Incoming Assistant Prof
@mcgillu
interested in using human genetics for drug discovery | Endocrinologist | Research Fellow
@broadinstitute
and
@harvard
Excited to share our work in Nature Metabolism
@NatMetabolism
🎉!
Why does obesity increase COVID severity risk? What mediates this?
We integrated genetics, proteomics & scRNAseq to identify an actionable mediator NPNT, which can be ↓ by ↓body fat.
🧵:
Broad Institute of MIT and Harvardが無料公開してる、医学/ゲノム講座がかなり良い。
・GWAS
・医療画像ディープラーニングの活用法
・scRNAseq
などなど、医学の最先端知識を世界トップレベルの研究者が1時間かけてレクチャーしてる。
これが無料で見れちゃうとは…!
Excited to share our work in Nature Metabolism
@NatMetabolism
🎉!
Why does obesity increase COVID severity risk? What mediates this?
We integrated genetics, proteomics & scRNAseq to identify an actionable mediator NPNT, which can be ↓ by ↓body fat.
🧵:
This could be another genome-to-drug success story like PCSK9 — this time for Alzheimer's disease!
・アルツハイマー病の発症を強力に抑制する遺伝子が見つかる
・40歳位で皆がADを発症する家系で、reelinに変異があった人だけ発症が20年も後だった
これは凄い!
I know, Coke Zero makes us feel less guilty. But it may weaken our immunity.
人工甘味料のスクロースが、T細胞免疫を弱めるという報告がNatureに。
嗚呼、コーラゼロやめねば…
The dietary sweetener sucralose is a negative modulator of T cell-mediated responses
Tomorrow morning at
#ASHG2023
, I’ll talk about how we used proteomics and genomics to identify an actionable plasma protein linking obesity to coronary artery disease!
Join us in the session: Using proteomics to elucidate mechanisms underlying cardiometabolic traits and T2D.
Excited to share our latest work - a meta-regression analysis of all cardiovascular trials of diabetes drugs!
全糖尿病薬の心血管試験をメタ解析した論文を出しました!
✅HbA1c1%低下毎に心血管リスクは14%↓
✅体重1%低下毎に心不全リスクは7%↓
→治療, 大事です
I'm excited to give an oral presentation (2 yrs in a row!) at
#ASHG
about how we used proteome-wide Mendelian randomization to identify endotrophin as an actionable mediator for the effect of obesity on coronary artery disease!
Preprint:
DCで口演します!:)
Tomorrow morning at
#ASHG2023
, I’ll talk about how we used proteomics and genomics to identify an actionable plasma protein linking obesity to coronary artery disease!
Join us in the session: Using proteomics to elucidate mechanisms underlying cardiometabolic traits and T2D.
@BrentRichards19
Thank you so much
@BrentRichards19
! It’s been an exciting 18 months, and I couldn't be where I am today without you and the amazing lab members. So grateful for your unwavering support and mentorship. Very much looking forward to the next chapter!
Scenescent cells, which increase with age and also by injury, damage the body throughout life.
年齢とともに増える老化細胞/ゾンビ細胞は炎症を起こし、組織障害時の再生のジャマをする。
このゾンビ細胞は、年齢関係なくケガでも増えるらしい。
ケガはしないに限りますね。健康な一年を!
happy to be a small part of this great study led by
@CYiheng
and
@BrentRichards19
published in
@NatureGenet
!
✅one of the largest metabolomics GWAS
✅revealed the genetic architecture of metabolites
✅identified causal metabolites for BMI, CAD, and more!
Our article is now free to read
@NatMetabolism
Thank you to the handling editor Yanina and the great editorial team for helping us tackle the pandemic.
こちらのNature Metabolismの論文、editorial teamのおかげでオープンアクセスになりました。ぜひご覧ください
Excited to share our work in Nature Metabolism
@NatMetabolism
🎉!
Why does obesity increase COVID severity risk? What mediates this?
We integrated genetics, proteomics & scRNAseq to identify an actionable mediator NPNT, which can be ↓ by ↓body fat.
🧵:
Our new preprint is out!
Obesity strongly increases cardiometabolic risk – but how?
We used integrative proteogenomics to identify seven circulating protein mediators, including COL6A3-endotrophin for CAD, which can be reduced by lowering body fat.
🧵1/n
Mild COVID-19 influences future response to vaccination against influenza — & does so in distinct ways for men vs women
これは面白い。
軽症のコロナでも免疫系に爪痕を残し、
その後に受けるインフルワクチンの効果に影響。
更に男性と女性で影響は違う。
本日のNature論文。免疫は奥深い👀
HIV-1 remission and possible cure in a woman after haplo-cord blood transplant - Cell
臍帯血移植でHIVが完治した可能性の高い、初の女性症例。
男性完治症例は既に2例報告あり
現時点では全員が受けられる治療ではないですが、エイズの誰もが完治を目指せるような日も遠くないかもですね
Finally!
“data are reassuring with regard to the use of metformin during pregnancy in women with type 2 diabetes and the long-term health of their children”
メトホルミンは胎児奇形を増やさないことを示した研究!
現状は妊娠中はインスリンしか使えませんが、飲み薬の選択肢、期待ですね
Excited to share our latest work - a meta-regression analysis of all cardiovascular trials of diabetes drugs!
全糖尿病薬の心血管試験をメタ解析した論文を出しました!
✅HbA1c1%低下毎に心血管リスクは14%↓
✅体重1%低下毎に心不全リスクは7%↓
→治療, 大事です
BMJ Chrismas issue: Can artificial intelligence pass the Fellowship of the Royal College of Radiologists examination?
今年のBMJクリスマス号は”AIは英国放射線専門医試験に合格できるか?”
結果は、いい線行くけどまだ人の手助けがいる、また筋骨格系の画像に弱い、と👀
Listen to how plants 'cry' when thirsty or under stress.
植物も、喉が渇く、切られるといったストレスを受けると、人には聞こえない高音で泣いているという研究の紹介。ちゃんと水あげましょう
The sound can be found here/音声↓:
I am excited to share our preprint with
@BrentRichards19
!
We used Proteome-wide Mendelian randomization, colocalization, mediation analysis, and scRNA-seq to identify nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity.
Rounding on COVID wards, I often wondered why obesity obesity led to increased risk of severe disease.
Here Satoshi Yoshiji identifies, Nephronectin, a circulating protein that is strongly modified by obesity.
Babies should be given peanut products between 4 and 6 months to reduce allergy - BMJ
・生後4-6ヶ月の期間にピーナッツを与えると、ピーナッツアレルギーのリスクを77%減らせる可能性ありと、英国から
・大抵のピーナッツアレルギーは生後1歳までに発症する為、この短い期間を狙うべきと
Our study
@NatMetabolism
is featured in McGill Health News!
Key takeaway: reducing body fat and increasing muscle can decrease severe COVID risk by modulating circulating protein levels. Time to exercise💪
我々のNature Metabolism論文が記事に! 嬉しいです
Excited to share our work in Nature Metabolism
@NatMetabolism
🎉!
Why does obesity increase COVID severity risk? What mediates this?
We integrated genetics, proteomics & scRNAseq to identify an actionable mediator NPNT, which can be ↓ by ↓body fat.
🧵:
In 1990, sequencing the entire genome cost $2.7 billion. Now it's just $200. Stunning progress.
1990年に初めてヒトの全ゲノムがシークエンスされたときは27億ドルもかかりました。それからわずか30年強で、なんと今や200ドル。
ムーアの法則をはるかに上回る速度の技術革新で、驚異的です。
AlphaCode, developed by DeepMind, beats half of humans at code competition.
・Google傘下のDeepMindが開発したAIプログラミングツールAlphaCodeがScienceに掲載。
・コンテストで約半数のプログラマをしのぐ性能あり。
またとんでもないものが登場しましたね😲
#AlphaCode
—a new
#AI
system for developing computer code developed by
@DeepMind
—can achieve average human-level performance in solving programming contests.
Learn more this week in Science:
1/8 The new High Potential UK Visa that opens on May 30, 2022 allows those who have completed a degree from one of 37 universities outside of the UK in the last 5 years to move there freely without an employer for 2 or 3 years (for PhD grads).
This is a HUGE deal!