Encouraging data in
@APAPubJournals
from our double-blinded RCT evaluating Stanford Neuromodulation Therapy (SNT) for treatment-resistant
#depression
. After 5 days, 79% in the active group experienced remission from depression compared to 13% in sham.
Our new open-label trial suggests safety, feasibility, and high efficacy for treatment-refractory OCD of an accelerated, fMRI-guided, high-dose, cTBSmod protocol targeting right frontal pole.
@brainstimj
@EleanorJCole
@Stanford_PMHW
@CRodriguezMDPhD
1st trial comparing TMS to other augmentation strategies for MDD.
Spoiler: TMS outperformed switch to venlafaxine, while Abilify augmentation (the only strategy that's ever been shown to be superior to others) did not.
Our new research published in
@PNASNews
indicates SAINT therapy is effective because it helps to reverse the direction of signaling within
#brain
networks involved in emotion regulation. Thank you
@BBRFFoundation
for the informative coverage.
Depression remains the leading cause of disability worldwide, affecting almost 300 million people, half of whom can't find lasting relief from drugs or therapy. However, a new experimental treatment seems to be hopeful
New Treatment for Depression:
A new therapy using brain stimulation and neuromodulation found 80% of participants saw their severe depression go into remission
Dr.
@NolanRyWilliams
is the Director of
@Stanford_BSL
With
@NolanRyWilliams
we talk about the SAINT protocol that led to remission in 19 of 21 participants w/ depression after a single week of (intensive) transcranial magnetic stimulation. Guest questions by
@foxmdphd
&
@shansiddiqi
!
Tune in 🎧🔈🎶💫💥:
I was thrilled to wake up this morning and see that our SAINT study was featured on national news! Thank you to
@VickyNguyenTV
and the team at
@TODAYshow
on
@NBC
for highlighting how this technology is already helping patients.
NBC interviewed, Chase,
26 years ago today - on April 14th, 1998, at 8am in the morning, Eric Meyer leaned forward, tapped a few keys on his laptop, and launched
#Netflix
to the world.
That first day was a long one. We crashed our servers. Ran out of mailing labels. Scrambled to get everything to the
INTERVENTIONAL PSYCHIATRY | A rapid-response major depressive disorder therapy, with a 2-week response rate of 50%—a considerable improvement over current treatments—could mitigate the economic strain of
#MDD
by $29 billion in 2023.
#Psychiatry
#PsychX
Research indicates a new fast-acting major
#depression
treatment is effective because it helps to reverse the direction of signaling within an important
#brain
network that is likely out of synch.
@andreashorn_
@stimbrains
The neuromodulation community is outgrowing the artificial divide between two medical specialties rooted in centuries of history rather than created from logic…
After struggling with longstanding
#depression
for decades patients were symptom-free in five days. FIVE DAYS! The stories are incredibly inspiring. Learn more about a new study.
@NolanRyWilliams
@StanfordMed
The more rapid acting the treatment, the more one can reduce time for regression to the mean to happen allowing for greater differences between groups..
Incredibly, the placebo effect is (mostly) not real.
It is a result of statistical confusion. Whenever you have a group with extreme values, they tend to exhibit regression to the mean. Eg. on average, sick people tend to become more healthy over time.
Thus if you give one
Contract Supports Research into Personalized Treatments for Depression Check out Dr. Liston's contribution to the 2021 NPP Reviews issue:
@WeillCornell
@npp_journal
@shansiddiqi
@MarkLRuffalo
‘We must recollect that all of our provisional ideas in psychology will presumably one day be based on an organic substructure.’
Sigmund Freud, “On Narcissism”
Today concluded the Brainclinics Foundation TMS Masterclass and Certification course, I thoroughly enjoyed it and learned a lot.
Thanks a lot to all attendees for a great interaction and a special thanks to a great speaker line-up:
@NolanRyWilliams
Dirk de Ridder,
An enhanced form of non-invasive
#brain
stimulation called SNT generated "a large
#antidepressant
effect" that brought remission to 79% of treatment-resistant
#depression
patients within 4 weeks of a 5-day treatment course.
Excited to see this published in
@NatMentHealth
: Probing prefrontal-sgACC connectivity using TMS-induced heart–brain coupling (HBC)
Read the article here:
Here we validated TMS induced heart-brain coupling as an agile technique to probe DLPFC-sgACC
My Sabbatical
I am excited to share a personal and transformative decision I have made – I’m embarking on a sabbatical for an extended time. It is time to reinvent myself, explore new opportunities and gain fresh perspectives on the exciting field of interventional
NEW podcast episode is up!
The New Frontiers of Mental Health — Dr. Nolan Williams on Brain Stimulation, Ibogaine, Rapid-Acting Tools for Depression, Enhancing Sports Performance, and More
cc:
@NolanRyWilliams
Please enjoy! 🙌
Study staff will review your information to ensure that the study is appropriate for your given need
For more information on the initial study, you can view the full version published by
@APAPubJournals
#apa
#ajp
#saint
#depression
#study
who participated in the clinical trial. “It just works. The symptoms are gone. It’s just immediate relief,” said Sergio.
I’m happy to see that this story has such a wide reach. Anyone interested in participating in an outpatient study can go to our website and sign-up.
A remarkable story about new hope for people with treatment resistant depression and bipolar disorder via
@CBSSunday
. Congratulations
@NolanRyWilliams
and the SAINT team on this milestone.
Exciting profile of a treatment developed at
@StanfordMed
by One Mind Bipolar Research Awardee
@NolanRyWilliams
! Using repetitive transcranial magnetic stimulation, the team was able to provide relief from
#depression
in as little as 5 days.
Ruminating about TRD: In cancer, after first and second-line treatments fail, many/most people end up in a research protocol – and thus new interventions enter the clinic in oncology much more efficiently (in relative terms) than in psychiatry – see
At long last, new paper out in Brainstim!! A semi-provocative piece suggesting that spatial overlap between TMS eFields and fMRI alcohol cue reactivity may improve treatment outcomes in AUD!! A big thanks to
@brainstimgrl
for supporting this idea!!
Patients struggling with pain often seek out hypnosis when they've run out of options. But if you ask
@StanfordMed
's David Spiegel, a leading expert in clinical hypnosis, it should be a first -- not last -- resort
It has been a career highlight to film the work of
@NolanRyWilliams
and the Stanford University Brain Stimulation Lab as they conducted this research using Ibogaine to treat TBI and PTSD among Special Forces Veterans.
@ActualFilms
It has been a career highlight to film the work of
@NolanRyWilliams
and the Stanford University Brain Stimulation Lab as they conducted this research using Ibogaine to treat TBI and PTSD among Special Forces Veterans.
@ActualFilms
Rising Star Awardee Dr.
@NolanRyWilliams
discusses the results of his SAINT trial on
@CBSSunday
. 80% of the study's participants saw their severe
#depression
go into remission following experimental targeted magnetic stimulation. Learn more here:
“[Steve] had such a deep understanding and reverence for the creative process,” writes Sir Jony Ive on the 10th anniversary of Steve Jobs’s death. “He understood creating should be afforded rare respect.”
I'm honored to share that I have been selected as a recipient of one of the 2023 Society of Biological Psychiatry (
@SOBP
) Travel Fellowship Awards!
#MedTwitter
#PsychTwitter
Bryan Johnson sold his company to PayPal for $800 million in 2013.
Since then, he's been investing millions to reduce aging.
In 2021, he reduced his epigenetic age by 5.1 years in 7 months (World Record)
Here’s a breakdown of his “Blueprint” and my own experience with it: 🧵