Thoracic Medical Oncologist at Georgetown University | Lung Cancer & Thymic Epithelial Tumors | Father/husband/immigrant |
#SoMeEditor
@ClinicalLung
|
#LCSM
Thrilled to announce that I have been promoted to Associate Professor of Medicine!
I am incredibly grateful for the unwavering support and guidance of my mentors, colleagues, and beloved family throughout my career journey.
‘KRAS(G12C)-mutant cancer cells can rapidly bypass the effects of treatment with KRAS(G12C) inhibitors because a subset of cells escapes drug-induced quiescence by producing new KRAS(G12C) that is maintained in its active, drug-insensitive state’
Celebrating 7 years of relentless effort, hard work, and sleepless nights encapsulated in these photos
Overjoyed to see my better half, now Dr. Jihye Park, DDS, reach this milestone
Her journey exemplifies resilience as a first-gen immigrant, devoted mom, & tenacious student
Patient: "I feel like I am a different person with this pill (targeted therapy). I have never felt better. Thank you"
Being an oncologist is often not easy
Moments like this are so precious
This picture brings back memories of
@ASCO
2018, my first ASCO as an attending.
The baby in the picture became my tumor board buddy during the pandemic 😆
On my way to the airport to visit family in S. Korea. It has been 4 years since the last visit. Missed several family events including my brother’s wedding. Excited 😊
This recognition from hematology/oncology fellows
@LombardiCancer
@MedStarGUH
means a lot to me. I always aspired to be a good teacher, but never thought I would make a good one. I am deeply honored and humbled to receive the teaching award.
At the airport en route to Singapore for
#WCLC23
!
Excited about reconnecting with colleagues from around the world and making new collaborative connections.
My first text book chapter is out!
It was my honor to work with my mentor, colleague, and friend, Dr. Beppe Giaccone.
#thymoma
#thymic_carcinoma
#thymus
While there is much more work to be done, the field of thoracic oncology has seen tremendous advances in the past decade.
I am sure that in 10 years, the list would be filled with more molecular targets and more effective/novel therapies.
#LCSM
Life can throw a lot at you, but it’s nice when some things stay the same. I am in my old room at my parents’ place, and looking out the window. Seoul has not changed much from here, and I am thankful for that.
Our own Dr.
@StephenVLiu
won the Heine H. Hansen Lectureship Award for Small Cell Lung Cancer!
Very well deserved recognition. Big congratulations!!
@LombardiCancer
@MedStarGUH
Really happy to see
@StephenVLiu
Lectureship Award for Small Cell Lung Cancer. Really eager to attend on Monday (also live streamed) at Hall C1, 1:30-2:30 PM. Well deserved my friend. Congrats!👏
#WCLC22
#LCSM
@IASLC
NYC marked my first encounter with the U.S. as I undertook my clerkship at Mount Sinai for two months, being a medical student from South Korea
The summer of 2006 continues to hold a prominent place in my memory
Each time I visit NYC, those past memories and feelings resurface
Logged into
@IASLC
website to renew my IASLC membership.
Hmm, that serious looking guy looks familiar.
…..
Oh it was me!! My honor to be on the IASLC homepage :)
#LungCancerAwarenessMonth
With my mentee, Dr. Vanya Aggarwal, a 2nd-year fellow at
@GeorgetownHOF
@LombardiCancer
. Congratulations on receiving the Travel Award for
#TTLC24
. It’s a well-deserved honor. I am fortunate to work with Dr. Aggarwal.
IIT of pembro + platinum-based chemo in recurrent EGFR/ALK+ NSCLC by Dr. Gadgeel & colleagues
ORR/PFS/OS in EGFR (N=26): 42.3%/8.3 mo/22.2 mo
ORR/PFS/OS in ALK (N=7): 28.6%/2.9 mo/2.9 mo
Ongoing KEYNOTE-789 will shed further light on the role of chemoIO in EGFR+ NSCLC
#WCLC21
Our project on the expression of Trop-2 in thymic epithelial tumors (TETs) presented
@Itmig_society
Trop-2 is highly expressed in thymoma (94%) and thymic carcinomas (100%) with lower expression in normal thymic tissue.
Trop-2 is a potential therapeutic target in TETs!
A phase II trial of first-line cisplatin, pemetrexed, and nivolumab for unresectable malignant pleural mesothelioma (JME-001)
N=18
ORR=77.8% (14 PRs out of 18)
mPFS=8.02 mo
mOS=20.8 mo
Grade 3 or higher AEs=55.6%
Small study, but encouraging results
Our phase I trial of lutathera/nivolumab in ES-SCLC & pulm NETs is finally published
@jitcancer
.
5 years of teamwork.
Many thanks to all the co-authors
@StephenVLiu
, Deepa Subramaniam, Tisdrey Torres,
@MassimoLodaMD
, Giuseppe Esposito & Beppe Giaccone.
Thank you to
@ASCO
for naming me an Advocacy Champion for my continued commitment to advocating for issues affecting the
#oncology
community.
You can be an Advocacy Champion too by getting involved today:
#ASCOAdvocacySummit
Our paper on safety/efficacy of IO based therapy in pts with HIV and/or viral hepatitis out! Notable findings: 1) IO not a/w viral reactivation c/w prior reports, 2) no concerning irAEs with chemo+IO, 3) among responders, some had low CD4 (need validation in larger studies).
Had a farewell lunch with Dr. Vincent Yeung, my mentee who will join
@RutgersCancer
as a thoracic oncologist
Very proud of his achievements and excited about his next chapter in life and career.
He will be sorely missed.
Our case report is out
#JTOCRR
@JTOonline
!
Here we describe a patient with KRAS G12C-mutated lung adenocarcinoma and untreated brain metastases who achieved significant clinical and radiographical response to
#sotorasib
.
At fellowship graduation last night, our fearless leader, Dr. Marshall
@marshalj23
received Teaching Attending Award chosen by
@LombardiCancer
hematology/oncology fellows!
Congratulations! 🍾🎊🎉
Our paper describing longitudinal ctDNA analysis in blood and saliva in EGFR-mutant lung adenocarcinoma is out
@cancers
!
Here we utilized three different ctDNA platforms (ddPCR and NGS for blood, EFIRM liquid biopsy for saliva).
(Thread)
This phase I trial means much to me
First IIT I wrote as a cancer researcher
Can't thank enough my colleagues. This was team work.
I will remain forever grateful to the patient and their caregivers for their participation and believing in our team for care.
@LombardiCancer
Phase I study of first line osimertinib + dasatinib in patients with
#EGFR
NSCLC led by Dr.
@chulkimMD
now online
@FrontOncology
. Based on targeting CRIPTO via Src which may mediate EGFR TKI resistance. Small study but 90% had a response with one ongoing.
Happy to share a case report of ALK fusion mediating resistance to osimertinib
@JTOonline
.
Partial response seen with osimertinib/alectinib.
Understanding resistance mechanisms is important after progression on osimertinib.
@StephenVLiu
@Joshua_Reuss
People with HIV are diagnosed with lung cancer 10-15 years earlier than the general population. We need to better understand the risk factors and optimize lung cancer screening for PWH. Our team, led by
@randimwilliams2
, will delve into this topic! Grateful for funding from
MET alteration is an important resistance mechanism to EGFR-TKI therapy
Great work by Dr. Molly Wilgucki on our case report "Osimertinib and capmatinib combination therapy to overcome MET Y1003N-mediated resistance in EGFR-mutant NSCLC"
@JTOonline
It truly takes a village to conduct and care for patients in clinical trials. Clinical trial team dinner hosted by our leader
@StephenVLiu
. Grateful to work with such supportive and dedicated colleagues
@LombardiCancer
!
Thrilled for my mentee, Dr. Jacob Zaemes
@GeorgetownHOF
receiving ASCO
#YIA
!
His project centers on B7-H3 ADC (MGC018) development for ES-SCLC, including EGFR+ NSCLC to SCLC transformation.
Grateful for co-mentorship of
@StephenVLiu
and research support from
@ChristianRolfo
.
STK11 and KEAP1 mutations in KEYNOTE-042. STK11 mutation a/w lower PD-L1 expression. Pembro a/w better outcomes compared with chemo, regardless of STK11 or KEAP1 mutation status. Very low ORR with chemo in STK11 mutation+ NSCLC.
#AACR20
@OncoAlert
Dr. Janne presented the awaited
#FLAURA2
trial results, comparing osimertinib plus platinum-pemetrexed to osimertinib alone.
The combination yielded a mPFS of 25.5 months versus 16.7 months, with a HR of 0.62.
This benefit, especially evident in patients with baseline CNS
Phase II trial of durvalumab in HIV+ pts with cancer. 14/20 had NSCLC. 4 (29%) of 14 NSCLC responded to durva (3/4 responders PD-L1 +). No G3 or 4 trAEs. CD4/CD8/viral load stable during treatment. PD-(L)1 blockade feasible and safe in HIV+ pts
@JAMAOnc
As an oncologist, one of the joys is seeing patients respond well to immunotherapy, which can often induce a lasting response.
Increasing the reach of IO to driver-positive NSCLC (e.g. EGFR/ALK+ NSCLC), where immunotherapies tend not to work well, is an urgent and unmet need.
Although I miss catching up with colleagues at
#TTLC23
, I'm overjoyed that today my wife has been given the green light to walk again after 6 weeks of non-weight bearing due to a fracture.
Thankful for the excellent care provided by the whole
@MedStarGUH
team ♥️
Durvalumab plus chemo (CASPIAN) published in
@lancet
. OS benefit with durva in recalcitrant ES-SCLC. Still lots of Qs: predictive biomarkers, ways to make the triplet therapy better (need a 4th drug?).
#LCMS
@OncoAlert
Life leads us down various pathways, and often times, it becomes challenging to spend as much time with our loved ones as we desire.
However, in those moments, we come to realize that these instances may actually be among the most precious days of our lives.
Check out our poster on genomic/immunologic characterization of LCNEC of the lung.
We show that LCNEC and SCLC share molecular features, but distinct patterns of genomic alterations and transcriptome profiles were demonstrated.
Grateful to all the co-investigators!
@carisls
Our very own Dr.
@StephenVLiu
presenting the 5-year OS data from IMpower133 and its extension, Imbrella A.
5-year OS rate for first-line platinum chemotherapy combined with atezolizumab stands at 12%.
A critical benchmark for upcoming studies!
#WCLC23
Phase III trial of benmelstobart (anti-PD-L1), anlotinib & chemo for ES-SCLC. PFS & OS improved: mOS 19.3 vs 11.9 mo (HR: 0.61).
Despite promising data, IMO, the exact role of adding anti-angiogenesis to chemo-IO is unanswered due to a missing chemo-IO w/o anlotinib arm.
#WCLC23
Fascinating keynote by Dr.
@christine_lovly
. Ground breaking advances in thoracic oncology in the past two decades, exemplified by developments of EGFR targeting therapies. So much work has been accomplished by pioneers and giants in the field (many of whom in the audience).
Honored to have had medical students from Yonsei University in South Korea rotate at
@LombardiCancer
for three weeks.
We had a farewell lunch today, joined by a special guest who accompanied me in the clinic due to snow day school closure.
Of all the data from
#CheckMate_816
, the clear separation of the overall survival (OS) curves shortly after year 1 is most impressive to me.
We need to see more mature OS data to fully appreciate the impact, but this looks promising.
#LCSM
Our systematic review on checkpoint inhibitor therapy in cancer patients with HIV infection is out!
Many thanks to
@ConquerCancerFd
and Sher research grant from
@LombardiCancer
for support for this work and other ongoing projects on this topic!
I feel lucky to have been surrounded by great mentors and colleagues
@LombardiCancer
.
Advancing cancer care is teamwork, and I have the most supportive colleagues one could ask for, including
@StephenVLiu
and
@Joshua_Reuss
.
I am deeply honored to receive this award.
Hello Chicago.
Look forward to exploring latest data and discussing new ideas.
Most excited about reconnecting with friends and colleagues, and forging new connections!
#ASCO23
Being able to witness a patient's life milestone, like the anticipated arrival of their first grandchild, is a privilege for an oncologist.
This baby shower feels special 🎊
The bond we build with our patients can be incredibly strong and personal.
Sometimes, it leaves a hole in the heart when they are not with us.
There are days when the heart feels heavier.
No new safety signal with treatment with durvalumab in HIV+ patients (n=20, 75% lung cancer) and responses were seen. We should consider broader inclusion of HIV+ patients in clinical trials.
A single arm phase II trial of carbo/pem/bev/atezo in EGFR-mutant NSCLC after TKI Tx
N=40
ORR=62.5%
PFS=9.4 mo
1-year OS=72.5%
Grade ≥3 TRAE=37.5% (IMpower150=57%)
Efficacy similar to IMpower150 regimen with potentially less toxicity
@LungCaJournal
I am one of them. The reason why I decided to move to the U.S. is to become an oncologist who develops better treatments for patients suffering from cancer. The administration's immigration policy has direct negative impacts on many of us, immigrant doctors, caring for patients.
Many immigrant doctors come to train in the US on J-1 or H-1 visas. They work in various settings from rural underserved areas to academic centers discovering new treatments.
If you are an American who sought healthcare, it’s likely you have been cared for by one of us.
Lucky to be able to catch up with friend/colleague/mentee, Dr. Vince Yeung
@RutgersCancer
during a quick trip to New Jersey for a meeting.
True privilege to see him thrive at his new institution.
Follow-up report on pembrolizumab in thymic carcinoma finally out in
@JTOonline
. With median f/u of 4.9 yrs, ORR remained at 22.5%. Durable responses seen: mDOR 2.99 yrs, mOS 2.12 yrs. Close monitoring on Tx needed given irAEs. Work with
#BeppeGiaccone
.
Excited to present our research showing high Trop-2 expression in thymic epithelial tumors
@LungCaJournal
Great work by Dr. Vincent Yeung, former fellow
@LombardiCancer
A multicenter IIT of sacituzumab govitecan in TETs under design by
@jennifermarksmd
!
Insightful talk by Dr. PC Yang. Estimated lung cancer not associated with smoking is up to 30-40% globally. Ongoing efforts to understand the role of lung cancer screening in people without smoking history are underway. Very important topic
#ASCO23
End-of-year thoracic oncology party started!! Wine and food delivered to home. Fantastic idea organized by our fearless leader
@StephenVLiu
Lucky to work with all the wonderful colleagues
@LombardiCancer
@MedStarGUH
.
It was a tough week with loss of two young patients due to rare thoracic tumors.
Rare tumors get less resources and attention, leading to less discovery and therapeutic development.
How do we challenge the status quo?
HER2 is a relevant target in many tumor types
In DESTINY-PanTumor02, T-DXd showed activity across HER2 expressing many solid tumors
ORR 37.1% in all patients and 61.3% in patients with IHC 3+ with DOR 11.8 months in all patients and 22.1 months in patients with IHC 3+!
#ASCO23