#Novavax
#UniversalCovidVaccine
: More durable than mRNA vaccines with 90% efficacy after booster at 8 months without need to update for every new strain and far safer. They use conserved epitopes common in ALL variants.
Good news from Novavax today- they will use single dose vials in the upcoming fall booster campaign in the US. This hopefully means that scheduling and availability will be better as they won’t have to wait for certain days to include enough recipients for 5 or 10 dose vials.
Didn’t want to tweet this until I was absolutely sure. But I had tinnitus & brain fog from Covid in Nov 2022. Was able to get a Novavax booster a month ago. No side effects like I had with mRNA except pain at injection site. Tinnitus & brain fog also gone.
Finally a comparison of Novavax vs mRNA for protection in the upper airways. Only Novavax showed protection in the upper airways. While other studies evaluated peak protection, this one actually evaluated protection after 3 months.
Two doses of Novavax is shown to be universal-like with superior antibody levels vs 3x mRNA in trial participants. It is broad spectrum so annual boosting is actually achievable. High durability of protein platform similar to Novavax vs mRNA is here:
@StoneColdPillar
We currently provide updated 2023-2024 COVID-19 Moderna and Pfizer vaccines. Once it receives FDA approval, Novavax will be available.
Novavax is already a pan-coronavirus vaccine for Covid19. Graphic explains how Novavax protects from ALL current & future variants with durability that is so sadly missing from existing mRNA vaccines. Great print on what's needed for a pan-coronavirus:
Looks like Novavax will be presenting their latest boosting data at World Vaccine Congress this week. Hope to see more compelling data of durability and broad protection. Additional speaking slots for safety and their Covid/Flu vaccine progress as well.
This is a first for Novavax where they have data before Pfizer on JN.1. It also makes me wonder why Pfizer doesn’t have data yet with tons more resources.
I realized novavax has helped 5 things: allowed my shoulders 2 move again after 16 mos & took 80% of the pain away in 48 hrs. 2nd jab made them back 2 norm. It got rid of 95% of internal tremors, my painful GI flare ups, 80% heart pain gone, & heartburn basically gone.
#novavax
But I also started lion’s mane supplements 2.5 months ago. Not sure if it was due to a combo of Novavax booster and the mushroom supplement or just Novavax alone. But glad the last symptoms are gone.
It can provide mucosal immunity which means sterilizing immunity. It's the only way to get out of our current predicament. We all need to send the message to our governments to reject the mRNA experiment that can't keep up with the high degree of mutations
We finally have data on what Novavax booster protection looks like after 2x mRNA, 3x mRNA and even J&J. It looks very good and gets IgG titers back to levels correlated to 90%+ efficacy in P3. Monovalent OG is still best which confirms broad protection against future variants.
Study of protein based vaccine vs mRNA for durability showed that after a year, IgA was detectable in nasal, salivary and rectal secretions in the protein group- consistent with viral clearance when challenged which showed superiority in protein group.
Finally a comparison of Novavax vs mRNA for protection in the upper airways. Only Novavax showed protection in the upper airways. While other studies evaluated peak protection, this one actually evaluated protection after 3 months.
Everyone please write to WH & FDA so that we can access Novavax before they do the government shutdown. Who knows how long it’s take if it isn’t approved this week.
For everyone waiting for
#Novavax
, please send a letter to the White House and the FDA requesting immediate approval before the potential government shutdown this week. Here's my letter.
Write yours here:
Additionally, they said that they’re going to measure mucosal effects in a study. They are also testing a higher dose Covid vaccine for older population as it’s shown to induce a better immune response in already primed individuals.
Novavax’s stand-alone flu vax showed better immune response than existing flu vaccines while their Covid/flu combo showed similar results as existing flu vaccines. Both Moderna and Pfizer failed on their endpoints for Covid/flu combo vaccines.
Let’s make Rite Aid trend for carrying Novavax. They’ve been the only one I’m aware of that has publicly given a nod to Novavax. Maybe others would follow if they see them getting attention for Novavax?
Consider this- Novavax would've held up for 3 years without needing an update if it was available day 0. Now compare it to mRNA vaccines that aren't durable and need updating to keep up with the variants. It is still a far superior vaccine.
Novavax's Covid vaccine: 1) Highly effective against circulating variants- including Omicron 2) More durable than mRNA vaccines with 83% efficacy after 6 months 3) Far safer than mRNA vaccines 4) Less expensive 5) Easier to store, transport & administer.
Anyone that refuses mRNA can opt to take Novavax instead. Reach out to OCOD
@fda
.hhs.gov or call 1-800-835-4709 to tell them to make their guidance more clear. There is hope for those of us that can’t have mRNA. Guidance has to be reflected or we’ll go back & forth at pharmacy.
NIAID funded test of different vaccines show Novavax is best overall for ALL variants. With BA.2.75 on the horizon, it seems Novavax is best for that. Researchers also say that variant specific boost isn't significantly better than original formulation.
My previous thread for all things Novavax is here. Saves people research time as it includes studies and videos to explain why Novavax is better than mRNA vaccines.
#Novavax
#UniversalCovidVaccine
: More durable than mRNA vaccines with 90% efficacy after booster at 8 months without need to update for every new strain and far safer. They use conserved epitopes common in ALL variants.
I'll reiterate the significance of mucosal immunity in the Novavax vaccine. Sterilizing immunity in upper respiratory AND lower respiratory track as Omicron likes to infect upper track. Astra Zeneca (ChAdOx1nCoV-19) can't do this.
Here's a different way of looking at how Novavax provides protection across all variants. It simply presents something that's common across all variants that the immune system can key on in the future. mRNA vaccines simply do not present the non-mutating regions(not very durable)
People wonder why it needs 3 shots to get the high antibodies vs newer variants. It's because the immune system needs to be trained against the non-mutating epitopes/regions of the spike. Because mRNA does not include this, you have to start over on square one after each shot.
Latest data from Novavax from 3/7/23 shows that 3x shots of their monovalent vaccine against XBB.1, BQ.1.1 or BF.7 yields the equivalent Anti-rS IgG as a 1x Novavax + 3x Pfizer or Moderna for BA.5. Not too bad at all considering XBB can be considered SARS3
This is what we’re hoping for. With this afternoon’s show of support from the public as well as Dr. Hildreth, their task has become easier! Novavax access for everyone!
Latest data from Novavax from 3/7/23 shows that 3x shots of their monovalent vaccine against XBB.1, BQ.1.1 or BF.7 yields the equivalent Anti-rS IgG as a 1x Novavax + 3x Pfizer or Moderna for BA.5. Not too bad at all considering XBB can be considered SARS3
@rey_purple
@joaquinlife
Very likely. There is no scientific reason not to especially since FDA made a huge mistake by requiring bivalents in the first place.
@muppetK
@CZEdwards
If it’s any help, I had the novaVAX a few months ago, and the only side-effect was a slightly sore arm, but even that was less sore than from the Pfizer. Nothing else, no chills, no fever, no headaches, nothing.
#Novavax
is the safest Covid19 vaccine you can get. My prediction is that it will become a household name for this reason in addition to the broad efficacy against current and future variants.
From a safety perspective,
#Novavax
has the best safety profile of any Covid vaccine. Novavax chief safety officer says you can expect to see natural background events of myocarditis in any sufficiently large database.
The mRNA answer is to use an "updated" vaccine for Ba.1 that is already gone. Their proposal is to just use manufacturing data and skip trials. This means they want us to be guinea pigs for "updates". We are not guinea pigs. "Move fast and break fast" is not for public health.
When experts say we need a pan-coronavirus vaccine, it is actually more ambitious than Covid-19. They want it to protect against future corona viruses like SARS & MERS. Novavax is IT for Covid-19.
@AshishKJha46
Get the FDA to approve Novavax for all without restrictions. Don’t you know many of us don’t want to go through the bad experience of mRNA? It’s also a broad spectrum vaccine that is more durable. But you know this.
Surprise surprise.
@US_FDA
wants to see additional data to allow for 4th booster dose of Novavax. How about 8 mice data now for approval followed by a clinical trial next quarter like you allow Pfizer and Moderna?
@Gobbluthmagicma
@joaquinlife
Yes. I agree 100%. mRNA was a stop gap and Novavax should be the workhorse with broad spectrum protection, high durability and best safety profile.
We mean protection from transmission when we say Novavax protects you. Not from death and hospitalization which is what the mRNA vaccine makers mean when they say protection. It's protection from symptomatic and asymptomatic infection.
#Novavax
#UniversalCovidVaccine
: More durable than mRNA vaccines with 90% efficacy after booster at 8 months without need to update for every new strain and far safer. They use conserved epitopes common in ALL variants.
Study of Novavax
#COVID19
vaccine estimates 100% efficacy against hospitalizations
A post hoc analysis of a randomized, controlled trial estimates that 2 doses are 100% effective against hospitalization by 95 days
Many experts ask for a pan-coronavirus vaccine but never dive deeper.
#Novavax
already does that. It reduces the antigenic distance of variants to give broad protection against future variants. We already have a pan-coronavirus vaccine people. Explainer:
Today, the
@EMA_News
#CHMP
recommended for approval our updated protein-based non-mRNA
#COVID19
vaccine in the European Union to protect against emerging variants.
Learn more:
Novavax is already a pan-coronavirus vaccine for Covid19. Graphic explains how Novavax protects from ALL current & future variants with durability that is so sadly missing from existing mRNA vaccines. Great print on what's needed for a pan-coronavirus:
This study based on real world vaccinations from South Korea compare Novavax with Pfizer. Shows Novavax is twice as good at protecting against severe infection and a 4th homologous dose of Novavax showed broad protection against emerging variants.
This one is huge! Novavax confirms they DO NOT cause IgG4 class switching like the mRNA.Reminder: IgG4 will identify an antigen as benign like when a bee keeper gets repeated stings & his immune system no longer reacts to it. You don't want that for Covid!
Dr Paul Offit from the FDA vaccine committee is saying that boosting with
#Novavax
ancestral strain will be better than any bivalent vaccine that the mRNA companies will have. Novavax will have a bivalent cuz FDA requires it as mRNA vaccines can’t keep up.
Sounds like Novavax modified their agreement with US Federal government which will allow them to continue to supply free doses to states and federally qualified health centers. Hopeful it’ll be free to the underinsured.
Great graphics that simplify how the different vaccines work from
@michaelzlin
. This shows that the traditional protein based vaccine from
#Novavax
is the least intrusive of the different vaccines being used today for Covid19.
After mRNA priming, antigen expressing cells from mRNA boosters are killed off by antibodies which leaves less antigen for immune system to learn new variants. A low durability mRNA platform requiring frequent boosting means it isn’t suitable for vaccines.
@Novavax
's Filip Dubovsky said they are currently developing vaccine vulk and virus seed ahead of a fall COVID booster pick by
@US_FDA
"approach may shorten the time between strain selection and deployment of vaccine"
22%-31% of people aren’t taking updated vaccines because of bad reaction to previous shots. That’s a big portion of people that Novavax could help. How do we let these people know that a new alternative is available?
You can shout from the rooftops that Covid is airborne, that everyone should wear a mask. The real problem is here in this picture.
They will have to learn the hardest possible way.
Study from Singapore shows that hybrid immunity is not enough against fast evolving Omicron variants. XBB should be considered SARS3 and next-gen vaccines should be used to target conserved epitopes, highly durable and protection in the nasal mucosa.
Finally starting to see articles that point to Novavax’s broad protection against all variants. mRNA vaccines fall short in durability and protection against variants and need reformulation to keep up.
Makes you think why Novavax which can stop transmission is slow walked while the US government keeps buying $ billions in ineffective mRNA vaccines. Pfizer can double dip on the Paxlovid too. 🤔
Pfizer stated⬇️ their goal is “generating demand”😲
Things increasing demand
🔸Non-sterilizing 💉allowing infection/spread
🔸No measures➡️rampant spread
These decrease demand
❌N95 use
❌Air disinfection
❌More tests, isolate infected
🤔 Gee why were these dropped/discouraged?
#Novavax
looks even better as a booster for Pfizer, Astra Zeneca, SinoPharm, SinoVax primed. Moderna isn't here but I'd expect similar great results as with the Pfizer mRNA primed.
Another thing
#Novavax
did is they further engineered the protein to make it harder for the S1 and S2 parts to break off from each other at the furin cleavage site. That's how it can better teach the immune system to achieve better durability against variants. S2 doesn’t mutate.
A real world study that compared reactogenicity of covid vaccines. This one compares mRNA with Novavax. There is no comparison. For every category, Novavax shows less side effects.
Countries are starting to see the benefits of a protein based vaccine like Novavax. Taiwan may be the first country to phase out Pfizer in favor of Novavax. I expect more countries will do the same.
Why is S2 important? Here’s a great print that says it’s hugely important for a pan-coronavirus vaccine. The author of the paper says any mutations with S2 makes the virus non-viable. This essentially means
#Novavax
is a pan-coronavirus vaccine.
Novavax will reduce antigenic distance as it targets conserved epitopes that are common across variants. It helps your immune system recognize different variants as you keep boosting with it. If we do annual boosting, the durability and broad spectrum Novavax is the way to go.
It does look like Novavax will need to update their vaccine as the XBB variant has drifted far from the original. It's like trying to use a SARS vaccine for Covid19 at this point for all of the vaccine makers. You're probably protected from death and serious outcomes- that's it.
Dr. Hildreth has always been a great advocate and has asked that the FDA and CDC remove any barriers for people that want to access Novavax that previously had mRNA. He said he'd choose to use Novavax if given the choice as well.
EMA Europe confirms that there are no safety concerns with Novavax. This aligns nicely with data from South Korea and Taiwan. If you want a safe Covid vaccine, Novavax is it!
COVID-19: How good is a Novavax booster and with previous mRNA doses?
This long thread explores what kind of immune response a Novavax booster is giving people as a primary series and after 2 or 3 mRNA doses in recent studies, and what some of the benefits seem to be. 🧵1/
Novavax says they have evidence that they’re 90%+ effective against the latest Omicron variants and data to support that their durability for up to a year.
I'll reiterate the significance of mucosal immunity in the Novavax vaccine. Sterilizing immunity in upper respiratory AND lower respiratory track as Omicron likes to infect upper track. Astra Zeneca (ChAdOx1nCoV-19) can't do this.
When boosting with the next strain selected for update, Novavax will reduce the antigenic distance with the next variant of concern too. There is no reason to go to mRNA bivalents as they wane too quickly and don't have the added broad protection from boosting. Hope FDA listens.
People that vaxxed with Novavax say it just works. They get exposed to it through close contacts like family, friends or co-workers and they don’t catch Covid.
I just took my 154th covid test since this 'thing' started. Negative. Again. You wonder if
@Novavax
vax works? Yeah I'm a clinical trial guinea pig but the proof is in data. Rock solid science. Rock solid vax. Enough said. And i've been exposed 2 it more than most. Love, Toby.
@DrCaliff_FDA
The stakes are getting higher for those that can’t tolerate mRNA vaccines. Why is your FDA slow walking Novavax again and again? Again and again. When does that stop?
@tkradio
@Novavax
This is what I hear from lots of people that has taken Novavax. It just provides the broad protection against all variants and very durable.
Novavax is already a pan-coronavirus vaccine for Covid19. Graphic explains how Novavax protects from ALL current & future variants with durability that is so sadly missing from existing mRNA vaccines. Great print on what's needed for a pan-coronavirus: