Ever wonder why nature uses coenzymes and what role they might have played before enzymes had emerged?
Check out our mini-review
@ScienceAdvances
summarizing our recent work on the nonenzymatic reactivity of PL(P), NADH and ATP.
@QDherbassy
@RJ_Mayer
Exciting news! Our lab is moving to the
@uOttawaScience
Department of Chemistry & Biomolecular Sciences. We're looking for graduate students to join us starting May-September 2024. For more information, please email me.
📢 ERC Consolidator Grant results are out! 327 top researchers received
#ERCCoG
funding worth in total €655 million - to address frontier research questions, build up their teams & have far-reaching impact.
The full story ➡️
🇪🇺
#EUfunded
@GabrielMariya
Can stereochemistry be transferred in metabolism before enzymes? We show that metal ions allow the RNA-derived cofactor NADH to reduce keto acids stereoselectively, linking the worlds of metabolism and genetic molecules at the emergence of life.
Primary aliphatic alcohols (>C2) and electronically deactivated epoxides were off limits to dehydrative Friedel-Crafts reactions. No longer!
with
@djpleboeuf
, now open access in
@Chem_CP
Congrats
@ShaofeiZ
,
@MarieVayer
, & thanks to
@RowleyGroup
for DFT!
A first step towards uniting “genetics-first” and “metabolism-first” theories for life’s origins. The biosynthetic reactions that convert aspartate into orotate, the precursor to pyrimidine nucleobases, occur nonenzymatically in the presence of metals.
#prebiotic
#OoL
Hydrogen gas powers the metabolisms of many modern organisms and likely drove the metabolism of the last universal common ancestor to all life. Could H2 have driven prebiotic metabolism as well?
@SophiaRauscher
tried to find out, now in
@angew_chem
1/3
Our latest in
@sciencemagazine
: Rates and now selectivities can be altered by quantum effects by running a reaction between appropriately spaced mirrors. Congrats to
@LucasLethuillie
and our close collaborators in the Ebbesen group.
Transamination between biological keto and amino acids is typically mediated by enzymes, but metal ions can do it too. To understand how, we did a mechanistic deep dive, now out in
@J_A_C_S
. Congrats
@RJ_Mayer
, Harpreet &
@SophiaRauscher
!
On Friday, the lab celebrated its 10th anniversary. Several former group members from around Europe were able to attend the celebration and shared short presentations about their jobs and life since leaving the lab. A day to remember!
Very happy to become a Junior member of the
@InstUnivFr
for the next 5 years! Thanks to my group,
@unistra
,
@Fondation_FRC
and to those who wrote letters of support.
👏 L’Administrateur de l’IUF, Olivier Houdé, félicite les Lauréats Juniors et Seniors 2021, distingués pour leurs qualités scientifiques exceptionnelles et, parmi eux, les 14 premiers membres aux profils Innovation et Médiation.
La liste des lauréats :
Why does biology synthesize only one amino acid by reductive amination and not others? Is it inherent reactivity or evolution?
@RJ_Mayer
performed an in-depth mechanistic study to find out, now in
@angew_chem
. 1/5
Metabolic models for the origin of life predict NADH should reduce keto acids without enzymes. We found such reactivity is turned on by Fe(III) or Al(III) ions (again) and it's stereoselective! Full mechanistic study. Out in
@Chem_CP
. Congrats
@RJ_Mayer
!
Transamination between biological keto and amino acids is typically mediated by enzymes, but metal ions can do it too. To understand how, we did a mechanistic deep dive, now out in
@J_A_C_S
. Congrats
@RJ_Mayer
, Harpreet &
@SophiaRauscher
!
Ferrous iron reduces phosphate to phosphite at 140 C. Getting to phosphine with reduced metal/minerals at higher temperatures seems likely. Metals should be considered here, not just atmospheric photochemistry. My money's on the above, not life.
This is an issue for synthetic methodology at the moment. Simple solutions to problems don’t get sent to review. Solve the same or even a more mundane problem with a photoredox catalyst or transition metal, or better yet, both, and now it’s worthy.
If you carry out a reaction with only light, no longer cool enough. If you do the same with light+ $150/100 mg catalyst, it’s super impressive because it is “photocatalytic”: definition of BS.
Look what just arrived! For the synthetic organic chemist, the barrier to entry into biocatalysis, computational chemistry, DoE, HTE, electrochem, or computer assisted synthesis planning is often high. Not anymore! Thanks for putting this together,
@TheNewmanLab
!
Coenzymes are involved in a third of enzymatic reactions, but did they have a function before enzymes? We show that catalysis of transamination by the pyridoxal scaffold is greatly and specifically enhanced by Fe(III) or Al(III) ions. Out now in
@J_A_C_S
1/2
To reconstruct the origin of metabolism, conditions where multiple metabolic subnetworks can work together must be identified. Here, hydrogen gas drives nonenzymatic analogs of amino acid biosynthesis and the reverse Krebs cycle together in one pot without human intervention.
When I was a kid I used to peruse the pages of
@NatGeo
, and now our research topic is the subject of an article there. Thanks,
@m_c_marshall
! Check it out!
Danke to
@GDCh_aktuell
for selecting me for the 2022 Liebig Lectureship, to the kind German colleagues who nominated me, and to my awesome group for their hard work. Mentors are critical too, as evidenced by two in a row from
@KrischeLab
.
Congratulations to both Prof. Joseph Moran
@MoranLabUdS
and to Prof. John Bower
@Bower_Research
. These Krische group alumni are consecutive recipients of the Liebig Lectureship by the German Chemical Society
@GDCh_aktuell
!
This
@ACSChemRev
sets the stage for much upcoming work from our lab and hopefully will inspire others to work in this direction. Submitted just before we found out our lab would shut down for COVID-19. At 37 pages and 297 refs, my longest paper so far.
We re-examined boronic acid-catalyzed reactions involving alcohols and oximes and found that in most cases the boronic acid was likely a pre-catalyst to make a strong Brønsted acid or acted as an H-bond catalyst. Congrats,
@ShaofeiZ
!
@djpleboeuf
Valentyn
@gradcscunistra
and
@MarieVayer
's 1,2-aminoarylation paper is accepted. Congrats! Thanks for leading
@djpleboeuf
. Our fourth
@angew_chem
in 9 months - a record for the group. Time for vacation - just one referee report to submit first.
My return to Canada and
@uOttawa
wouldn't be possible without the support of a Tier 1 Canada Research Chair
@TIPS_SPIIE
and the John R. Evans Leaders Fund
@InnovationCA
. Thanks to both!
.
@uOttawa
continues its momentum with 8 new Canada Research Chairs! Each
#CRC
will examine a critical aspect of society, including the complexities of health care, the impact of climate change on wildlife distribution, and macroeconomic policy issues. ➡️
The backlog after a long visit to Canada,
#ACSBoston
and
@GECO_Congress
has been overwhelming, but I have some good news to share. Today was my first day as Professor at
@unistra
. Thanks to all group members and mentors past and present. Exciting times ahead!
My son took his first steps today at
@GECO_Congress
. Really glad I brought him there so I could witness it. Thanks to Raphael Rodriguez for filming.
#familytravel
Ligands of lower enantiopurity lead to higher %ee than the enantiopure ligand . A hyperpositive non-linear effect! New
@NatureCatalysis
paper from my
@unistra
colleague Stéphane Bellemin-Laponnaz
The value of graduate and postdoc scholarships in Canada has finally been updated for inflation. 27k for MSc, 40k for PhD, 70 k for postdoc. Good news!
La recherche a une place dans le budget 2024. Chap4pp.196-201 et autres:plusieurs des recommandations de notre
#BouchardReport
. Soulignons le geste majeur pour mieux soutenir nos étudiantes et étudiants,la relève en recherche dont nous avons tant besoin.
Thrilled to receive funding from
@volkswagenst
for our new collaboration "Forming catalysts: a basic principle of deep chemistry, life chemistry and life" with Prof. William F. Martin and Dr. Harun Tüysüz!
@christine_m_le
@Chemjobber
@cenmag
@TheNewPI
1) be selective in who you hire. Don’t just fill your lab with bodies. 2) go after the real projects that you really want to do from the start. Filler projects designed to get quick, easy papers suck up incredible amounts of energy and time, distracting you from your goals.
[📝Press Release]
#MakeOurPlanetGreatAgain
: 12 new high-level researchers will be joining French labs. The response to the climate crisis is being built in the research labs and by attracting the best researchers from all over the world as France stands amongst the world leaders
Back from the Bürgenstock conference🇨🇭 Speakers list only revealed when you arrive and you can only speak once in your career (unless radically different topic). Was JSP Fellow in 2014, speaker in 2023, and participant in 2024. Amazing science and colleagues.
#SCS_BC2024
In this paper, we describe an enzyme-free reaction network that harnesses chemical energy from the breakdown of metabolites by forming thioesters. De Duve’s “Thioester World” may indeed be a reality!
#prebioticchemistry
Energy Conservation via Thioesters in a Non-Enzymatic Metabolism-like Reaction Network by Elodie Chevallot-Beroux, Jan Gorges, Joseph Moran (
@MoranLabUdS
)
Good news: An excellent future PhD student and an excellent future postdoc have both secured external funding to join our lab. Another grant submitted. The bad news: Sick! Trying to cure myself fast before heading to Rennes tomorrow to visit
@YTrolez
and colleagues!
Focus on quality, not quantity. Encourage year-long sabbaticals. Grants should fund riskier, long-term projects or fund careers rather than projects. Give "scholars the gift of time".
Here's the 2 hour update. Looks like teflon on the outside is worse than useless, though not much worse than nothing at all. Teflon on the inside is fading too, Parafilm is doing something to help, but electrical tape is the clear winner.
What's better than getting an author profile in
@angew_chem
? When a group member gets one! Congrats and well deserved
@RJ_Mayer
. Outstanding and on the academic job market, folks!
Today was my first time giving a departmental seminar in my hometown of Montréal. Thanks to André Charette and Shawn Collins for the invite
@chimie_UdeM
. Hopefully the next time will be in person.
@SophiaRauscher
found that catalytic amounts of transition metals allow hydrogen to drive a key sequence of the reverse Krebs cycle under mild aqueous non-enzymatic conditions. She also tested three Fe meteorites and all three catalyzed the reaction under H2. Yes, METEORITES! 2/3
Martin Karplus once offered to sell me his car, an old grey Peugeot that hadn't been driven in so long that the tires were totally flat. After discussing it with my wife, we decided to decline. He won the Nobel Prize a few months later. I could have had the "Karplus car"!
Happy Holidays! This year's party was a tad bittersweet. Our last in Strasbourg, with all but 5 leaving within one year's time. 2024 will see
@RJ_Mayer
off to
@TU_Muenchen
and
@djpleboeuf
off to
@LIMA_UMR7042
to start their own labs, the others to jobs/PhDs/postdocs. 1/2
Must show off what I received in our holiday gift exchange. A metabolic advent calendar made by
@MullerCyprien
, who doesn't even work on prebiotic chemistry. Each box had a homemade cookie inside. Amazing creativity!
Had a great time at the 5th ERC Grantees Conference in Edinburgh! Fantastic organization and speaker selection by Scott Cockroft and
@OScherman
. Our very own
@MullerCyprien
gave a poster on his recent
@ChemicalScience
paper. And the view during the walk to dinner....
I could not have pursued my research goals in France without the ERC StG and, soon to start, the CoG. Thank you,
@ERC_Research
! Very proud to be (twice) one of the
#ERC10kGrantees
Today we celebrate not only the 10,000th grantee, but also all scientists and scholars funded by the ERC over the years. 🎉 We are so proud of their contributions to research!
As we can't describe them all today, don't hesitate to share your own
#ERC10kGrantees
success story!
For future "metal-free" papers, that describe a reaction previously known to be catalyzed by a metal, what evidence should be presented before the claim should be taken seriously? Should the required evidence be greater for some metals/reactions than others?
One of the many highlights of the Phys Org
#GRC
for me was having
@RJ_Mayer
@unistra
selected for the top 8 posters and nailing the associated talk on short notice.
#Holderness
Watch out, academia!
Co-wrote a proposal for a review in a prominent review journal in May 2020. Proposal sent to review and deemed "not suitable" by both reviewers. Rejected. Today, we both receive requests from same editor to evaluate a review (not a proposal) on exactly the thing we proposed.
I should note that the first two authors on this paper are both Masters students (in Europe, they are considered undergrads)! Not buried in the middle. First time this happens in our lab. Congrats!
Valentyn Pozhydaiev and Martin Power published a Feature Article in
@ChemCommun
with
@MoranLabUdS
and
@djpleboeuf
on the solvent HFIP in specific types of catalysis. Written during their M1 and M2 internships, respectively, under lockdown.
There are fast-growing organisms living deep underground, and running their metabolisms off of highly reduced (metallic iron) or highly oxidized (MnO2) minerals. We still have a lot to learn about life itself before solving the origin of life.
Scientists of Twitter! The world needs more reminders that we're living, breathing human beings.
Quote tweet this with a picture of you doing not-science
Scientists of Twitter! The world needs more reminders that we're living, breathing human beings.
Quote tweet this with a picture of you doing not-science
The kind organizers of the 2019 Aulin-Erdtman Young Investigator Symposium at KTH Stockholm have arranged for
@LeonoriLab
@monicahperez
@CornellaLab
@MarchesanLab
and I to attend this year's Nobel lectures in Physics and Chemistry. Cool!!
The timing of this
@angew_chem
editorial is especially terrible. Was looking forward to Power Hour at my first GRC (hard to believe) this summer before it got cancelled.
Hey
#ChemTwitter
,
Now is your time to put your money where your mouth is, I want to know how many established white male professors will publically denounce the latest pathetic excuse for an opinion by Tomáš Hudlický published in
@angew_chem
.
President Macron reelected…
Much more than relief - a historic opportunity to profoundly reform the European Union’s defence, health, energy, democracy… as outlined in the radical proposals of the Conference on the Future of Europe !
🇫🇷🇪🇺
Are you a physical organic chemist or electrochemist interested in uncovering the origins of life? Three days left to apply for this ERC-funded postdoc position in Strasbourg!
Nearly everyone in my family and lab is now vaccinated, and cafés are opening up in France. Still, I just learned that one of my friends from grad school, who later became a fitness instructor, has passed from COVID. We're not out of this yet, folks.
📢Mark your calendars for the next EurJOC Virtual Symposium on Dec 15, 2020!
We look forward to two great presentations by
@tatifernandezi
and
@MoranLabUdS
and an interactive "Meet the Chemists" session moderated by
@ChemistryKoenig
.
👉Register here:
Learned some fascinating insights about non-equilibrium processes from
@giuliosflask
, origins of life research by
@MoranLabUdS
, multicatalytic systems of
@DydioLab
, and lots of other things yesterday in Strasbourg
@unistra
#ISIS
. Thank you!