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Yuancheng (Ryan) Lu

@Y_Ryan_Lu

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I study the biology of aging and its reversal. @LSRFdtn & @AFARorg postdoc @JswLab at Whitehead/MIT. Former PhD with @DavidaSinclair @Harvard .

Cambridge, MA
Joined July 2013
Don't wanna be here? Send us removal request.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
My PhD work from @davidasinclair lab with our amazing collaborators has come out today, indicating that in vivo reprogramming can recover the youthful epigenetic information within injured or aged cells and allow optic nerve regeneration and vision restoration. Feeling blessed!
@NaturePortfolio
Nature Portfolio
@NaturePortfolio
4 years
A Nature paper reports that neurons in the eyes of mice can be reprogrammed to a more youthful state in which they re-acquire the ability to regenerate and restore vision.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
It feels bittersweet to finish my last week in @davidasinclair lab. I was so lucky to find this dream match in the 4th rotation and start an incredible 6y journey with some low lows and high highs🍾. Now onto the next chapter with @JswLab to keep learning and growing💪. Excited!
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Happy 52nd birthday to my PhD mentor @davidasinclair who still looks like in his 30s and probably never wasted a minute, even at a Friday night before his birthday. Thanks for being an inspiration to me, and maybe to the little boy in the back as well 😁
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
I became Dr. Lu on May.4th.2020 🎓Feel blessed. #HarvardPhD #Sinclairlab #AntiAging #InVivoReprogramming
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Beautiful @NEJM illustration and review of our work @nature on age reversal and vision restoration. @davidasinclair @Harvard
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
10 months
Delving into our newly released result, a thread:
@CellRepJrnl
Cellular Reprogramming
@CellRepJrnl
10 months
Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma: A year-long functional tracking of in vivo partial reprogramming demonstrates safety and efficacy. Work from @margaretekarg @YuanchengLu @davidasinclair @bruce_ksander
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Interesting in vivo reprogramming paper, the effect is predominantly driven by Myc (Sup.Fig1 and …), but OSK was needed to rejuvenate the heart and unleash the Myc driven effect. Heart seems even harder to regenerate than neurons!
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Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice

Reversible, cardiomyocyte-specific reprogramming by OCT4, SOX2, KLF4, and c-MYC confers regenerative potential to the mouse heart.

www.science.org
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
1 year
I am a huge fan of Elon, but disagree with him on this one. There is no reproduction incentive for fruit flies to evolve a longer lifespan. And none of previous breakthroughs in our healthcare was targeting aging. We need one to explore outer space - I am optimistic about it.
@elonmusk
Elon Musk
@elonmusk
1 year
@paulg Our lifespan is programmed into our genes, just like it is for fruit flies or pets. Fruit are already vegan & even if they do yoga every day & take every supplement, they still only live 50 days.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
2yrs ago on this date, I had the 1st big result in my career. It was one ray of light shed on me after 4yrs of darkness/struggle in PhD. I celebrate this date as an anniversary. It reminds me to keep humble, and remember the unmatchable joy of making discoveries when exhausted.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
10 months
This unifying piece of “The Information Theory of Aging” took us 3 years to craft, with valuable input from reviewers & editor @NatureAging . Thrilled to share it today! Check out David’s thread and grab a free copy:
@davidasinclair
David Sinclair
@davidasinclair
10 months
“The Information Theory of Aging” was published today. Free copy @NatureAging
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
It is really exciting time for rejuvenation research. The field is blooming.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
Dear Michael, I still cannot believe you have gone from us this suddenly. You are the most generous person I have met, you are like my second dad. You trained me into the scientist I am today, I can only pass on your legacy. I love you Michael!! Rest In Peace🙏
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
A very cool tool for epigenetic editing!
@WhiteheadInst
Whitehead Institute
@WhiteheadInst
3 years
Introducing CRISPRoff: a new, reversible CRISPR method that can control gene expression while leaving the underlying DNA sequence unchanged. Designed by Jonathan Weissman @JSWlab , @jamesknunez , @LukeGilbertSF , and collaborators. Read more:
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
1 year
The discovery of nerve regeneration was on Jun.28.2018, only a little less than five years ago. Still remember the feeling in the microscope room vividly. Great efforts from @lifebiosciences @MGH_RI team, now it’s one step closer to clinic to help patients🤞
@davidasinclair
David Sinclair
@davidasinclair
1 year
Epigenetic reprogramming is a new frontier. This day comes after many years of work by @lifebiosciences , @MassEyeAndEar & my lab @harvardmed to develop safe age reversal technologies to reset old, damaged tissues. Image: mouse nerves regrowing (Lu, 2020 @Nature ) 4/
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
2 years
Glad to see this new preprint from @rejuvenatebio using the same strategy we reported previously - dual AAVs to express OSK - to achieve lifespan extension in 2y-old WT mice without any teratoma observed: remaining lifespan was DOUBLED🤩
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Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in...

Aging is a complex process best characterized as the chronic dysregulation of cellular processes leading to deteriorated tissue and organ function. While aging cannot currently be prevented, its...

www.biorxiv.org
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
What can I say besides THANK YOU! @nature @TeeHeemels @davidasinclair @harvardmed & our artists, collaborators.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
In this article we highlighted the potential of harnessing epigenetic reprogramming to treat a leading cause of irreversible blindness- Glaucoma. with @davidasinclair & Meredith Ksander & Bruce Ksander
@GlaucomaToday
Glaucoma Today
@GlaucomaToday
3 years
Could reversing the age of RGCs restore youthful function that would rescue vision lost because of #glaucoma ? A recent study sought to answer this question.
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Yuancheng (Ryan) Lu
@Y_Ryan_Lu
2 years
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
2 years
Deeply honored to be selected as a @LSRFdtn fellow and congrats to other awardees. I am grateful to the generous support from my sponsors and amazing mentors @davidasinclair @JswLab @bruce_ksander &Zhigang He, and my colleagues who kindly helped along the way!
@LSRFdtn
Life Sciences Research Foundation
@LSRFdtn
2 years
Finally! It's been hard to keep this under wraps until August 1st. We are excited to announce our 2022 awardees. Our entire current awardee group is listed on our website: #lifescience #postdoc #earlycareer #funding #basicresearch , #postdocfunding , #award
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
7 months
Something we’ve been waiting for.
@CellRepJrnl
Cellular Reprogramming
@CellRepJrnl
8 months
Our new article reveals that gene therapy-mediated partial reprogramming extends lifespan and reverses age-related changes in aged mice, showcasing lifespan extension in wild-type animals through in vivo reprogramming. @eskamoah @cc_biology_ @rejuvenatebio
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
2 years
Remembering Michael in a talk at CSHL “Mechanisms of Aging” conference has been on my To Do List the past two years. Today I crossed off this task. ps: That was him presenting in the same conference room in the first pic.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
And we were fortunate to have our paper featured on the cover, and accompanied by a News & Views from @hubermanlab
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
2 years
9 years since mCiPSC: hCiPSC.
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Chemical reprogramming of human somatic cells to pluripotent stem cells

Nature - Human somatic cells were reprogrammed to human chemically induced pluripotent stem cells that demonstrate key features of embryonic stem cells.

www.nature.com
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
5 years
Is ending aging possible? I guarantee you won’t be disappointed by this book “lifespan” from my mentor/great aging scientist @davidasinclair and the talented writer @mdlaplante . Huge honor for me to be a part of it. Here is the link to order
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
A touching msg today from a girl who suffers congenital glaucoma: she got abandoned and then adopted to US, got treated & became a science writer, but she still couldn’t drive etc. She has been waiting for a restoration therapy for life. Stories like this fuel me when exhausted.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
5 years
One ray of light after four years of darkness, end up with this prerprint. Thanks to all my great co-authors/labmates, especially my PhD mentors Michael Bonkowski and @davidasinclair , also my dear family and wife. This is a start.
@biorxivpreprint
bioRxiv
@biorxivpreprint
5 years
Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming #bioRxiv
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
5 years
It was great honor to meet 2012 Nobel Laureate Shinya Yamanaka, who invented the method to generate iPSC. I showed him our paper and briefly described the story, he was impressed and very interested in the potential of in vivo reprogramming:
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
Super excited to see the launch of Nature Aging. It will definitely encourage more brilliant minds getting into this field.
@NatureAging
Nature Aging
@NatureAging
4 years
We're excited to launch @NatureAging today! The content of our first issue, "Aging in Unity", reflects the diversity of all communities working on aging: biologists, clinicians, social scientists, civil society and industry. Free to access for all here:
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Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Nature and Science. #autumn #boston
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Absolutely love this amazing gift from dear collaborator @bruce_ksander @MassEyeAndEar .
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Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
This supports that the rejuvenation happens first during reprogramming, and is separable from the pluripotency: even the cells get over-reprogrammed and lose cell identity transiently, no worry! They can regain their identity and get an even greater extend of rejuvenation.
@AgingHighlights
Aging Highlights
@AgingHighlights
4 years
Multi-omic #rejuvenation of human cells by maturation phase transient reprogramming
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
2 years
Visited @salkinstitute @scrippsresearch at the end of 2022, a trip overdue for 2.5 yrs. 2023 is a new start 🙏 ps: pointing at lab space of two great scientists I favor @ardemp @xinjin in photo 2.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Proud to join the Editoral Board of Cellular Reprogramming and run its Twitter account in my spare time! Give it a follow to keep up with reprogramming related research!
@CellRepJrnl
Cellular Reprogramming
@CellRepJrnl
3 years
Hello Twitter World! We are officially here. Stay tuned for all the exciting research and event update related to Cellular Reprogramming, arguably the most fascinating process in biology😉
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
10 months
To our surprise, extending the OSK treatment to 8 weeks fully restored the once lost vision in glaucomatous eyes, and this was also achieved with a Dox-induced AAV version that is clinically favorable.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Great and fun time ahead in this exciting field. Congrats to everyone involved including my co-authors Steve Horvath and @DrMorganLevine !
@altos_labs
Altos Labs
@altos_labs
3 years
With today’s launch of Altos Labs, we celebrate this community of leading scientists, clinicians, and industry leaders. We are excited to pursue cellular rejuvenation programming to restore cell health with the goal to reverse disease.
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Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
“Our ability to make the most out of uncertainty is what creates the most potential value.”
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
Congrats to @davidasinclair and @mdlaplante , the Chinese version of Lifespan is out and becoming super hot! Great popularization for aging science. Friends were reading it before I knew it. The translation is well-done!! How did they even figure out our Chinese name correctly?😄
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Game changer for DNAm clock analysis. Work from my previous baymate @patrick_griffN at @davidasinclair lab🎉
@biorxivpreprint
bioRxiv
@biorxivpreprint
3 years
Ultra-cheap and scalable epigenetic age predictions with TIME-Seq #bioRxiv
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Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Have been waiting for this spring for too long
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Congrats on the paper and the beautiful cover! @AlexandreTrapp @gladyshev_lab
@NatureAging
Nature Aging
@NatureAging
3 years
Our December issue is live! Read about conferences in 2022, #longevity -ready cities, #senolytic vaccination, #COVID -19 and mental health, #telomeres and #AD , muscle #regeneration , a new approach to estimate #epigenetic age in single cells and more
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Yuancheng (Ryan) Lu
@Y_Ryan_Lu
2 years
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
2 years
First Whitehead retreat at Waterville since pandemic. Gorgeous place and a lot of cool science.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
1 year
My first ARVO meeting is full of fun. Many exciting sciences and new friends. See you all at Seattle next year. #ARVO2023
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
🙏
@AFARorg
AFAR
@AFARorg
3 years
Meet 2021 #grantee @YuanchengLu . Learn more about his #research using #genomic technologies & #AI machine-learning to search for novel rejuvenation cocktails to target tissue-specific age-related #diseases : @MIT #PostDoc
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
1 year
Congratulations! Proud of my first intern student Doudou. Well-deserved.
@TheWebbLab
Webb Lab @ The Buck Institute
@TheWebbLab
1 year
✨Big news!✨ @BrownMolBio student Doudou Yu was just awarded a prestigious F99/K00 from the NIA to continue her work on hypothalamic aging. Congratulations Doudou on this well-deserved award!🎉⭐️🧬
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
Q: What’s the secret of productive research from Boston? A: Scientists don’t have much else to do in winter. 😂Wisdom from @pdhsu , I see no lies.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
10 months
My PhD work with @davidasinclair , Zhigang He, @bruce_ksander and colleagues utilized dual AAVs to express OSK, effectively rejuvenating retinal ganglion cells and restoring 40% of lost vision after one month of treatment in microbead-induced glaucoma: .
@NaturePortfolio
Nature Portfolio
@NaturePortfolio
4 years
A Nature paper reports that neurons in the eyes of mice can be reprogrammed to a more youthful state in which they re-acquire the ability to regenerate and restore vision.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
I am extremely lucky to have great mentors like @davidasinclair and late Michael Bonkowski during my PhD. Forever grateful.
@davidasinclair
David Sinclair
@davidasinclair
4 years
@PoHienEar @nature @YuanchengLu Thanks Po. I'm so very proud today of @YuanchengLu , our lab members, and our world-class collaborators
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
This daylight saving thing makes so much sense. Can we just stick with it and not switch back ever?
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
2 years
A chance to educate and influence 1.4 billion people, how exciting!
@davidasinclair
David Sinclair
@davidasinclair
2 years
LIFESPAN: Mandarin edition. When Matt and I released Lifespan, just before the pandemic, our predictions — aging as a disease, emergence of a new virus, telehealth, home testing, biosensors, age tests & age reversal — were merely predictions. Not anymore. What’s next? Lifespan 2
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
6 years
Had fun representing @davidasinclair lab, to share what we have achieved to our Harvard colleagues.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
1 year
Will always brought us HEAT fans joy and energy, and we were lucky to have him by our side at our favorite life moments! A kind and special human being! Great to meet you again at HOF.
@WillManso
Will Manso
@WillManso
1 year
Remember this couple from China who credits their love of Dwyane Wade for help bringing them together? They surprised him at his Legacy celebration with their son named after him Raymond Wade. Well, they came to his HOF enshrinement. Little Raymond Wade is growing up fast ❤️
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Yuancheng (Ryan) Lu
@Y_Ryan_Lu
6 years
Fun teaching day by @davidasinclair and the lab.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
6 years
My student caught me dancing on the chair. Yea there was some good news today.
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Yuancheng (Ryan) Lu
@Y_Ryan_Lu
11 months
We previously reported @Nature the acceleration of the aging in mouse retina neurons due to trauma injury. Dr. Joe Rizzo, @MadhuraShah2 , @DrenusheKV , and us delved into supporting human clinical cases and the potential of epigenetic rejuvenation to treat various nerve injuries.
@agingdoc1
Agingdoc⭐David Barzilai🔔MD PhD MS MBA DipABLM🩺
@agingdoc1
11 months
The Role of Epigenetics in Accelerated Aging: A Reconsideration of Later-Life Visual Loss After Early Optic Neuropathy
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Comprehensive paper from Serrano group and ⁦ @ReikLab ⁩, showing that one week of OSKM induction in 1y-old-mice rejuvenates DNAm and transcription patterns in multiple internal organs and even restores several serum metabolites. #invivoreprogramming
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Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

A single cycle of transient OSKM activation in naturally aged mice is able to partially reverse age-associated changes in several tissues. Specifically, we could capture reversion of alterations...

onlinelibrary.wiley.com
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
So impressed! Great summary and discussion for our paper, worth a look if interested.
@EleanorSheekey
Eleanor Sheekey
@EleanorSheekey
4 years
In my latest video I cover the eye-opening ;) study by @YuanchengLu at the @davidasinclair lab --> Reversing aging through cellular reprogramming!? via @YouTube #epigenetics #aging #longevity #scicomm #AcademicYouTube
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Yuancheng (Ryan) Lu
@Y_Ryan_Lu
10 months
This study spanned several years and owes its completion to the collective efforts of the team. Kudos to all co-authors for their significant contributions!
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Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
@davidasinclair @gofundme Dear Michael, I still cannot believe you have gone from us this suddenly. You are the most generous person I have met, you are like my second dad. You trained me into the scientist I am today, I can only pass on your legacy. I love you Michael!! Rest In Peace🙏
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Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Certainly a fun piece to read. Excellent job ⁦ @adanguyenx ⁩
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Yuancheng (Ryan) Lu
@Y_Ryan_Lu
6 years
The right way to welcome 2019 I guess: dreaming the future with @davidasinclair
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
5 years
Aaron, I am impressed by your understanding of our research at this age, you got the big picture, better than I was 15. Keep up the good work! Typo: Sox2 not Sox3
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Today marks 1y since Michael’s passing. In memory of him, yesterday we went to Winthrop, his favorite 🎣 place, and eat at where he enjoyed getting takeouts. I am proud we have gone through this year together while carrying precious memory of him. He is forever in this way.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
Dear Michael, I still cannot believe you have gone from us this suddenly. You are the most generous person I have met, you are like my second dad. You trained me into the scientist I am today, I can only pass on your legacy. I love you Michael!! Rest In Peace🙏
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
These two methods will be nicely complementary to each other.
@mkaeberlein
Matt Kaeberlein
@mkaeberlein
3 years
Sorry senolytics, "reprogramming" is officially the shiny new object in geroscience. You had a good run.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Terrific effort by @MartinBJensen and @LNuzhna and others to support aging research in a paradigm shifting way! Please consider donating!
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
1 year
So yea this was us waiting in the line out of the now famous Rm 257, after police kicked out the standing audience. We actually got in before talk of Juan Carlos and met up finally. Encouraged to see epigenetic rejuvenation topic is attracting brilliant minds. A memorable @ISSCR !
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
Such great news for Science and Humanity! My son witness his first, and the most important election in history. #PresidentElectJoe
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
Michael, I know you must be incredibly proud today up there. I can smile thinking that our Nature completes your CNS journal collection. Miss you a ton bro.
@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
Dear Michael, I still cannot believe you have gone from us this suddenly. You are the most generous person I have met, you are like my second dad. You trained me into the scientist I am today, I can only pass on your legacy. I love you Michael!! Rest In Peace🙏
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
I am willing to review papers, folks in aging and eye research community @aginghighlights and editors at @NatureAging @AgingCell @NeuroCellPress @Cell_Metabolism @NatureComms @GlaucomaOrg , please reach out.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
10 months
Few questions remained to be answered: 1. What’s the maximum extent of recovery that can be achieved? 2. How long is vision improved by continuous OSK? 3. How stable is a single cycle of in vivo reprogramming?
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
@realNathanCheng @KKajderowicz @OnDeckLongevity @michellebkwok @adanguyenx @janechuprin @ArtirKel Why not? Haha. What time on Friday?
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
1 year
My colleague, collaborator and dear friend Xiaojie has been a great inspiration to me! So proud of you Xiaojie! Consider joining his lab if you are interested in machine learning, single cell, and spatial genomics 🚀
@Xiaojie_Qiu
evo-devo
@Xiaojie_Qiu
1 year
I am profoundly humbled and excited to officially announce that I will start my independent lab at Stanford this Dec. 16th. Growing up as the son of farmers in a remote village in China and facing the loss of my father at an age of 10, this journey has been anything but easy.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
2 years
Proud of my ex-intern student @doudou_yu_ , who played a critical role in our nerve regeneration discovery, now had her first author paper from @TheWebbLab featured on Nature Aging. Congratulations!🎉
@TheWebbLab
Webb Lab @ The Buck Institute
@TheWebbLab
2 years
Interested in how the hypothalamus ages? Check out our new study in @NatureAging . HUGE congrats to co-authors @KHajdarovic and @doudou_yu_ !
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
9 months
Congratulations @patrick_griffN !
@davidasinclair
David Sinclair
@davidasinclair
9 months
Our latest paper is out - a new method called "TIME-Seq" to measure biological age for just a few dollars. Great work Patrick Griffin! @NatureAging Free download
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
@dhakal_rasik @davidasinclair Great question, more work is needed, but here is our hypothesized mechanism: In the presence of OSK, the PRC2 complex recruits TET to specific sites (e.g. H3K27me3 enriched) in the genome and induces active demethylation, while adding methylation by DNMTs should be involved too.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
10 months
It highlights the therapeutic potential of rejuvenating gene therapies using OSK, not only for glaucoma but also for other ocular and systemic injuries and age-related diseases.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Super exciting news! Visionary move @pdhsu @patrickc @SKonermann !
@pdhsu
Patrick Hsu
@pdhsu
3 years
Delighted to announce the Arc Institute @arcinstitute , a new, independent scientific institution dedicated to the study of complex human disease. Working with our partners @UCBerkeley @Stanford @UCSF , our mission is to accelerate progress in biomedical research and therapeutics.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
10 months
We are confident this improvement is not due to spontaneous vision recovery as this glaucoma model has been widely used and no observation of recovery was observed. We then continued monitoring the AAV-treated groups.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
10 months
To address these, led by @margaretekarg and @bruce_ksander , partially funded by @lifebiosciences , we conducted to our knowledge the first year-long functional tracking of in vivo reprogramming with either continuous OSK or cyclic OSK in RGC, reading by an objective vision assay.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
5 years
Wisdom from Nobel Laureate “Most great discoveries start with an unexpected result and a receptive mind.”
@kaelin_lab
KaelinLab
@kaelin_lab
5 years
Bill out here dropping dimes 💡🔑
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
The GoFundMe page for helping Michael’s family. He has two young sons just lost their dad.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
6 years
Definitely not an easy path🤣
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
5 years
Blessed and thankful🙏
@BleacherReport
Bleacher Report
@BleacherReport
5 years
Raymond Wade Lu meet @DwyaneWade . This baby was named after D-Wade and they got to meet ❤️
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
6 years
Held Spark for 7 months, sold all I have two weeks ago at $48. Now the stock could be double Monday. Lesson: Believe in what you believe and never doubt. Easy to say but hard to do.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
This was the NC paper I tried to cite:
Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity

Nature Communications - Levels of the transcription factor Myc are deregulated in a range of different cancers. Here the authors show that Myc induces rapid transcriptional responses in some mouse...

www.nature.com
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
Finally someone tested if GHR KO in adult still extends lifespan. Looks like the lifespan benefit of messing up GHR/IGF-1 pathway is mostly awarded at early age. The trade off was to have a smaller body size and it doesn’t seem appealing in this society.. Better solution needed!
@MartinBJensen
Martin Borch Jensen
@MartinBJensen
3 years
More notable result is that GHR KO at 6mo does NOT extend #lifespan in male mice, and effect in females is much smaller than from-birth mutation. Different explanations possible, but one is that biological wiring during development drives much of the GH effect on lifespan.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
10 months
The DOX inducible AAVs were profiled by Nasrin Refaian; after DOX withdrawal, it takes about 4 wks and 6wks respectively for OSK mRNA and protein to go away.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
5 years
You can’t miss this awesome book about aging! I have seen how hard @davidasinclair @mdlaplante working on it. Hug congrats! I need you two signing a copy for me.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
10 months
Together with our other results @nature , these results indicate that the eye, particularly in the context of this glaucoma model and retinal neurons, represents an ideal system and condition to evaluate the efficiency and safety of novel interventions to rejuvenate tissues.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
This is wonderful.
@MartinBJensen
Martin Borch Jensen
@MartinBJensen
3 years
Please RT! Putting our 💰 where our mouth is, Norn Group is launching a new program to help talented foreigners reach the US and contribute to #longevity research. We need a half/full-time Ops lead to plow through obstacles. Apply here (more info below):
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
3 years
A method enables simultaneous analysis of single-cell lineage, gene expression, and spatial organization in the same tissue! Congrats for this beautiful work.
@GraceKC
Grace Edmonds
@GraceKC
3 years
So excited to share our publication today! Working with the awesome @markwbudde , A. Granados, and other brilliant minds in the @ElowitzLab , Lois Lab, and @LongCai_Lab , we developed a synthetic recording system to image single cell lineage history.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
@Faris43211 Reversal of aging via in vivo epigenetic reprogramming
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
This one hit many of us hard. Jay was one of my favorite scientists in the aging field since our first interaction 5yrs ago. He taught me a class on mechanism of aging and gave me advice anytime I need, including one just before his relocation. We lost a great great soul today.
@davidasinclair
David Sinclair
@davidasinclair
4 years
Can’t believe it. Our buddy, Jay Mitchell, a young professor who helped figure out why fasting is healthy & how to treat rare diseases in kids, just passed away. A huge loss to the aging field. I’ll miss you, man.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
1 year
Wonderful recognition but not surprised. Proud of you Kat!
@katclone
kat
@katclone
1 year
Extremely grateful to be chosen as a 2023 @PDSoros Fellow!!! Thank you to my amazing science mentors across career stages! @MIT ( @mitbrainandcog + @WhiteheadInst ): @Hrvatin_Sinisa / @JSWLab / @YuanchengLu / @HeatherKPhD @Harvard : @_emmarosewest /Connie Cepko @Cornell : @CornellBirds
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
10 months
Congratulations @AndreaCipr83541 @mahdi_moqri @SunMaybury Ryan Rogers Hammond, @davidasinclair & Vittorio Sebastien and all. A great summary and a beautiful piece to read.
@AgingHighlights
Aging Highlights
@AgingHighlights
10 months
Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
All net🏀
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
During my talk, I shared the scientific wisdom from James Watson.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
4 years
That’s so exciting! I am sure I will be submitting one to it in the future!
@TeeHeemels
MarieTherese Heemels
@TeeHeemels
4 years
Nature Aging is open for submissions! Chief Editor: Sebastien Thuault (unrelated, Picasso's self-portraits at different ages)
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
10 months
1. Ceasing OSK after 8 wks maintains improved vision at a level similar to healthy eyes for an additional two months before a slight decline. 2. Sustained OSK expression beyond 8 wks enhanced vision even more, which was maintained at a healthy state thereafter.
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@Y_Ryan_Lu
Yuancheng (Ryan) Lu
@Y_Ryan_Lu
5 years
Literally in tears of joy right now. Fight through all stress and doubts from outside, sometimes even from ourselves, but keep standing straightly! Unreal feeling!
@davidasinclair
David Sinclair
@davidasinclair
5 years
After all the hard work and repeated failures you experience as a young scientist, moments like this make it all worthwhile:
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