Although generally considered a simple support tissue, extra-embryonic primitive endoderm has the capacity to regenerate a complete blastocyst and continue post-implantation development.

Immunosenescence poses a significant challenge to tumor immunotherapy in elderly individuals. In this issue of Cell, Zhivaki et al. elucidate that dendritic cells “hyperactivated” by specific...

AE is a genome editing tool that can efficiently and precisely engineer the chromosomal structure through duplication, expanding the landscape of precision genome editing from single genetic locus to...

Open-ST is an end-to-end experimental and computational workflow for do-it-yourself subcellular spatial transcriptomics in 2D or 3D at low cost.

(Cell 186, 3182–3195.e1–e14; July 20, 2023)

During allergen challenge, degranulating mast cells re-route and trap living neutrophils in vivo, resulting in functional and metabolic alteration of the mast cell and the acquisition of neutrophilic...

The replisome component Mrc1 chaperones H3-H4 tetramers, alone or with Mcm2, and facilitates parental histone transmission to leading and lagging DNA strands and epigenetic silencing.

A genetically engineered, healthy donor-derived CD19-targeted chimeric antigen receptor (CAR)-T cell treatment achieved safe, deep remission in one patient with severe immune-mediated necrotizing...

Degradation of hyaluronan in the extracellular matrix leads to mitochondrial remodeling, activation of mitochondrial stress responses, and augmented immune signaling.

The microglial-secreted complement protein C1q is internalized by neurons in an age-dependent manner, undergoes RNA-mediated interactions with neuronal ribonucleoprotein complexes, and alters...

The high-resolution in situ structural analysis of the prototype foamy virus icosahedral capsid and envelope glycoprotein provides insight into the viral infection process and evolutionary history.

Clovibactin, a new antibiotic isolated from soil bacteria, blocks bacterial cell wall synthesis by targeting essential peptidoglycan precursors, allowing it to kill drug-resistant bacterial pathogens...

The foundational research recognized by this year’s Lasker Basic Science Research Award “for discoveries concerning the integrins—key mediators of cell-matrix and cell-cell adhesion in physiology and...

The plant helper NRC4 immune receptor forms a hexameric resistosome upon activation, triggering calcium influx and immune responses.

De novo proteins can be computationally designed with sub-picomolar affinity and extreme stability to enable oral administration and were effective in a model of colitis.

Structural analyses clarify how the Duffy antigen receptor for chemokines (DARC) binds a wider range of ligands and functions differently from prototypical GPCR chemokine receptors.

RNAs present on the outer cell surface have been recently identified in mammalian cells, but the functional significance of these cell surface RNAs hasn’t been clear. This study reveals roles of cell...

Glucose is the main source of energy for cells. In this issue of Cell, a study now shows that glucose has additional non-energetic functions, acting as a biomolecular cue that regulates alternative...

mRNA transcription in budding yeast increases with cell size due to the equilibrium kinetics of dosage-limiting RNA polymerase II and the genome. This is then supported by a global increase in mRNA...

Natural killer (NK)-based therapies against cancer are emerging, but the understanding of NK cell functions needs to be completed to optimize these treatments. In this issue, Pan et al. (2022) show...

Tumor-associated macrophages (TAMs) fuel the evolution of the cancer ecosystem. This review discusses recent advances in our knowledge of macrophages in the tumor microenvironment, broadly covering...

Development of SUM-PAINT, an approach that is capable of potentially unlimited super-resolution multiplexing, enables rapid visualization of distinct synapse types at single-molecule resolution.

Enhanced efflux of PGD2 across the BBB during prolonged sleep deprivation induces a cytokine-storm-like syndrome via the PGD2/DP1 axis. Sleep deprivation in mice that involves disruption of REMS and...

Transcriptional condensate dynamically interacts with the gene locus, resulting in a burst increase when in proximity and a return to basal bursting when the condensate moves away.

The analysis of multi-tissue gene expression signatures associated with longevity across mammalian species and their interaction with biomarkers of aging and signatures of lifespan-extending interv...

We are the editors of a science journal, committed to publishing and disseminating exciting work across the biological sciences. We are 13 scientists. Not one of us is Black. Underrepresentation of...

The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive functions of wild-type p53 or the oncogenic activities of its cancer-associated mutants are still not, and our...

Queosine (Q) is a modified nucleoside present in tRNA anticodons. Identification and characterization of two vertebrate Q-glycosylases unveil new regulatory mechanism in protein translation and...

The field of cancer metabolism provides us with a framework to understand basic cellular metabolic principles and pathways.

RNAs present on the outer cell surface have been recently identified in mammalian cells, but the functional significance of these cell surface RNAs hasn’t been clear. This study reveals roles of cell...

An analytical resource of post-translational modifications from over 1,000 patients across 11 cancer types reveals pan-cancer changes involved in hallmark cancer processes and reveals potential new...

Sekine et al. provide a functional and phenotypic map of SARS-CoV-2-specific T cells across the full spectrum of exposure, infection, and COVID-19 severity. They observe that SARS-CoV-2 elicits...