Beyond thrilled to present our first (!) work
@TheCrick
! A tour de force by
@tobyandrews
et al combining imaging, solid morphometrics, theory, perturbations to show how a developing heart grows and scales up its morphological complexity to keep beating...
Pumped to share our latest and first (!) work from
@_Priya_R
lab
@TheCrick
! Using the powers of
#zebrafish
, we uncover how multiscale mechanochemical coupling drives morphological and functional maturation of the developing heart 🫀
Stay tuned for the🧵
Out Now!!! Our paper on how differential tension generate higher order pattern and
diverse cell fate in a developing heart
@nature
.
#zebrafish
#imaging
A tweetorial 1/n
And an update! Very excited to share that I will be starting my lab
@TheCrick
early 2021! We will use interdisciplinary approaches to study organ morphogenesis using
#zebrafish
👉. 1/3
We are recruiting! Fully funded post-doctoral positions are available. Interested in
#morphogenesis
#imaging
#zebrafish
? Join us
@TheCrick
to help us understand how embryos build a functional beating heart during development. Please RT 🙏
A new kind of cell division in
#zebrafish
skin - Asynthetic fission, by Chen-Hui Chen, great N&V from
@WickstromLab
Larvae growth - expanding skin cells get stretched - triggers cell division WITHOUT replication 🤯 - increase in surface area
What a fascinating article by
@jbwallingford
@Dev_journal
😮highlighting the rich history of developmental embryology in Asia and Latin America.
“if we mention Aristotle in developmental biology textbooks…we should also mention the Garbhāvakrāntisūtra”
We are hiring (PhD and Postdoc)
@TheCrick
! Join our team and help us dissect Heart Morphogenesis using
#Zebrafish
. Love
#imaging
, morphogenesis, tissue mechanics, genetics and image analysis? Apply! More details below 👇 Please RT and spread the word 🙏 (1/3)
We are hiring! Please RT 🙏 Love
#zebrafish
#Microscopy
#Genetics
? Interested in doing independent projects, lab management, collaboration? We have a permanent research scientist position available
@TheCrick
!
Extremely grateful to the
@wellcometrust
for this award! I couldn’t have achieved this without this incredible team I’m privileged to work with. We’re hiring at all levels—come join us
@TheCrick
😀
Congratulations,
@_Priya_R
! 🎉
Rashmi heads up our Organ Morphodynamics Lab and has received more than £2m from
@wellcometrust
to study how hearts develop, using zebrafish as a model 🐟
And 1 year has passed! It's been a ...ride!
#newPI
moving countries to set up the lab in the middle of a pandemic 😅 Very grateful to the
@TheCrick
, colleagues, and friends for all the support and this wonderful (no-selfie) team who decided to share this ride with me 😀
Fantastic paper from
@ksedzinski
lab on mechanical crosstalk between migrating cells and their surrounding tissue in Xenopus MCC.
MCC cells probing their environment using actin-rich filopodia in the movie. Many congratulations Kuba 🎉
And it's here 😀 Very grateful to the
@InfoIzfs
and
#zebrafish
community for this recognition! How much I wish to have received this and see you all in person...but for now, looking forward to
#IZFC2021
next week!
Our work on
#zebrafish
heart morphogenesis got highlighted in this wonderful new issue of
@Dev_Cell
focussed on
#mechanics
behind Cell and Development Biology.
"Cardiac Morphogenesis: Crowding and Tension Resolved through Social Distancing" 😇
Meeting alert! Join us in London next year
@TheCrick
for the next Developmental Biology symposium. Stellar lineup of speakers and more talks to be selected from abstracts.
Out Now! My first review on heart development 😀 we focus on cellular mechanisms transforming the heart from a simple tube to a complex organ. Free download link here
(1/2)
Extremely grateful for this recognition by
@InfoIzfs
🙏and
@phil1pingham
for delivering this news in a very special way! I am indebted to my mentors and friends for their continuous support. Looking forward to more adventures with
#zebrafish
@TheCrick
#newPI
Congratulations to the IZFS 2021 Chi-Bin Chien Award winner, Dr. Rashmi Priya! The award recognizes early career investigators who have made significant contributions to zebrafish research and will be presented at the
#IZFC2021
virtual meeting on June 16-22, 2021
@_Priya_R
What makes a heart beat for the first time? Using powerful zebrafish embryos, all-optical electrophysiology and computational modelling,
@BillZJia
@SeanMegason
et al study the very first heartbeat!
Out now from E. Fuchs lab with N&V by
@WickstromLab
! How basement membrane mechanics influence tumour architecture?
Soft BM and crowding > buckling > tumour budding (non-invasive).
Stiff BM and stiff suprabasal layer > folds > rupture of BM > invasion.
What a beautiful sight - children with Microscopes, curiosity in their eyes learning the wonders of Developmental Biology! Terrific outreach event organised by
@InSDB_79
and fantastic students at
@NCBS_Bangalore
. Great start to InSDB 2024!
Alpha Yap
@TheYapLab
in the town
@TheCrick
!
Three Science generations here with Alpha, me and Toby
@tobyandrews
in the same frame 😃 I started my Science career with Alpha and it was a great decision! So fortunate to have him as my mentor 🙏
This was a fun nostalgic ride! How I got into Science purely by accident, the joys and challenges of starting my lab
@TheCrick
during a pandemic, and why I am convinced now is the best time to be a Developmental Biologist!
Thank You
@katemmabrown1
@Dev_journal
#newPI
#zebrafish
In our latest ‘Transitions in development’ interview, our Executive Editor
@katemmabrown1
caught up with
@_Priya_R
to discuss her route into research, being a pandemic-PI and the role of mentorship in her career.
Geometry guides Fate! Out now from Lutolf’s Lab - they recapitulated the stereotypical cell-fate patterning in intestinal organoids by mimicking the geometry of native crypts.
How organs build up their complexity from simple beginnings? How Form influences Cell Fate? Interested in heart development and
#zebrafish
? See me speak
#2020SDB
9th July 17:40 EDT. Thanks
@___SDB___
for this opportunity!
#2020SDB
Speaker Previews
Join us July 9-16 ONLINE
Register now!
Concurrent Session 1 “Pattern Formation across scales”
Rashmi Priya
@_Priya_R
from Didier Stainier's lab will discuss the feedback between Form, Forces and (Cell) Fate during zebrafish heart development.
Thrilled to be selected as an Early Career Editor
@MBoCjournal
and be a part of this amazing team! Looking forward to all the fun 😀 Thanks for featuring us
@ASCBiology
.
Looking for a PhD? Join us and kick-start your academic career in a vibrant, collaborative and nurturing environment
@TheCrick
. Interested in imaging, morphogenesis,
#zebrafish
? Apply to my lab 😀
Applications to our PhD programme are now open! We're looking for graduates of any nationality 🌍 with backgrounds in biology, physics, chemistry, maths, engineering or computer science to join us in 2021 🧫🧪💻📊
Find our more and apply by 12 November ➡️
One of the best parts of being a
#NewPI
has been talking to PhD candidates! I always feel so inspired after engaging with these young brilliant minds. Their enthusiasm and positivity is infectious. You are terrific 👏 Future of research is in good hands!
Postdoc
@Tobyandrews
in our Organ Morphodynamics Lab shows us how he and his lab-mates create 3D videos of beating zebrafish hearts 🐟🫀
Being able to properly visualise this process can help advance our understanding of heart development defects
#BOARD24
'The Mechanics of building functional organs - our take on this fundamental problem. We discuss general design rules building complex 3D geometries, advocate for a holistic understanding of morphogenesis by embracing the complexity of embryonic development.
How do embryos build organs with the right shape, size and function to keep our bodies ticking?🫀🫁👀
@_Priya_R
and I give our take here, in a rollercoaster ride from local cell behaviors to organ-scale physiology and back
Jean-Léon
@maitrejl
in the house
@TheCrick
sharing his recent work on mechanics/morphogenesis of human embryos. Stunning movies, ultra cool Science, and great discussion!
Researchers need community because good ideas don’t just come from reading literature and thinking deep thoughts; it’s helpful to bounce ideas off others, particularly in a nonthreatening environment.
In beautiful Algarve to attend
#ISDB2021
Looking fwd to catching up with old and new friends! Interested in organ morphogenesis, stretchy cells, mechanics of heart development...I will be presenting our work on the 17th, Monday morning
@IntSocDevBiol
#zebrafish
ECM instructs tissue shape during semicircular canal morphogenesis in zebrafish!
Exciting preprint from Akankshi Munjal
@akankshi
,
@EdouardHannezo
et al.
An absolute pleasure to meet these women behind
@IndiaBioscience
which has done an excellent job in expanding the footprint of scientific research in India through community engagements, outreach efforts, mentorship initiatives, truly enabling changes at the grassroots level.
And PhD done!!! Presenting Dr. Allanki
@srini_allanki
@StainierLab
with Summa cum Laude. So much joy and pride! Well done Srini. Onwards and upwards from here...
What a glorious day to visit
@UniofOxford
for sun 🌞 give a talk, and engage in some great scientific discussions! Thank You Paul Riley
@GroupRiley
for the invite.
So so stoked about this!
#InSDB24
program looks fantastic! If you want to know more about how embryos build one of the most efficient pumps, that is the heart, do register for
#InSDB24
.
We are pleased to welcome Dr. Rashmi Priya to
#InSDB24
. Her lab looks at developing embryos to understand how simpler structures like cells develop into complex organs. Ultimately, they want to identify if there are unifying principles underlying complex organ morphogenesis.
Applications for our PhD programme are open! Join us for…
🔬Innovative science
🗺️An international, collaborative environment
🤝Structured PhD programme, training and career support
💰£22k tax-free stipend + tuition and visa fees
Apply by 11 November ⤵️
Heading to
#scdb2022
? Don't miss
@tobyandrews
talk on how the
#zebrafish
heart acquires its complex structure and function. Toby has done wonders with this beautiful system in our lab
@TheCrick
, couldn't be more proud of him! Way to go Toby 👏 ...and look at that speaker list 😲
One week left to apply for a full-time permanent research scientist position in our lab at
@TheCrick
👇 Come and Join us! Questions? DM me!
#ZebrafishJobs
We are hiring! Please RT 🙏 Love
#zebrafish
#Microscopy
#Genetics
? Interested in doing independent projects, lab management, collaboration? We have a permanent research scientist position available
@TheCrick
!
The “Saree Trailblazers” of the Indian Space Research Organisation! "...these photos remind the world—and science—that greatness comes in all colours, shapes and sizes, not to mention clothing..."
(late post)....wonderful two days of the lovely English countryside...Morphogen, Mechanics and Matrix with this most wonderful crowd
@z_hvas
@AEloseguiArtola
🙌
And the latest from
#StainierLab
in
@eLife
, where we found an EMT independent role of Snail in preserving the tissue architecture during heart development. Loss of Snail > weakened cell adhesion, upregulation of desmin > cell extrusion (2/2).
#Zebrafish
Didier Stainier lab
#StainierLab
is looking for a postdoc in RNA/Protein Biochemistry/Molecular Biology to study the quickly developing field of Genetic Compensation. Please spread the word.
adieu KITP
@KITP_UCSB
, thank you for hosting me.
What a stimulating creative environment! I had a great time meeting old and new friends and indulging in the pure joy of Science, leaving inspired!
Don's miss this one 👇The first time I heard
@jbwallingford
when I was a young PhD student, and I still remember leaving the room so full of excitement and enthusiasm.
"One cannot use the laws learned at a certain scale as building blocks to directly explain the emergent properties at higher scales. Reality is a collection of layers of emergence..."
A terrific and timely read
We are now concluding this amazing meeting.
@tgalli
is now waiting for the winners of the best talk (really hard choice). And the winners are:
congrats to
@Audreydsg
and Kristina S. STAPORNWONGKUL
@jpvincentlab
special price to
@_Priya_R
! so well deserved!
Romain Levayer
@LevayerR
in the house
@TheCrick
talking all cool things about cell death ☠️ in epithelial morphogenesis. Brilliant Science and inspiring discussions. Thanks Romain for visiting us.
I will be hiring at multiple levels (PhDs, post-docs, technicians), stay tuned for more details.
And if you want to know more about my work, listen me speak at
#2020SDB
@___SDB___
(online recording available).
#InSDB24
comes to a close!✨
We thank all of you who participated, contributed, and connected during our meeting.
Let us know what you enjoyed the most!
Interesting preprint by
@Yusuke_Toyama
. Why only a subset of cells proliferate to compensate for apoptosis? Heterogeneity in nuclear size and forces leads to YAP translocation, thus selecting cells for proliferation.
We find the spatial inhomogeneity in mechanotransduction through YAP in the neighboring cells accounts for the spatial pattern of apoptosis-induced compensatory proliferation. Only a small number of neighboring cells show nuclear translocation of YAP around the dead cell (*). 2/
Latest from
#Stainierlab
. An EMT-independent (!) role for Snail in preserving myocardial tissue integrity by regulating intermediate filament expression.
Loss of Snail > weakened cell adhesion, upregulation of desmin > cell extrusion.
#Zebrafish
#devbio
Really appreciate the shout out
@Dev_journal
#ISDB2021
. It was super fun talking to
@katemmabrown1
about how I ended up being here!
And thank you so much for all your efforts towards promoting early career researchers...
Now on the platform
#ISDB2021
:
@_Priya_R
talking about heart morphogenesis. To find out more about Rashmi, take a look at our recent interview with her: Part of our 'Transitions in Development' series of interviews with junior PIs
Sara Wickström
@WickstromLab
in the house
@TheCrick
...as always, terrific Science, terrific talk and inspiring discussions. Thank you Sara for visiting us!
1) What drives axis elongation in fast-developing species like zebrafish, where there is little to no growth happening? Our recent preprint proposes a novel mechanism: “compression-extension”
“an epithelium growing under spherical confinement buckles due to the compressive stresses arising from cell proliferation”
Very cool work from
@RouxLab
Wonderful few days of visiting Janelia Research Campus
@HHMIJanelia
and NIDDK-NIH.
Stunning autumn hues and terrific terrific Science! Thank You
@KateMiro1
and
@Isa_Espinosa_M
for having me and everyone for great discussions! Leaving inspired 🙏
Want some positive distraction?
Register for this wonderful seminar series organised by
@KITP_UCSB
on Morphogenesis: in search of principles. Looking forward to hear
@ErzbergerGroup
!
Kicking off the new year with a monthly seminar series on physics of morphogenesis
@KITP_UCSB
. First wonderfull speaker
@ErzbergerGroup
Jan 20 8AM PST. Register here: .
Could not be prouder and happier to see this out!
@tobyandrews
has done some very cool imaging/analysis to reveal the rules of notochord morphogenesis 👇 and he is already doing his magic with
#zebrafish
heart in our lab
@TheCrick
! Way to go Toby 👏
It's out! 🙌 Delighted to see our work on amphioxus notochord morphogenesis published in the awesome
@Dev_journal
!
Grateful to all authors, our editor and 3 thoughtful reviewers for helping the piece evolve to its final state
Check it out here:
Interesting preprint by
@EyalKarzbrun
and
@StreichanS
! Geometrical constraints and mechanics regulate neural tube morphogenesis.
Broad implications for organogenesis.
Well done
@YEN_community
@tobyandrews
+ the organizing committee! Young developmental biology community is indeed flourishing! So proud of my lab 😌Chris (short talk award) and Laura (poster award) 🥇
🏅Congratulations to Christopher Chan!🏅
Christopher Chan secures 2nd place for his brilliant short talk on "Mechanical Remodelling of Cardiac Extracellular Matrix Drives Myocardial Wall Patterning." Well done, Christopher! 🌟
#YEN2024
#YEN24
#Congratulations
How tissue curvature can specify patterns of proliferation…terrific work from Celeste Nelson lab.
High mechanical stress > membrane depolarization> Yap/Taz nuclear localization> proliferation.
Cells located in regions of high MECHANICAL tension display higher ELECTRIC depolarisation 🤩
I am amazed by the constant high level of innovation in the work of Celeste Nelson !
...and if you find this work exciting, we have fully-funded PhD/post-doc positions available
@TheCrick
! International, collaborative environment, terrific Science and plenty of training & career support at every stage. Do get in touch, more details here
Pumped to share our latest and first (!) work from
@_Priya_R
lab
@TheCrick
! Using the powers of
#zebrafish
, we uncover how multiscale mechanochemical coupling drives morphological and functional maturation of the developing heart 🫀
Stay tuned for the🧵
Must holiday read from
@akankshi
. Bravo👏 ECM forces (and not my favorite actomyosin) shape inner ear in
#zebrafish
. Akankshi is starting her lab
@MunjalLab
and hiring, do not miss this opportunity!
2021 brought with it many challenges and equally many celebrations. To wrap it up- here is the “final” and free version of our manuscript describing the role of a hyaluronan rich ECM in the morphogenesis of the inner ear. We even made it to the cover!
I have been fortunate to have this guy
@srini_allanki
on my side as a collaborator and a friend in
#StainierLab
. An incredibly tenacious scientist and a very generous colleague, who will be on the job market soon...don't miss a chance to work with him.