania:

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Hattie Chung

@hattaca

4 years

Emma Magee is a fantastic RA in the Regev lab who is currently on the PhD admissions market. Admissions committees, get in line 😉! Many thanks to dear friend @ehshabibi for his help even during his busiest, Fei Chen who was essential for buffer debugging + all others!

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Hattie Chung

@hattaca

2 years

FFPE have damaged RNA. To increase RNA capture, we extracted nuclei *with ribosomes attached* to the nuclear membrane, and confirmed intact nuclei using transmission electron microscopy.

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Hattie Chung

@hattaca

4 years

Every time I chop veggies, I’m in awe of their tissue complexity, e.g the bell pepper. Its white sponge-y inner walls — how do they stem from a single progenitor? The outer dimples are surely regulated — they predictably occur 3-4x (via gene expression or mechanics)!

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Hattie Chung

@hattaca

4 years

Protein != RNA levels, especially for TFs. Nuclear TFs are impt in fundamental q’s, from cell fates to cell state changes. E.g. cells can respond to environmental signals by transforming signal into nuclear translocation of TFs. We show how inCITE-seq can be used for that.

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Hattie Chung

@hattaca

1 year

Clever work from Dan to reprogram viral vectors to be cell-type-specific

Daniel Strebinger

@DStrebinger

1 year

Excited to share DIRECTED (Delivery to Intended REcipient Cells Through Envelope Design): a programmable platform for cell-type-specific delivery. Thank you to @FrangiehChris , @mircoscopy , @GuilhemFaure , Rhiannon Macrae, @zhangf 1/7

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Hattie Chung

@hattaca

4 years

Wish I could flee to Canada and work with @CarldeBoerPhD !

Carl de Boer

@CarldeBoerPhD

4 years

Attempt #1 for hiring a Research Associate and Postdoc(s) failed in the midst of a global pandemic, so now we're trying again! Short descriptions follow. RTs appreciated!

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Hattie Chung

@hattaca

2 years

Of course, many challenges remain. A key factor is high variability in the prep and storage of FFPE samples. For severe degradation: random primers, polyA'ing short RNA (e.g. SMART-Seq-total), or targeted sequencing (just out) are exciting possibilities.

Luciano Martelotto 🛠🧬💻🇦🇺

@LGMartelotto

2 years

SO timely! A short teaser preprint from a wonderful collab w/ ⁦ @dralexswarbrick ⁩ lab. Full protocol available for in supporting material. snPATHO-seq: unlocking the FFPE archives for single nucleus RNA profiling ⁦⁦⁦ @10xGenomics ⁩

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Hattie Chung

@hattaca

8 years

Excited to share our work in @NatureComms on detecting genes under local selection in the CF lung! @RoyKishony @AlexanderMcAda5

Tami Lieberman

@conTaminatedsci

8 years

One reason why bacterial sublineages coexist in infections despite strong selection: location-specific selection

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Hattie Chung

@hattaca

4 years

Excited to see future applications for identifying cell type-specific genes that are associated with TFs directly in tissues, like we show as an example for the mouse brain!

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Hattie Chung

@hattaca

8 years

Our work on identifying optimal codon choices with MAGE-Seq! With @ekelsic @RoyKishony @wanglab_nyc

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Hattie Chung

@hattaca

4 years

Finally, America will be great again 🇺🇸

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Hattie Chung

@hattaca

4 years

@Caroline_Bartma this was on the wall of Walter Fontana's lab at HMS (maybe it's still there)

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Hattie Chung

@hattaca

3 years

I am so relieved to share the last chapter of my PhD. Grateful to all mentors and collaborators for their endless support and patience @RoyKishony @AlexanderMcAda5 @TechnionLive @harvardmed + many others. A press release here

Could genomic surveillance outsmart bacteria? - Boston Children's Answers

Bacteria mutate quickly to evade antibiotics. Real-time genomic surveillance could keep close tabs, enabling more effective treatment.

answers.childrenshospital.org

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Hattie Chung

@hattaca

2 years

We tested several deparaffinization conditions, and chose xylene at room temp. A side-by-side comparison of RNA detection in frozen vs. FFPE tissue across hemispheres from the same mouse brain showed RNA reduction by ~2.7X

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Hattie Chung

@hattaca

4 years

@NTallapragada @Caroline_Bartma Depends on which specific fat components, I think. Small chain fatty acids are volatile and could bind ORs, but larger ones (>7 Carbons?) are less volatile so I wouldn’t expect that they trigger ORs in the nose. Interesting abstract

OR31-3 Role of a Novel Short Chain Fatty Acid Receptor OLFR78 in Mediating Gluco-metabolic Hormone...

Abstract. Olfactory receptor OLFR78 is a G protein-coupled receptor (GPCR) which is activated by short chain fatty acids (SCFAs), especially propionate. OL

academic.oup.com

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Hattie Chung

@hattaca

2 years

This was a big team effort with co-lead authors Alexandre Melnikov and Cristin McCabe, our mentors Aviv Regev and Orit Rozenblatt-Rosen, collaborators Sarah Mazzilli @DrSMazzand Avrum Spira, @insitubiology , and so many others! @broadinstitute @BU_Tweets /end

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Hattie Chung

@hattaca

7 years

@arjunrajlab Slightly diff: most great musicians also sight-read well. Scientific equiv. is spot-on critiques of problems in totally different field

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Hattie Chung

@hattaca

4 years

@Symbionticism Yes, was obsessed with this early postdoc ! NPs could have evolved from AMPs — early nerve nets evolved in marine organisms that swim in a solution full of bacteria with neurons exposed, perhaps could sense + process external bacterial info.

Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont - PubMed

Here we evaluate our current understanding of the function of the nervous system in Hydra, a non-bilaterian animal which is among the first metazoans that contain neurons. We highlight growing...

pubmed.ncbi.nlm.nih.gov

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Hattie Chung

@hattaca

4 years

@satijalab thank you Rahul!! Very clearly inspired by your original groundbreaking work (down to the name), of course :)

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Hattie Chung

@hattaca

2 years

We tested both plate-based (SMART-Seq2) and droplet-based (10X) snRNA-Seq in the mouse brain. Major cell types are all detected despite reduced RNA complexity.

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Hattie Chung

@hattaca

3 years

We also show comparisons to commercially available intracellular buffers as a technical note for the community that capturing intracellular vs. intranuclear targets may require different optimizations 2/n

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Hattie Chung

@hattaca

2 years

We applied snFFPE-Seq to a human lung adenocarcinoma sample. Gene detection was sparse, as expected, so we used an atlas to assign cell types to each nucleus. As a sanity check, we reciprocally examined top FFPE-derived marker genes in the atlas.

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Hattie Chung

@hattaca

5 years

@mashaals @A_A_Zaidi @riveramichael @Bschaef_ @starr_iz @TLJordanScience @ssnorkels @ChemistryCayk @brttnytrnh @prasha88 @theSTEMsquad @circe_verba @KrishanaSankar @vgquintanaa @superchiasmatic @tumblr @cecelia_kinane @Pragmatist24 @michmuzz @ReadMoreScience @khwalsh_ @LivWithoutLimit @Finetraces786 @starstrickenSF @IsabelOtt @idpgrace @TriumphantBass @whatsmybodydoin @fungi_femme @ArielleLBaker @TheLabAndField @DrMarinaRamirez @ScientistaMaggs @TinaLasisi @farbandish @sanatajs @smaspellssam @rickwasmith @JuengstExplores @robertnulrich @sporcle @toothkate @Lenrica @DakotaEHolmes @acnzimmer -My childhood dream was to be a fiction writer -Moved from Korea to North Carolina at age 8, didn't speak any English, was confused, cried a lot -Almost went to music school to be a professional pianist instead @xinniej @NOFOKitchen @yarbsalocin @curiouswavefn @deboramarks

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Hattie Chung

@hattaca

4 years

SO excited for @cambearon !!

Cameron Myhrvold

@cambearon

4 years

Some exciting news - I will be joining the Department of Molecular Biology @Princeton as an Assistant Professor in January 2021! The Myhrvold Lab will develop CRISPR-based technologies for detecting and destroying RNA viruses, and for studying RNA more broadly @PrincetonMolBio

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Hattie Chung

@hattaca

4 years

What do we do w/ data? We model gene expression as a linear combination of protein levels to quantify how the expression of each gene changes wrt to protein levels. We did this genome-wide and found that gene modules coincide with specific TF effects!

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Hattie Chung

@hattaca

4 years

@meghan_daum I have a PhD and never ask to be called Dr (only when joking). But expert knowledge is increasingly disrespected in our society and if emphasizing & embracing status of PhDs collectively ⬆️ respect, then by all means! E.g., referring to priests as “reverend” is respectful.

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Hattie Chung

@hattaca

7 years

With mentorship from @AndyWeberNCB , we assessed state of knowledge on NK's bioweapons program started in the 1960s

Belfer Center

@BelferCenter

7 years

North Korea’s Biological Weapons Program: The Known and Unknown @hattaca

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Hattie Chung

@hattaca

1 year

I am infinitely grateful to my advisors @RoyKishony , Aviv Regev, and Fei Chen @insitubiology . Fei adopted me during his Year 0 as a junior faculty and has been an unwavering source of support, generosity, and boundless creativity. Without him, I wouldn't be where I am today.

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Hattie Chung

@hattaca

1 year

So many directions are brewing, and we can’t wait to start. We are recruiting at all levels. If you are interested, please reach out! We welcome all backgrounds – wet, dry, or amphibious.

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Hattie Chung

@hattaca

2 years

Many pathway signatures in databases have redundant and overlapping gene members (!). To avoid scoring the same genes repeatedly, we identified which signatures were redundant by using pairwise Jaccard similarity, and reduced into representative ones.

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Hattie Chung

@hattaca

7 months

We develop tools to study cellular heterogeneity and tissue remodeling in the context of ovarian aging and cardiovascular disease. Contact us:

Contact — Hattie Chung Lab

www.hattiechunglab.bio

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Hattie Chung

@hattaca

9 years

Hello twitter! Reviving my account after prodding from @cambearon

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Hattie Chung

@hattaca

1 year

We work at the interface of tech dev and computation. Our theme is hormone signaling, a fundamental driver of human health in aging, cardiovascular diseases, and cancer. With cutting-edge tools, we're taking on this age-old problem in new ways.

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Hattie Chung

@hattaca

2 years

Using the "meta-gene" counts matrix of reduced signatures, we clustered nuclei from lung adenocarcinoma FFPE. This unsupervised approach revealed distinct subpopulations that reflect upregulation of KRAS, downregulation of KRAS, and tumor suppressor PTEN programs!

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Hattie Chung

@hattaca

2 years

To highlight the potential for data-driven discovery, we created a computational approach: Gene Aggregation across Pathway Signatures (GAPS). Basically, we make a nuclei-by-signature matrix instead of nuclei-by-gene using known pathway signatures, but after a key step:

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Hattie Chung

@hattaca

4 years

@NTallapragada RNA velocity analysis?

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Hattie Chung

@hattaca

5 years

what an amazing work led by @CChu1989 ! very excited to have played a small part in showing how gut bacteria affect fear extinction learning

Coco Chu

@CChu_89

5 years

Check out our new paper #GutBrainAxis #Neuroimmunology #Microbiota Many thanks to our collaborators - it's a multidisciplinary project; we wouldn't be able to make it without your help!!

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Hattie Chung

@hattaca

3 years

As always, big thanks to my advisors Aviv Regev and Fei Chen, and special thanks to @naturemethods for making the review process thorough yet painless!

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Hattie Chung

@hattaca

1 year

And most of all, thank you to my better half @nsmoores for being a rock throughout this entire journey. Now we're both Yalies :)

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Hattie Chung

@hattaca

4 years

inCITE-seq also enables protein + RNA profiling in solid tissues. Intact whole cell dissociations are hard for solid tissues. Many original sc tools and CITE-seq were developed for free-floating cells like PBMCs. Single nucleus methods are v. good for solid/frozen tissues.

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Hattie Chung

@hattaca

7 years

Already used this to get much better annotations for bacterial proteins! Great tool

Seth Bordenstein

@Symbionticism

7 years

Amazing resource here -> PaperBLAST links 414,070 protein seqs to 746,192 science articles

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Hattie Chung

@hattaca

2 years

@ele_tt @aedicorato @broadinstitute This is so beautiful, congratulations Elena, Eran, and team !!

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Hattie Chung

@hattaca

4 years

@zurisullivan @RMedzhitov @ScienceMagazine Amazing work, congratulations Zuri!! 🤗

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Hattie Chung

@hattaca

5 years

Sartre would approve.

Oded Rechavi

@OdedRechavi

5 years

New peer-review format: The authors and the reviewers are isolated in a small apartment until the paper is accepted.

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Hattie Chung

@hattaca

6 years

@srikosuri @DrewEndy @reshmapshetty @bcanton @jrkelly @SuttonPhD You don’t know me but just wanted to say doing iGEM 2006 in high school & learning about your works & synbio made me go into research!

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Hattie Chung

@hattaca

3 years

@InterSciFellows @tanlongzhi @Harvard @Stanford Big congrats!! but no surprises here @tanlongzhi 😊

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Hattie Chung

@hattaca

3 years

This project was an incredibly old “friend” that kept me company as I switched fields, and now wrapping up my postdoc in totally different areas 😅

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Hattie Chung

@hattaca

4 years

Finally, a huge thanks to the team! Chris Parkhurst is a postdoc with David Artis at @WeillCornell whose other life as an MD/PhD is a pulmonary critical care fellow. He sprinted to ship us samples the day before labs closed + had to treat COVID patients in NYC non-stop in March.

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Hattie Chung

@hattaca

2 years

Note: spatial genomics has been making rapid progress for FFPE (e.g. Visium, GeoMx), but they are not truly at single-cell scale *yet*. As these tools mature, we are excited about all the data integration possibilities.

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Hattie Chung

@hattaca

4 years

A fav observation was the relationship b/t NeuN protein and its encoding RNA Rbfox3. NeuN is an RNA-binding protein, and these typically negatively regulate their own transcripts. Our unspliced intron counts vs. mRNA for Rbfox3 hinted at this too!

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Hattie Chung

@hattaca

4 years

@seankenneths But we love your encyclopedic knowledge as a result 😅

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Hattie Chung

@hattaca

7 months

And we are very excited for our neighbor @jennkwanMDPhD to round out the space soon! :)

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Hattie Chung

@hattaca

4 years

@t_ouspenskaia they form fused, elongated, tubular networks under certain conditions! i saw a talk on this years ago, and was curious whether it has sth to do with increasing their surface area. here's a bioessay about mito networks: cc @LeifLudwig

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal...

Mitochondria can change their shape from discrete isolated organelles to a large continuous reticulum. The cellular advantages underlying these fused networks are still incompletely understood. In...

pmc.ncbi.nlm.nih.gov

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Hattie Chung

@hattaca

5 years

@laura_boykin @cambearon @The__Taybor Yay glad this resolved :) I’ve known Cameron for years as a colleague and friend, and he’s anything but some “punk” - he’s a very serious and rigorous scientist (also nice person)

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Hattie Chung

@hattaca

1 year

Our research spans various areas: spatiotemporal dynamics of ovarian aging (with star team @jenngarrison @tammyinlab @davidsebfischer + others), mapping PROTAC response with single-cell proteogenomics, and modeling multi-cell-type state transitions in spatial data.

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Hattie Chung

@hattaca

4 years

@vscooper how do i cite this

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Hattie Chung

@hattaca

4 years

@mashaals That is fantastic news, congratulations Mashaal!! 🥂

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Hattie Chung

@hattaca

4 years

These slides would be great material for any course in biophysics !

Navish Wadhwa

@WadhwaLab

4 years

1/3 I am doing something new (for me) for my talk tomorrow at the #apsmarch meeting. I will be using web-based slides, openly available at . If you have any suggestions on the slides, I would love to incorporate them into my talk tomorrow. #OpenScience

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Hattie Chung

@hattaca

2 years

@insitubiology Brainchild of @HuChenlei and the twitterless Kevin Chao

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Hattie Chung

@hattaca

7 years

Dima Ter-Ovanesyan @StanleyCenter @broadinstitute on exosome RNA seq as a diagnostic, even isolate cell type specific exosomes #SCSym17

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Hattie Chung

@hattaca

7 years

@arjunrajlab *not just critiques, also new ideas & solutions

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Hattie Chung

@hattaca

7 years

Amazing talk today @icouzin on the emergent property of fish moving together & how social behaviors propagate throughout a group

Iain Couzin

@icouzin

7 years

Thrilled, and more than a tad nervous, to be speaking at both @Harvard and @MIT today.

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Hattie Chung

@hattaca

2 years

@oana__ursu @genentech Woohoo! Congratulations Oana 🤗

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Hattie Chung

@hattaca

6 years

@Anders_S_Hansen @MIT @MITdeptofBE congratulations Anders!!!

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Hattie Chung

@hattaca

2 years

@DrWilliamHwang @NatureGenet Congratulations Will, Karthik, Jimmy, Hannah, and team! So great to see it out!

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Hattie Chung

@hattaca

3 years

@tanlongzhi @BWFUND @KarlDeisseroth @HowardYChang Congratulations Tan!! Very well deserved 🎉

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Hattie Chung

@hattaca

4 years

where science is like art. our materials are the remnants & shadows of processes, and the reconstruction can be quite beautiful

Steve Stewart-Williams

@SteveStuWill

4 years

This photo of the sun might not look too impressive... until you realize it was taken at night – not looking up but looking down, through the entire Earth, using neutrinos rather than light. Amazing!

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Hattie Chung

@hattaca

3 years

Our work suggests that resistance mutations could be driven to extinction during early stages of infection by designing patient-specific antibiotic cycling strategies, informed by deep genomic surveillance.

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Hattie Chung

@hattaca

4 years

@HarmitMalik Sufficient to stop at: “You’ve had me at garlic” 😂

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Hattie Chung

@hattaca

2 years